The efficiency of organic semiconductor photocatalysts is typically limited by their capability of photogenerated electron transport.Herein,a photocatalyst is proposed initially through the specific axial coordination...The efficiency of organic semiconductor photocatalysts is typically limited by their capability of photogenerated electron transport.Herein,a photocatalyst is proposed initially through the specific axial coordination interaction between imidazole-C_(60)(ImC_(60))and zinc tetraphenyl porphyrin(ZnTPP)named ImC_(60)-ZnTPP.Subsequently,detailed structural characterizations along with theoretical calculation reveal that the unique ImC_(60)-ZnTPP possesses head-to-tail stacking supra-structures,leading to the formation of a continuous array of C_(60)–C_(60) with ultrashort spacing and ensuring strongπ–πinteractions and homogeneous electronic coupling,which could tremendously promote electron transport along the(−111)crystal facet of ImC_(60)-ZnTPP.Consequently,compared to other fullerene-based photocatalysts,ImC_(60)-ZnTPP shows exceptional photocatalytic hydrogen production activity,with an efficiency of up to 80.95 mmol g^(-1) h^(-1).This study provides a novel strategy to design highly efficient fullerene-based photocatalytic systems for solar-driven energy conversion and extend their artificial photosynthetic use.展开更多
Unstable electrode/electrolyte interfaces and heterogeneous Zn deposition would reduce the Coulombic efficiency and cycle life of Zn metal batteries(ZMBs). Applying water-in-salt(WIS) electrolytes has proven to be an ...Unstable electrode/electrolyte interfaces and heterogeneous Zn deposition would reduce the Coulombic efficiency and cycle life of Zn metal batteries(ZMBs). Applying water-in-salt(WIS) electrolytes has proven to be an effective strategy to address the above issues. However, an understanding of the reaction mechanisms on the Zn anode at nanoscale is still elusive. Here we utilize in situ atomic force microscopy to visualize the solid electrolyte interphase(SEI) formation and Zn deposition/dissolution processes in WIS electrolyte and construct relationships between interfacial behavior and electrochemical performance. The formation processes, chemical properties, and structure of the on-site formed SEI are deeply explored.The SEI with a “plum-pudding” model can guide uniform Zn deposition and reversible dissolution. Mechanistic understanding of the interfacial evolution of the SEI layer and Zn deposition/dissolution has been achieved and will benefit the structural optimization and interfacial engineering of ZMBs.展开更多
Zn metal batteries are highly attractive because of their high theoretical specific capacity,intrinsic safety and resource availability.However,further development is significantly hindered by low Coulomb efficiency,w...Zn metal batteries are highly attractive because of their high theoretical specific capacity,intrinsic safety and resource availability.However,further development is significantly hindered by low Coulomb efficiency,which is closely linked to reaction processes occurring at electrode/electrolyte interfaces.Herein,we have achieved a real-time visualization and comprehensive analysis of the interfacial evolution of Zn metal anode via in situ AFM in organic and aqueous electrolytes,respectively.The processes of uneven nucleation,dendrite growth,the Zn O formation and the dissolution of Zn substrate are directly probed in aqueous electrolyte,which induces interfacial deterioration and ultimately results in battery failure.In organic electrolyte,the in situ observations show that the homogeneous nuclei form on the Zn surface to induce the dendrite-free deposition,however,exhibiting poor Zn plating/stripping reversibility.This work delves into the dynamic evolution and electrochemical behaviors regulated by solvents,which provides in-depth understanding of structure-reactivity correlations and further interfacial engineering.展开更多
The performance of lithium metal batteries(LMBs)is greatly hampered by the unstable solid electrolyte interphase(SEI)and uncontrollable growth of Li dendrites.To address this question,we developed a weak polar additiv...The performance of lithium metal batteries(LMBs)is greatly hampered by the unstable solid electrolyte interphase(SEI)and uncontrollable growth of Li dendrites.To address this question,we developed a weak polar additive strategy to develop stable and dendrite-free electrolyte for LMBs.In this paper,the effects of additives on the Li^(+)solvation kinetics and the electrode-electrolyte interphases(EEI)formation are discussed.The function of synergistically boosting the superior Li^(+)kinetics and alleviating solvent decomposition on the electrodes is confirmed.From the thermodynamic view,the exothermic process of defluorination reaction for 3,5-difluoropyridine(3,5-DFPy)results in the formation of LiF-rich SEI layer for promoting the uniform Li nucleation and deposition.From the dynamic view,the weakened Li^(+)solvation structure induced by weak polar 3,5-DFPy contributes to better Li^(+)kinetics through the easier Li^(+)desolvation.As expected,Li||Li cell with 1.0 wt%3,5-DFPy exhibits 400 cycles at 1.0 mA cm^(-2)with a deposition capacity of 0.5 mAh cm^(-2),and the Li||LiNi_(0.6)Mn_(0.2)Co_(0.2)O_(2)batteries delivers the highly reversible capacity after 200 cycles.展开更多
In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in cables.The cable life and the reliability are predicted by estimating the accumulated electro-thermal degrada...In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in cables.The cable life and the reliability are predicted by estimating the accumulated electro-thermal degradation during seasonal load cycles.The degradation is considered,in a novel approach,as stochastic in nature due to variations in the manufacturing process of insulation raw material and in operational and environmental conditions.The methodology is based on estimation of life by using combined electro-thermal life model,simulation of degradation accumulation process under electro-thermal stress in each season of the year based on Miner’s cumulative damage theory and reliability prediction from a probabilistic point of view.A case study is demonstrated on 10 k V XLPE cables which are directly buried in the UK and China.Results show that,the electro-thermal life of the cable is 56 and 69 years in China and the UK,respectively at 50%failure probability,or the life of the cable in the UK would be 13 years longer than in China,when other stresses such as mechanical and environmental are also considered and assumed to be the same.展开更多
Lithium (Li) metal is a promising anode for the next generation high-energy–density batteries. However, the growth of Li dendrites, low coulombic efficiency and dramatic volume change limit its development. Here, we ...Lithium (Li) metal is a promising anode for the next generation high-energy–density batteries. However, the growth of Li dendrites, low coulombic efficiency and dramatic volume change limit its development. Here, we report a new synthetic poly-dioxolane (PDOL) approach to constructing an artificial 'elastic' SEI to stabilize the Li/electrolyte interface and the Li deposition/dissolution behavior in a variety of electrolytes. By coating PDOL with optimized molecular weights and synthetic routes on Li metal anode, the 'elastic' SEI layer could be maintained on top of the Li metal anode to accommodate the Li deposition/dissolution. No dendrite formation was observed during the cycling process, and the interfacial side reactions were reduced significantly. Consequently, we successfully achieved 330 cycles with a CE of 98.4% in ether electrolytes and 90 cycles with a CE of 94.3% in carbonate electrolytes. Simultaneously, the Li-metal batteries with LiFePO_(4) as cathodes also exhibited improved cycling performance. This strategy could promote the development of dendrite-free metal anodes toward high-performance Li-metal batteries.展开更多
Gel polymer electrolytes(GPEs)are one of the promising candidates for high-energy-density quasi-solid-state lithium metal batteries(QSSLMBs),for their high ionic conductivity and excellent interfacial compatibility.Th...Gel polymer electrolytes(GPEs)are one of the promising candidates for high-energy-density quasi-solid-state lithium metal batteries(QSSLMBs),for their high ionic conductivity and excellent interfacial compatibility.The comprehension of dynamic evolution and structure-reactivity correlation at the GPE/Li interface becomes significant.Here,in situ electrochemical atomic force microscopy(EC-AFM)provides insights into the LiNO_(3)-regulated micromechanism of the Li plating/stripping processes upon cycles in GPE-based LMBs at nanoscale.The additive LiNO_(3)induces the formation of amorphous nitride SEI film and facilitates Li^(+) ion diffusion.It stabilizes a compatible interface and regulates the Li nucleation/growth at steady kinetics.The deposited Li is in the shape of chunks and tightly compact.The Li dissolution shows favorable reversibility,which guarantees the cycling performance of LMBs.In situ AFM monitoring provides a deep understanding into the dynamic evolution of Li deposition/dissolution and the interphasial properties of tunable SEI film,regulating the rational design of electrolyte and optimizing interfacial establishment for GPE-based QSSLMBs.展开更多
The solid electrolyte interphase(SEI),a passivation film covering the electrode surface,is crucial to the lifetime and efficiency of the lithium-ion(Li-ion)battery.Understanding the Li-ion diffusion mechanism within p...The solid electrolyte interphase(SEI),a passivation film covering the electrode surface,is crucial to the lifetime and efficiency of the lithium-ion(Li-ion)battery.Understanding the Li-ion diffusion mechanism within possible components in the mosaic-structured SEI is an essential step to improve the Li-ion conductivity and thus the battery performance.Here,we investigate the Li-ion diffusion mechanism within three amorphous SEI components(i.e.,the inorganic inner layer,organic outer layer,and their mixture with 1:1 molar ratio)via ab initio molecular dynamic(AIMD)simulations.Our simulations show that the Li-ion diffusion coefficient in the inorganic layer is two orders of magnitude faster than that in the organic layer.Therefore,the inorganic layer makes a major contribution to the Li-ion diffusion.Furthermore,we find that the Li-ion diffusivity in the organic layer decreases slightly with the increase of the carbon chain from the methyl to ethyl owing to the steric hindrance induced by large groups.Overall,our current work unravels the Li-ion diffusion mechanism,and provides an atomic-scale insight for the understanding of the Li-ion transport in the SEI components.展开更多
BACKGROUND Ferroptosis has recently been associated with multiple degenerative diseases.Ferroptosis induction in cancer cells is a feasible method for treating neoplastic diseases.However,the association of iron proli...BACKGROUND Ferroptosis has recently been associated with multiple degenerative diseases.Ferroptosis induction in cancer cells is a feasible method for treating neoplastic diseases.However,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is unclear.AIM To identify and evaluate fresh ferroptosis-related biomarkers for HER2+BC.METHODS First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC cohort.Patients were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk groupings.Additionally,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk score.Finally,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial cells.RESULTS We found that the higher the risk score was,the worse the prognosis was(P<0.05).We also found that the immune cell infiltration,mutation,and drug sensitivity were different between the different risk groups.The highrisk subgroup was associated with lower immune scores and high TMB.Moreover,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct prognoses.HRisk-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(P<0.0001).Analysis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer patients,and its combination with the TMB can aid in more accurate assessment of patient prognosis and provide new ideas for further diagnosis and treatment.展开更多
Convolution Neural Networks(CNN)can quickly diagnose COVID-19 patients by analyzing computed tomography(CT)images of the lung,thereby effectively preventing the spread of COVID-19.However,the existing CNN-based COVID-...Convolution Neural Networks(CNN)can quickly diagnose COVID-19 patients by analyzing computed tomography(CT)images of the lung,thereby effectively preventing the spread of COVID-19.However,the existing CNN-based COVID-19 diagnosis models do consider the problem that the lung images of COVID-19 patients in the early stage and incubation period are extremely similar to those of the non-COVID-19 population.Which reduces the model’s classification sensitivity,resulting in a higher probability of the model misdiagnosing COVID-19 patients as non-COVID-19 people.To solve the problem,this paper first attempts to apply triplet loss and center loss to the field of COVID-19 image classification,combining softmax loss to design a jointly supervised metric loss function COVID Triplet-Center Loss(COVID-TCL).Triplet loss can increase inter-class discreteness,and center loss can improve intra-class compactness.Therefore,COVID-TCL can help the CNN-based model to extract more discriminative features and strengthen the diagnostic capacity of COVID-19 patients in the early stage and incubation period.Meanwhile,we use the extreme gradient boosting(XGBoost)as a classifier to design a COVID-19 images classification model of CNN-XGBoost architecture,to further improve the CNN-based model’s classification effect and operation efficiency.The experiment shows that the classification accuracy of the model proposed in this paper is 97.41%,and the sensitivity is 97.61%,which is higher than the other 7 reference models.The COVID-TCL can effectively improve the classification sensitivity of the CNN-based model,the CNN-XGBoost architecture can further improve the CNN-based model’s classification effect.展开更多
BACKGROUND Benign lymphoepithelial cyst(BLEC)of the parotid gland is a rare benign embryonic-dysplastic cystic tumor in the anterolateral neck that occurs most commonly in human immunodeficiency virus(HIV)-positive ad...BACKGROUND Benign lymphoepithelial cyst(BLEC)of the parotid gland is a rare benign embryonic-dysplastic cystic tumor in the anterolateral neck that occurs most commonly in human immunodeficiency virus(HIV)-positive adults and rarely in non-acquired immune deficiency syndrome patients.The main presentation is a slow-growing,painless mass,and secondary infection may cause acute inflammatory symptoms.CASE SUMMARY A 44-year-old Chinese male patient presented with a 1-year history of a mass in the left side of the neck.On physical examination,a mass similar in size and shape to a quail egg was found in the left parotid gland.The mass was tough,without tenderness,and easily moveable.The results of HIV tests,including antibody and nucleic acid tests and CD4+T cell examination,were negative.Imaging examination revealed a left parotid gland mass.The patient underwent surgical treatment,and BLEC was diagnosed based on postoperative pathology.After 2years of follow-up,the patient survived well without related discomfort.CONCLUSION The detailed characteristics of a BLEC in a patient without HIV infection contribute to an improved understanding of this rare disease.展开更多
Objective:To prepare folate liposome complexes of recombinant plasmid pEGFP/SDF-1/KDEL wich contained intrakine SDF-1/KDEL gene and to observe its targeting for breast cancer cells.Methods:Reverse phase evaporation me...Objective:To prepare folate liposome complexes of recombinant plasmid pEGFP/SDF-1/KDEL wich contained intrakine SDF-1/KDEL gene and to observe its targeting for breast cancer cells.Methods:Reverse phase evaporation method was employed for preparing folate-liposome complexeses of pEGFP/SDF-1/KDEL,so that preparation condition was optimized;and fluorometric method was taken for testing encapsulation efficiency.Particle diameter of liposome was tested by transmission electron microscopy.Complexeses encapsulated with 0.05-0.25 mg/ml calcein were got and incubated with breast cancer cell line MDA-MB-231 cells for 2 to 12 h,then dissolved them with dimethyl sulfoxide,then detected absorbance with microplate reader.Results:The optimized encapsulation condition are as follows:molecular ratio of lecithin and cholesterol was 3:1,rotary speed was 150 r/min under temperature of 43℃,and encapsulation efficiency reached 81%in this experiment.Average liposome particle diameter was 210 nm;8 h after incubation, the intake of MDA-MB-231 cells to 0.25 mg/ml compounds achieved saturation. Conclusion:The pEGFP/SDF-1/KDEL folic acid liposome complexes prepared has a high encapsulating rate,liposome particle diameters are homogeneous,which is available for targeting for breast cancer cells in vitro.展开更多
In recent years,with the rise of video media such as YouTube and Tik Tok,the short video creation industry has emerged.How to spread China's excellent culture and how to“tell a good Chinese story”have become a h...In recent years,with the rise of video media such as YouTube and Tik Tok,the short video creation industry has emerged.How to spread China's excellent culture and how to“tell a good Chinese story”have become a hot concern.Using the 5W Model of Communication as a framework for analysis,this paper selects Chinese short videos with high popularity on YouTube as the object of the study.Studies found that the success of these videos was associated with five factors in the process of communication,which are communication main forces,communication content,communication channels,communication audience,and audience effects.Through theoretical and data analysis,the study concluded five strategies in video production to help promote Intercultural communication.展开更多
In this study,we investigated the impact of rotation on the thermodynamic properties of QCD matter using the three-flavor NJL model.We examined the dependencies of key thermodynamic quantities,such as the trace anomal...In this study,we investigated the impact of rotation on the thermodynamic properties of QCD matter using the three-flavor NJL model.We examined the dependencies of key thermodynamic quantities,such as the trace anomaly,specific heat,speed of sound,angular momentum,and moment of inertia,on temperature,quark chemical potential,and angular velocity.Our main finding is that the speed of sound exhibits a nonmonotonic behavior as the angular velocity varies.展开更多
基金supported by the National Natural Science Foundation of China(52322204,52072374,52272052)the National Key R&D Program of China(Grant No.2022YFA1205900)the Youth Innovation Promotion Association of CAS(Y2022015).
文摘The efficiency of organic semiconductor photocatalysts is typically limited by their capability of photogenerated electron transport.Herein,a photocatalyst is proposed initially through the specific axial coordination interaction between imidazole-C_(60)(ImC_(60))and zinc tetraphenyl porphyrin(ZnTPP)named ImC_(60)-ZnTPP.Subsequently,detailed structural characterizations along with theoretical calculation reveal that the unique ImC_(60)-ZnTPP possesses head-to-tail stacking supra-structures,leading to the formation of a continuous array of C_(60)–C_(60) with ultrashort spacing and ensuring strongπ–πinteractions and homogeneous electronic coupling,which could tremendously promote electron transport along the(−111)crystal facet of ImC_(60)-ZnTPP.Consequently,compared to other fullerene-based photocatalysts,ImC_(60)-ZnTPP shows exceptional photocatalytic hydrogen production activity,with an efficiency of up to 80.95 mmol g^(-1) h^(-1).This study provides a novel strategy to design highly efficient fullerene-based photocatalytic systems for solar-driven energy conversion and extend their artificial photosynthetic use.
基金financially supported by the National Key R&D Program of China (No. 2021YFB2500300)the CAS Project for Young Scientists in Basic Research (No. YSBR-058)+1 种基金the National Science Foundation of China (No. 22205241)the National Postdoctoral Program for Innovative Talents (No. BX20220306) of the Chinese Postdoctoral Science Foundation。
文摘Unstable electrode/electrolyte interfaces and heterogeneous Zn deposition would reduce the Coulombic efficiency and cycle life of Zn metal batteries(ZMBs). Applying water-in-salt(WIS) electrolytes has proven to be an effective strategy to address the above issues. However, an understanding of the reaction mechanisms on the Zn anode at nanoscale is still elusive. Here we utilize in situ atomic force microscopy to visualize the solid electrolyte interphase(SEI) formation and Zn deposition/dissolution processes in WIS electrolyte and construct relationships between interfacial behavior and electrochemical performance. The formation processes, chemical properties, and structure of the on-site formed SEI are deeply explored.The SEI with a “plum-pudding” model can guide uniform Zn deposition and reversible dissolution. Mechanistic understanding of the interfacial evolution of the SEI layer and Zn deposition/dissolution has been achieved and will benefit the structural optimization and interfacial engineering of ZMBs.
基金financially supported by the CAS Project for Young Scientists in Basic Research(No.YSBR-058)the National Key R&D Program of China(No.2021YFB2500300)+1 种基金the National Natural Science Foundation of China(Nos.92372125,22205241)the National Postdoctoral Program for Innovative Talents(No.BX20220306)of the Chinese Postdoctoral Science Foundation。
文摘Zn metal batteries are highly attractive because of their high theoretical specific capacity,intrinsic safety and resource availability.However,further development is significantly hindered by low Coulomb efficiency,which is closely linked to reaction processes occurring at electrode/electrolyte interfaces.Herein,we have achieved a real-time visualization and comprehensive analysis of the interfacial evolution of Zn metal anode via in situ AFM in organic and aqueous electrolytes,respectively.The processes of uneven nucleation,dendrite growth,the Zn O formation and the dissolution of Zn substrate are directly probed in aqueous electrolyte,which induces interfacial deterioration and ultimately results in battery failure.In organic electrolyte,the in situ observations show that the homogeneous nuclei form on the Zn surface to induce the dendrite-free deposition,however,exhibiting poor Zn plating/stripping reversibility.This work delves into the dynamic evolution and electrochemical behaviors regulated by solvents,which provides in-depth understanding of structure-reactivity correlations and further interfacial engineering.
基金supported by the National Natural Science Foundation of China(U21A20311)Researchers Supporting Project Number(RSP2025R304),King Saud University,Riyadh,Saudi Arabia。
文摘The performance of lithium metal batteries(LMBs)is greatly hampered by the unstable solid electrolyte interphase(SEI)and uncontrollable growth of Li dendrites.To address this question,we developed a weak polar additive strategy to develop stable and dendrite-free electrolyte for LMBs.In this paper,the effects of additives on the Li^(+)solvation kinetics and the electrode-electrolyte interphases(EEI)formation are discussed.The function of synergistically boosting the superior Li^(+)kinetics and alleviating solvent decomposition on the electrodes is confirmed.From the thermodynamic view,the exothermic process of defluorination reaction for 3,5-difluoropyridine(3,5-DFPy)results in the formation of LiF-rich SEI layer for promoting the uniform Li nucleation and deposition.From the dynamic view,the weakened Li^(+)solvation structure induced by weak polar 3,5-DFPy contributes to better Li^(+)kinetics through the easier Li^(+)desolvation.As expected,Li||Li cell with 1.0 wt%3,5-DFPy exhibits 400 cycles at 1.0 mA cm^(-2)with a deposition capacity of 0.5 mAh cm^(-2),and the Li||LiNi_(0.6)Mn_(0.2)Co_(0.2)O_(2)batteries delivers the highly reversible capacity after 200 cycles.
文摘In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in cables.The cable life and the reliability are predicted by estimating the accumulated electro-thermal degradation during seasonal load cycles.The degradation is considered,in a novel approach,as stochastic in nature due to variations in the manufacturing process of insulation raw material and in operational and environmental conditions.The methodology is based on estimation of life by using combined electro-thermal life model,simulation of degradation accumulation process under electro-thermal stress in each season of the year based on Miner’s cumulative damage theory and reliability prediction from a probabilistic point of view.A case study is demonstrated on 10 k V XLPE cables which are directly buried in the UK and China.Results show that,the electro-thermal life of the cable is 56 and 69 years in China and the UK,respectively at 50%failure probability,or the life of the cable in the UK would be 13 years longer than in China,when other stresses such as mechanical and environmental are also considered and assumed to be the same.
基金This research was supported financially by the Major Program of the National Natural Science Foundation of China(21890731).
文摘Lithium (Li) metal is a promising anode for the next generation high-energy–density batteries. However, the growth of Li dendrites, low coulombic efficiency and dramatic volume change limit its development. Here, we report a new synthetic poly-dioxolane (PDOL) approach to constructing an artificial 'elastic' SEI to stabilize the Li/electrolyte interface and the Li deposition/dissolution behavior in a variety of electrolytes. By coating PDOL with optimized molecular weights and synthetic routes on Li metal anode, the 'elastic' SEI layer could be maintained on top of the Li metal anode to accommodate the Li deposition/dissolution. No dendrite formation was observed during the cycling process, and the interfacial side reactions were reduced significantly. Consequently, we successfully achieved 330 cycles with a CE of 98.4% in ether electrolytes and 90 cycles with a CE of 94.3% in carbonate electrolytes. Simultaneously, the Li-metal batteries with LiFePO_(4) as cathodes also exhibited improved cycling performance. This strategy could promote the development of dendrite-free metal anodes toward high-performance Li-metal batteries.
基金financially supported by the National Key R&D Program of China(Grant No.2016YFA0202500)the National Natural Science Fund for Excellent Young Scholars(Grant No.21722508)。
文摘Gel polymer electrolytes(GPEs)are one of the promising candidates for high-energy-density quasi-solid-state lithium metal batteries(QSSLMBs),for their high ionic conductivity and excellent interfacial compatibility.The comprehension of dynamic evolution and structure-reactivity correlation at the GPE/Li interface becomes significant.Here,in situ electrochemical atomic force microscopy(EC-AFM)provides insights into the LiNO_(3)-regulated micromechanism of the Li plating/stripping processes upon cycles in GPE-based LMBs at nanoscale.The additive LiNO_(3)induces the formation of amorphous nitride SEI film and facilitates Li^(+) ion diffusion.It stabilizes a compatible interface and regulates the Li nucleation/growth at steady kinetics.The deposited Li is in the shape of chunks and tightly compact.The Li dissolution shows favorable reversibility,which guarantees the cycling performance of LMBs.In situ AFM monitoring provides a deep understanding into the dynamic evolution of Li deposition/dissolution and the interphasial properties of tunable SEI film,regulating the rational design of electrolyte and optimizing interfacial establishment for GPE-based QSSLMBs.
基金R.Wen acknowledges the financial support from the National Key R&D Program of China(No.2021YFB2500300)the CAS Project for Young Scientists in Basic Research(No.YSBR-058)+2 种基金S.Xu acknowledges funding support from the Chinese Ministry of Science and Technology(No.2021YFB3800303)DP Technology Corporation(No.2021110016001141)the School of Materials Science and Engineering at Peking University.
文摘The solid electrolyte interphase(SEI),a passivation film covering the electrode surface,is crucial to the lifetime and efficiency of the lithium-ion(Li-ion)battery.Understanding the Li-ion diffusion mechanism within possible components in the mosaic-structured SEI is an essential step to improve the Li-ion conductivity and thus the battery performance.Here,we investigate the Li-ion diffusion mechanism within three amorphous SEI components(i.e.,the inorganic inner layer,organic outer layer,and their mixture with 1:1 molar ratio)via ab initio molecular dynamic(AIMD)simulations.Our simulations show that the Li-ion diffusion coefficient in the inorganic layer is two orders of magnitude faster than that in the organic layer.Therefore,the inorganic layer makes a major contribution to the Li-ion diffusion.Furthermore,we find that the Li-ion diffusivity in the organic layer decreases slightly with the increase of the carbon chain from the methyl to ethyl owing to the steric hindrance induced by large groups.Overall,our current work unravels the Li-ion diffusion mechanism,and provides an atomic-scale insight for the understanding of the Li-ion transport in the SEI components.
基金The Science and Technology Commission of Shanxi province,No.201901D111428.
文摘BACKGROUND Ferroptosis has recently been associated with multiple degenerative diseases.Ferroptosis induction in cancer cells is a feasible method for treating neoplastic diseases.However,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is unclear.AIM To identify and evaluate fresh ferroptosis-related biomarkers for HER2+BC.METHODS First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC cohort.Patients were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk groupings.Additionally,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk score.Finally,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial cells.RESULTS We found that the higher the risk score was,the worse the prognosis was(P<0.05).We also found that the immune cell infiltration,mutation,and drug sensitivity were different between the different risk groups.The highrisk subgroup was associated with lower immune scores and high TMB.Moreover,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct prognoses.HRisk-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(P<0.0001).Analysis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer patients,and its combination with the TMB can aid in more accurate assessment of patient prognosis and provide new ideas for further diagnosis and treatment.
基金This work was supported,in part,by the Natural Science Foundation of Jiangsu Province under Grant Numbers BK20201136,BK20191401in part,by the National Nature Science Foundation of China under Grant Numbers 62272236,61502096,61304205,61773219,61502240in part,by the Public Welfare Fund Project of Zhejiang Province Grant Numbers LGG20E050001.
文摘Convolution Neural Networks(CNN)can quickly diagnose COVID-19 patients by analyzing computed tomography(CT)images of the lung,thereby effectively preventing the spread of COVID-19.However,the existing CNN-based COVID-19 diagnosis models do consider the problem that the lung images of COVID-19 patients in the early stage and incubation period are extremely similar to those of the non-COVID-19 population.Which reduces the model’s classification sensitivity,resulting in a higher probability of the model misdiagnosing COVID-19 patients as non-COVID-19 people.To solve the problem,this paper first attempts to apply triplet loss and center loss to the field of COVID-19 image classification,combining softmax loss to design a jointly supervised metric loss function COVID Triplet-Center Loss(COVID-TCL).Triplet loss can increase inter-class discreteness,and center loss can improve intra-class compactness.Therefore,COVID-TCL can help the CNN-based model to extract more discriminative features and strengthen the diagnostic capacity of COVID-19 patients in the early stage and incubation period.Meanwhile,we use the extreme gradient boosting(XGBoost)as a classifier to design a COVID-19 images classification model of CNN-XGBoost architecture,to further improve the CNN-based model’s classification effect and operation efficiency.The experiment shows that the classification accuracy of the model proposed in this paper is 97.41%,and the sensitivity is 97.61%,which is higher than the other 7 reference models.The COVID-TCL can effectively improve the classification sensitivity of the CNN-based model,the CNN-XGBoost architecture can further improve the CNN-based model’s classification effect.
基金Supported by Zunyi Medical College Research Start Fund,No.2017CK-1130-038。
文摘BACKGROUND Benign lymphoepithelial cyst(BLEC)of the parotid gland is a rare benign embryonic-dysplastic cystic tumor in the anterolateral neck that occurs most commonly in human immunodeficiency virus(HIV)-positive adults and rarely in non-acquired immune deficiency syndrome patients.The main presentation is a slow-growing,painless mass,and secondary infection may cause acute inflammatory symptoms.CASE SUMMARY A 44-year-old Chinese male patient presented with a 1-year history of a mass in the left side of the neck.On physical examination,a mass similar in size and shape to a quail egg was found in the left parotid gland.The mass was tough,without tenderness,and easily moveable.The results of HIV tests,including antibody and nucleic acid tests and CD4+T cell examination,were negative.Imaging examination revealed a left parotid gland mass.The patient underwent surgical treatment,and BLEC was diagnosed based on postoperative pathology.After 2years of follow-up,the patient survived well without related discomfort.CONCLUSION The detailed characteristics of a BLEC in a patient without HIV infection contribute to an improved understanding of this rare disease.
基金National Natural Science Foundation of Chinagrant number:30572209
文摘Objective:To prepare folate liposome complexes of recombinant plasmid pEGFP/SDF-1/KDEL wich contained intrakine SDF-1/KDEL gene and to observe its targeting for breast cancer cells.Methods:Reverse phase evaporation method was employed for preparing folate-liposome complexeses of pEGFP/SDF-1/KDEL,so that preparation condition was optimized;and fluorometric method was taken for testing encapsulation efficiency.Particle diameter of liposome was tested by transmission electron microscopy.Complexeses encapsulated with 0.05-0.25 mg/ml calcein were got and incubated with breast cancer cell line MDA-MB-231 cells for 2 to 12 h,then dissolved them with dimethyl sulfoxide,then detected absorbance with microplate reader.Results:The optimized encapsulation condition are as follows:molecular ratio of lecithin and cholesterol was 3:1,rotary speed was 150 r/min under temperature of 43℃,and encapsulation efficiency reached 81%in this experiment.Average liposome particle diameter was 210 nm;8 h after incubation, the intake of MDA-MB-231 cells to 0.25 mg/ml compounds achieved saturation. Conclusion:The pEGFP/SDF-1/KDEL folic acid liposome complexes prepared has a high encapsulating rate,liposome particle diameters are homogeneous,which is available for targeting for breast cancer cells in vitro.
基金supported by 2023 Wenzhou Philosophy and Social Science Planning Annual Project(2023年温州市社科联项目)(23WSK131YBM)Student Science Research Project of Wenzhou University(2023kx038)+2 种基金Student Innovation and Entrepreneurship Training Program Project of WZU(JWXC2023075)Zhejiang Foreign Language Society Project(ZWYB2023023)Zhejiang University Student Science and Technology Innovation Activity Plan(XMS2206006).
文摘In recent years,with the rise of video media such as YouTube and Tik Tok,the short video creation industry has emerged.How to spread China's excellent culture and how to“tell a good Chinese story”have become a hot concern.Using the 5W Model of Communication as a framework for analysis,this paper selects Chinese short videos with high popularity on YouTube as the object of the study.Studies found that the success of these videos was associated with five factors in the process of communication,which are communication main forces,communication content,communication channels,communication audience,and audience effects.Through theoretical and data analysis,the study concluded five strategies in video production to help promote Intercultural communication.
基金Supported by the National Natural Science Foundation of China(NSFC)(12375137,12205309)the Yichang Natural Science Foundation(A25-3-002)+1 种基金the startup funding from University of Chinese Academy of Sciences(UCAS)the Fundamental Research Funds for the Central Universities。
文摘In this study,we investigated the impact of rotation on the thermodynamic properties of QCD matter using the three-flavor NJL model.We examined the dependencies of key thermodynamic quantities,such as the trace anomaly,specific heat,speed of sound,angular momentum,and moment of inertia,on temperature,quark chemical potential,and angular velocity.Our main finding is that the speed of sound exhibits a nonmonotonic behavior as the angular velocity varies.
