The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills(CDDP)in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction(AAMI).Betwee...The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills(CDDP)in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction(AAMI).Between February 2021 and February 2023,247 eligible patients with AAMI after primary percutaneous coronary intervention were enrolled and randomly assigned(1∶1)to receive CDDP(n=126)or placebo(n=121),with a follow-up of 48 weeks.Compared with the placebo group,the CDDP group demonstrated a significant increase in left ventricular ejection fraction values after 24 weeks of treatment(least squares mean:3.31;95%confidence interval[CI]:1.72–4.90;P<0.001)and at the 48-week follow-up(least squares mean:4.35;95%CI:2.76–5.94;P<0.001).Significant reductions in N-terminal pro-B-type natriuretic peptide levels were observed in both groups at the 24-and 48-week visits with no significant difference between the two groups(P>0.1 for all).The incidence of major adverse cardiovascular and cerebrovascular events was 6.35%in the CDDP group and 5.79%in the placebo group(P=0.822).Notably,no serious adverse events were attributed to CDDP.These findings suggest that CDDP may be well tolerated and could improve left ventricular ejection fraction in patients with AAMI at 24 and 48 weeks.展开更多
The high-energy cosmic radiation detector(HERD)is a planned experimental instrument at the Chinese Space Station.The silicon charge detector(SCD),a subdetector in HERD,is used to detect cosmic-ray nuclei with a high c...The high-energy cosmic radiation detector(HERD)is a planned experimental instrument at the Chinese Space Station.The silicon charge detector(SCD),a subdetector in HERD,is used to detect cosmic-ray nuclei with a high charge resolution.In this study,we present a compact readout electronic system for the SCD that is designed for the HERD heavy-ion beam test.It comprises front-end readout electronics with 200 input channels as well as data acquisition and data management electronics.The test results showed that the SCD readout system had low noise with a silicon-strip detector connected.The dynamic range could be extended from 200 to 1200 fC,and the cosmic-ray test was performed as expected.展开更多
A new hypocrellin B （HB） derivative bearing a bispyrrolecarboxamide-containing side chain was synthesized, which presents improved absorptivity in phototherapeufic window than HB and affinity feature towards dsDNA.
Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM),consisting of two microsatellites,is designed to detect gamma-ray bursts associated with gravitational-wave events.Here,we introduce th...Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM),consisting of two microsatellites,is designed to detect gamma-ray bursts associated with gravitational-wave events.Here,we introduce the real-time burst alert system of GECAM,with the adoption of the BeiDou-3 short message communication service.We present the post-trigger operations,the detailed ground-based analysis,and the performance of the system.In the first year of the in-flight operation,GECAM was triggered by 42 gamma-ray bursts.The GECAM real-time burst alert system has the ability to distribute the alert within~1 minute after being triggered,which enables timely follow-up observations.展开更多
Effectively identifying and preventing the threat of Byzantine nodes to the security of distributed systems is a challenge in applying consortium chains.Therefore,this paper proposes a new consortium chain generation ...Effectively identifying and preventing the threat of Byzantine nodes to the security of distributed systems is a challenge in applying consortium chains.Therefore,this paper proposes a new consortium chain generation model,deeply analyzes the vulnerability of the consortium chain consensus based on the behavior of the nodes,and points out the effects of Byzantine node proportion and node state verification on the consensus process and system security.Furthermore,the normalized verification node aggregation index that represents the consensus ability of the consortium organization and the trust evaluation function of the verification node set is derived.When either of the two is lower than the threshold,the consortium institution or the verification node set members are dynamically adjusted.On this basis,an innovative consortium chain generation mechanism based on the Asynchronous Binary Byzantine Consensus Mechanism(ABBCM)is proposed.Based on the extended consortium chain consensus mechanism,a certain consensus value set can be combined into multiple proposals,which can realize crossdomain asynchronous message passing between multi-consortium chains without reducing the system’s security.In addition,experiments are carried out under four classical Byzantine Attack(BA)behaviors,BA1 to BA4.The results show that the proposed method can obtain better delay than the classical random Byzantine consensus algorithm Coin,effectively improving the consensus efficiency based on asynchronous message passing in the consortium chain and thus meeting the throughput of most Internet of Things(IoT)applications.展开更多
Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up observations.Localization based on the relative counts of different detectors has b...Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up observations.Localization based on the relative counts of different detectors has been widely used for all-sky gamma-ray monitors.There are two major methods for this count distribution localization:χ^(2)minimization method and the Bayesian method.Here we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the χ^(2)method.With comprehensive simulations,we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than the χ^(2)method,especially for weak bursts.We further proposed a location-spectrum iteration approach based on the Bayesian inference,which could alleviate the problems caused by the spectral difference between the burst and location templates.Our method is very suitable for scenarios with limited computation resources or timesensitive applications,such as in-flight localization software,and low-latency localization for rapidly follow-up observations.展开更多
Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December 10.We developed a multifunctional trigger and localization software operating in the CP...Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December 10.We developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic Box.This onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation system.This paper provides a detailed description of the design and development of the trigger and localization software system for GECAM.It covers the general design,workflow,the main functions,and the algorithms used in the system.The paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.展开更多
The Gravitational wave burst high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is a dedicated mission for monitoring high-energy transients.Here we report the design of the GECAM Scientific Ground Segment(...The Gravitational wave burst high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is a dedicated mission for monitoring high-energy transients.Here we report the design of the GECAM Scientific Ground Segment(GSGS)in terms of the scientific requirements,including the architecture,the external interfaces,the main function,and workflow.Judging from the analysis and verification results during the commissioning phase,the GSGS functions well and is able to monitor the status of the payloads,adjust the parameters,develop the scientific observation plans,generate the scientific data products,analyze the data,etc.Thus,the on-orbit operation and scientific researches of GECAM are guaranteed.展开更多
The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient sources...The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient sources.The mission consists of two microsatellites which are planned to operate at the opposite sides of the Earth.Each GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning phase.Besides,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.展开更多
DArk Matter Particle Explorer(DAMPE) is a general purpose high energy cosmic ray and gamma ray observatory, aiming to detect high energy electrons and gammas in the energy range 5 Ge V to 10 Te V and hundreds of Te V ...DArk Matter Particle Explorer(DAMPE) is a general purpose high energy cosmic ray and gamma ray observatory, aiming to detect high energy electrons and gammas in the energy range 5 Ge V to 10 Te V and hundreds of Te V for nuclei. This paper provides a method using machine learning to identify electrons and separate them from gammas, protons, helium and heavy nuclei with the DAMPE data acquired from 2016 January 1 to 2017 June 30, in the energy range from 10 to 100 Ge V.展开更多
Objective:This study aimed to investigate the protective effects of Tuina on the blood–brain barrier(BBB)in hypoxic-ischemic encephalopathy(HIE)rats and evaluate the underlying mechanisms of endothelial PARthanatos a...Objective:This study aimed to investigate the protective effects of Tuina on the blood–brain barrier(BBB)in hypoxic-ischemic encephalopathy(HIE)rats and evaluate the underlying mechanisms of endothelial PARthanatos attenuation.Materials and Methods:Male Sprague-Dawley(SD)rats were subjected to occlusion of the left common carotid artery and hypoxia-ischemia.Tuina treatment was performed once daily for 15 min.Body weight,righting reflex,and balance beam tests were conducted to evaluate the growth state.Evans blue(EB)staining and magnetic resonance imaging(MRI)were used to assess BBB permeability.Cortical cell morphology was analyzed using the electron microscopy and hematoxylin and eosin staining.Immunofluorescence co-staining revealed Poly(ADP-ribose)polymerase-1(PARP1)hyperactivation in cortical endothelial cells.Tight junction and PARthanatos-related proteins were detected by western blotting.Results:Tuina significantly increased body weight and reduced righting reflex time in rats with HIE.Tuina-treated HIE rats exhibited fewer hind limb slips and required less time to cross the balance beam.The EB content in the brains of Tuina-treated HIE rats was significantly lower than in the brains of HIE rats.MRI showed that the intensity in Tuina-treated HIE rats was significantly lower than in untreated HIE rats.After HI injury,Tuina alleviated neuronal mitochondrial and ER damage and diminished CD31+/PARP1+immunofluorescence in the cortex.In the Tuina+HIE group,the level of tight junction proteins increased,while PARP1 and apoptosis-inducing factors levels were reduced in the cortex compared to the HIE group.Conclusions:Tuina attenuated BBB disruption in rats with HIE by increasing the expression of tight junction proteins and reducing the expression of endothelial PARthanatos in the cortex.展开更多
In the era of time-domain,multi-messenger astronomy,the detection of transient events on the high-energy electromagnetic sky has become more important than ever.The gravitational wave high-energy electromagnetic count...In the era of time-domain,multi-messenger astronomy,the detection of transient events on the high-energy electromagnetic sky has become more important than ever.The gravitational wave high-energy electromagnetic counterpart all-sky monitor(GECAM)is a dedicated mission to monitor gamma-ray transients,launched in December,2020.A real-time on-board trigger and location software,using the traditional signal-to-noise ratio(SNR)method for blind search,is constrained to relatively bright signals due to the limitations in on-board computing resources and the need for real-time search.In this work,we developed a ground-based pipeline for GECAM to search for various transients,especially for weak bursts missed by on-board software.This pipeline includes both automatic and manual mode,offering options for blind search and targeted search.The targeted search is specifically designed to search for interesting weak bursts,such as gravitational wave-associated gamma-ray bursts(GRBs).From the ground search of the data in the first year,GECAM has been triggered by 54 GRBs and other transients,including soft gamma-ray repeaters,X-ray binaries,solar flares,terrestrial gamma-ray flashes.We report the properties of each type of triggers,such as trigger time and light curves.With this search pipeline and assuming a soft Band spectrum,the GRB detection sensitivity of GECAM is increased to about 1.1×10^(-8)erg cm^(-2)s^(-1)(10-1000 ke V,burst duration of 20 s).These results demonstrate that the GECAM ground search system(both blind search and targeted search)is a versatile pipeline to recover true astrophysical signals which were too weak to be found in the on-board search.展开更多
Charged particle precipitation typically manifests as a gradual increase and decrease of flux observed by space detectors.Cases with rapid flux variation are very rare,while periodic events are even more extraordinary...Charged particle precipitation typically manifests as a gradual increase and decrease of flux observed by space detectors.Cases with rapid flux variation are very rare,while periodic events are even more extraordinary.These oscillating particle precipitation(OPP)events are usually attributed to the bounce motion of electrons probably induced by lightning.However,the origin of these oscillation events is still on debate.Here we report three peculiar charged particle precipitation events detected by GECAM during a geomagnetic storm on March 21,2024,with two exhibiting significant periodicity.These events were observed around the same region during three consecutive orbits with a life time of more than 3.5 h.Through comprehensive temporal and spectral analyses,we find that one of the OPP events exhibited a transition in spectral lag of mini-pulses,shifting from“softer-earlier”to“softer-later”while showing no significant time evolution in overall frequency characteristics,and that there is no association found between these two OPP events and lightning activity nearby.Finally,we discussed possible scenarios to explain these GECAM-detected OPP events,and we found that they may represent a new type of particle precipitation event or a peculiar lightning-induced electron precipitation(LEP).展开更多
Geminiviruses are a group of plant viruses that cause severe diseases in many economically important crops worldwide, leading to devastating losses to agricultural production. Here we summarize the occurrence and dist...Geminiviruses are a group of plant viruses that cause severe diseases in many economically important crops worldwide, leading to devastating losses to agricultural production. Here we summarize the occurrence and distribution of geminiviruses in China,which provides valuable information for further epidemiological studies and supports the development of effective disease management strategies.展开更多
GaAs wafers have been decorated with Ag nanoplates through direct galvanic reaction between aqueous AgNO_(3) solutions and GaAs,resulting in Ag nanoplate/GaAs composite surfaces with varying hydrophobocity after the A...GaAs wafers have been decorated with Ag nanoplates through direct galvanic reaction between aqueous AgNO_(3) solutions and GaAs,resulting in Ag nanoplate/GaAs composite surfaces with varying hydrophobocity after the Ag nanoplates were coated with self-assembled monolayers of alkyl thiol molecules.By carefully controlling the reaction conditions,such as growth time and concentration of the AgNO_(3) solution,the size,thickness,and surface roughness of the individual Ag nanoplates can be tuned in order to produce different topographic structures and roughness of the composite surfaces,which in turn infl uences the hydrophobicity of the surfaces.The as-synthesized composite surfaces have been found to exhibit various levels of hydrophobicity and different wetting states such as the Wenzel wetting state,Cassie impregnating wetting state,and Cassie nonwetting state.The relationship between surface structure and hydrophobic state is also discussed.展开更多
Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for replic...Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for replication.Based on current evidence,viral proteins are translated via viral+RNAs,whereas-RNA is considered to be a viral replication intermediate without coding capacity.Here,we report that plant and animal+ssRNA viruses contain small open reading frames(ORFs)in their-RNA(reverse ORFs[rORFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssRNA viruses,we demonstrate that small proteins encoded by rORFs display specific subcellularlocalizations,and confirm the presence of rORF2 in infected cells through mass spectrometry analysis.The protein encoded by TuMV rORF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication complexes.The rORF2 protein can directly interact with the viral RNA-dependent RNA polymerase,and mutation of rORF2 completely abolishes virus infection,whereas ectopic expression of rORF2 rescues the mutant virus.Furthermore,we show that several rORFs in the-RNA of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis virus.In addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small rORFs.Taken together,these findings indicate that the-RNA of+ssRNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought.展开更多
RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable ...RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in plants.Here,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide.Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all potyvirids.This allows Pelota to target the virus and act as a viral restriction factor.Furthermore,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta.Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation.These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants.展开更多
We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durat...We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak struc-tures.These subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive phase.The periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence level.The paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our observation.The precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.展开更多
Precise measurements of the energy spectra of cosmic rays(CRs)show various kinds of features deviating from single power-laws,which give very interesting and important implications on their origin and propagation.Prev...Precise measurements of the energy spectra of cosmic rays(CRs)show various kinds of features deviating from single power-laws,which give very interesting and important implications on their origin and propagation.Previous measurements from a few balloon and space experiments indicate the existence of spectral softenings around 10 TV for protons(and probably also for Helium nuclei).Very recently,the DArk Matter Particle Explorer(DAMPE)measurement about the proton spectrum clearly reveals such a softening with a high significance.Here we study the implications of these new measurements,as well as the groundbased indirect measurements,on the origin of CRs.We find that a single component of CRs fails to fit the spectral softening and the air shower experiment data simultaneously.In the framework of multiple components,we discuss two possible scenarios,the multiple source population scenario and the background plus nearby source scenario.Both scenarios give reasonable fits to the wide-band data from TeV to 100 PeV energies.Considering the anisotropy observations,the nearby source model is favored.展开更多
基金supported by Tasly Pharmaceutical Group Co.,Ltd.(Grant No.303100031BA20)。
文摘The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills(CDDP)in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction(AAMI).Between February 2021 and February 2023,247 eligible patients with AAMI after primary percutaneous coronary intervention were enrolled and randomly assigned(1∶1)to receive CDDP(n=126)or placebo(n=121),with a follow-up of 48 weeks.Compared with the placebo group,the CDDP group demonstrated a significant increase in left ventricular ejection fraction values after 24 weeks of treatment(least squares mean:3.31;95%confidence interval[CI]:1.72–4.90;P<0.001)and at the 48-week follow-up(least squares mean:4.35;95%CI:2.76–5.94;P<0.001).Significant reductions in N-terminal pro-B-type natriuretic peptide levels were observed in both groups at the 24-and 48-week visits with no significant difference between the two groups(P>0.1 for all).The incidence of major adverse cardiovascular and cerebrovascular events was 6.35%in the CDDP group and 5.79%in the placebo group(P=0.822).Notably,no serious adverse events were attributed to CDDP.These findings suggest that CDDP may be well tolerated and could improve left ventricular ejection fraction in patients with AAMI at 24 and 48 weeks.
基金supported by the CNSA program(D050102)National Natural Science Foundation of China(Nos.12061131007,12003038,42365006)Young Scientists Fund of the National Natural Science Foundation of China(No.11903037).
文摘The high-energy cosmic radiation detector(HERD)is a planned experimental instrument at the Chinese Space Station.The silicon charge detector(SCD),a subdetector in HERD,is used to detect cosmic-ray nuclei with a high charge resolution.In this study,we present a compact readout electronic system for the SCD that is designed for the HERD heavy-ion beam test.It comprises front-end readout electronics with 200 input channels as well as data acquisition and data management electronics.The test results showed that the SCD readout system had low noise with a silicon-strip detector connected.The dynamic range could be extended from 200 to 1200 fC,and the cosmic-ray test was performed as expected.
文摘A new hypocrellin B （HB） derivative bearing a bispyrrolecarboxamide-containing side chain was synthesized, which presents improved absorptivity in phototherapeufic window than HB and affinity feature towards dsDNA.
基金supported by the National Key R&D Program of China(2021YFA0718500,2022YFF0711404)the Strategic Priority Research Program on Space Science,the Chinese Academy of Sciences(grant Nos.XDA15360300,XDA15052700 and E02212A02S)+1 种基金the National Natural Science Foundation of China(grant Nos.U2031205,12133007)supported by the Strategic Priority Research Program on Space Science,the Chinese Academy of Sciences,grant No.XDA15360000。
文摘Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM),consisting of two microsatellites,is designed to detect gamma-ray bursts associated with gravitational-wave events.Here,we introduce the real-time burst alert system of GECAM,with the adoption of the BeiDou-3 short message communication service.We present the post-trigger operations,the detailed ground-based analysis,and the performance of the system.In the first year of the in-flight operation,GECAM was triggered by 42 gamma-ray bursts.The GECAM real-time burst alert system has the ability to distribute the alert within~1 minute after being triggered,which enables timely follow-up observations.
基金supported by Henan University Science and Technology Innovation Talent Support Program(23HASTIT029)the National Natural Science Foundation of China(61902447)+3 种基金Tianjin Natural Science Foundation Key Project(22JCZDJC00600)Research Project of Humanities and Social Sciences in Universities of Henan Province(2024-ZDJH-061)Key Scientific Research Projects of Colleges and Universities in Henan Province(23A520054)Henan Science and Technology Research Project(232102210124).
文摘Effectively identifying and preventing the threat of Byzantine nodes to the security of distributed systems is a challenge in applying consortium chains.Therefore,this paper proposes a new consortium chain generation model,deeply analyzes the vulnerability of the consortium chain consensus based on the behavior of the nodes,and points out the effects of Byzantine node proportion and node state verification on the consensus process and system security.Furthermore,the normalized verification node aggregation index that represents the consensus ability of the consortium organization and the trust evaluation function of the verification node set is derived.When either of the two is lower than the threshold,the consortium institution or the verification node set members are dynamically adjusted.On this basis,an innovative consortium chain generation mechanism based on the Asynchronous Binary Byzantine Consensus Mechanism(ABBCM)is proposed.Based on the extended consortium chain consensus mechanism,a certain consensus value set can be combined into multiple proposals,which can realize crossdomain asynchronous message passing between multi-consortium chains without reducing the system’s security.In addition,experiments are carried out under four classical Byzantine Attack(BA)behaviors,BA1 to BA4.The results show that the proposed method can obtain better delay than the classical random Byzantine consensus algorithm Coin,effectively improving the consensus efficiency based on asynchronous message passing in the consortium chain and thus meeting the throughput of most Internet of Things(IoT)applications.
基金supported by the National Key R&D Program of China(2021YFA0718500)support from the Strategic Priority Research Program on Space Science,the Chinese Academy of Sciences(grant Nos.XDA15360102,XDA15360300,XDA15052700 and E02212A02S)+1 种基金the National Natural Science Foundation of China(grant Nos.12173038 and U2038106)the National HEP Data Center(grant No.E029S2S1)。
文摘Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up observations.Localization based on the relative counts of different detectors has been widely used for all-sky gamma-ray monitors.There are two major methods for this count distribution localization:χ^(2)minimization method and the Bayesian method.Here we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the χ^(2)method.With comprehensive simulations,we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than the χ^(2)method,especially for weak bursts.We further proposed a location-spectrum iteration approach based on the Bayesian inference,which could alleviate the problems caused by the spectral difference between the burst and location templates.Our method is very suitable for scenarios with limited computation resources or timesensitive applications,such as in-flight localization software,and low-latency localization for rapidly follow-up observations.
基金supported by the Strategic Priority Research Program on Space Science of the Chinese Academy of Sciences,the support from the Strategic Priority Research Program on Space Science(grant Nos.XDA15360300,XDA15360000,XDA15360102,XDA15052700 and E02212A02S)of the Chinese Academy of Sciencesthe National Natural Science Foundation of China(NSFC,Grant No.12173038)and BeiDou navigation system。
文摘Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December 10.We developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic Box.This onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation system.This paper provides a detailed description of the design and development of the trigger and localization software system for GECAM.It covers the general design,workflow,the main functions,and the algorithms used in the system.The paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.
基金supported by the National Key R&D Program of China(2022YFF0711404,2021YFA0718500)International Partnership Program of Chinese Academy of Sciences(grant No.113111KYSB20190020)+2 种基金the National Natural Science Foundation of China(NSFC,Grant No.U1938106)the open subject of the National HEP Data Center(E029S2S1)support from the Strategic Priority Research Program on Space Science,the Chinese Academy of Sciences(grant Nos.XDA15360102,XDA15360300,XDA15052700 and E02212A02S)。
文摘The Gravitational wave burst high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is a dedicated mission for monitoring high-energy transients.Here we report the design of the GECAM Scientific Ground Segment(GSGS)in terms of the scientific requirements,including the architecture,the external interfaces,the main function,and workflow.Judging from the analysis and verification results during the commissioning phase,the GSGS functions well and is able to monitor the status of the payloads,adjust the parameters,develop the scientific observation plans,generate the scientific data products,analyze the data,etc.Thus,the on-orbit operation and scientific researches of GECAM are guaranteed.
基金supported by the Strategic Priority Program on Space Science,the Chinese Academy of Sciences,grant Nos.XDA15360102,XDA15360300 and E02212A02Sthe National Natural Science Foundation of China(Project:12061131007)。
文摘The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient sources.The mission consists of two microsatellites which are planned to operate at the opposite sides of the Earth.Each GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning phase.Besides,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.
基金supported by the State Key Project of Research and Development Plan (2016YFA0400204)the National Natural Science Foundation of China (U1738133)+3 种基金Strategic Pioneer Research Program in Space Science of the Chinese Academy of Science (CAS)Youth Innovation Promotion Association of CASMinistry of Science and Technology of Jiangsu Province (17KJD510001)Changzhou Institute of Technology (YN1611)
文摘DArk Matter Particle Explorer(DAMPE) is a general purpose high energy cosmic ray and gamma ray observatory, aiming to detect high energy electrons and gammas in the energy range 5 Ge V to 10 Te V and hundreds of Te V for nuclei. This paper provides a method using machine learning to identify electrons and separate them from gammas, protons, helium and heavy nuclei with the DAMPE data acquired from 2016 January 1 to 2017 June 30, in the energy range from 10 to 100 Ge V.
基金supported by the National Natural Science Foundation of China(grant numbers 82174522,81774444,81860886,and 82305428)。
文摘Objective:This study aimed to investigate the protective effects of Tuina on the blood–brain barrier(BBB)in hypoxic-ischemic encephalopathy(HIE)rats and evaluate the underlying mechanisms of endothelial PARthanatos attenuation.Materials and Methods:Male Sprague-Dawley(SD)rats were subjected to occlusion of the left common carotid artery and hypoxia-ischemia.Tuina treatment was performed once daily for 15 min.Body weight,righting reflex,and balance beam tests were conducted to evaluate the growth state.Evans blue(EB)staining and magnetic resonance imaging(MRI)were used to assess BBB permeability.Cortical cell morphology was analyzed using the electron microscopy and hematoxylin and eosin staining.Immunofluorescence co-staining revealed Poly(ADP-ribose)polymerase-1(PARP1)hyperactivation in cortical endothelial cells.Tight junction and PARthanatos-related proteins were detected by western blotting.Results:Tuina significantly increased body weight and reduced righting reflex time in rats with HIE.Tuina-treated HIE rats exhibited fewer hind limb slips and required less time to cross the balance beam.The EB content in the brains of Tuina-treated HIE rats was significantly lower than in the brains of HIE rats.MRI showed that the intensity in Tuina-treated HIE rats was significantly lower than in untreated HIE rats.After HI injury,Tuina alleviated neuronal mitochondrial and ER damage and diminished CD31+/PARP1+immunofluorescence in the cortex.In the Tuina+HIE group,the level of tight junction proteins increased,while PARP1 and apoptosis-inducing factors levels were reduced in the cortex compared to the HIE group.Conclusions:Tuina attenuated BBB disruption in rats with HIE by increasing the expression of tight junction proteins and reducing the expression of endothelial PARthanatos in the cortex.
基金supported by the National Natural Science Foundation of China(Grant Nos.12303045,12273042,and 12373047)the National Key R&D Program of China(Grant No.2022YFF0711404)+3 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant Nos.XDA15360102,XDA15360300,and XDA15052700)The GECAM(Huairou-1)mission was supported by the Strategic Priority Research Program on Space Science(Grant No.XDA15360000)of the Chinese Academy of Sciencesthe support from the Natural Science Foundation of Hebei Province(Grant No.A2023205020)the Science Foundation of Hebei Normal University(Grant No.L2023B11)。
文摘In the era of time-domain,multi-messenger astronomy,the detection of transient events on the high-energy electromagnetic sky has become more important than ever.The gravitational wave high-energy electromagnetic counterpart all-sky monitor(GECAM)is a dedicated mission to monitor gamma-ray transients,launched in December,2020.A real-time on-board trigger and location software,using the traditional signal-to-noise ratio(SNR)method for blind search,is constrained to relatively bright signals due to the limitations in on-board computing resources and the need for real-time search.In this work,we developed a ground-based pipeline for GECAM to search for various transients,especially for weak bursts missed by on-board software.This pipeline includes both automatic and manual mode,offering options for blind search and targeted search.The targeted search is specifically designed to search for interesting weak bursts,such as gravitational wave-associated gamma-ray bursts(GRBs).From the ground search of the data in the first year,GECAM has been triggered by 54 GRBs and other transients,including soft gamma-ray repeaters,X-ray binaries,solar flares,terrestrial gamma-ray flashes.We report the properties of each type of triggers,such as trigger time and light curves.With this search pipeline and assuming a soft Band spectrum,the GRB detection sensitivity of GECAM is increased to about 1.1×10^(-8)erg cm^(-2)s^(-1)(10-1000 ke V,burst duration of 20 s).These results demonstrate that the GECAM ground search system(both blind search and targeted search)is a versatile pipeline to recover true astrophysical signals which were too weak to be found in the on-board search.
基金supported by the National Natural Science Foundation of China(Grant Nos.12273042,and 12303045)the National Key R&D Program of China(Grant No.2021YFA0718500)+2 种基金the Natural Science Foundation of Hebei Province(Grant No.A2023205020)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDB0550300,and XDA30050000)The GECAM(Huairou-1)mission is supported by the Strategic Priority Research Program on Space Science of the Chinese Academy of Sciences(Grant No.XDA15360000).We thank the World Wide Lightning Location Network(http://wwlln.net)as a collaboration of more than 50 universities.Chenwei Wang appreciates Wen Cheng,Yixin Sun,and Lu Wang for helpful discussions.
文摘Charged particle precipitation typically manifests as a gradual increase and decrease of flux observed by space detectors.Cases with rapid flux variation are very rare,while periodic events are even more extraordinary.These oscillating particle precipitation(OPP)events are usually attributed to the bounce motion of electrons probably induced by lightning.However,the origin of these oscillation events is still on debate.Here we report three peculiar charged particle precipitation events detected by GECAM during a geomagnetic storm on March 21,2024,with two exhibiting significant periodicity.These events were observed around the same region during three consecutive orbits with a life time of more than 3.5 h.Through comprehensive temporal and spectral analyses,we find that one of the OPP events exhibited a transition in spectral lag of mini-pulses,shifting from“softer-earlier”to“softer-later”while showing no significant time evolution in overall frequency characteristics,and that there is no association found between these two OPP events and lightning activity nearby.Finally,we discussed possible scenarios to explain these GECAM-detected OPP events,and we found that they may represent a new type of particle precipitation event or a peculiar lightning-induced electron precipitation(LEP).
基金supported by the National Natural Science Foundation of China (31720103914, 32172385)the National Key Research and Development Program of China (2021YFD1400400)the China National Tobacco Corporation (110202001030(JY-13))。
文摘Geminiviruses are a group of plant viruses that cause severe diseases in many economically important crops worldwide, leading to devastating losses to agricultural production. Here we summarize the occurrence and distribution of geminiviruses in China,which provides valuable information for further epidemiological studies and supports the development of effective disease management strategies.
基金The submitted manuscript has been created by UChicago Argonne,LLC,Operator of Argonne National Laboratory(“Argonne”).Argonne,a U.S.Department of Energy Offi ce of Science Laboratory,is operated under Contract No.DE-AC02-06CH11357Use of the Center for Nanoscale Materials and the Electron Microscopy Center for Materials Research at Argonne was supported by the U.S.Department of Energy,Office of Science,Office of Basic Energy Sciences,under Contract No.DE-AC02-06CH11357.
文摘GaAs wafers have been decorated with Ag nanoplates through direct galvanic reaction between aqueous AgNO_(3) solutions and GaAs,resulting in Ag nanoplate/GaAs composite surfaces with varying hydrophobocity after the Ag nanoplates were coated with self-assembled monolayers of alkyl thiol molecules.By carefully controlling the reaction conditions,such as growth time and concentration of the AgNO_(3) solution,the size,thickness,and surface roughness of the individual Ag nanoplates can be tuned in order to produce different topographic structures and roughness of the composite surfaces,which in turn infl uences the hydrophobicity of the surfaces.The as-synthesized composite surfaces have been found to exhibit various levels of hydrophobicity and different wetting states such as the Wenzel wetting state,Cassie impregnating wetting state,and Cassie nonwetting state.The relationship between surface structure and hydrophobic state is also discussed.
基金funded by the National Key Research and Development Program of China(2021YFD1400400)to F.L.the National Natural Science Foundation of China(31930089 and 31972244)to X.Z.and F.L.+2 种基金a startup grant for High-level Talents of Fujian Medical University(XRCZX2019019)the Natural Science Foundation of Fujan Province,China(2020J01604)to Q.S.Work in the R.L.-D.lab is partially funded by the ERC-COG grant GemOmics(101044142)to R.L.-D.
文摘Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for replication.Based on current evidence,viral proteins are translated via viral+RNAs,whereas-RNA is considered to be a viral replication intermediate without coding capacity.Here,we report that plant and animal+ssRNA viruses contain small open reading frames(ORFs)in their-RNA(reverse ORFs[rORFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssRNA viruses,we demonstrate that small proteins encoded by rORFs display specific subcellularlocalizations,and confirm the presence of rORF2 in infected cells through mass spectrometry analysis.The protein encoded by TuMV rORF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication complexes.The rORF2 protein can directly interact with the viral RNA-dependent RNA polymerase,and mutation of rORF2 completely abolishes virus infection,whereas ectopic expression of rORF2 rescues the mutant virus.Furthermore,we show that several rORFs in the-RNA of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis virus.In addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small rORFs.Taken together,these findings indicate that the-RNA of+ssRNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought.
基金funded by the National Key Research and Development Program of China(2021YFD1400400)National Natural Science Foundation of China(31972244)to F.L.
文摘RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in plants.Here,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide.Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all potyvirids.This allows Pelota to target the virus and act as a viral restriction factor.Furthermore,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta.Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation.These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants.
基金supported by the National Natural Science Foundation of China (Grant Nos. U1938102, and 11973092)the National Program on Key Research and Development Project (Grant No. 2016YFA0400802)supported by the Surface Project of Jiangsu Province (Grant No. BK20211402)
文摘We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak struc-tures.These subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive phase.The periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence level.The paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our observation.The precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.
基金the Na-tional Key Research and Development Program of China(No.2016YFA0400200)the National Natural Science Foundation of China(Nos.11722328,11525313,U1738205,and 11851305)the 100 Talents Program of Chinese Academy of Sciences.
文摘Precise measurements of the energy spectra of cosmic rays(CRs)show various kinds of features deviating from single power-laws,which give very interesting and important implications on their origin and propagation.Previous measurements from a few balloon and space experiments indicate the existence of spectral softenings around 10 TV for protons(and probably also for Helium nuclei).Very recently,the DArk Matter Particle Explorer(DAMPE)measurement about the proton spectrum clearly reveals such a softening with a high significance.Here we study the implications of these new measurements,as well as the groundbased indirect measurements,on the origin of CRs.We find that a single component of CRs fails to fit the spectral softening and the air shower experiment data simultaneously.In the framework of multiple components,we discuss two possible scenarios,the multiple source population scenario and the background plus nearby source scenario.Both scenarios give reasonable fits to the wide-band data from TeV to 100 PeV energies.Considering the anisotropy observations,the nearby source model is favored.
