Personalized health services are of paramount importance for the treatment and prevention of cardiorespiratory diseases,such as hypertension.The assessment of cardiorespiratory function and biometric identification(ID...Personalized health services are of paramount importance for the treatment and prevention of cardiorespiratory diseases,such as hypertension.The assessment of cardiorespiratory function and biometric identification(ID)is crucial for the effectiveness of such personalized health services.To effectively and accurately monitor pulse wave signals,thus achieving the assessment of cardiorespiratory function,a wearable photonic smart wristband based on an all-polymer sensing unit(All-PSU)is proposed.The smart wristband enables the assessment of cardiorespiratory function by continuously monitoring respiratory rate(RR),heart rate(HR),and blood pressure(BP).Furthermore,it can be utilized for biometric ID purposes.Through the analysis of pulse wave signals using power spectral density(PSD),accurate monitoring of RR and HR is achieved.Additionally,utilizing peak detection algorithms for feature extraction from pulse signals and subsequently employing a variety of machine learning methods,accurate BP monitoring and biometric ID have been realized.For biometric ID,the accuracy rate is 98.55%.Aiming to monitor RR,HR,BP,and ID,our solution demonstrates advantages in integration,functionality,and monitoring precision.These enhancements may contribute to the development of personalized health services aimed at the treatment and prevention of cardiorespiratory diseases.展开更多
Yunnan in southwest China is a geographically and ethnically complex region at the intersection of southern China and Southeast Asia,and a focal point for human migrations.To clarify its maternal genetic history,we ge...Yunnan in southwest China is a geographically and ethnically complex region at the intersection of southern China and Southeast Asia,and a focal point for human migrations.To clarify its maternal genetic history,we generated 152 complete mitogenomes from 17 Yunnan archaeological sites.Our results reveal distinct genetic histories segregated by geographical regions.Maternal lineages of ancient populations from northwestern and northern Yunnan exhibit closer affinities with past and present-day populations from northern East Asia and Xizang,providing important genetic evidence for the migration and interaction of populations along the Tibetan-Yi corridor since the Neolithic.Between 5500 and 1800 years ago,central Yunnan populations maintained their internal genetic relationships,including a 7000-year-old basal lineage of the rare and widely dispersed haplogroup M61.At the Xingyi site,changes in mitochondrial DNA haplogroups occurred between the Late Neolithic and Bronze Age,with haplogroups shifting from those predominant in the Yellow River region to those predominant in coastal southern China.These results highlight the high diversity of Yunnan populations during the Neolithic to Bronze Age.展开更多
The loach tribe Yunnanilini from China is reviewed here using morphological characters and complete mitochondrial genomes of select species.Molecular data suggest that the tribe Yunnanilini is not monophyletic and can...The loach tribe Yunnanilini from China is reviewed here using morphological characters and complete mitochondrial genomes of select species.Molecular data suggest that the tribe Yunnanilini is not monophyletic and can be divided into three clades.Species of the Yunnanilus nigromaculatus group form an independent genus and are placed in Eonemachilus.In the phylogenetic tree,Y.jinxiensis clusters with Paranemachilus genilepis,and Y.pulcherrimus clusters with Micronemacheilus cruciatus,indicating that Y.jinxiensis and Y.pulcherrimus belong to Paranemachilus and Micronemacheilus,respectively.Based on while Y.jinxiensis and Y.pulcherrimus,are placed in Paranemachilus and Micronemacheilus,respectively.Yunnanilus niulanensis and Y.qujinensis are treated as junior synonyms of Eonemachilus caohaiensis.Eonemachilus,Micronemacheilus,and Yunnanilus are show short separation between anterior and posterior nostrils.The genera can be distinguished from each other by mouth structure,lateral line and cephalic lateral-line canals,and papillae on median part of both lips.The anterior and posterior nostrils of Heminoemacheilus and Paranemachilus are closely set.Paranemachilus and Micronemacheilus are distinguished by cheeks covered with scales and lips with papillae,respectively.Our phylogenetic tree and morphological characters support Traccatichthys as a valid genus,which can be distinguished from Micronemacheilus by anterior and posterior nostrils closely set(vs.clearly separated).Four species are placed in Traccatichthys.展开更多
Objective Hepatitis B virus(HBV)infection,which has been recognized as an international public health challenge,has caused significant morbidity for the entire world.This research focused on patients with HBV in China...Objective Hepatitis B virus(HBV)infection,which has been recognized as an international public health challenge,has caused significant morbidity for the entire world.This research focused on patients with HBV in China to examine health utilization and expenses.Methods Patients hospitalized with HBV from 2017 to 2019 in tertiary hospitals in Hubei,a province located in central China,were selected as the study population.Healthcare information was collected from the provincial inpatient electronic system database.Univariate and regression analyses were performed to describe the basic situation of healthcare services and determine the influencing indicators of inpatient service expenditure.Results A total of 367381 cases of HBV infection were identified in the study area.Most of these cases were patients who were married(90.2%)and males(63%).With the great efforts by the universal coverage of the basic medical insurance(BMI)in China,the increasing rate of inpatient hospitalization for HBV was 3.5 times higher than that of the total inpatient health service cases in the study area.The average age of this group was 52.84±14.10 years and 11.1%of patients paid for their own medical expenditures without insurance.The average length of stay(LOS)was 11.10 days,and the average cost per patient was 15712.05 RMB.Both values were higher than the average level in study area.Gender,marital status,career,payment type,and kind of hospitals significantly influenced healthcare utilization.Males and the elderly might incur higher healthcare costs than their counterparts.Conclusion The BMI operated by government has played a role in the utilization release of health services for HBV carriers.However,researchers must pay more attention to the continuing increase in the medical expenses of this group.展开更多
BACKGROUND Pancreatic mucinous cystic neoplasms(MCNs)represent one of the precursor lesions of pancreatic ductal adenocarcinoma,and their detection has been facilitated by advances in preoperative imaging.Due primaril...BACKGROUND Pancreatic mucinous cystic neoplasms(MCNs)represent one of the precursor lesions of pancreatic ductal adenocarcinoma,and their detection has been facilitated by advances in preoperative imaging.Due primarily to the rarity of MCNs,however,there is limited knowledge regarding the prognostic variables and high-risk factors for malignant transformation.A more comprehensive and nuanced approach is necessary to fill this gap and provide a basis for improved treatment decisions and patient outcomes.AIM To investigate the high-risk factors associated with malignant MCNs and to explore the prognostic factors of MCN with associated invasive carcinoma(MCNAIC).METHODS All cases of resected MCNs from a single high-volume institution between January 2012 and January 2022 were retrospectively reviewed.Only cases with ovarian-type stroma verified by progesterone receptor staining were included.Preoperative features,histological findings and postoperative course were documented.Multivariate logistic regression was employed to investigate variables related to malignancy.Survival analysis was performed using the Kaplan-Meier curve,and the prognostic factors were assessed to evaluate the postoperative course of patients with MCN-AIC.RESULTS Among the 48 patients,36 had benign MCNs,and 12 had malignant MCNs(1 high-grade atypical hyperplasia and 11 MCN-AIC).Age,tumour size,presence of solid components or mural nodules and pancreatic duct dilatation were identified as independent risk factors associated with malignancy.The follow-up period ranged from 12 mo to 120 mo,with a median overall survival of 58.2 mo.Only three patients with MCN-AIC died,and the 5-year survival rate was 70.1%.All 11 cases of MCN-AIC were stage I,and extracapsular invasion was identified as a prognostic factor for poorer outcomes.CONCLUSION The risk factors independently associated with malignant transformation of MCNs included age,tumour size,presence of solid components or mural nodules,and pancreatic duct dilatation.Our study also revealed that encapsulated invasion was a favourable prognostic factor in MCN-AIC patients.展开更多
基金funded by the National Key R&D Program of China(2022YFE0140400)the National Natural Science Foundation of China(62405027, 62111530238, 62003046)+3 种基金Supporting project of major scientific research projects of Beijing Normal University at Zhuhai (ZHPT2023007)supported by the Tang Scholar of Beijing Normal Universityco-funded by the financial support of the European Union under the REFRESH-Research Excellence For REgion Sustainability and High-tech Industries project number CZ.10.03.01/00/22003/0000048 via the Operational Programme Just Transitionthe scope of the projects CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020) financed by national funds through the FCT/MCTES (PIDDAC)
文摘Personalized health services are of paramount importance for the treatment and prevention of cardiorespiratory diseases,such as hypertension.The assessment of cardiorespiratory function and biometric identification(ID)is crucial for the effectiveness of such personalized health services.To effectively and accurately monitor pulse wave signals,thus achieving the assessment of cardiorespiratory function,a wearable photonic smart wristband based on an all-polymer sensing unit(All-PSU)is proposed.The smart wristband enables the assessment of cardiorespiratory function by continuously monitoring respiratory rate(RR),heart rate(HR),and blood pressure(BP).Furthermore,it can be utilized for biometric ID purposes.Through the analysis of pulse wave signals using power spectral density(PSD),accurate monitoring of RR and HR is achieved.Additionally,utilizing peak detection algorithms for feature extraction from pulse signals and subsequently employing a variety of machine learning methods,accurate BP monitoring and biometric ID have been realized.For biometric ID,the accuracy rate is 98.55%.Aiming to monitor RR,HR,BP,and ID,our solution demonstrates advantages in integration,functionality,and monitoring precision.These enhancements may contribute to the development of personalized health services aimed at the treatment and prevention of cardiorespiratory diseases.
基金supported by the National Natural Science Foundation of China(41925009)National Key R&D Program of China(2022YFE0203800)+2 种基金the Ministry of Finance of the People’s Republic of China(YSBR-019)Science and Technology Innovation Team of Shaanxi Province(2024RS-CXTD-74)Xiaohong Wu was supported by the Key National Social Science Foundation of China(No.16ZDA144).
文摘Yunnan in southwest China is a geographically and ethnically complex region at the intersection of southern China and Southeast Asia,and a focal point for human migrations.To clarify its maternal genetic history,we generated 152 complete mitogenomes from 17 Yunnan archaeological sites.Our results reveal distinct genetic histories segregated by geographical regions.Maternal lineages of ancient populations from northwestern and northern Yunnan exhibit closer affinities with past and present-day populations from northern East Asia and Xizang,providing important genetic evidence for the migration and interaction of populations along the Tibetan-Yi corridor since the Neolithic.Between 5500 and 1800 years ago,central Yunnan populations maintained their internal genetic relationships,including a 7000-year-old basal lineage of the rare and widely dispersed haplogroup M61.At the Xingyi site,changes in mitochondrial DNA haplogroups occurred between the Late Neolithic and Bronze Age,with haplogroups shifting from those predominant in the Yellow River region to those predominant in coastal southern China.These results highlight the high diversity of Yunnan populations during the Neolithic to Bronze Age.
基金This study was supported by the Middle-Aged and Young Teachers’Basic Ability Promotion Project of Guangxi,China(2020KY02026)Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University)+7 种基金Ministry of Education(ERESEP2020Z22)Guangxi Key Laboratory of Rare and Endangered Animal Ecology,Guangxi Normal University(19A0104)Special Funds for Young Scholars of Taxonomy of the Chinese Academy of Sciences(ZSBR-011)National Natural Science Foundation of China(31872202,NSFC 31860600,U1702233,31800454)Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences(Y4ZK111B01)Guangxi Natural Science Foundation(2017GXNSFFA198010)Yunnan Provincial Science and Technology Department Foundation(202003AD150017,2019BC002)Sino BON-Inland Water Fish Diversity Observation Network。
文摘The loach tribe Yunnanilini from China is reviewed here using morphological characters and complete mitochondrial genomes of select species.Molecular data suggest that the tribe Yunnanilini is not monophyletic and can be divided into three clades.Species of the Yunnanilus nigromaculatus group form an independent genus and are placed in Eonemachilus.In the phylogenetic tree,Y.jinxiensis clusters with Paranemachilus genilepis,and Y.pulcherrimus clusters with Micronemacheilus cruciatus,indicating that Y.jinxiensis and Y.pulcherrimus belong to Paranemachilus and Micronemacheilus,respectively.Based on while Y.jinxiensis and Y.pulcherrimus,are placed in Paranemachilus and Micronemacheilus,respectively.Yunnanilus niulanensis and Y.qujinensis are treated as junior synonyms of Eonemachilus caohaiensis.Eonemachilus,Micronemacheilus,and Yunnanilus are show short separation between anterior and posterior nostrils.The genera can be distinguished from each other by mouth structure,lateral line and cephalic lateral-line canals,and papillae on median part of both lips.The anterior and posterior nostrils of Heminoemacheilus and Paranemachilus are closely set.Paranemachilus and Micronemacheilus are distinguished by cheeks covered with scales and lips with papillae,respectively.Our phylogenetic tree and morphological characters support Traccatichthys as a valid genus,which can be distinguished from Micronemacheilus by anterior and posterior nostrils closely set(vs.clearly separated).Four species are placed in Traccatichthys.
基金the Fundamental Research Funds for the Central Universities(No.2020kfyXJJS057)China Association for Science and Technology Foundation(No.20200608CG111320).
文摘Objective Hepatitis B virus(HBV)infection,which has been recognized as an international public health challenge,has caused significant morbidity for the entire world.This research focused on patients with HBV in China to examine health utilization and expenses.Methods Patients hospitalized with HBV from 2017 to 2019 in tertiary hospitals in Hubei,a province located in central China,were selected as the study population.Healthcare information was collected from the provincial inpatient electronic system database.Univariate and regression analyses were performed to describe the basic situation of healthcare services and determine the influencing indicators of inpatient service expenditure.Results A total of 367381 cases of HBV infection were identified in the study area.Most of these cases were patients who were married(90.2%)and males(63%).With the great efforts by the universal coverage of the basic medical insurance(BMI)in China,the increasing rate of inpatient hospitalization for HBV was 3.5 times higher than that of the total inpatient health service cases in the study area.The average age of this group was 52.84±14.10 years and 11.1%of patients paid for their own medical expenditures without insurance.The average length of stay(LOS)was 11.10 days,and the average cost per patient was 15712.05 RMB.Both values were higher than the average level in study area.Gender,marital status,career,payment type,and kind of hospitals significantly influenced healthcare utilization.Males and the elderly might incur higher healthcare costs than their counterparts.Conclusion The BMI operated by government has played a role in the utilization release of health services for HBV carriers.However,researchers must pay more attention to the continuing increase in the medical expenses of this group.
基金Supported by the Natural Science Key Project in Universities of Anhui Province,No.KJ2021A0701Natural Science Key Project of Bengbu Medical College,No.2020byzd030Postgraduate Scientific Research Innovation Program of the Bengbu Medical College,No.Byycx22016.
文摘BACKGROUND Pancreatic mucinous cystic neoplasms(MCNs)represent one of the precursor lesions of pancreatic ductal adenocarcinoma,and their detection has been facilitated by advances in preoperative imaging.Due primarily to the rarity of MCNs,however,there is limited knowledge regarding the prognostic variables and high-risk factors for malignant transformation.A more comprehensive and nuanced approach is necessary to fill this gap and provide a basis for improved treatment decisions and patient outcomes.AIM To investigate the high-risk factors associated with malignant MCNs and to explore the prognostic factors of MCN with associated invasive carcinoma(MCNAIC).METHODS All cases of resected MCNs from a single high-volume institution between January 2012 and January 2022 were retrospectively reviewed.Only cases with ovarian-type stroma verified by progesterone receptor staining were included.Preoperative features,histological findings and postoperative course were documented.Multivariate logistic regression was employed to investigate variables related to malignancy.Survival analysis was performed using the Kaplan-Meier curve,and the prognostic factors were assessed to evaluate the postoperative course of patients with MCN-AIC.RESULTS Among the 48 patients,36 had benign MCNs,and 12 had malignant MCNs(1 high-grade atypical hyperplasia and 11 MCN-AIC).Age,tumour size,presence of solid components or mural nodules and pancreatic duct dilatation were identified as independent risk factors associated with malignancy.The follow-up period ranged from 12 mo to 120 mo,with a median overall survival of 58.2 mo.Only three patients with MCN-AIC died,and the 5-year survival rate was 70.1%.All 11 cases of MCN-AIC were stage I,and extracapsular invasion was identified as a prognostic factor for poorer outcomes.CONCLUSION The risk factors independently associated with malignant transformation of MCNs included age,tumour size,presence of solid components or mural nodules,and pancreatic duct dilatation.Our study also revealed that encapsulated invasion was a favourable prognostic factor in MCN-AIC patients.
