Research on changes in the redox conditions of bottom waters is essential for understanding deep water circulation,global ocean currents,climate change,and ecosystem health.Through sedimentary geological methods,a dee...Research on changes in the redox conditions of bottom waters is essential for understanding deep water circulation,global ocean currents,climate change,and ecosystem health.Through sedimentary geological methods,a deeper understanding of the complex relationships between various environmental changes can be achieved,providing detailed evidence and theoretical support for global climate change research.The Ross Sea in Antarctica plays a key role in the formation of Antarctic bottom water(AABW),and the complex climate changes since the last glacial maximum(LGM)make it particularly significant for study.This research analyzes core ANT32-RB16C from the Ross Sea using geochemical proxies such as major and trace elements,grain size,and redox-sensitive indicators like Mn/Ti,Co/Ti,Mo/Ti,Cd/Ti,U/Th,and Ni/Co molar concentration ratios.Combining this data with a previously established chronological framework,the study explores the evolution of redox conditions in the Ross Sea’s deep waters since the LGM.The results show that the deep waters have remained oxygen-rich since the LGM,with significant changes in four stages.Stage 1(24.7–15.7 cal ka BP):Strong oxidizing conditions,likely due to enhanced formation of Ross Sea bottom water(RSBW),increasing oxygen levels.Stage 2(15.7–4.5 cal ka BP):Weakened oxidizing conditions as temperatures rose and ice shelves retreated,increasing primary productivity and depleting oxygen.Stage 3(4.5–1.5 cal ka BP):Continued decline in oxidizing conditions,possibly linked to high primary productivity and oxygen consumption.Stage 4(1.5 cal ka BP to present):A rapid recovery of oxidizing conditions,likely driven by temperature drops,increased RSBW formation,and decreased productivity.展开更多
Effective separation of residual carbon and ash is the basis for the resource utilization of coal gasification fine slag(CGFS).The conventional flotation process of CGFS has the bottlenecks of low carbon recovery and ...Effective separation of residual carbon and ash is the basis for the resource utilization of coal gasification fine slag(CGFS).The conventional flotation process of CGFS has the bottlenecks of low carbon recovery and high collector dosage.In order to address these issues,CGFS sample taken from Shaanxi,China was used as the study object in this paper.A new process of size classification-fine grain ultrasonic pretreatment flotation(SC-FGUF)was proposed and its separation effect was compared with that of wholegrain flotation(WGF)as well as size classification-fine grain flotation(SC-FGF).The mechanism of its enhanced separation effect was revealed through flotation kinetic fitting,flotation flow foam layer stability,particle size composition,surface morphology,pore structure,and surface chemical property analysis.The results showed that compared with WGF,pre-classification could reduce the collector dosage by 84.09%and the combination of pre-classification and ultrasonic pretreatment could increase the combustible recovery by 17.29%and up to 93.46%.The SC-FGUF process allows the ineffective adsorption of coarse residual carbon to collector during flotation stage to be reduced by pre-classification,and the tightly embedded state of fine CGFS particles is disrupted and surface oxidizing functional group occupancy was reduced by ultrasonic pretreatment,thus carbon and ash is easier to be separated in the flotation process.In addition,some of the residual carbon particles were broken down to smaller sizes in the ultrasonic pretreatment,which led to an increase in the stability of flotation flow foam layer and a decrease in the probability of detachment of residual carbon particles from the bubbles.Therefore,SCFGUF could increase the residual carbon recovery and reduce the flotation collector dosage,which is an innovative method for carbon-ash separation of CGFS with good application prospect.展开更多
It is demonstrated experimentally and confirmed theoretically that highly defective boron nitride showed outstanding performance for oxidative dehydrogenation of ethylbenzene.The catalyst is derived from carbon-doped ...It is demonstrated experimentally and confirmed theoretically that highly defective boron nitride showed outstanding performance for oxidative dehydrogenation of ethylbenzene.The catalyst is derived from carbon-doped hexagonal boron nitride nanosheets synthesized via a two-step reaction when participating the oxidative dehydrogenation reaction.The first step yields a polymeric precursor with the atomic positions of B,C,N relatively constrained,which is conducive for the formation of carbon atomic clusters uniformly dispersed throughout the BN framework.During the oxidative dehydrogenation of ethylbenzene to styrene,the nanoscale carbon clusters are removed and highly defective boron nitride(D-BN)is obtained,exposing boron-rich zigzag edges of BN that act as the catalytic sites.The catalytic performance of D-BN is therefore remarkably better than un-doped h-BN.Our results indicate that dispersed C-doping in h-BN is highly effective in terms of defect formation and resultant enhanced activity in oxidative dehydrogenation reactions.展开更多
Precise forecasting of solar power is crucial for the development of sustainable energy systems.Contemporary forecasting approaches often fail to adequately consider the crucial role of weather factors in photovoltaic...Precise forecasting of solar power is crucial for the development of sustainable energy systems.Contemporary forecasting approaches often fail to adequately consider the crucial role of weather factors in photovoltaic(PV)power generation and encounter issues such as gradient explosion or disappearance when dealing with extensive time-series data.To overcome these challenges,this research presents a cutting-edge,multi-stage forecasting method called D-Informer.This method skillfully merges the differential transformation algorithm with the Informer model,leveraging a detailed array of meteorological variables and historical PV power generation records.The D-Informer model exhibits remarkable superiority over competing models across multiple performance metrics,achieving on average a 67.64%reduction in mean squared error(MSE),a 49.58%decrease in mean absolute error(MAE),and a 43.43%reduction in root mean square error(RMSE).Moreover,it attained an R2 value as high as 0.9917 during the winter season,highlighting its precision and dependability.This significant advancement can be primarily attributed to the incorporation of a multi-head self-attention mechanism,which greatly enhances the model’s ability to identify complex interactions among diverse input variables,and the inclusion of weather variables,enriching the model’s input data and strengthening its predictive accuracy in time series analysis.Additionally,the experimental results confirm the effectiveness of the proposed approach.展开更多
Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming,but these feedstuffs are fibrous in nature.This study investigated the relationship b...Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming,but these feedstuffs are fibrous in nature.This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization,energy metabolism,and gut microbiota in growing pigs.Methods Thirty-six growing barrows(47.2±1.5 kg)were randomly allotted to 6 dietary treatments with 2 apparent viscosity levels and 3β-glucan-to-arabinoxylan ratios.In the experiment,nutrient utilization,energy metabolism,fecal microbial community,and production and absorption of short-chain fatty acid(SCFA)of pigs were investigated.In vitro digestion and fermentation models were used to compare the fermentation characteristics of feedstuffs and ileal digesta in the pig’s hindgut.Results The production dynamics of SCFA and dry matter corrected gas production of different feedstuffs during in vitro fermentation were different and closely related to the physical properties and chemical structure of the fiber.In animal experiments,increasing the dietary apparent viscosity and theβ-glucan-to-arabinoxylan ratios both increased the apparent ileal digestibility(AID),apparent total tract digestibility(ATTD),and hindgut digestibility of fiber components while decreasing the AID and ATTD of dry matter and organic matter(P<0.05).In addition,increasing dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased gas exchange,heat production,and protein oxidation,and decreased energy deposition(P<0.05).The dietary apparent viscosity andβ-glucanto-arabinoxylan ratios had linear interaction effects on the digestible energy,metabolizable energy,retained energy(RE),and net energy(NE)of the diets(P<0.05).At the same time,the increase of dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased SCFA production and absorption(P<0.05).Increasing the dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios increased the diversity and abundance of bacteria(P<0.05)and the relative abundance of beneficial bacteria.Furthermore,increasing the dietaryβ-glucan-to-arabinoxylan ratios led to a linear increase in SCFA production during the in vitro fermentation of ileal digesta(P<0.001).Finally,the prediction equations for RE and NE were established.Conclusion Dietary fiber physicochemical properties alter dietary fermentation patterns and regulate nutrient utilization,energy metabolism,and pig gut microbiota composition and metabolites.展开更多
Erratum to:Current Medical Science 44(5):987–1000,2024 https://doi.org/10.1007/s11596-024-2908-9 In the originally published article,there was an error in the funding information.Instead of“Shenzhen Science and Tech...Erratum to:Current Medical Science 44(5):987–1000,2024 https://doi.org/10.1007/s11596-024-2908-9 In the originally published article,there was an error in the funding information.Instead of“Shenzhen Science and Technology Program(No.2021-22154)”,it should be corrected to“Shenzhen Science and Technology Program(No.JCYJ20210324111609024)”.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.展开更多
Predicting molecular properties is essential for advancing for advancing drug discovery and design. Recently, Graph Neural Networks (GNNs) have gained prominence due to their ability to capture the complex structural ...Predicting molecular properties is essential for advancing for advancing drug discovery and design. Recently, Graph Neural Networks (GNNs) have gained prominence due to their ability to capture the complex structural and relational information inherent in molecular graphs. Despite their effectiveness, the “black-box” nature of GNNs remains a significant obstacle to their widespread adoption in chemistry, as it hinders interpretability and trust. In this context, several explanation methods based on factual reasoning have emerged. These methods aim to interpret the predictions made by GNNs by analyzing the key features contributing to the prediction. However, these approaches fail to answer critical questions: “How to ensure that the structure-property mapping learned by GNNs is consistent with established domain knowledge”. In this paper, we propose MMGCF, a novel counterfactual explanation framework designed specifically for the prediction of GNN-based molecular properties. MMGCF constructs a hierarchical tree structure on molecular motifs, enabling the systematic generation of counterfactuals through motif perturbations. This framework identifies causally significant motifs and elucidates their impact on model predictions, offering insights into the relationship between structural modifications and predicted properties. Our method demonstrates its effectiveness through comprehensive quantitative and qualitative evaluations of four real-world molecular datasets.展开更多
The flotation of diasporic bauxite is to separate diaspore(valuable mineral)from aluminosilicate minerals(gangue minerals,mainly including kaolinite,illite and pyrophyllite),and the microscopic interaction force betwe...The flotation of diasporic bauxite is to separate diaspore(valuable mineral)from aluminosilicate minerals(gangue minerals,mainly including kaolinite,illite and pyrophyllite),and the microscopic interaction force between the two types of minerals and air bubbles determines the separation efficiency.In this paper,based on the extended Derjaguin-Landau-Verwey-Overbeek(DLVO)theory,the van der Waals,electrostatic and hydrophobic interaction between particles of the four minerals mentioned above and air bubbles in collectorless solution were calculated first,and then diaspore and kaolinite were taken as examples to analyze the influence of various factors such as electrolyte concentration,mineral particle size,air bubble size,collector type(dodecylamine hydrochloride(DAH)and sodium oleate(NaOL))and concentration,and pulp pH on the interactions between the particles of valuable mineral and gangue minerals and air bubbles.The results showed that the total extended DLVO interactions between the four minerals and air bubbles were repulsive in most cases in collectorless solution.The increase in electrolyte concentration reduced the interaction force or even changed the direction of the force under certain circumstances.The addition of DAH and NaOL can reduce the adhesion energy barrier of kaolinitebubble and diaspore-bubble respectively.Each type of minerals exhibited a specific interface interaction response with air bubbles in each collector with different pH values.The research results have theoretical guiding significance for the optimization and directional control of diasporic bauxite flotation conditions.展开更多
A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy（BNCT） was designed to evaluate whether the world＇s first in-hospital neutron irradiator（IHNI） was qualified for BNCT. ...A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy（BNCT） was designed to evaluate whether the world＇s first in-hospital neutron irradiator（IHNI） was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography（PET/CT） scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals.展开更多
Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the t...Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the time-of-flight technique. Accuracy of the nuclear data for tungsten was examined by comparing the measured neutron spectra with the leakage neutron spectra simulated using the MCNP-4C code with evaluated nuclear data of the JEFF-3.2, FENDL-3.0 and TENDL-2014 libraries. The results show that the calculations with JEFF-3.2 agree well with the measurements in the whole energy range and all angles, whereas the spectra calculated with FENDL-3.0 and TENDL-2014 have some discrepancies with the experimental data.展开更多
Volatile organic compounds(VOCs)with high toxicity and carcinogenicity are emitted from kinds of industries,which endanger human health and the environment.Adsorption is a promising method for the treatment of VOCs du...Volatile organic compounds(VOCs)with high toxicity and carcinogenicity are emitted from kinds of industries,which endanger human health and the environment.Adsorption is a promising method for the treatment of VOCs due to its low cost and high efficiency.In recent years,activated carbons,zeolites,and mesoporous materials are widely used to remove VOCs because of their high specific surface area and abundant porosity.However,the hydrophilic nature and low desorption rate of those materials limit their commercial application.Furthermore,the adsorption capacities of VOCs still need to be improved.Porous organic polymers(POPs)with extremely high porosity,structural diversity,and hydrophobic have been considered as one of the most promising candidates for VOCs adsorption.This review generalized the superiority of POPs for VOCs adsorption compared to other porous materials and summarized the studies of VOCs adsorption on different types of POPs.Moreover,the mechanism of competitive adsorption between water and VOCs on the POPs was discussed.Finally,a concise outlook for utilizing POPs for VOCs adsorption was discussed,noting areas in which further work is needed to develop the next-generation POPs for practical applications.展开更多
Coal gasification fine slag(FS)is a typical solid waste generated in coal gasification.Its current disposal methods of stockpil-ing and landfilling have caused serious soil and ecological hazards.Separation recovery a...Coal gasification fine slag(FS)is a typical solid waste generated in coal gasification.Its current disposal methods of stockpil-ing and landfilling have caused serious soil and ecological hazards.Separation recovery and the high-value utilization of residual carbon(RC)in FS are the keys to realizing the win-win situation of the coal chemical industry in terms of economic and environmental benefits.The structural properties,such as pore,surface functional group,and microcrystalline structures,of RC in FS(FS-RC)not only affect the flotation recovery efficiency of FS-RC but also form the basis for the high-value utilization of FS-RC.In this paper,the characteristics of FS-RC in terms of pore structure,surface functional groups,and microcrystalline structure are sorted out in accordance with gasification type and FS particle size.The reasons for the formation of the special structural properties of FS-RC are analyzed,and their influence on the flotation separation and high-value utilization of FS-RC is summarized.Separation methods based on the pore structural characterist-ics of FS-RC,such as ultrasonic pretreatment-pore-blocking flotation and pore breaking-flocculation flotation,are proposed to be the key development technologies for improving FS-RC recovery in the future.The design of low-cost,low-dose collectors containing polar bonds based on the surface and microcrystalline structures of FS-RC is proposed to be an important breakthrough point for strengthening the flotation efficiency of FS-RC in the future.The high-value utilization of FS should be based on the physicochemical structural proper-ties of FS-RC and should focus on the environmental impact of hazardous elements and the recyclability of chemical waste liquid to es-tablish an environmentally friendly utilization method.This review is of great theoretical importance for the comprehensive understand-ing of the unique structural properties of FS-RC,the breakthrough of the technological bottleneck in the efficient flotation separation of FS,and the expansion of the field of the high value-added utilization of FS-RC.展开更多
The substitution of Fe by Co in the 2:14:1 phase is an effective method to increase the Curie temperature and enhance the thermal stability of the Nd-Fe-B magnets.However,the accumulation of Co ele ment at the grain b...The substitution of Fe by Co in the 2:14:1 phase is an effective method to increase the Curie temperature and enhance the thermal stability of the Nd-Fe-B magnets.However,the accumulation of Co ele ment at the grain boundaries(GBs) changes the GBs from nonmagnetic to ferromagnetic and causes the thinlayer GBs to become rare,In this paper,the method of diffusing Tb element was chosen to improve the microstructure and temperature stability of high-Co magnets.Three original sintered Nd_(28.5)Dy_(3)-CO_(x)e_(bal)M_(0.6)B_(i)(x=0,6 wt%,12 wt%;M = Cu,Al,Zr) magnets with different Co contents were diffused with Tb by grain boundary diffusion(GBD).After GBD,high-Co magnets exhibit more continuously distributed thin-layer GBs,and their thermal stability is significantly improved.In high-Co magnets(x=6 wt%),the absolute value of the temperature coefficient of coercivity decreases from 0.603%/K to0.508%/K in the temperature range of 293-413 K,that of remanence decreases from 0.099%/K to 0.091%/K,and the coercivity increases from 18.44 to 25.04 kOe.Transmission electron microscopy(TEM)characterization reveals that there are both the 1:2 phase and the amorphous phase in the high-Co magnet before and after GBD,EDS elemental analysis shows that Tb element is more likely to preferentially replace the rare earth elements in the 2:14:1 main phase than in the 1:2 phase and the amorphous phase.The concentration of Tb at the edge of the main phase is much higher than that in the 1:2phase and amorphous phase,which is beneficial to the improvement of the microstructure.The preferential replacement of Tb elements at the edge of the 2:14:1 phase and thin-layer GBs with a more continuous distribution are synergistically responsible for improving the thermal stability of high-Co magnets.The study indicates that GBD is an effective method to improve the microstructure and thermal stability of high-Co magnets.展开更多
基金The National Key R&D Program of China under contract No. 2023YFC28 11305the Scientific Research Fund of the Second Institute of Oceanography,MNR under contract No. SZ2405the Impact and Response of Antarctic Seas to Climate Change under contract No. IRASCC
文摘Research on changes in the redox conditions of bottom waters is essential for understanding deep water circulation,global ocean currents,climate change,and ecosystem health.Through sedimentary geological methods,a deeper understanding of the complex relationships between various environmental changes can be achieved,providing detailed evidence and theoretical support for global climate change research.The Ross Sea in Antarctica plays a key role in the formation of Antarctic bottom water(AABW),and the complex climate changes since the last glacial maximum(LGM)make it particularly significant for study.This research analyzes core ANT32-RB16C from the Ross Sea using geochemical proxies such as major and trace elements,grain size,and redox-sensitive indicators like Mn/Ti,Co/Ti,Mo/Ti,Cd/Ti,U/Th,and Ni/Co molar concentration ratios.Combining this data with a previously established chronological framework,the study explores the evolution of redox conditions in the Ross Sea’s deep waters since the LGM.The results show that the deep waters have remained oxygen-rich since the LGM,with significant changes in four stages.Stage 1(24.7–15.7 cal ka BP):Strong oxidizing conditions,likely due to enhanced formation of Ross Sea bottom water(RSBW),increasing oxygen levels.Stage 2(15.7–4.5 cal ka BP):Weakened oxidizing conditions as temperatures rose and ice shelves retreated,increasing primary productivity and depleting oxygen.Stage 3(4.5–1.5 cal ka BP):Continued decline in oxidizing conditions,possibly linked to high primary productivity and oxygen consumption.Stage 4(1.5 cal ka BP to present):A rapid recovery of oxidizing conditions,likely driven by temperature drops,increased RSBW formation,and decreased productivity.
基金supported by the National Natural Science Foundation of China(No.52374279)the Natural Science Foundation of Shaanxi Province(No.2023-YBGY-055).
文摘Effective separation of residual carbon and ash is the basis for the resource utilization of coal gasification fine slag(CGFS).The conventional flotation process of CGFS has the bottlenecks of low carbon recovery and high collector dosage.In order to address these issues,CGFS sample taken from Shaanxi,China was used as the study object in this paper.A new process of size classification-fine grain ultrasonic pretreatment flotation(SC-FGUF)was proposed and its separation effect was compared with that of wholegrain flotation(WGF)as well as size classification-fine grain flotation(SC-FGF).The mechanism of its enhanced separation effect was revealed through flotation kinetic fitting,flotation flow foam layer stability,particle size composition,surface morphology,pore structure,and surface chemical property analysis.The results showed that compared with WGF,pre-classification could reduce the collector dosage by 84.09%and the combination of pre-classification and ultrasonic pretreatment could increase the combustible recovery by 17.29%and up to 93.46%.The SC-FGUF process allows the ineffective adsorption of coarse residual carbon to collector during flotation stage to be reduced by pre-classification,and the tightly embedded state of fine CGFS particles is disrupted and surface oxidizing functional group occupancy was reduced by ultrasonic pretreatment,thus carbon and ash is easier to be separated in the flotation process.In addition,some of the residual carbon particles were broken down to smaller sizes in the ultrasonic pretreatment,which led to an increase in the stability of flotation flow foam layer and a decrease in the probability of detachment of residual carbon particles from the bubbles.Therefore,SCFGUF could increase the residual carbon recovery and reduce the flotation collector dosage,which is an innovative method for carbon-ash separation of CGFS with good application prospect.
基金support under the Australian Research Council’s Discovery Projects funding scheme(project number DP170101773)support from Alexander von Humboldt Foundation.T.T.+3 种基金financial support from the program of the Ministry of Education,Culture,Sports,Science,and Technology(MEXT,Japan)“Priority Issue on Post-K computer”(Development of new fundamental technologies for high-efficiency energy creation,conversion/storage and use)support from the Ministry of Science and Technology(2016YFA0204100)the National Natural Science Foundation of China(21961160722,91845201,21573254)the Liaoning Revitalization Talents Program XLYC1907055。
文摘It is demonstrated experimentally and confirmed theoretically that highly defective boron nitride showed outstanding performance for oxidative dehydrogenation of ethylbenzene.The catalyst is derived from carbon-doped hexagonal boron nitride nanosheets synthesized via a two-step reaction when participating the oxidative dehydrogenation reaction.The first step yields a polymeric precursor with the atomic positions of B,C,N relatively constrained,which is conducive for the formation of carbon atomic clusters uniformly dispersed throughout the BN framework.During the oxidative dehydrogenation of ethylbenzene to styrene,the nanoscale carbon clusters are removed and highly defective boron nitride(D-BN)is obtained,exposing boron-rich zigzag edges of BN that act as the catalytic sites.The catalytic performance of D-BN is therefore remarkably better than un-doped h-BN.Our results indicate that dispersed C-doping in h-BN is highly effective in terms of defect formation and resultant enhanced activity in oxidative dehydrogenation reactions.
基金supported by the Shenzhen Science and Technology Plan,Sustainable Development Technology Special Project (Dual-Carbon Special Project),Research and Development of Intelligent Virtual Power Plant Technology (KCXST20221021111402006)the Science and Technology project of Tianjin,China (No.22YFYSHZ00330).
文摘Precise forecasting of solar power is crucial for the development of sustainable energy systems.Contemporary forecasting approaches often fail to adequately consider the crucial role of weather factors in photovoltaic(PV)power generation and encounter issues such as gradient explosion or disappearance when dealing with extensive time-series data.To overcome these challenges,this research presents a cutting-edge,multi-stage forecasting method called D-Informer.This method skillfully merges the differential transformation algorithm with the Informer model,leveraging a detailed array of meteorological variables and historical PV power generation records.The D-Informer model exhibits remarkable superiority over competing models across multiple performance metrics,achieving on average a 67.64%reduction in mean squared error(MSE),a 49.58%decrease in mean absolute error(MAE),and a 43.43%reduction in root mean square error(RMSE).Moreover,it attained an R2 value as high as 0.9917 during the winter season,highlighting its precision and dependability.This significant advancement can be primarily attributed to the incorporation of a multi-head self-attention mechanism,which greatly enhances the model’s ability to identify complex interactions among diverse input variables,and the inclusion of weather variables,enriching the model’s input data and strengthening its predictive accuracy in time series analysis.Additionally,the experimental results confirm the effectiveness of the proposed approach.
基金supported by the National Key Research and Development Program(No.2021YFD1300201)Jilin Provincial Department of Science and Technology Innovation Platform and Talent Special Project(No.20230508090RC).
文摘Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming,but these feedstuffs are fibrous in nature.This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization,energy metabolism,and gut microbiota in growing pigs.Methods Thirty-six growing barrows(47.2±1.5 kg)were randomly allotted to 6 dietary treatments with 2 apparent viscosity levels and 3β-glucan-to-arabinoxylan ratios.In the experiment,nutrient utilization,energy metabolism,fecal microbial community,and production and absorption of short-chain fatty acid(SCFA)of pigs were investigated.In vitro digestion and fermentation models were used to compare the fermentation characteristics of feedstuffs and ileal digesta in the pig’s hindgut.Results The production dynamics of SCFA and dry matter corrected gas production of different feedstuffs during in vitro fermentation were different and closely related to the physical properties and chemical structure of the fiber.In animal experiments,increasing the dietary apparent viscosity and theβ-glucan-to-arabinoxylan ratios both increased the apparent ileal digestibility(AID),apparent total tract digestibility(ATTD),and hindgut digestibility of fiber components while decreasing the AID and ATTD of dry matter and organic matter(P<0.05).In addition,increasing dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased gas exchange,heat production,and protein oxidation,and decreased energy deposition(P<0.05).The dietary apparent viscosity andβ-glucanto-arabinoxylan ratios had linear interaction effects on the digestible energy,metabolizable energy,retained energy(RE),and net energy(NE)of the diets(P<0.05).At the same time,the increase of dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased SCFA production and absorption(P<0.05).Increasing the dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios increased the diversity and abundance of bacteria(P<0.05)and the relative abundance of beneficial bacteria.Furthermore,increasing the dietaryβ-glucan-to-arabinoxylan ratios led to a linear increase in SCFA production during the in vitro fermentation of ileal digesta(P<0.001).Finally,the prediction equations for RE and NE were established.Conclusion Dietary fiber physicochemical properties alter dietary fermentation patterns and regulate nutrient utilization,energy metabolism,and pig gut microbiota composition and metabolites.
文摘Erratum to:Current Medical Science 44(5):987–1000,2024 https://doi.org/10.1007/s11596-024-2908-9 In the originally published article,there was an error in the funding information.Instead of“Shenzhen Science and Technology Program(No.2021-22154)”,it should be corrected to“Shenzhen Science and Technology Program(No.JCYJ20210324111609024)”.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
文摘Predicting molecular properties is essential for advancing for advancing drug discovery and design. Recently, Graph Neural Networks (GNNs) have gained prominence due to their ability to capture the complex structural and relational information inherent in molecular graphs. Despite their effectiveness, the “black-box” nature of GNNs remains a significant obstacle to their widespread adoption in chemistry, as it hinders interpretability and trust. In this context, several explanation methods based on factual reasoning have emerged. These methods aim to interpret the predictions made by GNNs by analyzing the key features contributing to the prediction. However, these approaches fail to answer critical questions: “How to ensure that the structure-property mapping learned by GNNs is consistent with established domain knowledge”. In this paper, we propose MMGCF, a novel counterfactual explanation framework designed specifically for the prediction of GNN-based molecular properties. MMGCF constructs a hierarchical tree structure on molecular motifs, enabling the systematic generation of counterfactuals through motif perturbations. This framework identifies causally significant motifs and elucidates their impact on model predictions, offering insights into the relationship between structural modifications and predicted properties. Our method demonstrates its effectiveness through comprehensive quantitative and qualitative evaluations of four real-world molecular datasets.
基金supported by the National Natural Science Foundation of China(No.51904240,51904239,52104268)the Natural Science Foundation of Shaanxi Province(No.2020JQ-752,2021JQ-571)+3 种基金the Postdoctoral Science Foundation of China(No.2019M653877XB)the Outstanding Youth Science Foundation of Xi’an University of Science and Technology(No.2019YQ3-08)the Huo Yingdong Education Foundation(No.171102)the 2019 Merit-based Science and Technology Project Foundation for Shannxi Overseas-educated Scholars(No.14).
文摘The flotation of diasporic bauxite is to separate diaspore(valuable mineral)from aluminosilicate minerals(gangue minerals,mainly including kaolinite,illite and pyrophyllite),and the microscopic interaction force between the two types of minerals and air bubbles determines the separation efficiency.In this paper,based on the extended Derjaguin-Landau-Verwey-Overbeek(DLVO)theory,the van der Waals,electrostatic and hydrophobic interaction between particles of the four minerals mentioned above and air bubbles in collectorless solution were calculated first,and then diaspore and kaolinite were taken as examples to analyze the influence of various factors such as electrolyte concentration,mineral particle size,air bubble size,collector type(dodecylamine hydrochloride(DAH)and sodium oleate(NaOL))and concentration,and pulp pH on the interactions between the particles of valuable mineral and gangue minerals and air bubbles.The results showed that the total extended DLVO interactions between the four minerals and air bubbles were repulsive in most cases in collectorless solution.The increase in electrolyte concentration reduced the interaction force or even changed the direction of the force under certain circumstances.The addition of DAH and NaOL can reduce the adhesion energy barrier of kaolinitebubble and diaspore-bubble respectively.Each type of minerals exhibited a specific interface interaction response with air bubbles in each collector with different pH values.The research results have theoretical guiding significance for the optimization and directional control of diasporic bauxite flotation conditions.
基金supported by the National Science&Technology Pillar Program during the 12th Five-Year Plan Period(No.2013BAI01B08)the Major Program of the National Natural Science Foundation of China(No.51290295)
文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy（BNCT） was designed to evaluate whether the world＇s first in-hospital neutron irradiator（IHNI） was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography（PET/CT） scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals.
基金supported by the National Natural Science Foundation of China(No.11605097,91426301,and 11605257)Doctoral Scientific Research Foundation of Inner Mongolia University for the Nationalities(No.BS365)the‘‘ADS project 302’’of the Chinese Academy of Sciences(No.XDA03030200)
文摘Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the time-of-flight technique. Accuracy of the nuclear data for tungsten was examined by comparing the measured neutron spectra with the leakage neutron spectra simulated using the MCNP-4C code with evaluated nuclear data of the JEFF-3.2, FENDL-3.0 and TENDL-2014 libraries. The results show that the calculations with JEFF-3.2 agree well with the measurements in the whole energy range and all angles, whereas the spectra calculated with FENDL-3.0 and TENDL-2014 have some discrepancies with the experimental data.
基金supported by the National Key R&D Pro-gram of China(Nos.2019YFC1904100,2019YFC1904102,2019YFC1903902,and 2016YFC0205300)the National En-gineering Laboratory for Mobile Source Emission Control Technology of China(No.NELMS2017A03)+3 种基金the Natural Na-tional Science Foundation of China(Nos.21503144,21690083)Tianjin Research Program of Ecological Environmental Treat-ment(Nos.18ZXSZSF00210,18ZXSZSF00060)the Tianjin Research Program of Application Foundation and Advanced Technique(No.16JCQNJC05400)Major Science and Tech-nology Project for Ecological Environment Management in Tianjin(No.18ZXSZSF00210)。
文摘Volatile organic compounds(VOCs)with high toxicity and carcinogenicity are emitted from kinds of industries,which endanger human health and the environment.Adsorption is a promising method for the treatment of VOCs due to its low cost and high efficiency.In recent years,activated carbons,zeolites,and mesoporous materials are widely used to remove VOCs because of their high specific surface area and abundant porosity.However,the hydrophilic nature and low desorption rate of those materials limit their commercial application.Furthermore,the adsorption capacities of VOCs still need to be improved.Porous organic polymers(POPs)with extremely high porosity,structural diversity,and hydrophobic have been considered as one of the most promising candidates for VOCs adsorption.This review generalized the superiority of POPs for VOCs adsorption compared to other porous materials and summarized the studies of VOCs adsorption on different types of POPs.Moreover,the mechanism of competitive adsorption between water and VOCs on the POPs was discussed.Finally,a concise outlook for utilizing POPs for VOCs adsorption was discussed,noting areas in which further work is needed to develop the next-generation POPs for practical applications.
基金the National Natural Science Foundation of China(No.52374279)the Natural Science Foundation of Shaanxi Province(No.2023-YBGY-055).
文摘Coal gasification fine slag(FS)is a typical solid waste generated in coal gasification.Its current disposal methods of stockpil-ing and landfilling have caused serious soil and ecological hazards.Separation recovery and the high-value utilization of residual carbon(RC)in FS are the keys to realizing the win-win situation of the coal chemical industry in terms of economic and environmental benefits.The structural properties,such as pore,surface functional group,and microcrystalline structures,of RC in FS(FS-RC)not only affect the flotation recovery efficiency of FS-RC but also form the basis for the high-value utilization of FS-RC.In this paper,the characteristics of FS-RC in terms of pore structure,surface functional groups,and microcrystalline structure are sorted out in accordance with gasification type and FS particle size.The reasons for the formation of the special structural properties of FS-RC are analyzed,and their influence on the flotation separation and high-value utilization of FS-RC is summarized.Separation methods based on the pore structural characterist-ics of FS-RC,such as ultrasonic pretreatment-pore-blocking flotation and pore breaking-flocculation flotation,are proposed to be the key development technologies for improving FS-RC recovery in the future.The design of low-cost,low-dose collectors containing polar bonds based on the surface and microcrystalline structures of FS-RC is proposed to be an important breakthrough point for strengthening the flotation efficiency of FS-RC in the future.The high-value utilization of FS should be based on the physicochemical structural proper-ties of FS-RC and should focus on the environmental impact of hazardous elements and the recyclability of chemical waste liquid to es-tablish an environmentally friendly utilization method.This review is of great theoretical importance for the comprehensive understand-ing of the unique structural properties of FS-RC,the breakthrough of the technological bottleneck in the efficient flotation separation of FS,and the expansion of the field of the high value-added utilization of FS-RC.
基金Tianjin Science and Technology Plan Project:Study on the action mechanism of Traditional Chinese Medicine against new coronavirus(Omicron)(22ZXGBSY00020)2022 Chinese Medicine Clinical Efficacy Improvement Project of the State Administration of Traditional Chinese Medicine.
基金supported by the National Key R&D Program of China (2021YFB3502902,2021YFB3503100,2022YFB3503300,2022YFB3505200)。
文摘The substitution of Fe by Co in the 2:14:1 phase is an effective method to increase the Curie temperature and enhance the thermal stability of the Nd-Fe-B magnets.However,the accumulation of Co ele ment at the grain boundaries(GBs) changes the GBs from nonmagnetic to ferromagnetic and causes the thinlayer GBs to become rare,In this paper,the method of diffusing Tb element was chosen to improve the microstructure and temperature stability of high-Co magnets.Three original sintered Nd_(28.5)Dy_(3)-CO_(x)e_(bal)M_(0.6)B_(i)(x=0,6 wt%,12 wt%;M = Cu,Al,Zr) magnets with different Co contents were diffused with Tb by grain boundary diffusion(GBD).After GBD,high-Co magnets exhibit more continuously distributed thin-layer GBs,and their thermal stability is significantly improved.In high-Co magnets(x=6 wt%),the absolute value of the temperature coefficient of coercivity decreases from 0.603%/K to0.508%/K in the temperature range of 293-413 K,that of remanence decreases from 0.099%/K to 0.091%/K,and the coercivity increases from 18.44 to 25.04 kOe.Transmission electron microscopy(TEM)characterization reveals that there are both the 1:2 phase and the amorphous phase in the high-Co magnet before and after GBD,EDS elemental analysis shows that Tb element is more likely to preferentially replace the rare earth elements in the 2:14:1 main phase than in the 1:2 phase and the amorphous phase.The concentration of Tb at the edge of the main phase is much higher than that in the 1:2phase and amorphous phase,which is beneficial to the improvement of the microstructure.The preferential replacement of Tb elements at the edge of the 2:14:1 phase and thin-layer GBs with a more continuous distribution are synergistically responsible for improving the thermal stability of high-Co magnets.The study indicates that GBD is an effective method to improve the microstructure and thermal stability of high-Co magnets.
