In this work,a highly sensitive electrochemical sensor based on Zn-doped copper gallium oxide@ordered mesoporous carbon(Zn-CuGaO_(2)@CMK-3)for signal amplification was successfully developed for the simultaneous detec...In this work,a highly sensitive electrochemical sensor based on Zn-doped copper gallium oxide@ordered mesoporous carbon(Zn-CuGaO_(2)@CMK-3)for signal amplification was successfully developed for the simultaneous detection of sunset yellow(SY)and tartrazine(TZ)in foods.Compared with CuGaO_(2)@CMK-3,Zn-CuGaO_(2)@CMK-3 offered enhanced conductivity and catalytic properties owing to the improved carrier density,which was beneficial to the electrooxidation of SY and TZ.Under the optimal testing conditions,the constructed Zn-CuGaO_(2)@CMK-3/GCE sensor offered a wide linear concentration range(0.25-100.00μmol/L)for the detection of both SY and TZ.The limits of detection for SY and TZ were 0.044 and 0.059μmol/L,respectively.Recovery experiments were performed in milk,white vinegar and biscuit samples,yielding satisfactory recoveries(82.70%-114.80%).Furthermore,the sensor was successfully applied to the determination of the SY and TZ residues in two kinds of carbonated drinks,and the results were nearly consistent with those detected by the high performance liquid chromatography(HPLC)method(P>0.05).展开更多
As a cell proliferation regulator involved in wide biological processes in plants,GRF-INTERACTING FACTOR(GIF)controls different tissues development.However,whether GIF participates in fruit development remains unclear...As a cell proliferation regulator involved in wide biological processes in plants,GRF-INTERACTING FACTOR(GIF)controls different tissues development.However,whether GIF participates in fruit development remains unclear.According to transcriptome data,we identified PbGIF1was highly expressed during fruit development in cytokinins induced parthenocarpy pear.In the present study,the biofunction of PbGIF1 was initially verified.Overexpression of PbGIF1 promoted fruit size of transgenic tomato.The size of flesh fruit was not affected by cell expansion but the cell proliferation was promoted by overexpressing Pb GIF1.The accelerated cell proliferation process was also observed in PbGIF1-overexpressed transgenic pear fruit calli.The transcriptional regulation of cytokinins on PbGIF1 was further confirmed by exogenous CPPU treatments in pear fruitlets.To investigate the underlying mechanism,the cytokinins-responded factor,PbRR1,was further focused on.The results of Yeast-one-hybrid assay suggested that PbRR1 can bind to the promoter sequence of PbGIF1.The transcriptional activation of PbRR1 on PbGIF1 was also confirmed by Dual-Luciferase assays.Taken together,the results showed that cytokinins control pear fruit development via the transcriptional activation of PbGIF1 by PbRR1.展开更多
Microwave thermochemotherapy(MTC)has been applied to treat lip squamous cell carcinoma(LSCC),but a deeper understanding of its therapeutic mechanisms and molecular biology is needed.To address this,we used single-cell...Microwave thermochemotherapy(MTC)has been applied to treat lip squamous cell carcinoma(LSCC),but a deeper understanding of its therapeutic mechanisms and molecular biology is needed.To address this,we used single-cell transcriptomics(scRNA-seq)and spatial transcriptomics(ST)to highlight the pivotal role of tumor-associated neutrophils(TANs)among tumor-infiltrating immune cells and their therapeutic response to MTC.MNDA+TANs with anti-tumor activity(N1-phenotype)are found to be abundantly infiltrated by MTC with benefit of increased blood perfusion,and these TANs are characterized by enhanced cytotoxicity,ameliorated hypoxia,and upregulated IL1B,activating T&NK cells and fibroblasts via IL1B-IL1R.In this highly anti-tumor immunogenic and hypoxia-reversed microenvironment under MTC,fibroblasts accumulated in the tumor front(TF)can recruit N1-TANs via CXCL2-CXCR2 and clear N2-TANs(pro-tumor phenotype)via CXCL12-CXCR4,which results in the aggregation of N1-TANs and extracellular matrix(ECM)deposition.In addition,we construct an N1-TANs marker,MX2,which positively correlates with better prognosis in LSCC patients,and employ deep learning techniques to predict expression of MX2 from hematoxylin-eosin(H&E)-stained images so as to conveniently guide decision making in clinical practice.Collectively,our findings demonstrate that the N1-TANs/fibroblasts defense wall formed in response to MTC effectively combat LSCC.展开更多
Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock...Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock for the inheritance and development of TM.To meet the growing demand for high-quality healthcare,it is imperative to integrate TM with modern technology to address the issue of insufficient evidence for the efficacy of TM.展开更多
BACKGROUND Tendon tissue engineering requires biomimetic scaffolds and mechanical cues to direct mesenchymal stem cell differentiation toward tenogenic lineages.Bone marrow-derived mesenchymal stem cells(BMSCs),aligne...BACKGROUND Tendon tissue engineering requires biomimetic scaffolds and mechanical cues to direct mesenchymal stem cell differentiation toward tenogenic lineages.Bone marrow-derived mesenchymal stem cells(BMSCs),aligned nanofiber scaffolds,and cyclic uniaxial stretching can be used to create a functional engineered ligament tissue.AIM To investigate the effects of aligned nanofiber scaffolds and cyclic stretch on BMSC tenogenesis for ligament engineering.METHODS BMSCs were cultured on aligned and random poly-lactic acid nanofiber scaffolds under static and cyclic tensile conditions(0.5 Hz,2%strain,2 hours/day)for 7 days using a mechanical loading system(CFILLOAD-300).The Ras homolog gene family(Rho)-associated coiled coil-containing kinase(ROCK)inhibitor Y27632 was applied to explore its role in tenogenic differentiation.Scaffold morphology was assessed by scanning electron microscopy,while cell morphology,viability,and alignment were evaluated via confocal microscopy with F-actin and 4’,6-diamidino-2-phenylindole staining.Tenogenic gene expression(collagen type I alpha 2,collagen type III alpha 1,tenascin C,and tenomodulin)was quantified by quantitative polymerase chain reaction,and ligament-related protein levels(collagen I,collagen III,tenascin C,and tenomodulin)were analyzed by western blot.RESULTS Scanning electron microscopy revealed that aligned scaffolds provided consistent directional structure,whereas random scaffolds displayed a disordered fiber arrangement.Confocal microscopy showed that under static conditions,BMSCs on aligned scaffolds grew parallel to fiber alignment,while those on random scaffolds grew randomly.Under cyclic tensile strain,BMSCs on both scaffold types exhibited elongation along the direction of strain,adopting a spindle-shaped morphology.Cyclic uniaxial strain enhanced cell viability and metabolic activity based on CCK-8 assay results and upregulated ligament-specific gene and protein expression on aligned scaffolds compared to static conditions.BMSCs on aligned scaffolds under tensile strain showed the highest expression of tenogenic markers,suggesting a synergistic effect of scaffold alignment and mechanical loading.ROCK inhibition with Y27632 upregulated alternative signaling pathways(focal adhesion kinase and runt-related transcription factor 2),further promoting tenogenic differentiation.CONCLUSION Aligned nanofiber scaffolds combined with cyclic tensile strain provide an optimal environment for guiding BMSC differentiation toward ligamentous lineages,as assessed by increased expression of ligament-specific markers.Mechanical stimulation(uniaxial stretching)significantly influences BMSC tenogenic differentiation,and the combined use of aligned nanofibers and tensile strain further enhances this effect.The ROCK pathway plays a regulatory role in this process,though its precise mechanisms require further investigation.展开更多
The chemistry of sulfur cycle contributes significantly to the atmospheric nucleation process,which is the first step of new particle formation(NPF).In the present study,cycloaddition reaction mechanism of sulfur trio...The chemistry of sulfur cycle contributes significantly to the atmospheric nucleation process,which is the first step of new particle formation(NPF).In the present study,cycloaddition reaction mechanism of sulfur trioxide(SO_(3))to hydrogen sulfide(H_(2)S)which is a typical air pollutant and toxic gas detrimental to the environment were comprehensively investigate through theoretical calculations and Atmospheric Cluster Dynamic Code simulations.Gas-phase stability and nucleation potential of the product thiosulfuric acid(H_(2)S_(2)O_(3),TSA)were further analyzed to evaluate its atmospheric impact.Without any catalysts,the H_(2)S+SO_(3)reaction is infeasible with a barrier of 24.2 kcal/mol.Atmospheric nucleation precursors formic acid(FA),sulfuric acid(SA),and water(H_(2)O)could effectively lower the reaction barriers as catalysts,even to a barrierless reaction with the efficiency of cis-SA>trans-FA>trans-SA>H_(2)O.Subsequently,the gas-phase stability of TSA was investigated.A hydrolysis reaction barrier of up to 61.4 kcal/mol alone with an endothermic isomerization reaction barrier of 5.1 kcal/mol under the catalytic effect of SA demonstrates the sufficient stability of TSA.Furthermore,topological and kinetic analysis were conducted to determine the nucleation potential of TSA.Atmospheric clusters formed by TSA and atmospheric nucleation precursors(SA,ammonia NH_(3),and dimethylamine DMA)were thermodynamically stable.Moreover,the gradually decreasing evaporation coefficients for TSA-base clusters,particularly for TSA-DMA,suggests that TSA may participate in NPF where the concentration of base molecules are relatively higher.The present new reaction mechanismmay contributes to a better understanding of atmospheric sulfur cycle and NPF.展开更多
Permian—Triassic granitoids are widely distributed along the Jinshajiang suture belt,eastern Xizang,and are regarded as the result of the tectonic-magmatic activity associated with the evolution of Paleo-Tethys Ocean...Permian—Triassic granitoids are widely distributed along the Jinshajiang suture belt,eastern Xizang,and are regarded as the result of the tectonic-magmatic activity associated with the evolution of Paleo-Tethys Ocean.This paper focuses on the high-K calc-alkaline I-type Rennong(~235 Ma)and Jiaduoling(~232 Ma)granitoid plutons,eastern Xizang,which are enriched in light rare earth elements(LREEs)and large ion lithophile elements(LILEs),but depleted in high field strength elements(HFSEs)with moderate-weak negative Eu anomalies(0.61–0.90).The Rennong granites are characterized by uniform zircon ε_(Hf)(t)values(-7.3 to-3.5)and negative ε_(Nd)(t)values(-7.6 to-5.7),with old two-stage Nd model ages(T_(DM2)=1.51-1.46 Ga)and was likely formed by partial melting of the basement rocks,whereas the Jiaduoling rock samples have variable zircon ε_(Hf)(t)values(-5.7 to+5.5)but negativeεNd(t)values(-7.6 to-7.7)and are proposed to be formed by hybridization of mantle-derived mafic magma,Rennong felsic magma and sediments.Mafic microgranular enclaves(MMEs)in the Jiaduoling granitic rocks,have similar zircon U-Pb ages(~237 Ma)and zircon ε_(Hf)(t)values(-4.4 to+6.3)to the host rocks,indicating that zircons in the MMEs were actually xenocrysts that formed at an early stage in the granitic magma chamber.These results reveal that the break-off of the Jinshajiang oceanic slab beneath Changdu(Qamdo)-Simao Block was in a post-collisional setting,resulted in the upwelling of asthenosphere in the Late Triassic,and then,generated the wide-spread intermediate-felsic magmatism along the Jinshajing belt,including the Rennong and Jiaduoling plutons.展开更多
Engineered water systems such as wastewater treatment plants(WWTPs)are potential reservoirs of various biological risk factors(BRFs),including pathogens,antibiotic resistance genes(ARGs),and virulence factors(VFs).Cur...Engineered water systems such as wastewater treatment plants(WWTPs)are potential reservoirs of various biological risk factors(BRFs),including pathogens,antibiotic resistance genes(ARGs),and virulence factors(VFs).Currently,a BRF database relevant to engineered water systems on a global geographic scale is lacking.Here,we present the Global Wastewater Pathogen Database(GWPD),an online database that provides information on the diversity,abundance,and distribution of BRFs from 1302 metagenome samples obtained from 186 cities,68 countries,and six continents.We sorted these samples into six types:sewer networks,influent,anoxic activated sludge,oxic activated sludge,effluent,and receiving/natural waters.In total,476 pathogens,442 ARGs,and 246 VFs were identified.As a multifunctional database,GWPD provides an interactive visualization of these BRFs in a world map,an information retrieval interface,and an online one-click service for BRF annotation from metagenome sequencing data.GWPD is built on a web service framework,which can be readily extended to future versions of GWPD by adding more functional modules and connecting to other data sources,such as epidemic databases,to support risk assessment and control in the context of“One Health.”展开更多
Biological contaminants(BCs),including but not limited to various pathogens and their endogenous pol-lutants such as intracellular pathogens and antimicrobial resistance genes(ARGs),are ubiquitously detected in efflue...Biological contaminants(BCs),including but not limited to various pathogens and their endogenous pol-lutants such as intracellular pathogens and antimicrobial resistance genes(ARGs),are ubiquitously detected in effluent of wastewater and drinking water treatment systems which were originally designed to remove common indicator bacteria,resulting in potential impacts on public health.Although there are many emerging technologies that showing promising antimicrobial effects,few have progressed to the actual water scenarios.It’s crucial to understand the main knowledge gaps and thereby design the future developments to better meet engineering requirements.In this review,we first summarize the perfor-mance of conventional water treatment towards BCs removal.Then we showcase the advances of proof-of-concept strategies,including nanotechnology,advanced oxidation process,biological control process and integrated techniques,for BCs control in light of antimicrobial mechanisms,characteristics,proper niches in water treatment,challenges and latest improvements.Further,we proposed a semi-quantitative framework coupling life cycle assessment(LCA)and analytic hierarchy process(AHP)to assess and compare the application potential of representative pilot technologies,in which the antimicro-bial effects,economic issues and sustainability are comprehensively considered.For wastewater treat-ment,non-thermal plasma weights highest among the emerging technologies and outperforms conventional disinfection in terms of efficacy indicators(overall inactivation rate,ARGs removal rate,and growth inhibition),but fall behind overall mainly due to more energy input.Bacteriophage-based treatment has the potential to synergistically inactive the persistent pathogens in combination with con-ventional disinfection,serving as a cost-effective and environmental-friendly supplement.For drinking water treatment,the integrated photocatalytic nanocomposite receives the highest application potential among the emerging technologies and appears to be supplementary or even alternative next-generation disinfectants.This review shares valuable insights to propel the proof-of-concept antimicrobial trials towards industrial procedures.展开更多
Water-soluble organic aerosol(WSOA)plays a significant role in air quality and human health.Here we characterized the chemical properties and molecular compositions of WSOA at a rural site in North China Plain during ...Water-soluble organic aerosol(WSOA)plays a significant role in air quality and human health.Here we characterized the chemical properties and molecular compositions of WSOA at a rural site in North China Plain during winter using a high-resolution aerosol mass spectrometer and electrospray ionization high-resolution orbitrap mass spectrometer(ESI-HRMS).Our results show that the mass concentration of WSOA was significantly higher than that observed in Beijing in winter 2020,contributing about 56%of OA on average.CHO compounds(56%-74%)and CHN compounds(66%-80%)dominated in negative mode and positive mode,respectively,while CHON accounted for 15%-41%across both modes.The chemical characteristics of WSOA varied with polluted levels and between day and night.As pollution intensified,the abundance of CHO-compounds with condensed aromatics increased by 9%and the number of highly oxygenated molecules(HOMs)molecular formula detected in server haze was more than double that of clean days.CHO-compounds with ten carbon atoms(C_(10))were more abundant at night while those with nine carbon atoms(C_(9))were higher during the day.High levels of CHN+compounds were linked to nighttime biomass burning,whereas CHON compounds were more abundant during the day.Increased pollution also led to the formation of more complex CHON-compounds,indicating that organonitrates continue to play a significant role in rural pollution.展开更多
In this work,an effective catalyst of Cu/MnOOH has been successfully constructed for electrochemical nitrate reduction reaction(e NO_(3)RR)for synthesis of ammonia(NH_(3))under ambient conditions.The substrate of MnOO...In this work,an effective catalyst of Cu/MnOOH has been successfully constructed for electrochemical nitrate reduction reaction(e NO_(3)RR)for synthesis of ammonia(NH_(3))under ambient conditions.The substrate of MnOOH plays an important role on the size and electronic structure of Cu nanoparticles,where Cu has the ultrafine size of 2.2 nm and positive shift of its valence states,which in turn causes the increased number of Cu active sites and enhanced intrinsic activity of every active site.As a result,this catalyst realizes an excellent catalytic performance on eNO_(3)RR with the maximal NH_(3)Faraday efficiency(FE)(96.8%)and the highest yield rate(55.51 mg h^(-1)cm^(-2))at a large NH_(3)partial current density of700 m A/cm^(2),which could help to promote the industrialization of NH_(3)production under ambient conditions.展开更多
2,6-Diisopropylaniline reacts with an open-cage fullerene derivative with a 11-membered orifice and forms an open-cage derivative containing one imino group on the rim of the expanded orifice.Further treatment with Le...2,6-Diisopropylaniline reacts with an open-cage fullerene derivative with a 11-membered orifice and forms an open-cage derivative containing one imino group on the rim of the expanded orifice.Further treatment with Lewis acids leads to open-cage fullerenes with an 18-membered orifice.Instead of the direct addition process observed before for less bulky anilines,an electron transfer process takes place in the initial step in the present reaction with bulky 2,6-diisopropylaniline.As a result,the chemo-selectivity is completely different affording the mono imino open-cage derivative selectively.展开更多
Oxygen evolution reaction(OER) is one of the most important half-reactions related to metal-air batteries,fuel cells, and water-splitting. Due to the sluggish kinetic and multi-electron transfer, catalysts appear to b...Oxygen evolution reaction(OER) is one of the most important half-reactions related to metal-air batteries,fuel cells, and water-splitting. Due to the sluggish kinetic and multi-electron transfer, catalysts appear to be particularly important for the OER. Knowing the reaction mechanism is fundamental to developing new catalysts and improving OER efficiency. In this work, phase transition and atomic reconstruction on Co O(111) plane were revealed through ex-situ diffraction methods and X-ray absorption spectroscopy.At the same time, the electronic state evolution of Co(Ⅱ)/Co(Ⅲ) during the OER process has also been concluded by analyzing the magnetic properties. This work shows that during the OER process, Co(Ⅲ)experiences surface electron rearrangement from IS(intermediate-spin state) to LS(low-spin state) and then returns to IS/HS(high-spin state) under high voltage region. This work provides a new view to reveal the reaction mechanism through the magnetic property and it can be extended to more magnetic 3d transition metals for future catalyst design.展开更多
The deployment of non-precious metal catalysts for the production of COx-free hydrogen via the ammonia decomposition reaction(ADR)presents a promising yet great challenge.In the present study,two crystal structures of...The deployment of non-precious metal catalysts for the production of COx-free hydrogen via the ammonia decomposition reaction(ADR)presents a promising yet great challenge.In the present study,two crystal structures of α-MoC and β-Mo_(2)C catalysts with different Mo/C ratios were synthesized,and their ammonia decomposition performance as well as structural evolution in ADR was investigated.The β-Mo_(2)C catalyst,characterized by a higher Mo/C ratio,demonstrated a remarkable turnover frequency of 1.3 s^(-1),which is over tenfold higher than that ofα-MoC(0.1 s^(-1)).An increase in the Mo/C ratio of molybdenum carbide revealed a direct correlation between the surface Mo/C ratio and the hydrogen yield.The transient response surface reaction indicated that the combination of N*and N*derived from NH_(3) dissociation represents the rate-determining step in the ADR,andβ-Mo2C exhibited exceptional proficiency in facilitating this pivotal step.Concurrently,the accumulation of N*species on the carbide surface could induce the phase transition of molybdenum carbide to nitride,which follows a topological transformation.It is discovered that such phase evolution was affected by the Mo-C surface and reaction temperature simultaneously.When the kinetics of combination of N*was accelerated by rising temperatures and its accumulation on the carbide surface was mitigated,β-Mo_(2)C maintained its carbide phase,preventing nitridation during the ADR at 810℃.Our results contribute to an in-depth understanding of the molybdenum carbides’catalytic properties in ADR and highlight the nature of the carbide-nitride phase transition in the reaction.展开更多
Recent advances in spatially resolved transcriptomics(SRT)have provided new opportunities for characterizing spatial structures of various tissues.Graph-based geometric deep learning has gained widespread adoption for...Recent advances in spatially resolved transcriptomics(SRT)have provided new opportunities for characterizing spatial structures of various tissues.Graph-based geometric deep learning has gained widespread adoption for spatial domain identification tasks.Currently,most methods define adjacency relation between cells or spots by their spatial distance in SRT data,which overlooks key biological interactions like gene expression similarities,and leads to inaccuracies in spatial domain identification.To tackle this challenge,we propose a novel method,SpaGRA(https://github.com/sunxue-yy/SpaGRA),for automatic multi-relationship construction based on graph augmentation.SpaGRA uses spatial distance as prior knowledge and dynamically adjusts edge weights with multi-head graph attention networks(GATs).This helps SpaGRA to uncover diverse node relationships and enhance message passing in geometric contrastive learning.Additionally,SpaGRA uses these multi-view relationships to construct negative samples,addressing sampling bias posed by random selection.Experimental results show that SpaGRA presents superior domain identification performance on multiple datasets generated from different protocols.Using SpaGRA,we analyze the functional regions in the mouse hypothalamus,identify key genes related to heart development in mouse embryos,and observe cancer-associated fibroblasts enveloping cancer cells in the latest Visium HD data.Overall,SpaGRA can effectively characterize spatial structures across diverse SRT datasets.展开更多
Objective: To explore the application effect of self-management based on Snyder’s hope theory in diabetic patients. Methods: A total of 260 patients with diabetes from a community were selected through convenient sam...Objective: To explore the application effect of self-management based on Snyder’s hope theory in diabetic patients. Methods: A total of 260 patients with diabetes from a community were selected through convenient sampling and randomly divided into an experimental group and a control group using the random number table method, with 130 cases in each group. Five cases were lost in the experimental group, resulting in 125 effective cases, while all 130 cases in the control group were effective. The control group received standard lectures on diabetes self-management behavior and traditional approaches, such as the distribution of educational manuals. The experimental group underwent a self-management behavior intervention program for diabetic patients based on Snyder’s hope theory model, encompassing three components: goals, pathways, and motivational thinking. The levels of hope and self-management behavior were compared between the two groups. Results: After the intervention, the scores for hope levels and self-management behaviors in both groups were significantly higher than those recorded before the intervention (P < 0.05). Furthermore, the hope level and self-management behavior scores of the experimental group were significantly higher than those of the control group (P < 0.05). Conclusion: The application of Snyder’s hope theory model in diabetic patients demonstrates significant benefits, improving patients’ hope levels and, consequently, enhancing their self-management behaviors.展开更多
Magmatism at continental margins is of great significance in understanding the continental rifting.We present a twodimensional P-wave velocity model derived from an ocean bottom seismometer experiment,conducted across...Magmatism at continental margins is of great significance in understanding the continental rifting.We present a twodimensional P-wave velocity model derived from an ocean bottom seismometer experiment,conducted across the middle northern continental margin of the South China Sea(SCS).The detailed velocity structures reveal significant heterogeneities extending from the continental shelf to the continent-ocean transition zone.The crust exhibits its greatest thickness below the continental shelf,measuring~23 km and gradually thins to~13 km at the distal margin.Furthermore,a narrow and distinct continent-ocean transition with only 40-km width is revealed.We also observe a high-velocity layer within the transition zone,reaching thickness of up to 4 km,characterized by P-wave velocities ranging from 7.0 km/s to 7.6 km/s in the lower crust.Based on the syn-rift melt generation using decompression melting model,we ascertain that syn-rift magmatism cannot fully account for the observed thick high-velocity layer.By integrating findings from previous geophysical and geochemical studies presenting extensive volcanic edifice on the seafloor at the northern margin,as well as ocean-island-basalt-type magmaticsamples in the SCS area,we propose that post-rifting magmatism associated with the Hainan Plume may have influenced theformation of the high-velocity lower crust within the transition zone and the northern margin of the SCS can thus be recognizedas magma-poor type margin.展开更多
Based on the financial data and stock price information of Bengang Steel Plates Co.Ltd.from 2004 to 2023,this paper uses SPSS 26 software,combined with DuPont Analysis and Wall Score Method,to explore the correlation ...Based on the financial data and stock price information of Bengang Steel Plates Co.Ltd.from 2004 to 2023,this paper uses SPSS 26 software,combined with DuPont Analysis and Wall Score Method,to explore the correlation between stock price and nine key financial indicators selected from three dimensions:profitability,development capability,and operating capability,including fixed asset growth rate,price-to-book ratio(P/B ratio),and gross profit margin.Through correlation analysis,multiple regression analysis,and curve fitting,the study finds that:fixed asset growth rate,P/B ratio,and gross profit margin show a significant positive correlation with stock price;return on equity(ROE),operating income,and accounts receivable turnover days show a significant negative correlation with stock price;earnings per share(EPS)and net profit growth rate do not show a significant correlation with stock price.The research results indicate that the stock price of Bengang Steel Plates Co.Ltd.is greatly affected by its asset scale and market valuation,while some profitability indicators have not been effectively transmitted to the stock price.Finally,countermeasures and suggestions are put forward from the aspects of cost control,technological innovation,market expansion,and financial structure optimization,so as to provide references for corporate operation and investment decisions.展开更多
This study aims to explore the effect of project-based teaching methods on improving students’ abilities in normal universities. This study delves into the practice teaching system based on ability training implement...This study aims to explore the effect of project-based teaching methods on improving students’ abilities in normal universities. This study delves into the practice teaching system based on ability training implemented in normal universities, examining the application of this teaching model in teacher education and the potential challenges it may encounter. Our case study reveals that the Project-Based Learning (PBL) approach can effectively transform students from passive recipients of knowledge into active problem solvers, thereby enhancing their critical thinking, problem-solving, teamwork, and communication skills. However, challenges do exist, including ensuring active participation from all students, providing equal opportunities for each student to develop and showcase their abilities, and completing complex projects within a limited timeframe. Therefore, teachers may need to adjust their teaching strategies, and schools need to provide more resources and support. These adjustments can help the practice teaching system based on ability training better serve teacher education and offer students a higher-quality educational experience.展开更多
基金financially supported by the Key R&D Program of Shandong Province,China(2023CXGC010712)GINW acknowledges funding support from the MacDiarmid Institute for Advanced Materials and Nanotechnology.
文摘In this work,a highly sensitive electrochemical sensor based on Zn-doped copper gallium oxide@ordered mesoporous carbon(Zn-CuGaO_(2)@CMK-3)for signal amplification was successfully developed for the simultaneous detection of sunset yellow(SY)and tartrazine(TZ)in foods.Compared with CuGaO_(2)@CMK-3,Zn-CuGaO_(2)@CMK-3 offered enhanced conductivity and catalytic properties owing to the improved carrier density,which was beneficial to the electrooxidation of SY and TZ.Under the optimal testing conditions,the constructed Zn-CuGaO_(2)@CMK-3/GCE sensor offered a wide linear concentration range(0.25-100.00μmol/L)for the detection of both SY and TZ.The limits of detection for SY and TZ were 0.044 and 0.059μmol/L,respectively.Recovery experiments were performed in milk,white vinegar and biscuit samples,yielding satisfactory recoveries(82.70%-114.80%).Furthermore,the sensor was successfully applied to the determination of the SY and TZ residues in two kinds of carbonated drinks,and the results were nearly consistent with those detected by the high performance liquid chromatography(HPLC)method(P>0.05).
基金supported by the China Agriculture Research System of MOF and MARA。
文摘As a cell proliferation regulator involved in wide biological processes in plants,GRF-INTERACTING FACTOR(GIF)controls different tissues development.However,whether GIF participates in fruit development remains unclear.According to transcriptome data,we identified PbGIF1was highly expressed during fruit development in cytokinins induced parthenocarpy pear.In the present study,the biofunction of PbGIF1 was initially verified.Overexpression of PbGIF1 promoted fruit size of transgenic tomato.The size of flesh fruit was not affected by cell expansion but the cell proliferation was promoted by overexpressing Pb GIF1.The accelerated cell proliferation process was also observed in PbGIF1-overexpressed transgenic pear fruit calli.The transcriptional regulation of cytokinins on PbGIF1 was further confirmed by exogenous CPPU treatments in pear fruitlets.To investigate the underlying mechanism,the cytokinins-responded factor,PbRR1,was further focused on.The results of Yeast-one-hybrid assay suggested that PbRR1 can bind to the promoter sequence of PbGIF1.The transcriptional activation of PbRR1 on PbGIF1 was also confirmed by Dual-Luciferase assays.Taken together,the results showed that cytokinins control pear fruit development via the transcriptional activation of PbGIF1 by PbRR1.
基金supported by National Natural Science Foundation of China grants(Nos.82173326 and 82473058)Key Research and Development Project of Sichuan Province(Nos.2024YFFK0374 and 2024YFFK0198)Interdisciplinary Innovation Project of West China College of Stomatology,Sichuan University(RD-03-202004).
文摘Microwave thermochemotherapy(MTC)has been applied to treat lip squamous cell carcinoma(LSCC),but a deeper understanding of its therapeutic mechanisms and molecular biology is needed.To address this,we used single-cell transcriptomics(scRNA-seq)and spatial transcriptomics(ST)to highlight the pivotal role of tumor-associated neutrophils(TANs)among tumor-infiltrating immune cells and their therapeutic response to MTC.MNDA+TANs with anti-tumor activity(N1-phenotype)are found to be abundantly infiltrated by MTC with benefit of increased blood perfusion,and these TANs are characterized by enhanced cytotoxicity,ameliorated hypoxia,and upregulated IL1B,activating T&NK cells and fibroblasts via IL1B-IL1R.In this highly anti-tumor immunogenic and hypoxia-reversed microenvironment under MTC,fibroblasts accumulated in the tumor front(TF)can recruit N1-TANs via CXCL2-CXCR2 and clear N2-TANs(pro-tumor phenotype)via CXCL12-CXCR4,which results in the aggregation of N1-TANs and extracellular matrix(ECM)deposition.In addition,we construct an N1-TANs marker,MX2,which positively correlates with better prognosis in LSCC patients,and employ deep learning techniques to predict expression of MX2 from hematoxylin-eosin(H&E)-stained images so as to conveniently guide decision making in clinical practice.Collectively,our findings demonstrate that the N1-TANs/fibroblasts defense wall formed in response to MTC effectively combat LSCC.
文摘Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock for the inheritance and development of TM.To meet the growing demand for high-quality healthcare,it is imperative to integrate TM with modern technology to address the issue of insufficient evidence for the efficacy of TM.
基金Supported by Sichuan Province Science and Technology Support Program,No.2024NSFSC1292the Program of General Hospital of Western Theater Command,No.2021-XZYG-C45 and No.2021-XZYG-B32+1 种基金the Natural Science Foundation of Gansu Province,No.23JRRA538the National Natural Science Foundation of China,No.81601905.
文摘BACKGROUND Tendon tissue engineering requires biomimetic scaffolds and mechanical cues to direct mesenchymal stem cell differentiation toward tenogenic lineages.Bone marrow-derived mesenchymal stem cells(BMSCs),aligned nanofiber scaffolds,and cyclic uniaxial stretching can be used to create a functional engineered ligament tissue.AIM To investigate the effects of aligned nanofiber scaffolds and cyclic stretch on BMSC tenogenesis for ligament engineering.METHODS BMSCs were cultured on aligned and random poly-lactic acid nanofiber scaffolds under static and cyclic tensile conditions(0.5 Hz,2%strain,2 hours/day)for 7 days using a mechanical loading system(CFILLOAD-300).The Ras homolog gene family(Rho)-associated coiled coil-containing kinase(ROCK)inhibitor Y27632 was applied to explore its role in tenogenic differentiation.Scaffold morphology was assessed by scanning electron microscopy,while cell morphology,viability,and alignment were evaluated via confocal microscopy with F-actin and 4’,6-diamidino-2-phenylindole staining.Tenogenic gene expression(collagen type I alpha 2,collagen type III alpha 1,tenascin C,and tenomodulin)was quantified by quantitative polymerase chain reaction,and ligament-related protein levels(collagen I,collagen III,tenascin C,and tenomodulin)were analyzed by western blot.RESULTS Scanning electron microscopy revealed that aligned scaffolds provided consistent directional structure,whereas random scaffolds displayed a disordered fiber arrangement.Confocal microscopy showed that under static conditions,BMSCs on aligned scaffolds grew parallel to fiber alignment,while those on random scaffolds grew randomly.Under cyclic tensile strain,BMSCs on both scaffold types exhibited elongation along the direction of strain,adopting a spindle-shaped morphology.Cyclic uniaxial strain enhanced cell viability and metabolic activity based on CCK-8 assay results and upregulated ligament-specific gene and protein expression on aligned scaffolds compared to static conditions.BMSCs on aligned scaffolds under tensile strain showed the highest expression of tenogenic markers,suggesting a synergistic effect of scaffold alignment and mechanical loading.ROCK inhibition with Y27632 upregulated alternative signaling pathways(focal adhesion kinase and runt-related transcription factor 2),further promoting tenogenic differentiation.CONCLUSION Aligned nanofiber scaffolds combined with cyclic tensile strain provide an optimal environment for guiding BMSC differentiation toward ligamentous lineages,as assessed by increased expression of ligament-specific markers.Mechanical stimulation(uniaxial stretching)significantly influences BMSC tenogenic differentiation,and the combined use of aligned nanofibers and tensile strain further enhances this effect.The ROCK pathway plays a regulatory role in this process,though its precise mechanisms require further investigation.
基金supported by the Budget Surplus of Central Financial Science and Technology Plan (No.2021-JY-14)the Project funded by China Postdoctoral Science Foundation (No.2020M680636)+3 种基金the Fundamental Research Funds for Central Public Welfare Scientific Research Institutes of China,Chinese Research Academy of Environmental Sciences (Nos.2022YSKY-21 and 2022YSKY-27)the National Natural Science Foundation of China (No.41375133)the Science Foundation of Chinese Research Academy of Environmental Sciences (No.JY-41375133)Tian He Qingsuo Project-special fund project.
文摘The chemistry of sulfur cycle contributes significantly to the atmospheric nucleation process,which is the first step of new particle formation(NPF).In the present study,cycloaddition reaction mechanism of sulfur trioxide(SO_(3))to hydrogen sulfide(H_(2)S)which is a typical air pollutant and toxic gas detrimental to the environment were comprehensively investigate through theoretical calculations and Atmospheric Cluster Dynamic Code simulations.Gas-phase stability and nucleation potential of the product thiosulfuric acid(H_(2)S_(2)O_(3),TSA)were further analyzed to evaluate its atmospheric impact.Without any catalysts,the H_(2)S+SO_(3)reaction is infeasible with a barrier of 24.2 kcal/mol.Atmospheric nucleation precursors formic acid(FA),sulfuric acid(SA),and water(H_(2)O)could effectively lower the reaction barriers as catalysts,even to a barrierless reaction with the efficiency of cis-SA>trans-FA>trans-SA>H_(2)O.Subsequently,the gas-phase stability of TSA was investigated.A hydrolysis reaction barrier of up to 61.4 kcal/mol alone with an endothermic isomerization reaction barrier of 5.1 kcal/mol under the catalytic effect of SA demonstrates the sufficient stability of TSA.Furthermore,topological and kinetic analysis were conducted to determine the nucleation potential of TSA.Atmospheric clusters formed by TSA and atmospheric nucleation precursors(SA,ammonia NH_(3),and dimethylamine DMA)were thermodynamically stable.Moreover,the gradually decreasing evaporation coefficients for TSA-base clusters,particularly for TSA-DMA,suggests that TSA may participate in NPF where the concentration of base molecules are relatively higher.The present new reaction mechanismmay contributes to a better understanding of atmospheric sulfur cycle and NPF.
基金supported by the National Natural Science Foundation of China(Nos.42072069,41403023)China Geological Survey(No.1212011121270)the Natural Science Foundation of Hainan Province(Nos.521QN274 and 421CXTD441).
文摘Permian—Triassic granitoids are widely distributed along the Jinshajiang suture belt,eastern Xizang,and are regarded as the result of the tectonic-magmatic activity associated with the evolution of Paleo-Tethys Ocean.This paper focuses on the high-K calc-alkaline I-type Rennong(~235 Ma)and Jiaduoling(~232 Ma)granitoid plutons,eastern Xizang,which are enriched in light rare earth elements(LREEs)and large ion lithophile elements(LILEs),but depleted in high field strength elements(HFSEs)with moderate-weak negative Eu anomalies(0.61–0.90).The Rennong granites are characterized by uniform zircon ε_(Hf)(t)values(-7.3 to-3.5)and negative ε_(Nd)(t)values(-7.6 to-5.7),with old two-stage Nd model ages(T_(DM2)=1.51-1.46 Ga)and was likely formed by partial melting of the basement rocks,whereas the Jiaduoling rock samples have variable zircon ε_(Hf)(t)values(-5.7 to+5.5)but negativeεNd(t)values(-7.6 to-7.7)and are proposed to be formed by hybridization of mantle-derived mafic magma,Rennong felsic magma and sediments.Mafic microgranular enclaves(MMEs)in the Jiaduoling granitic rocks,have similar zircon U-Pb ages(~237 Ma)and zircon ε_(Hf)(t)values(-4.4 to+6.3)to the host rocks,indicating that zircons in the MMEs were actually xenocrysts that formed at an early stage in the granitic magma chamber.These results reveal that the break-off of the Jinshajiang oceanic slab beneath Changdu(Qamdo)-Simao Block was in a post-collisional setting,resulted in the upwelling of asthenosphere in the Late Triassic,and then,generated the wide-spread intermediate-felsic magmatism along the Jinshajing belt,including the Rennong and Jiaduoling plutons.
基金supported by the National Natural Science Foundation of China(52321005,52293441,52293443,52230004)the Shenzhen Stability Support Key Program in Colleges and Universities of China(GXWD20231127195344001)+3 种基金the Natural Science Foundation of Guangdong Basic and Applied Basic Research Foundation(2024A1515010085)the Shenzhen Overseas High-level Talents Research Startup Program(20200518750C)the Shenzhen Science and Technology Program(KQTD20190929172630447)the Open Project of the Key Laboratory of Environmental Biotechnology,CAS(KF2021006).
文摘Engineered water systems such as wastewater treatment plants(WWTPs)are potential reservoirs of various biological risk factors(BRFs),including pathogens,antibiotic resistance genes(ARGs),and virulence factors(VFs).Currently,a BRF database relevant to engineered water systems on a global geographic scale is lacking.Here,we present the Global Wastewater Pathogen Database(GWPD),an online database that provides information on the diversity,abundance,and distribution of BRFs from 1302 metagenome samples obtained from 186 cities,68 countries,and six continents.We sorted these samples into six types:sewer networks,influent,anoxic activated sludge,oxic activated sludge,effluent,and receiving/natural waters.In total,476 pathogens,442 ARGs,and 246 VFs were identified.As a multifunctional database,GWPD provides an interactive visualization of these BRFs in a world map,an information retrieval interface,and an online one-click service for BRF annotation from metagenome sequencing data.GWPD is built on a web service framework,which can be readily extended to future versions of GWPD by adding more functional modules and connecting to other data sources,such as epidemic databases,to support risk assessment and control in the context of“One Health.”
基金supported by the National Natural Science Foundation of China(52293443,52321005,52230004)the Natural Science Foundation of Guangdong Basic and Applied Basic Research Foundation(2024A1515010085)+1 种基金Shenzhen Science and Technology Program(GXWD20231127195344001 and JCYJ20241202123735045)Shenzhen Overseas High-level Talents Research Startup Program(20200518750C).
文摘Biological contaminants(BCs),including but not limited to various pathogens and their endogenous pol-lutants such as intracellular pathogens and antimicrobial resistance genes(ARGs),are ubiquitously detected in effluent of wastewater and drinking water treatment systems which were originally designed to remove common indicator bacteria,resulting in potential impacts on public health.Although there are many emerging technologies that showing promising antimicrobial effects,few have progressed to the actual water scenarios.It’s crucial to understand the main knowledge gaps and thereby design the future developments to better meet engineering requirements.In this review,we first summarize the perfor-mance of conventional water treatment towards BCs removal.Then we showcase the advances of proof-of-concept strategies,including nanotechnology,advanced oxidation process,biological control process and integrated techniques,for BCs control in light of antimicrobial mechanisms,characteristics,proper niches in water treatment,challenges and latest improvements.Further,we proposed a semi-quantitative framework coupling life cycle assessment(LCA)and analytic hierarchy process(AHP)to assess and compare the application potential of representative pilot technologies,in which the antimicro-bial effects,economic issues and sustainability are comprehensively considered.For wastewater treat-ment,non-thermal plasma weights highest among the emerging technologies and outperforms conventional disinfection in terms of efficacy indicators(overall inactivation rate,ARGs removal rate,and growth inhibition),but fall behind overall mainly due to more energy input.Bacteriophage-based treatment has the potential to synergistically inactive the persistent pathogens in combination with con-ventional disinfection,serving as a cost-effective and environmental-friendly supplement.For drinking water treatment,the integrated photocatalytic nanocomposite receives the highest application potential among the emerging technologies and appears to be supplementary or even alternative next-generation disinfectants.This review shares valuable insights to propel the proof-of-concept antimicrobial trials towards industrial procedures.
基金supported by the National Natural Science Foundation of China(No.42307139)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0760200)。
文摘Water-soluble organic aerosol(WSOA)plays a significant role in air quality and human health.Here we characterized the chemical properties and molecular compositions of WSOA at a rural site in North China Plain during winter using a high-resolution aerosol mass spectrometer and electrospray ionization high-resolution orbitrap mass spectrometer(ESI-HRMS).Our results show that the mass concentration of WSOA was significantly higher than that observed in Beijing in winter 2020,contributing about 56%of OA on average.CHO compounds(56%-74%)and CHN compounds(66%-80%)dominated in negative mode and positive mode,respectively,while CHON accounted for 15%-41%across both modes.The chemical characteristics of WSOA varied with polluted levels and between day and night.As pollution intensified,the abundance of CHO-compounds with condensed aromatics increased by 9%and the number of highly oxygenated molecules(HOMs)molecular formula detected in server haze was more than double that of clean days.CHO-compounds with ten carbon atoms(C_(10))were more abundant at night while those with nine carbon atoms(C_(9))were higher during the day.High levels of CHN+compounds were linked to nighttime biomass burning,whereas CHON compounds were more abundant during the day.Increased pollution also led to the formation of more complex CHON-compounds,indicating that organonitrates continue to play a significant role in rural pollution.
基金supported in part by National Natural Science Foundation of China(No.51925102)National Key R&D Program of China(No.2022YFA1504101)。
文摘In this work,an effective catalyst of Cu/MnOOH has been successfully constructed for electrochemical nitrate reduction reaction(e NO_(3)RR)for synthesis of ammonia(NH_(3))under ambient conditions.The substrate of MnOOH plays an important role on the size and electronic structure of Cu nanoparticles,where Cu has the ultrafine size of 2.2 nm and positive shift of its valence states,which in turn causes the increased number of Cu active sites and enhanced intrinsic activity of every active site.As a result,this catalyst realizes an excellent catalytic performance on eNO_(3)RR with the maximal NH_(3)Faraday efficiency(FE)(96.8%)and the highest yield rate(55.51 mg h^(-1)cm^(-2))at a large NH_(3)partial current density of700 m A/cm^(2),which could help to promote the industrialization of NH_(3)production under ambient conditions.
基金supported by Beijing National Laboratory for Molecular Sciences(No.BNLMS-CXXM-201904)National Natural Science Foundation of China(NSFC,Nos.22171009,and 22261039)。
文摘2,6-Diisopropylaniline reacts with an open-cage fullerene derivative with a 11-membered orifice and forms an open-cage derivative containing one imino group on the rim of the expanded orifice.Further treatment with Lewis acids leads to open-cage fullerenes with an 18-membered orifice.Instead of the direct addition process observed before for less bulky anilines,an electron transfer process takes place in the initial step in the present reaction with bulky 2,6-diisopropylaniline.As a result,the chemo-selectivity is completely different affording the mono imino open-cage derivative selectively.
基金financially supported by the National Natural Science Foundation of China(No.52171210)the Program for the Development of Science and Technology of Jilin Province(Nos.20240101004JC,20220201130GX,and 20240402072GH)。
文摘Oxygen evolution reaction(OER) is one of the most important half-reactions related to metal-air batteries,fuel cells, and water-splitting. Due to the sluggish kinetic and multi-electron transfer, catalysts appear to be particularly important for the OER. Knowing the reaction mechanism is fundamental to developing new catalysts and improving OER efficiency. In this work, phase transition and atomic reconstruction on Co O(111) plane were revealed through ex-situ diffraction methods and X-ray absorption spectroscopy.At the same time, the electronic state evolution of Co(Ⅱ)/Co(Ⅲ) during the OER process has also been concluded by analyzing the magnetic properties. This work shows that during the OER process, Co(Ⅲ)experiences surface electron rearrangement from IS(intermediate-spin state) to LS(low-spin state) and then returns to IS/HS(high-spin state) under high voltage region. This work provides a new view to reveal the reaction mechanism through the magnetic property and it can be extended to more magnetic 3d transition metals for future catalyst design.
文摘The deployment of non-precious metal catalysts for the production of COx-free hydrogen via the ammonia decomposition reaction(ADR)presents a promising yet great challenge.In the present study,two crystal structures of α-MoC and β-Mo_(2)C catalysts with different Mo/C ratios were synthesized,and their ammonia decomposition performance as well as structural evolution in ADR was investigated.The β-Mo_(2)C catalyst,characterized by a higher Mo/C ratio,demonstrated a remarkable turnover frequency of 1.3 s^(-1),which is over tenfold higher than that ofα-MoC(0.1 s^(-1)).An increase in the Mo/C ratio of molybdenum carbide revealed a direct correlation between the surface Mo/C ratio and the hydrogen yield.The transient response surface reaction indicated that the combination of N*and N*derived from NH_(3) dissociation represents the rate-determining step in the ADR,andβ-Mo2C exhibited exceptional proficiency in facilitating this pivotal step.Concurrently,the accumulation of N*species on the carbide surface could induce the phase transition of molybdenum carbide to nitride,which follows a topological transformation.It is discovered that such phase evolution was affected by the Mo-C surface and reaction temperature simultaneously.When the kinetics of combination of N*was accelerated by rising temperatures and its accumulation on the carbide surface was mitigated,β-Mo_(2)C maintained its carbide phase,preventing nitridation during the ADR at 810℃.Our results contribute to an in-depth understanding of the molybdenum carbides’catalytic properties in ADR and highlight the nature of the carbide-nitride phase transition in the reaction.
基金supported by the National Natural Science Foundation of China(Nos.62303271,U1806202,62103397)the Natural Science Foundation of Shandong Province(ZR2023QF081)Funding for open access charge:the National Natural Science Foundation of China(Nos.62303271,U1806202).
文摘Recent advances in spatially resolved transcriptomics(SRT)have provided new opportunities for characterizing spatial structures of various tissues.Graph-based geometric deep learning has gained widespread adoption for spatial domain identification tasks.Currently,most methods define adjacency relation between cells or spots by their spatial distance in SRT data,which overlooks key biological interactions like gene expression similarities,and leads to inaccuracies in spatial domain identification.To tackle this challenge,we propose a novel method,SpaGRA(https://github.com/sunxue-yy/SpaGRA),for automatic multi-relationship construction based on graph augmentation.SpaGRA uses spatial distance as prior knowledge and dynamically adjusts edge weights with multi-head graph attention networks(GATs).This helps SpaGRA to uncover diverse node relationships and enhance message passing in geometric contrastive learning.Additionally,SpaGRA uses these multi-view relationships to construct negative samples,addressing sampling bias posed by random selection.Experimental results show that SpaGRA presents superior domain identification performance on multiple datasets generated from different protocols.Using SpaGRA,we analyze the functional regions in the mouse hypothalamus,identify key genes related to heart development in mouse embryos,and observe cancer-associated fibroblasts enveloping cancer cells in the latest Visium HD data.Overall,SpaGRA can effectively characterize spatial structures across diverse SRT datasets.
文摘Objective: To explore the application effect of self-management based on Snyder’s hope theory in diabetic patients. Methods: A total of 260 patients with diabetes from a community were selected through convenient sampling and randomly divided into an experimental group and a control group using the random number table method, with 130 cases in each group. Five cases were lost in the experimental group, resulting in 125 effective cases, while all 130 cases in the control group were effective. The control group received standard lectures on diabetes self-management behavior and traditional approaches, such as the distribution of educational manuals. The experimental group underwent a self-management behavior intervention program for diabetic patients based on Snyder’s hope theory model, encompassing three components: goals, pathways, and motivational thinking. The levels of hope and self-management behavior were compared between the two groups. Results: After the intervention, the scores for hope levels and self-management behaviors in both groups were significantly higher than those recorded before the intervention (P < 0.05). Furthermore, the hope level and self-management behavior scores of the experimental group were significantly higher than those of the control group (P < 0.05). Conclusion: The application of Snyder’s hope theory model in diabetic patients demonstrates significant benefits, improving patients’ hope levels and, consequently, enhancing their self-management behaviors.
基金supported by the Guangdong Pearl River Talent Program(No.017TZ07Z066)the Second Tibetan Plateau Scientific Expedition and Research Program(No.2019QZKK0701)+4 种基金the Southern Marine Laboratory(Zhuhai)Innovative R&D Program(No.311021003)the National Natural Science Foundation of China(No.42106067)the Natural Science Foundation of Guangdong Province,China(No.2022A1515010090)Shanghai Sheshan National Geophysical Observatory(No.SSOP202102)Guangzhou Science and Technology Planning Project(No.202102020456).
文摘Magmatism at continental margins is of great significance in understanding the continental rifting.We present a twodimensional P-wave velocity model derived from an ocean bottom seismometer experiment,conducted across the middle northern continental margin of the South China Sea(SCS).The detailed velocity structures reveal significant heterogeneities extending from the continental shelf to the continent-ocean transition zone.The crust exhibits its greatest thickness below the continental shelf,measuring~23 km and gradually thins to~13 km at the distal margin.Furthermore,a narrow and distinct continent-ocean transition with only 40-km width is revealed.We also observe a high-velocity layer within the transition zone,reaching thickness of up to 4 km,characterized by P-wave velocities ranging from 7.0 km/s to 7.6 km/s in the lower crust.Based on the syn-rift melt generation using decompression melting model,we ascertain that syn-rift magmatism cannot fully account for the observed thick high-velocity layer.By integrating findings from previous geophysical and geochemical studies presenting extensive volcanic edifice on the seafloor at the northern margin,as well as ocean-island-basalt-type magmaticsamples in the SCS area,we propose that post-rifting magmatism associated with the Hainan Plume may have influenced theformation of the high-velocity lower crust within the transition zone and the northern margin of the SCS can thus be recognizedas magma-poor type margin.
基金Innovation Team Project of Liaoning Institute of Science and Technology:“Smart Economy Practice and Innovation Team”College Students’Innovation and Entrepreneurship Training Program Projects:“Research on the Application of Big Data Analysis Tools”and“Zhice Quantitative Investment Studio”+2 种基金Teaching and Research Project:“Research on the Path of AI-Enabled Undergraduate Education and Teaching Reform Based on the Needs of Liaoning’s Revitalization and Development(Project No.:LKJY202510)”Teaching Reform Project:“Research and Practice on the Evaluation of Digital Talents in Application-Oriented Universities(Project No.:LNKJ202412)”Project of Liaoning Federation of Social Sciences:“Research on the Key Elements and Practical Paths of Educational Digital Transformation(Project No.:2025lslybkt-050)”。
文摘Based on the financial data and stock price information of Bengang Steel Plates Co.Ltd.from 2004 to 2023,this paper uses SPSS 26 software,combined with DuPont Analysis and Wall Score Method,to explore the correlation between stock price and nine key financial indicators selected from three dimensions:profitability,development capability,and operating capability,including fixed asset growth rate,price-to-book ratio(P/B ratio),and gross profit margin.Through correlation analysis,multiple regression analysis,and curve fitting,the study finds that:fixed asset growth rate,P/B ratio,and gross profit margin show a significant positive correlation with stock price;return on equity(ROE),operating income,and accounts receivable turnover days show a significant negative correlation with stock price;earnings per share(EPS)and net profit growth rate do not show a significant correlation with stock price.The research results indicate that the stock price of Bengang Steel Plates Co.Ltd.is greatly affected by its asset scale and market valuation,while some profitability indicators have not been effectively transmitted to the stock price.Finally,countermeasures and suggestions are put forward from the aspects of cost control,technological innovation,market expansion,and financial structure optimization,so as to provide references for corporate operation and investment decisions.
文摘This study aims to explore the effect of project-based teaching methods on improving students’ abilities in normal universities. This study delves into the practice teaching system based on ability training implemented in normal universities, examining the application of this teaching model in teacher education and the potential challenges it may encounter. Our case study reveals that the Project-Based Learning (PBL) approach can effectively transform students from passive recipients of knowledge into active problem solvers, thereby enhancing their critical thinking, problem-solving, teamwork, and communication skills. However, challenges do exist, including ensuring active participation from all students, providing equal opportunities for each student to develop and showcase their abilities, and completing complex projects within a limited timeframe. Therefore, teachers may need to adjust their teaching strategies, and schools need to provide more resources and support. These adjustments can help the practice teaching system based on ability training better serve teacher education and offer students a higher-quality educational experience.
