Layered transition metal(TM)oxides have gained significant attention for achieving high specific capac-ity and energy density utilizing the lattice oxygen redox for sodium-ion batteries.However,the highly oxidized lat...Layered transition metal(TM)oxides have gained significant attention for achieving high specific capac-ity and energy density utilizing the lattice oxygen redox for sodium-ion batteries.However,the highly oxidized lattice oxygen cannot be fully reduced due to irreversible structural deformation,phase tran-sition,and sluggish kinetics.Herein,the Cobalt(Co)content was tuned to synthesize a P2/P3-biphasic layered oxide cathode Na_(0.72)Li_(0.24)Co_(0.12)Mn_(0.64)O_(2)(NLM-Co12%),which exhibits pronounced lattice oxygen activity,leading to exceptional capacity and improved cyclability with superior structural stability.The distinct honeycomb ordering induces highly delocalizedπ-type interactions that generate additional elec-tron holes on oxygen,providing a record energy density and specific capacity of 767.98 Wh kg^(-1)and 287.19 mAh g^(-1),respectively.The strategic incorporation of Co in the TM layers mitigates the sluggish kinetics during the electrochemical reactions and improves the diffusion kinetics.The addition of elec-tron holes on Oxygen(O)is comprehensively investigated through different electrochemical and state-of-the-art spectroscopic techniques.Furthermore,in situ-XRD reveals the phase transition during Na^(+)insertion/extraction is eliminated due to the synergistic effect of the P2/P3 biphasic structure achieving superior structural stability.Benefiting from the superstructure ordering and P2/P3 biphasic structure,the NLM-Co12%electrode demonstrates simultaneously high lattice-oxygen activity and excellent structural stability,thus resulting in remarkable energy density and specific capacity.展开更多
Named Entity Recognition(NER)is vital in natural language processing for the analysis of news texts,as it accurately identifies entities such as locations,persons,and organizations,which is crucial for applications li...Named Entity Recognition(NER)is vital in natural language processing for the analysis of news texts,as it accurately identifies entities such as locations,persons,and organizations,which is crucial for applications like news summarization and event tracking.However,NER in the news domain faces challenges due to insufficient annotated data,complex entity structures,and strong context dependencies.To address these issues,we propose a new Chinesenamed entity recognition method that integrates transfer learning with word embeddings.Our approach leverages the ERNIE pre-trained model for transfer learning and obtaining general language representations and incorporates the Soft-lexicon word embedding technique to handle varied entity structures.This dual-strategy enhances the model’s understanding of context and boosts its ability to process complex texts.Experimental results show that our method achieves an F1 score of 94.72% on a news dataset,surpassing baseline methods by 3%–4%,thereby confirming its effectiveness for Chinese-named entity recognition in the news domain.展开更多
The development of alternative therapies to treat chicken coccidiosis has become a hot topic because of the widespread use of conventional medicines.This study aimed to investigate the effectiveness of eugenol in trea...The development of alternative therapies to treat chicken coccidiosis has become a hot topic because of the widespread use of conventional medicines.This study aimed to investigate the effectiveness of eugenol in treating Eimeria tenella infection in broilers.Broiers,at the age of 14 d,were orally infected with sporulated Eimeria tenella oocysts,and then,eugenol essential oil was added to chicken feed at three different dosages(0.1,0.2 or 0.4 g/kg).The anticoccidial effects of eugenol essential oil were assessed using the anticoccidial index(ACI).As a result,eugenol exhibited a moderate anticoccidial effect,with an ACI of 167.37 at 0.2 g/kg.After eugenol treatment,the expression of occludin in the epithelial cells of the chicken cecum was significantly greater(P<0.05)than that in the epithelial cells of the nontreated control(IC)group.The proportion of intestinal Lactobacillus_agilli increased.Eugenol therapy dramatically increased the activity of superoxide dismutase.After high-dose treatment,the expression of the proinflammatory factors IL-1βand IL-6 significantly decreased,while the expression of the cytokines IL-4 and IFN-γsignificantly increased.The safety of eugenol essential oil was evaluated at the 1,3 or 6 recommended doses.Overall,no significant differences were detected in the blood tests or serum biochemistry of the chickens between the treatment groups and the control group.As a result,eugenol essential oil can cure chicken coccidiosis by improving the intestinal microbial structure in the chicken cecum and decreasing the cecum's inflammatory reactions,thus strengthening immune function and eventually demonstrating anticoccidial properties.展开更多
The garnet-type electrolytes such as Ta-doped Li7La3Zr2Ol2 （LLZTO） have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance （1960 Ω&#...The garnet-type electrolytes such as Ta-doped Li7La3Zr2Ol2 （LLZTO） have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance （1960 Ω·cm^2） and short circuit when being cycled in Li/LLZTO/Li cells at the current density above 0.5 mA·cm^-2. Introduction of intermediate layers in between lithium and LLZTO is helpful for decreasing the interfacial resistance and suppressing the growth of lithium dendrites. In this work, three kinds of intermediate layers of Au, Nb and Si with the thickness of 100 nm were prepared. Although the interfacial resistance with the Au layer decreases from 1960 to 32 Ω·cm^2, the cells can only cycle for 0.67 h at 0.5 mA·cm^-2, related to the Au peeled off from the LLZTO. The Nb layers lead to the initial interfacial resistance of 14 Ω·cm^2, while showing extension of cycle time to 50 h with the increase in interracial resistance due to the formation of the resistive Li-Nb-O phase. The Si layers induce the interfacial resistance as low as 5 Ω·cm^2 and the cycles as long as 120 h, which is attributed to the improvement in electrical contact between Li and electrolyte as well as the maintenance of conductive interface during cycles.展开更多
The current research of the global chassis control problem for the full drive-by-wire vehicle focuses on the control allocation （CA） of the four-wheel-distributed trac- tion/braking/steering systems. However, the pa...The current research of the global chassis control problem for the full drive-by-wire vehicle focuses on the control allocation （CA） of the four-wheel-distributed trac- tion/braking/steering systems. However, the path following performance and the handling stability of the vehicle can be enhanced a step further by automatically adjusting the vehicle speed to the optimal value. The optimal solution for the combined longitudinal and lateral motion control （MC） problem is given. First, a new variable step-size spatial transformation method is proposed and utilized in the prediction model to derive the dynamics of the vehicle with respect to the road, such that the tracking errors can be explicitly obtained over the prediction horizon at varying speeds. Second, a nonlinear model predictive con- trol （NMPC） algorithm is introduced to handle the non- linear coupling between any two directions of the vehicular planar motion and computes the sequence of the optimal motion states for following the desired path. Third, a hierarchical control structure is proposed to separate the motion controller into a NMPC based path planner and a terminal sliding mode control （TSMC） based path fol- lower. As revealed through off-line simulations, the hier- archical methodology brings nearly 1700% improvement in computational efficiency without loss of control per- formance. Finally, the control algorithm is verified through a hardware in-the-loop simulation system. Double-lane- change （DLC） test results show that by using the optimalpredictive controller, the root-mean-square （RMS） values of the lateral deviations and the orientation errors can be reduced by 41% and 30%, respectively, comparing to those by the optimal preview acceleration （OPA） driver model with the non-preview speed-tracking method. Additionally, the average vehicle speed is increased by 0.26 km/h with the peak sideslip angle suppressed to 1.9~. This research proposes a novel motion controller, which provides the full drive-by-wire vehicle with better lane-keeping and colli- sion-avoidance capabilities during autonomous driving.展开更多
The objective of this work was to investigate the effects of oxidation and Maillard reaction on free and protein-bound N^ε-carboxymethyllysine(CML)and Nε-carboxyethyllysine(CEL)formation during braised chicken proce...The objective of this work was to investigate the effects of oxidation and Maillard reaction on free and protein-bound N^ε-carboxymethyllysine(CML)and Nε-carboxyethyllysine(CEL)formation during braised chicken processing.It was found that a positive correlation was observed between carbonyl,fat oxidation,Maillard reaction,CML and CEL(P<0.05).The sulfhydryl groups could be used as potential indicators to evaluate the compounds’interaction levels between Maillard reaction and protein oxidation.Frying promoted the formation of lysine(Lys),glyoxal(GO)and methylglyoxal(MGO)(P<0.05);boiling enhanced the formation of GO and MGO(P<0.05)while inhibited the levels of Lys(P<0.05);sterilizing blocked the formation of MGO and Lys(P<0.01)but improved GO levels(P<0.05).Finally,a perspective was concluded that the Maillard reaction combined with oxidation is one of the main reasons for the formation of free and protein-bound CML and CEL during braised chicken processing.展开更多
The high temperature creep behavior of fusion zone （FZ） and of a near-alpha titanium alloy Ti-60 has been investigated. base metal （BM） of the electron beam weldments While the BM shows a fully transformed, coarse...The high temperature creep behavior of fusion zone （FZ） and of a near-alpha titanium alloy Ti-60 has been investigated. base metal （BM） of the electron beam weldments While the BM shows a fully transformed, coarse primary β grains with large colonies consisting of aligned α lamellar, the FZ exhibits thin martensitic α′ platelets in the columnar β grains. The creep results show that the steady state creep rates of FZ follow the power-law creep, with the stress exponents obtained in the range from 5.6 （550℃） to 5.9 （600℃）, and corrected activation energies of 309-352 kJ/mol; the stress exponents of BM exhibit different values when the creep testing stress and temperature alternate. The values of 2.4-3.2 are obtained when the stresses are under 220 MPa or the temperature is 550℃, also an exponent of 6.6 is achieved at stresses above 220 MPa at 600℃. The corrected activation energies of BM corresponding to the stress exponents are 123-161 kJ/mol （n=2.4-3.2） and 344 kJ/mol （n=6.6）. The creep mechanisms of FZ and BM have been discussed in light of the creep microstructures, activation energies and the stress exponents. The creep mechanisms of FZ is the diffusion controlled dislocation climb, the creep of BM is controlled by ＇solute drag＇ creep and dislocation climb when the stress and temperature are different. Transmission electron microscopy （TEM） observations of the dislocation structures of crept specimens are presented to give some supports for the creep behavior of FZ and BM. In addition to the creep mechanism of dislocation movement, the interface sliding has been found to play an important role during creep of FZ.展开更多
Advanced glycation end products(AGE) are potential harmful substances formed in the advanced Maillard reaction and increasingly investigated in muscle foods. However, the contribution of oxidation to the AGE formation...Advanced glycation end products(AGE) are potential harmful substances formed in the advanced Maillard reaction and increasingly investigated in muscle foods. However, the contribution of oxidation to the AGE formation is controversial. Moreover, reports on glyoxal(GO) induced AGE formation in chicken meat emulsion(CME) are limited. Thus, the effects of GO on emulsifying properties, rheological behavior and AGE formation in CME were investigated. Our findings exhibited that levels of Nε-carboxymethyllysine(CML) and Nε-carboxyethyllysine(CEL) were associated with lipid oxidation but not significantly(P > 0.05). Levels of AGE peaked when GO concentration ranged from 5 mmol/L(CML) to 10 mmol/L(CEL). The droplets’ aggregation associated with the disulfide bond when the concentration of GO was at 0.5–30 mmol/L while non-disulfide bond association occurred at 30–50 mmol/L GO concentration. In conclusion, compared to the effect of oxidation, GO exhibited the main role in the AGE formation of CME. This study will provide theoretical significance for further understanding and controlling the formation of AGE in CME.展开更多
Alzheimer's disease is a neurodegenerative disease with complex etiology.Gut microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's disease.Additionally,di...Alzheimer's disease is a neurodegenerative disease with complex etiology.Gut microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's disease.Additionally,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut microbiota.This demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity strategies.Therefore,the present study reviews the association between these two interventions and gut microbiota in the human body.It also summarizes how these two interventions benefit Alzheimer's disease.Furthermore,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.展开更多
The concept of difference and sum co-array(DSCA)has become a new design idea for planar sparse arrays.Inspired by the shifting invariance property of DSCA,a specific configuration named here as the improved L-shaped a...The concept of difference and sum co-array(DSCA)has become a new design idea for planar sparse arrays.Inspired by the shifting invariance property of DSCA,a specific configuration named here as the improved L-shaped array is proposed.Compared to other traditional 2D sparse array configurations such as 2D nested arrays and hourglass arrays,the proposed configuration has larger central consecutive ranges in its DSCA,thus increasing the DOF.At the same time,the mutual coupling effect is also reduced due to the enlarged spacing between the adjacent sensors.Simulations further demonstrate the superiority of the proposed arrays in terms of detection performance and estimation accuracy.展开更多
AIM: To describe the clinical features of acute myopic onset of optic neuropathy and observe the effects of retrobulbar and systemic glucocorticoid therapy in a realworld setting.METHODS: A retrospective observational...AIM: To describe the clinical features of acute myopic onset of optic neuropathy and observe the effects of retrobulbar and systemic glucocorticoid therapy in a realworld setting.METHODS: A retrospective observational case series included 18 patients with a clinical diagnosis of acute onset of myopic optic neuropathy in a real-world setting. While the patients were using retrobulbar and systemic glucocorticoid therapy, various imaging examination data were analysed, and the clinical features of myopic optic neuropathy were summarized for 6 mo to 2 y. RESULTS: The included group of patients with acute onset of myopic optic neuropathy consisted mostly of females(n=11). The visual field(VF) showed abnormalities in bilateral eyes, including the spread of physiological blind spots, central and paracentral dark spots, and centripetal peripheral VF reduction;but central vision with no subjective changes. The visual evoked potential(VEP) was abnormal in all eyes with vision loss. The best corrected visual acuity(BCVA) was improved from 1.04±0.63 to 0.47±0.57(log MAR) af ter glucocor ticoid treatment(P<0.05). In patients with a short course(within 1 wk), recovery was fast and achieved the same BCVA as recorded before the onset within 6 d. However, in patients with the long course(1 to 2 wk), recovery was slow and did not achieve the BCVA recorded before the onset within 10 d. The changes of intraocular pressure(IOP) were not obvious before and after treatment(18.68±5.30 vs 19.55±5.34 mm Hg, P>0.05). There was no recurrence during long-term followup observation.CONCLUSION: The acute onset of myopic optic neuropathy is characterized by BCVA and VF abnormalities in bilateral eyes. Retrobulbar and systemic glucocorticoid therapy is effective.展开更多
Samaras or winged seeds spread themselves by wind. Ash seed, unlike other samaras, has a high aspect ratio wing which can generate enough lift force to slow down descent by rotating about the vertical axis and spinnin...Samaras or winged seeds spread themselves by wind. Ash seed, unlike other samaras, has a high aspect ratio wing which can generate enough lift force to slow down descent by rotating about the vertical axis and spinning around its wing span axis simultaneously. This unique kinematics and inherent fluid mechanism are definitely of great interest. Detailed kinematics of free falling ash seeds were measured using high-speed cameras, then corresponding aerodynamic forces and moments were calculated employing computational fluid dynamics. The results show that both rotating and spinning directions are in the same side and the spinning angular velocity is about 6 times of rotating speed. The terminal descending velocity and cone angles are similar to other samaras. Analysis of the forces and moments shows that the lift is enough to balance the weight and the vertical rotation results from a processional motion of total angular moment because the spin-cycle-averaged aer-odynamic moment is perpendicular to the total angular moment and can only change its direction but maintain its magnitude, which is very similar to a spinning top in processional motion except that the total angular moment of ash seed is not along the spin axis but almost normal to it. The flow structures show that both leading and trailing edge vortices contribute to lift generation and the spanwise spinning results in an augmentation of the lift, implying that ash seeds with high aspect ratio wing may evolve in a different way in utilizing fluid mechanisms to facilitate dispersal.展开更多
Background and aims:Adeno-associated virus(AAV)is becoming an attractive vector due to its low toxicity and minimal immunogenicity.However,liver-targeted AAV gene therapy still faces challenges,such as low delivery ef...Background and aims:Adeno-associated virus(AAV)is becoming an attractive vector due to its low toxicity and minimal immunogenicity.However,liver-targeted AAV gene therapy still faces challenges,such as low delivery efficiency and safety risks associated with high vector doses.Isolated hepatic perfusion(IHP)has been explored as a localized drug delivery method,yet its full potential in gene therapy remains under investigation.Here,we investigated the efficiency of AAV8 delivery via the IHP route and its preference for hepatic transduction.Methods:The IHP route was established through surgery in rats and cynomolgus monkey,and the AAV8-dTomato solution was injected into the entire liver through the inflow tract and maintained for 10 min.One week later,liver tissues were obtained,and the dTomato fluorescence expression area fraction and intensity were analyzed.Results:AAV8-dTomato delivery via the IHP resulted in over 60% dTomato-positive areas in rat liver and showed higher efficiency than the portal vein(PV)and inferior vena cava(IVC)routes at equivalent doses.In rats,AAV8-dTomato expression was primarily periportal across IHP,PV,and IVC routes,while in cynomolgus monkey,IHP delivery showed a pericentral pattern.Conclusions:In this study,we found that IHP is an effective strategy for AAV8 delivery.In addition,the distribution characteristics of AAV8,when delivered in cynomolgus monkey via IHP,provide candidate vector delivery schemes for gene therapy for different types of genetic liver diseases.展开更多
基金supported by the National Key R&D Program of China(2024YFE0209300)the National Natural Science Foun-dation of China(Nos.52072282,52150710537,and 52127816)+2 种基金the National Natural Science Foundation of Hubei Province(No.2023AFB230)the Fundamental Research Funds for the Central Universities(No.WUT:3120624473)the Postdoctoral Fellow-ship Program of CPSF(No.GZC20241292).
文摘Layered transition metal(TM)oxides have gained significant attention for achieving high specific capac-ity and energy density utilizing the lattice oxygen redox for sodium-ion batteries.However,the highly oxidized lattice oxygen cannot be fully reduced due to irreversible structural deformation,phase tran-sition,and sluggish kinetics.Herein,the Cobalt(Co)content was tuned to synthesize a P2/P3-biphasic layered oxide cathode Na_(0.72)Li_(0.24)Co_(0.12)Mn_(0.64)O_(2)(NLM-Co12%),which exhibits pronounced lattice oxygen activity,leading to exceptional capacity and improved cyclability with superior structural stability.The distinct honeycomb ordering induces highly delocalizedπ-type interactions that generate additional elec-tron holes on oxygen,providing a record energy density and specific capacity of 767.98 Wh kg^(-1)and 287.19 mAh g^(-1),respectively.The strategic incorporation of Co in the TM layers mitigates the sluggish kinetics during the electrochemical reactions and improves the diffusion kinetics.The addition of elec-tron holes on Oxygen(O)is comprehensively investigated through different electrochemical and state-of-the-art spectroscopic techniques.Furthermore,in situ-XRD reveals the phase transition during Na^(+)insertion/extraction is eliminated due to the synergistic effect of the P2/P3 biphasic structure achieving superior structural stability.Benefiting from the superstructure ordering and P2/P3 biphasic structure,the NLM-Co12%electrode demonstrates simultaneously high lattice-oxygen activity and excellent structural stability,thus resulting in remarkable energy density and specific capacity.
基金funded by Advanced Research Project(30209040702).
文摘Named Entity Recognition(NER)is vital in natural language processing for the analysis of news texts,as it accurately identifies entities such as locations,persons,and organizations,which is crucial for applications like news summarization and event tracking.However,NER in the news domain faces challenges due to insufficient annotated data,complex entity structures,and strong context dependencies.To address these issues,we propose a new Chinesenamed entity recognition method that integrates transfer learning with word embeddings.Our approach leverages the ERNIE pre-trained model for transfer learning and obtaining general language representations and incorporates the Soft-lexicon word embedding technique to handle varied entity structures.This dual-strategy enhances the model’s understanding of context and boosts its ability to process complex texts.Experimental results show that our method achieves an F1 score of 94.72% on a news dataset,surpassing baseline methods by 3%–4%,thereby confirming its effectiveness for Chinese-named entity recognition in the news domain.
基金supported by the National Key Research and Development Program(2016YFD0501303).
文摘The development of alternative therapies to treat chicken coccidiosis has become a hot topic because of the widespread use of conventional medicines.This study aimed to investigate the effectiveness of eugenol in treating Eimeria tenella infection in broilers.Broiers,at the age of 14 d,were orally infected with sporulated Eimeria tenella oocysts,and then,eugenol essential oil was added to chicken feed at three different dosages(0.1,0.2 or 0.4 g/kg).The anticoccidial effects of eugenol essential oil were assessed using the anticoccidial index(ACI).As a result,eugenol exhibited a moderate anticoccidial effect,with an ACI of 167.37 at 0.2 g/kg.After eugenol treatment,the expression of occludin in the epithelial cells of the chicken cecum was significantly greater(P<0.05)than that in the epithelial cells of the nontreated control(IC)group.The proportion of intestinal Lactobacillus_agilli increased.Eugenol therapy dramatically increased the activity of superoxide dismutase.After high-dose treatment,the expression of the proinflammatory factors IL-1βand IL-6 significantly decreased,while the expression of the cytokines IL-4 and IFN-γsignificantly increased.The safety of eugenol essential oil was evaluated at the 1,3 or 6 recommended doses.Overall,no significant differences were detected in the blood tests or serum biochemistry of the chickens between the treatment groups and the control group.As a result,eugenol essential oil can cure chicken coccidiosis by improving the intestinal microbial structure in the chicken cecum and decreasing the cecum's inflammatory reactions,thus strengthening immune function and eventually demonstrating anticoccidial properties.
文摘目的探讨肥胖少年的臂-踝脉搏波速度(brachial-ankle pulse wave velocity,BaPWV),与诱发心血管疾病发生的血生化指标的相关性。方法在北京市海淀区选取165例14~17岁的肥胖少年,男90例,女75例,测量体重、身高、血压后,计算BMI,采用动脉硬化检测仪测量臂-踝脉搏波速度(BaPWV),同时检测空腹血生化指标。分析BaPWV与肥胖相关指标,以及心血管疾病危险因素中血生化指标的关系。结果过度肥胖组的BaPWV,与总胆固醇(total cholesterol,TC)、低密度胆固醇(low density lipoprotein cholesterol,LDL-C)、三酰甘油(triglyceride,TG)呈正相关关系;与体重、体质指数(body mass index,BMI)、收缩压呈正相关关系。按照BaPWV测量值分组,BaPWV增高组(高于正常范围,>P_(95))的BaPWV,与总胆固醇(TC)、低密度胆固醇(LDL-C)呈正相关关系;与年龄、体重、体重指数(BMI)呈正相关关系。BaPWV增高与暴露于过度肥胖(BMI>P_(50))之间关联强度的比值比OR=2.159,OR的95%可信区间为1.011~4.613。说明过度肥胖会使BaPWV高于正常范围(>P_(95))的危险度增加2.159倍。结论总胆固醇(TC)和低密度胆固醇(LDL-C),与过度肥胖(BMI>P_(50)),以及BaPWV高于正常范围(>P_(95))有正相关性。过度肥胖会使BaPWV高于正常范围(>P_(95))的危险度增加。
基金financially supported by the National Natural Science Foundation of China(Nos.51532002 and 51771222)the National Basic Research Program of China(No.2014CB921004)+1 种基金the Natural Science Foundation of Shandong Province(No.ZR201702180185)‘‘Taishan Talent Scholar’’ Supports
文摘The garnet-type electrolytes such as Ta-doped Li7La3Zr2Ol2 （LLZTO） have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance （1960 Ω·cm^2） and short circuit when being cycled in Li/LLZTO/Li cells at the current density above 0.5 mA·cm^-2. Introduction of intermediate layers in between lithium and LLZTO is helpful for decreasing the interfacial resistance and suppressing the growth of lithium dendrites. In this work, three kinds of intermediate layers of Au, Nb and Si with the thickness of 100 nm were prepared. Although the interfacial resistance with the Au layer decreases from 1960 to 32 Ω·cm^2, the cells can only cycle for 0.67 h at 0.5 mA·cm^-2, related to the Au peeled off from the LLZTO. The Nb layers lead to the initial interfacial resistance of 14 Ω·cm^2, while showing extension of cycle time to 50 h with the increase in interracial resistance due to the formation of the resistive Li-Nb-O phase. The Si layers induce the interfacial resistance as low as 5 Ω·cm^2 and the cycles as long as 120 h, which is attributed to the improvement in electrical contact between Li and electrolyte as well as the maintenance of conductive interface during cycles.
基金Supported by National High Technology Research and Development Program 863(Grant No.2011AA11A286)
文摘The current research of the global chassis control problem for the full drive-by-wire vehicle focuses on the control allocation （CA） of the four-wheel-distributed trac- tion/braking/steering systems. However, the path following performance and the handling stability of the vehicle can be enhanced a step further by automatically adjusting the vehicle speed to the optimal value. The optimal solution for the combined longitudinal and lateral motion control （MC） problem is given. First, a new variable step-size spatial transformation method is proposed and utilized in the prediction model to derive the dynamics of the vehicle with respect to the road, such that the tracking errors can be explicitly obtained over the prediction horizon at varying speeds. Second, a nonlinear model predictive con- trol （NMPC） algorithm is introduced to handle the non- linear coupling between any two directions of the vehicular planar motion and computes the sequence of the optimal motion states for following the desired path. Third, a hierarchical control structure is proposed to separate the motion controller into a NMPC based path planner and a terminal sliding mode control （TSMC） based path fol- lower. As revealed through off-line simulations, the hier- archical methodology brings nearly 1700% improvement in computational efficiency without loss of control per- formance. Finally, the control algorithm is verified through a hardware in-the-loop simulation system. Double-lane- change （DLC） test results show that by using the optimalpredictive controller, the root-mean-square （RMS） values of the lateral deviations and the orientation errors can be reduced by 41% and 30%, respectively, comparing to those by the optimal preview acceleration （OPA） driver model with the non-preview speed-tracking method. Additionally, the average vehicle speed is increased by 0.26 km/h with the peak sideslip angle suppressed to 1.9~. This research proposes a novel motion controller, which provides the full drive-by-wire vehicle with better lane-keeping and colli- sion-avoidance capabilities during autonomous driving.
基金supported by China Agriculture Research System(CARS-41-Z06)National Key R&D Program(2016YFD040040303)+1 种基金Key R&D Program(Modern Agriculture)of Jiangsu Province(BE2019308)Nanjing Customs Scientific Research Project(No.2020KJ24).
文摘The objective of this work was to investigate the effects of oxidation and Maillard reaction on free and protein-bound N^ε-carboxymethyllysine(CML)and Nε-carboxyethyllysine(CEL)formation during braised chicken processing.It was found that a positive correlation was observed between carbonyl,fat oxidation,Maillard reaction,CML and CEL(P<0.05).The sulfhydryl groups could be used as potential indicators to evaluate the compounds’interaction levels between Maillard reaction and protein oxidation.Frying promoted the formation of lysine(Lys),glyoxal(GO)and methylglyoxal(MGO)(P<0.05);boiling enhanced the formation of GO and MGO(P<0.05)while inhibited the levels of Lys(P<0.05);sterilizing blocked the formation of MGO and Lys(P<0.01)but improved GO levels(P<0.05).Finally,a perspective was concluded that the Maillard reaction combined with oxidation is one of the main reasons for the formation of free and protein-bound CML and CEL during braised chicken processing.
文摘The high temperature creep behavior of fusion zone （FZ） and of a near-alpha titanium alloy Ti-60 has been investigated. base metal （BM） of the electron beam weldments While the BM shows a fully transformed, coarse primary β grains with large colonies consisting of aligned α lamellar, the FZ exhibits thin martensitic α′ platelets in the columnar β grains. The creep results show that the steady state creep rates of FZ follow the power-law creep, with the stress exponents obtained in the range from 5.6 （550℃） to 5.9 （600℃）, and corrected activation energies of 309-352 kJ/mol; the stress exponents of BM exhibit different values when the creep testing stress and temperature alternate. The values of 2.4-3.2 are obtained when the stresses are under 220 MPa or the temperature is 550℃, also an exponent of 6.6 is achieved at stresses above 220 MPa at 600℃. The corrected activation energies of BM corresponding to the stress exponents are 123-161 kJ/mol （n=2.4-3.2） and 344 kJ/mol （n=6.6）. The creep mechanisms of FZ and BM have been discussed in light of the creep microstructures, activation energies and the stress exponents. The creep mechanisms of FZ is the diffusion controlled dislocation climb, the creep of BM is controlled by ＇solute drag＇ creep and dislocation climb when the stress and temperature are different. Transmission electron microscopy （TEM） observations of the dislocation structures of crept specimens are presented to give some supports for the creep behavior of FZ and BM. In addition to the creep mechanism of dislocation movement, the interface sliding has been found to play an important role during creep of FZ.
基金supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX21_0579)the China Scholarship Council(No.202006850022)+1 种基金supported by Agriculture Research System of China(CARS-41-Z)Science and Technology Project of Nanjing City(No.202002040)。
文摘Advanced glycation end products(AGE) are potential harmful substances formed in the advanced Maillard reaction and increasingly investigated in muscle foods. However, the contribution of oxidation to the AGE formation is controversial. Moreover, reports on glyoxal(GO) induced AGE formation in chicken meat emulsion(CME) are limited. Thus, the effects of GO on emulsifying properties, rheological behavior and AGE formation in CME were investigated. Our findings exhibited that levels of Nε-carboxymethyllysine(CML) and Nε-carboxyethyllysine(CEL) were associated with lipid oxidation but not significantly(P > 0.05). Levels of AGE peaked when GO concentration ranged from 5 mmol/L(CML) to 10 mmol/L(CEL). The droplets’ aggregation associated with the disulfide bond when the concentration of GO was at 0.5–30 mmol/L while non-disulfide bond association occurred at 30–50 mmol/L GO concentration. In conclusion, compared to the effect of oxidation, GO exhibited the main role in the AGE formation of CME. This study will provide theoretical significance for further understanding and controlling the formation of AGE in CME.
基金financially supported by National Natural Science Foundation of China(32171035)the major fund project of Ningbo Science and Technology Bureau(2019B10034)+4 种基金Opened-end Fund of Key Laboratory(KFJJ-202101,ZPKLP202202)Public Project of Ningbo(202002N3167)Project of Yinzhou(2022AS025)Ningbo Rehabilitation Hospital(2022KY02)sponsored by a K.C.Wong Magna Fund in Ningbo University。
文摘Alzheimer's disease is a neurodegenerative disease with complex etiology.Gut microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's disease.Additionally,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut microbiota.This demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity strategies.Therefore,the present study reviews the association between these two interventions and gut microbiota in the human body.It also summarizes how these two interventions benefit Alzheimer's disease.Furthermore,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.
基金Supported by the National Natural Science Foundation of China(61801024)。
文摘The concept of difference and sum co-array(DSCA)has become a new design idea for planar sparse arrays.Inspired by the shifting invariance property of DSCA,a specific configuration named here as the improved L-shaped array is proposed.Compared to other traditional 2D sparse array configurations such as 2D nested arrays and hourglass arrays,the proposed configuration has larger central consecutive ranges in its DSCA,thus increasing the DOF.At the same time,the mutual coupling effect is also reduced due to the enlarged spacing between the adjacent sensors.Simulations further demonstrate the superiority of the proposed arrays in terms of detection performance and estimation accuracy.
文摘AIM: To describe the clinical features of acute myopic onset of optic neuropathy and observe the effects of retrobulbar and systemic glucocorticoid therapy in a realworld setting.METHODS: A retrospective observational case series included 18 patients with a clinical diagnosis of acute onset of myopic optic neuropathy in a real-world setting. While the patients were using retrobulbar and systemic glucocorticoid therapy, various imaging examination data were analysed, and the clinical features of myopic optic neuropathy were summarized for 6 mo to 2 y. RESULTS: The included group of patients with acute onset of myopic optic neuropathy consisted mostly of females(n=11). The visual field(VF) showed abnormalities in bilateral eyes, including the spread of physiological blind spots, central and paracentral dark spots, and centripetal peripheral VF reduction;but central vision with no subjective changes. The visual evoked potential(VEP) was abnormal in all eyes with vision loss. The best corrected visual acuity(BCVA) was improved from 1.04±0.63 to 0.47±0.57(log MAR) af ter glucocor ticoid treatment(P<0.05). In patients with a short course(within 1 wk), recovery was fast and achieved the same BCVA as recorded before the onset within 6 d. However, in patients with the long course(1 to 2 wk), recovery was slow and did not achieve the BCVA recorded before the onset within 10 d. The changes of intraocular pressure(IOP) were not obvious before and after treatment(18.68±5.30 vs 19.55±5.34 mm Hg, P>0.05). There was no recurrence during long-term followup observation.CONCLUSION: The acute onset of myopic optic neuropathy is characterized by BCVA and VF abnormalities in bilateral eyes. Retrobulbar and systemic glucocorticoid therapy is effective.
文摘Samaras or winged seeds spread themselves by wind. Ash seed, unlike other samaras, has a high aspect ratio wing which can generate enough lift force to slow down descent by rotating about the vertical axis and spinning around its wing span axis simultaneously. This unique kinematics and inherent fluid mechanism are definitely of great interest. Detailed kinematics of free falling ash seeds were measured using high-speed cameras, then corresponding aerodynamic forces and moments were calculated employing computational fluid dynamics. The results show that both rotating and spinning directions are in the same side and the spinning angular velocity is about 6 times of rotating speed. The terminal descending velocity and cone angles are similar to other samaras. Analysis of the forces and moments shows that the lift is enough to balance the weight and the vertical rotation results from a processional motion of total angular moment because the spin-cycle-averaged aer-odynamic moment is perpendicular to the total angular moment and can only change its direction but maintain its magnitude, which is very similar to a spinning top in processional motion except that the total angular moment of ash seed is not along the spin axis but almost normal to it. The flow structures show that both leading and trailing edge vortices contribute to lift generation and the spanwise spinning results in an augmentation of the lift, implying that ash seeds with high aspect ratio wing may evolve in a different way in utilizing fluid mechanisms to facilitate dispersal.
基金founded by the National Key Research and Development Program of China(No.2022YFA1104100,2018YFA0801404,2017YFA0104304,and 2024YFA1107200)The National Natural Science Foundation of China(No.82171617 and 82471689)+2 种基金Guangdong Special Support Program(No.2019BT02Y276)Sanming Project of Medicine in ShenzhenNanshan(No.SZSM202103012)Shenzhen Nanshan District Science and Technology Program(No.NS2022023,NS2023012,NSZD2024048,and NSZD2024051).
文摘Background and aims:Adeno-associated virus(AAV)is becoming an attractive vector due to its low toxicity and minimal immunogenicity.However,liver-targeted AAV gene therapy still faces challenges,such as low delivery efficiency and safety risks associated with high vector doses.Isolated hepatic perfusion(IHP)has been explored as a localized drug delivery method,yet its full potential in gene therapy remains under investigation.Here,we investigated the efficiency of AAV8 delivery via the IHP route and its preference for hepatic transduction.Methods:The IHP route was established through surgery in rats and cynomolgus monkey,and the AAV8-dTomato solution was injected into the entire liver through the inflow tract and maintained for 10 min.One week later,liver tissues were obtained,and the dTomato fluorescence expression area fraction and intensity were analyzed.Results:AAV8-dTomato delivery via the IHP resulted in over 60% dTomato-positive areas in rat liver and showed higher efficiency than the portal vein(PV)and inferior vena cava(IVC)routes at equivalent doses.In rats,AAV8-dTomato expression was primarily periportal across IHP,PV,and IVC routes,while in cynomolgus monkey,IHP delivery showed a pericentral pattern.Conclusions:In this study,we found that IHP is an effective strategy for AAV8 delivery.In addition,the distribution characteristics of AAV8,when delivered in cynomolgus monkey via IHP,provide candidate vector delivery schemes for gene therapy for different types of genetic liver diseases.
