Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serv...Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics,ofering new opportunities for both basic and applied research.The“Human Gastric Cancer Organoid”is part of a series of guidelines for human gastric cancer organoids in China,jointly drafted by experts from the Chinese Society for Cell Biology and its branches,and initially released on October 29,2024.This standard outlines terminology,technical requirements,assessment protocols,and applies to production,evaluation procedures,and quality control for human gastric cancer organoids.The publication of this guideline aims to assist institutions in endorsing,establishing,and applying best practices,advancing the international standardiza-tion of human gastric cancer organoids for clinical development and therapeutic application.展开更多
Organoid technology provides a transformative approach to understand human physiology and pathology,offering valuable insights for scientific research and therapeutic development.Human gastric organoids,in particular,...Organoid technology provides a transformative approach to understand human physiology and pathology,offering valuable insights for scientific research and therapeutic development.Human gastric organoids,in particular,have gained significant interest for applications in disease modeling,drug discovery,and studies of tissue regeneration and homeostasis.However,the lack of standardized quality control has limited their extensive clinical applications.The"Human Gastric Organoids"is part of a series of guidelines for human gastric organoids in China,which establishes comprehensive standards on terminology,technical specifications,testing methods,inspection rules,usage instruc-tions,labeling,transportation,and storage,developed by experts from the Chinese Society for Cell Biology and its branch societies.Released on October 29,2024,this guideline aims to establish standardized protocols,enhance insti-tutional practices,and promote international standardization for clinical and research applications of human gastric organoids.展开更多
Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serv...Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics,offering new opportunities for both basic and applied research.The“Human Gastric Cancer Organoid”is part of a series of guidelines for human gastric cancer organoids in China,jointly drafted by experts from the Chinese Society for Cell Biology and its branches,and initially released on October 29,2024.This standard outlines terminology,technical requirements,assessment protocols,and applies to production,evaluation procedures,and quality control for human gastric cancer organoids.The publication of this guideline aims to assist institutions in endorsing,establishing,and applying best practices,advancing the international standardiza-tion of human gastric cancer organoids for clinical development and therapeutic application.展开更多
基金supported by grants from the National Natural Science Foun-dation of China(31988101 to Y.-G.C.,32300586 to Y.L.W.)the National Key Research and Development Program of China(2023YFA1800603 to Y.-G.C)+1 种基金Major Project of Guangzhou National Laboratory(GZNL2023A02008 to Y.L.W.)Young Talent Support Project of Guangzhou Association for Science and Technology(QT2024-019 to Y.L.W.)。
文摘Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics,ofering new opportunities for both basic and applied research.The“Human Gastric Cancer Organoid”is part of a series of guidelines for human gastric cancer organoids in China,jointly drafted by experts from the Chinese Society for Cell Biology and its branches,and initially released on October 29,2024.This standard outlines terminology,technical requirements,assessment protocols,and applies to production,evaluation procedures,and quality control for human gastric cancer organoids.The publication of this guideline aims to assist institutions in endorsing,establishing,and applying best practices,advancing the international standardiza-tion of human gastric cancer organoids for clinical development and therapeutic application.
基金supported by grants from the National Natural Science Foun‑dation of China(31988101 to Y.‑G.C.,32300586 to Y.L.W.)the National Key Research and Development Program of China(2023YFA1800603 to Y.‑G.C)+1 种基金Major Project of Guangzhou National Laboratory(GZNL2023A02008 to Y.L.W.)Young Talent Support Project of Guangzhou Association for Science and Technology(QT2024‑019 to Y.L.W.)。
文摘Organoid technology provides a transformative approach to understand human physiology and pathology,offering valuable insights for scientific research and therapeutic development.Human gastric organoids,in particular,have gained significant interest for applications in disease modeling,drug discovery,and studies of tissue regeneration and homeostasis.However,the lack of standardized quality control has limited their extensive clinical applications.The"Human Gastric Organoids"is part of a series of guidelines for human gastric organoids in China,which establishes comprehensive standards on terminology,technical specifications,testing methods,inspection rules,usage instruc-tions,labeling,transportation,and storage,developed by experts from the Chinese Society for Cell Biology and its branch societies.Released on October 29,2024,this guideline aims to establish standardized protocols,enhance insti-tutional practices,and promote international standardization for clinical and research applications of human gastric organoids.
基金National Natural Science Foundation of China(31988101 to Y.‑G.C.,32300586 to Y.L.W.)National Key Research and Development Program of China(2023YFA1800603 to Y.‑G.C)+1 种基金Major Project of Guangzhou National Laboratory(GZNL2023A02008 to Y.L.W.)Young Talent Support Project of Guangzhou Association for Science and Technology(QT2024‑019 to Y.L.W.).
文摘Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics,offering new opportunities for both basic and applied research.The“Human Gastric Cancer Organoid”is part of a series of guidelines for human gastric cancer organoids in China,jointly drafted by experts from the Chinese Society for Cell Biology and its branches,and initially released on October 29,2024.This standard outlines terminology,technical requirements,assessment protocols,and applies to production,evaluation procedures,and quality control for human gastric cancer organoids.The publication of this guideline aims to assist institutions in endorsing,establishing,and applying best practices,advancing the international standardiza-tion of human gastric cancer organoids for clinical development and therapeutic application.
