Objective:This study primarily focuses on analyzing the inductive effects of emotional disturbances on the malignant transformation process of mammary gland epithelial cells.Methods:A total of 42 patients with maligna...Objective:This study primarily focuses on analyzing the inductive effects of emotional disturbances on the malignant transformation process of mammary gland epithelial cells.Methods:A total of 42 patients with malignant transformation of mammary gland epithelial cells(breast cancer,observation group)and 42 patients without malignant transformation of mammary gland epithelial cells(non-breast tumors,control group)were selected as research subjects.The earliest consultation time was January 2022,and the latest was January 2024.The extent of psychological stress impact on these patients was compared.Results:Compared with the control group,the observation group experienced a higher frequency and intensity(LEU value)of adverse life events,with P<0.05.The intensity of adverse life events in the observation group,except for mild events,was significantly higher than that in the control group(P<0.05).In terms of the content distribution of adverse life events,the proportion of marital and family problems in the observation group was significantly higher than that in the control group(P<0.05).The negative coping score and positive coping score in the observation group were significantly different from those in the control group(P<0.05).Regarding social support,the objective support score in the observation group was higher than that in the control group(P<0.05).Conclusion:During the malignant transformation process of mammary gland epithelial cells,long-term emotional disturbances have a significant impact,indicating a close relationship between psychological stress and the occurrence of breast cancer.展开更多
Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTT was developed harnessing the amino-type excited-state intramolecular ...Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTT was developed harnessing the amino-type excited-state intramolecular proton transfer(ESIPT) process.Relying on whether the ESIPT proceeds normally or not,ABTT exhibited the yellow fluorescence in acidic media,or cyan fluorescence in basic condition.According to the variation,ABTT behaved as a promising sensor which possessed fast and reversible response to pH change without interference from the biological substances,and exported a steady ratiometric signal(I_(478)/I_(546)).Moreover,due to the ESIPT effect,large Stokes shift and high quantum yield were also exhibited in ABTT.Furthermore,ABTT was applied for monitoring the pH changes in living cells and visualizing the pH fluctuations under oxidative stress successfully.These results elucidated great potential of ABTT in understanding pH-dependent physiological and pathological processes.展开更多
The roots of Angelica dahurica are a commonly used traditional Chinese herbal medicine.It has the effects of dispelling wind and relieving pain,expelling pus and dispersing swelling,clearing the nasal orifices,and eli...The roots of Angelica dahurica are a commonly used traditional Chinese herbal medicine.It has the effects of dispelling wind and relieving pain,expelling pus and dispersing swelling,clearing the nasal orifices,and eliminating dampness.In recent years,the cultivation of A.dahurica in Hunan Province has developed rapidly,but the research on new varieties selection and standardized cultivation techniques is lagging behind.This paper reviewed the germplasm resources,variety distribution and standardized cultivation technology of A.dahurica in China,hoping to provide technical support for the development of A.dahurica industry.展开更多
In this paper,the seedling raising,cultivation,field management,pest and disease control,harvesting and processing of Paris polyphylla Smith under the forest in Hunan Province were scientifically standardized,to provi...In this paper,the seedling raising,cultivation,field management,pest and disease control,harvesting and processing of Paris polyphylla Smith under the forest in Hunan Province were scientifically standardized,to provide technical support for standardized cultivation and sustainable development of Paris polyphylla Smith industry in Hunan Province.展开更多
The most predominant sphingoilipids bases are phytosphingosine(phyto-sph) and phytosphingosine-1-phosphate(phyto-S1 P), followed by dihydrosphingosine(dh-sph) and dihydroshingosine-1-phosphate(dh-S1 P). In this study,...The most predominant sphingoilipids bases are phytosphingosine(phyto-sph) and phytosphingosine-1-phosphate(phyto-S1 P), followed by dihydrosphingosine(dh-sph) and dihydroshingosine-1-phosphate(dh-S1 P). In this study, a fast, sensitive and selective method for determining those four of sphingolipids by high performance liquid chromatography coupled to electrospray ionization ion trap mass spectrometry was introduced. Comparing two methods, method B’s recovery was better than method A. And the limit of detection(LOD) was between 0.003 to 0.013 μM for 20 μl injection.展开更多
Large-scale synthesis of high-quality two dimensional(2D)semiconductors,such as molybdenum disulfide(MoS_(2)),is a prerequisite for their lab-to-fab transition.It is crucial to systematically explore and understand th...Large-scale synthesis of high-quality two dimensional(2D)semiconductors,such as molybdenum disulfide(MoS_(2)),is a prerequisite for their lab-to-fab transition.It is crucial to systematically explore and understand the influence of key synthetic conditions on the nucleation,uniformity,and quality of MoS_(2) wafers.Here,we report the epitaxial growth of high-quality and uniform monolayer MoS_(2) films on 2-in c-plane sapphire by chemical vapor deposition(CVD)method under optimized growth conditions(0–1 mg NaCl,adequate S/Mo ratio,and the addition of 0–1 sccm O2).We systematically explore the influence of critical synthetic conditions on the nucleation,and stitching of MoS_(2) domains over the wafer scale,including the dosage of the alkali metal salt NaCl additive,the evaporation temperature of MoO_(3),the distance between MoO_(3) and the substrate,and the flow rate of O_(2).Among them,the dosage of NaCl and the S/Mo ratio have important influences on the quality and film coverage of MoS_(2),while the flow rate of O_(2) plays a key role in controlling the nucleation density and domain size.We further discovered that a-plane sapphire could easily guide the unidirectional growth of MoS_(2) without the need for other specific synthetic conditions compared with c-plane and m-plane sapphire.The field-effect transistors(FETs)fabricated from the full-coverage films show an average and the highest mobilities of 28.5 and around 45 cm^(2)·V−1·s^(-1),respectively.展开更多
The main purpose of this paper is to investigate the effect of corrosion on mechanical behaviors of the Mg-Zn-Zr alloy immersed in simulated body fluid （SBF） with different immersion times. The corrosion behavior of...The main purpose of this paper is to investigate the effect of corrosion on mechanical behaviors of the Mg-Zn-Zr alloy immersed in simulated body fluid （SBF） with different immersion times. The corrosion behavior of the materials in SBF was determined by immersion tests. The surfaces of the corroded alloys were examined by SEM. The tensile samples of the extruded Mg-2Zn-0.8Zr magnesium alloy were immersed in the SBF for 0, 4, 7, 10, 14, 21 and 28 d. The tensile mechanical behaviors of test samples were performed on an electronic tensile testing machine. SEM was used to observe the fracture morphology. It was found that with extension of the immersion time, the ultimate tensile strength （UTS）, yield strength （YS） and elongation （EL） of the Mg-2Zn-0.8Zr samples decreased rapidly at first and then decreased slowly. The main fracture mechanism of the alloy transformed from ductile fracture to cleavage fracture with the increasing immersion times, which can be attributed to stress concentration and embrittlement caused by pit corrosion.展开更多
Doping can change the band structure of semiconductors,thereby affecting their electrical,optical,and magnetic properties.In this study,we describe the synthesis of two-dimensional(2D)Se-doped Cr_(2)S_(3)(Se-Cr_(2)S_(...Doping can change the band structure of semiconductors,thereby affecting their electrical,optical,and magnetic properties.In this study,we describe the synthesis of two-dimensional(2D)Se-doped Cr_(2)S_(3)(Se-Cr_(2)S_(3))nanosheets using the chemical vapor deposition method.In these semiconductor nanosheets,the Se doping concentration can be controlled by tuning the Se/S mass ratio in the precursor.At the doping concentrations of 10.05%and 2.05%,the room temperature conductivity and mobility were increased by nearly 4 and 2 orders of magnitude,respectively.In addition,the response time of an ultrathin Se-Cr_(2)S_(3)photodetector was 200 times shorter than that of an undoped Cr_(2)S_(3)nanosheet photodetector.4.07%-Se-Cr_(2)S_(3)nanosheets show ferrimagnetic behavior with a Curie temperature of~200 K,which is 80 K higher than that of undoped Cr_(2)S_(3)nanosheets.A density functional theory calculation indicated that the Se doping can induce the formation of intercalated Cr vacancies in SeCr_(2)S_(3)and enhance its metallic characteristics.Our results demonstrated that Se-Cr_(2)S_(3)has significant potential in future electronic,optoelectronic,and spintronic devices.展开更多
Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered widespread interest in the scientific community and industry for their exceptional physical and chemistry properties,and great potential for appli...Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered widespread interest in the scientific community and industry for their exceptional physical and chemistry properties,and great potential for applications in diverse fields including(opto)electronics,electrocatalysis,and energy storage.Chemical vapor deposition(CVD)is one of the most compelling growth methods for the scalable growth of high-quality 2D TMDs.However,the conventional CVD process for synthesis of 2D TMDs still encounters significant challenges,primarily attributed to the high melting point of precursor powders,and achieving a uniform distribution of precursor atmosphere on the substrate to obtain controllable smaple domains is difficult.The spin-coating precursor mediated chemical vapor deposition(SCVD)strategy provides refinement over traditional methods by eliminating the use of solid precursors and ensuring a more clean and uniform distribution of the growth material on the substrate.Additionally,the SCVD process allows fine-tuning of material thickness and purity by manipulating solution composition,concentration,and the spin coating process.This Review presents a comprehensive summary of recent advances in controllable growth of 2D TMDs with a SCVD strategy.First,a series of various liquid precursors,additives,source supply methods,and substrate engineering strategies for preparing atomically thin TMDs by SCVD are introduced.Then,2D TMDs heterostructures and novel doped TMDs fabricated through the SCVD method are discussed.Finally,the current challenges and perspectives to synthesize 2D TMDs using SCVD are discussed.展开更多
Studies have indicated the different effects of PM_(2.5)components on human health.However,specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain un...Studies have indicated the different effects of PM_(2.5)components on human health.However,specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain unclear.Therefore,a repeated measures study for schizophrenia was constructed based on Anhui Mental Health Center.We collected information,including demographics and thyroid hormones(TH)levels,on repeat admissions of schizophrenia patients during 2017−2020,assessing their illness severity by positive and negative symptom scales(PANSS).Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant’s exposure level.We assessed the effects of PM_(2.5)components individually and in combination on schizophrenia and explored the mediating role of THs.Results indicated that benzo[a]pyrene,sulfate,nitrate,chloride,ammonia,cadmium,chromium,lead,selenium,and thallium exposure were associated with increased PANSS scores,with more significant results observed in males.Mixed exposure to PM_(2.5)components was found to be associated with increased PANSS scores and decreased free triiodothyronine(FT3).Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM_(2.5)components and PANSS scores.The findings emphasize the impacts of PM_(2.5)components on schizophrenia and the potential value of focusing on changes in THs.展开更多
Di(2-ethylhexyl)phthalate(DEHP),an environ-mental endocrine disruptor,has hormone-like activity and endocrine-disrupting effects.However,the types of reproductive hormones associated with DEHP vary across the studies....Di(2-ethylhexyl)phthalate(DEHP),an environ-mental endocrine disruptor,has hormone-like activity and endocrine-disrupting effects.However,the types of reproductive hormones associated with DEHP vary across the studies.Thus,we conducted a systematic review and meta-analysis to pool existing epidemiological evidence.We searched three databases up to January 31,2024,for eligible original studies to ultimately include 37 studies from eight countries with a total of 28911 participants.DEHP exposure was evaluated with urinary metabolites.Since the main types,production sites,blood concentrations,and functions of reproductive hormones differ between men and women,we reported the combined effect values by gender.Subgroup analyses were conducted by age,subfertility status,and the national sociodemographic index(SDI)level.Furthermore,the effect of maternal exposure during pregnancy on children’s reproductive hormone levels was analyzed separately.Overall,in general,in men,DEHP was positively correlated with sex hormone binding-globulin(SHBG)and adversely correlated with total testosterone(TT),free androgen index(FAI),and follicle-stimulating hormone(FSH).Results indicated that among men of reproductive age,DEHP exposure was associated with more significant hormonal suppression in infertile men compared with fertile men.Notably,age subgroup analysis among women revealed that postmenopausal women were more vulnerable to DEHP,which was related to lower TT and estradiol(E2).However,this study did not observe a significant association between prenatal DEHP metabolites and reproductive hormone levels in children.Our research identifies the most susceptible hormones(androgen suppression)after DEHP exposure and suggests that infertile men and postmenopausal women are in great need of more attention as sensitive populations.展开更多
基金Bayan Nur Science and Technology Plan Project(Project No.:K202148)。
文摘Objective:This study primarily focuses on analyzing the inductive effects of emotional disturbances on the malignant transformation process of mammary gland epithelial cells.Methods:A total of 42 patients with malignant transformation of mammary gland epithelial cells(breast cancer,observation group)and 42 patients without malignant transformation of mammary gland epithelial cells(non-breast tumors,control group)were selected as research subjects.The earliest consultation time was January 2022,and the latest was January 2024.The extent of psychological stress impact on these patients was compared.Results:Compared with the control group,the observation group experienced a higher frequency and intensity(LEU value)of adverse life events,with P<0.05.The intensity of adverse life events in the observation group,except for mild events,was significantly higher than that in the control group(P<0.05).In terms of the content distribution of adverse life events,the proportion of marital and family problems in the observation group was significantly higher than that in the control group(P<0.05).The negative coping score and positive coping score in the observation group were significantly different from those in the control group(P<0.05).Regarding social support,the objective support score in the observation group was higher than that in the control group(P<0.05).Conclusion:During the malignant transformation process of mammary gland epithelial cells,long-term emotional disturbances have a significant impact,indicating a close relationship between psychological stress and the occurrence of breast cancer.
基金the financial supports from National Natural Science Foundation of China (Nos.81971678 and 81671756)the Innovation Fund for Postgraduate Students of Central South University (No.2019zzts1019)。
文摘Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTT was developed harnessing the amino-type excited-state intramolecular proton transfer(ESIPT) process.Relying on whether the ESIPT proceeds normally or not,ABTT exhibited the yellow fluorescence in acidic media,or cyan fluorescence in basic condition.According to the variation,ABTT behaved as a promising sensor which possessed fast and reversible response to pH change without interference from the biological substances,and exported a steady ratiometric signal(I_(478)/I_(546)).Moreover,due to the ESIPT effect,large Stokes shift and high quantum yield were also exhibited in ABTT.Furthermore,ABTT was applied for monitoring the pH changes in living cells and visualizing the pH fluctuations under oxidative stress successfully.These results elucidated great potential of ABTT in understanding pH-dependent physiological and pathological processes.
基金Modern Agriculture Traditional Chinese Medicine Industrial Technology System Construction Project of Hunan ProvinceNational Traditional Chinese Medicine Industrial Technology System Construction Special Project(CARS-21)Food Crop Safety Evaluation Project。
文摘The roots of Angelica dahurica are a commonly used traditional Chinese herbal medicine.It has the effects of dispelling wind and relieving pain,expelling pus and dispersing swelling,clearing the nasal orifices,and eliminating dampness.In recent years,the cultivation of A.dahurica in Hunan Province has developed rapidly,but the research on new varieties selection and standardized cultivation techniques is lagging behind.This paper reviewed the germplasm resources,variety distribution and standardized cultivation technology of A.dahurica in China,hoping to provide technical support for the development of A.dahurica industry.
基金Supported by Hunan Traditional Chinese Medicine Research Project (2021133)Technology System of Modern Agricultural Chinese Herbal Medicine Industry in Hunan Province
文摘In this paper,the seedling raising,cultivation,field management,pest and disease control,harvesting and processing of Paris polyphylla Smith under the forest in Hunan Province were scientifically standardized,to provide technical support for standardized cultivation and sustainable development of Paris polyphylla Smith industry in Hunan Province.
基金Supported by Science and Technology Innovation Project of Hunan Academy of Agricultural Sciences (2021CX32)。
文摘The most predominant sphingoilipids bases are phytosphingosine(phyto-sph) and phytosphingosine-1-phosphate(phyto-S1 P), followed by dihydrosphingosine(dh-sph) and dihydroshingosine-1-phosphate(dh-S1 P). In this study, a fast, sensitive and selective method for determining those four of sphingolipids by high performance liquid chromatography coupled to electrospray ionization ion trap mass spectrometry was introduced. Comparing two methods, method B’s recovery was better than method A. And the limit of detection(LOD) was between 0.003 to 0.013 μM for 20 μl injection.
基金This work was granted by the National Key Research and Development Program of the of China(No.2022YFA1203801)the National Natural Science Foundation of China(Nos.51991340,51991343,52221001,52102168,and 52372145)+4 种基金Hunan Key Research and Development Program Project(No.2022GK2005)the Natural Science Foundation of Hunan Province(No.2023JJ20009)the Hunan Province“Huxiang Talents”Project(No.2023RC3092)the Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-msxmX0321)the Doctoral Scientific Research Foundation of Hubei University of Automotive Technology(No.BK202486).
文摘Large-scale synthesis of high-quality two dimensional(2D)semiconductors,such as molybdenum disulfide(MoS_(2)),is a prerequisite for their lab-to-fab transition.It is crucial to systematically explore and understand the influence of key synthetic conditions on the nucleation,uniformity,and quality of MoS_(2) wafers.Here,we report the epitaxial growth of high-quality and uniform monolayer MoS_(2) films on 2-in c-plane sapphire by chemical vapor deposition(CVD)method under optimized growth conditions(0–1 mg NaCl,adequate S/Mo ratio,and the addition of 0–1 sccm O2).We systematically explore the influence of critical synthetic conditions on the nucleation,and stitching of MoS_(2) domains over the wafer scale,including the dosage of the alkali metal salt NaCl additive,the evaporation temperature of MoO_(3),the distance between MoO_(3) and the substrate,and the flow rate of O_(2).Among them,the dosage of NaCl and the S/Mo ratio have important influences on the quality and film coverage of MoS_(2),while the flow rate of O_(2) plays a key role in controlling the nucleation density and domain size.We further discovered that a-plane sapphire could easily guide the unidirectional growth of MoS_(2) without the need for other specific synthetic conditions compared with c-plane and m-plane sapphire.The field-effect transistors(FETs)fabricated from the full-coverage films show an average and the highest mobilities of 28.5 and around 45 cm^(2)·V−1·s^(-1),respectively.
基金Acknowledgements Thc authors are grateful for the supports from the National Natural Science Foundation of China （Grant No. 51271131）.
文摘The main purpose of this paper is to investigate the effect of corrosion on mechanical behaviors of the Mg-Zn-Zr alloy immersed in simulated body fluid （SBF） with different immersion times. The corrosion behavior of the materials in SBF was determined by immersion tests. The surfaces of the corroded alloys were examined by SEM. The tensile samples of the extruded Mg-2Zn-0.8Zr magnesium alloy were immersed in the SBF for 0, 4, 7, 10, 14, 21 and 28 d. The tensile mechanical behaviors of test samples were performed on an electronic tensile testing machine. SEM was used to observe the fracture morphology. It was found that with extension of the immersion time, the ultimate tensile strength （UTS）, yield strength （YS） and elongation （EL） of the Mg-2Zn-0.8Zr samples decreased rapidly at first and then decreased slowly. The main fracture mechanism of the alloy transformed from ductile fracture to cleavage fracture with the increasing immersion times, which can be attributed to stress concentration and embrittlement caused by pit corrosion.
基金supported by the National Natural Science Foundation of China(Grant Nos.51872086,62174051,51991340,and 51991343)the Natural Science Foundation of Hunan Province(Grant No.2020JJ1001)+2 种基金the Hunan Province“Huxiang Talents”Project(Grant No.2021RC3038)the Double First-Class Initiative of Hunan University(Grant No.531109100004)the Shenzhen Basic Research Project(Grant No.JCYJ20210324142012035)。
文摘Doping can change the band structure of semiconductors,thereby affecting their electrical,optical,and magnetic properties.In this study,we describe the synthesis of two-dimensional(2D)Se-doped Cr_(2)S_(3)(Se-Cr_(2)S_(3))nanosheets using the chemical vapor deposition method.In these semiconductor nanosheets,the Se doping concentration can be controlled by tuning the Se/S mass ratio in the precursor.At the doping concentrations of 10.05%and 2.05%,the room temperature conductivity and mobility were increased by nearly 4 and 2 orders of magnitude,respectively.In addition,the response time of an ultrathin Se-Cr_(2)S_(3)photodetector was 200 times shorter than that of an undoped Cr_(2)S_(3)nanosheet photodetector.4.07%-Se-Cr_(2)S_(3)nanosheets show ferrimagnetic behavior with a Curie temperature of~200 K,which is 80 K higher than that of undoped Cr_(2)S_(3)nanosheets.A density functional theory calculation indicated that the Se doping can induce the formation of intercalated Cr vacancies in SeCr_(2)S_(3)and enhance its metallic characteristics.Our results demonstrated that Se-Cr_(2)S_(3)has significant potential in future electronic,optoelectronic,and spintronic devices.
基金We acknowledge the support from the National Key R&D Program of the Ministry of Science and Technology of China(No.2022YFA1203801)the National Natural Science Foundation of China(grant numbers 51991340,51991343,52221001,62205055)+1 种基金the Hunan Key R&D Program Project(No.2022GK2005)Natural Science Foundation of Jiangsu Province(BK20220860).
文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered widespread interest in the scientific community and industry for their exceptional physical and chemistry properties,and great potential for applications in diverse fields including(opto)electronics,electrocatalysis,and energy storage.Chemical vapor deposition(CVD)is one of the most compelling growth methods for the scalable growth of high-quality 2D TMDs.However,the conventional CVD process for synthesis of 2D TMDs still encounters significant challenges,primarily attributed to the high melting point of precursor powders,and achieving a uniform distribution of precursor atmosphere on the substrate to obtain controllable smaple domains is difficult.The spin-coating precursor mediated chemical vapor deposition(SCVD)strategy provides refinement over traditional methods by eliminating the use of solid precursors and ensuring a more clean and uniform distribution of the growth material on the substrate.Additionally,the SCVD process allows fine-tuning of material thickness and purity by manipulating solution composition,concentration,and the spin coating process.This Review presents a comprehensive summary of recent advances in controllable growth of 2D TMDs with a SCVD strategy.First,a series of various liquid precursors,additives,source supply methods,and substrate engineering strategies for preparing atomically thin TMDs by SCVD are introduced.Then,2D TMDs heterostructures and novel doped TMDs fabricated through the SCVD method are discussed.Finally,the current challenges and perspectives to synthesize 2D TMDs using SCVD are discussed.
基金funded by the National Natural Science Foundation of China(Grant No.42375184)the Research Funds of Center for Big Data and Population Health of IHM(Grant No.JKS2022011)the Natural Science Research Key Project of University of Anhui Province(Grant No.2023AH050652).
文摘Studies have indicated the different effects of PM_(2.5)components on human health.However,specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain unclear.Therefore,a repeated measures study for schizophrenia was constructed based on Anhui Mental Health Center.We collected information,including demographics and thyroid hormones(TH)levels,on repeat admissions of schizophrenia patients during 2017−2020,assessing their illness severity by positive and negative symptom scales(PANSS).Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant’s exposure level.We assessed the effects of PM_(2.5)components individually and in combination on schizophrenia and explored the mediating role of THs.Results indicated that benzo[a]pyrene,sulfate,nitrate,chloride,ammonia,cadmium,chromium,lead,selenium,and thallium exposure were associated with increased PANSS scores,with more significant results observed in males.Mixed exposure to PM_(2.5)components was found to be associated with increased PANSS scores and decreased free triiodothyronine(FT3).Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM_(2.5)components and PANSS scores.The findings emphasize the impacts of PM_(2.5)components on schizophrenia and the potential value of focusing on changes in THs.
基金supported by the National Natural Science Foundation of China(Grant No.42375184 and 42105165)Research Funds of Center for Big Data and Population Health of IHM(Grant No.JKS2022011)Natural Science Research Key Project of University of Anhui Province(Grant No.2023AH050652).
文摘Di(2-ethylhexyl)phthalate(DEHP),an environ-mental endocrine disruptor,has hormone-like activity and endocrine-disrupting effects.However,the types of reproductive hormones associated with DEHP vary across the studies.Thus,we conducted a systematic review and meta-analysis to pool existing epidemiological evidence.We searched three databases up to January 31,2024,for eligible original studies to ultimately include 37 studies from eight countries with a total of 28911 participants.DEHP exposure was evaluated with urinary metabolites.Since the main types,production sites,blood concentrations,and functions of reproductive hormones differ between men and women,we reported the combined effect values by gender.Subgroup analyses were conducted by age,subfertility status,and the national sociodemographic index(SDI)level.Furthermore,the effect of maternal exposure during pregnancy on children’s reproductive hormone levels was analyzed separately.Overall,in general,in men,DEHP was positively correlated with sex hormone binding-globulin(SHBG)and adversely correlated with total testosterone(TT),free androgen index(FAI),and follicle-stimulating hormone(FSH).Results indicated that among men of reproductive age,DEHP exposure was associated with more significant hormonal suppression in infertile men compared with fertile men.Notably,age subgroup analysis among women revealed that postmenopausal women were more vulnerable to DEHP,which was related to lower TT and estradiol(E2).However,this study did not observe a significant association between prenatal DEHP metabolites and reproductive hormone levels in children.Our research identifies the most susceptible hormones(androgen suppression)after DEHP exposure and suggests that infertile men and postmenopausal women are in great need of more attention as sensitive populations.
