BACKGROUND Endoscopic colon polypectomy is a common procedure used to remove polyps that may develop into colorectal cancer if left untreated.Despite these advantages,patients frequently experience anxiety and other a...BACKGROUND Endoscopic colon polypectomy is a common procedure used to remove polyps that may develop into colorectal cancer if left untreated.Despite these advantages,patients frequently experience anxiety and other adverse reactions.Standardized evidence-based nursing practices are essential for enhancing patient care by addressing both physical and psychological health issues.AIM To analyze the impact of standardized evidence-based nursing on psychological status and adverse reactions of patients undergoing endoscopic colonic polypectomy.METHODS Data from 200 patients who underwent endoscopic colonic polypectomy at the authors’hospital between January and June 2024 were randomly assigned to two groups:Control[received routine nursing care(n=100)]and study[received standardized evidence-based nursing intervention(s)(n=100)].Psychological status,visual analog scale,and Short-Form 36 Health Survey scores,adverse events,and satisfaction with nursing were compared between the two groups.RESULTS After the interventions,the study group exhibited significantly lower scores on the Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale,along with a reduced incidence of adverse events compared with the control group(P<0.05).Short-Form 36 Health Survey scores and overall satisfaction with nursing care were also significantly higher in the intervention group(P<0.05).CONCLUSION Standardized evidence-based nursing interventions effectively reduced negative patient emotions and enhanced quality of life and satisfaction,demonstrating high safety.展开更多
Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammat...Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory process.NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling.However,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction.Additionally,it plays a complex role in various physiological processes and mediates several diseases.Sivelestat,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.展开更多
Various combinations of diamond, moissanite, zircon, quartz, corundum, rutile, titanite, almandine garnet, kyanite, and andalusite have been recovered from the Dangqiong peridotites. More than 80 grains of diamond hav...Various combinations of diamond, moissanite, zircon, quartz, corundum, rutile, titanite, almandine garnet, kyanite, and andalusite have been recovered from the Dangqiong peridotites. More than 80 grains of diamond have been recovered, most of which are pale yellow to reddish-orange to colorless. The grains are all 100-200 μm in size and mostly anhedral, but with a range of morphologies including elongated, octahedral and subhedral varieties. Their identification was confirmed by a characteristic shift in the Raman spectra between 1325 cm^-1 and 1333 cm^-1, mostly at 1331.51 cm^-1 or 1326.96 cm^-1. Integration of the mineralogical, petrological and geochemical data for the Dongqiong peridotites suggests a multi-stage formation for this body and similar ophiolites in the Yarlung-Zangbo suture zone. Chromian spinel grains and perhaps small bodies of chromitite crystallized at various depths in the upper mantle, and encapsulated the UHP, highly reduced and crustal minerals. Some oceanic crustal slabs containing the chromian spinel and their inclusion were later trapped in suprasubduction zones（SSZ）, where they were modified by island arc tholeiitic and boninitic magmas, thus changing the chromian spinel compositions and depositing chromitite ores in melt channels.展开更多
This paper establishes a new layered flying ad hoc networks(FANETs) system of mobile edge computing(MEC) supported by multiple UAVs,where the first layer of user UAVs can perform tasks such as area coverage, and the s...This paper establishes a new layered flying ad hoc networks(FANETs) system of mobile edge computing(MEC) supported by multiple UAVs,where the first layer of user UAVs can perform tasks such as area coverage, and the second layer of MEC UAVs are deployed as flying MEC sever for user UAVs with computing-intensive tasks. In this system, we first divide the user UAVs into multiple clusters, and transmit the tasks of the cluster members(CMs) within a cluster to its cluster head(CH). Then, we need to determine whether each CH’ tasks are executed locally or offloaded to one of the MEC UAVs for remote execution(i.e., task scheduling), and how much resources should be allocated to each CH(i.e., resource allocation), as well as the trajectories of all MEC UAVs.We formulate an optimization problem with the aim of minimizing the overall energy consumption of all user UAVs, under the constraints of task completion deadline and computing resource, which is a mixed integer non-convex problem and hard to solve. We propose an iterative algorithm by applying block coordinate descent methods. To be specific, the task scheduling between CH UAVs and MEC UAVs, computing resource allocation, and MEC UAV trajectory are alternately optimized in each iteration. For the joint task scheduling and computing resource allocation subproblem and MEC UAV trajectory subproblem, we employ branch and bound method and continuous convex approximation technique to solve them,respectively. Extensive simulation results validate the superiority of our proposed approach to several benchmarks.展开更多
Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source a...Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy.展开更多
According to the relationship between the meshing stiffness and the inherent characteristics of a seven-speed three-row coupled planetary transmission mechanism,a equivalent concentrated mass dynamics model of the pla...According to the relationship between the meshing stiffness and the inherent characteristics of a seven-speed three-row coupled planetary transmission mechanism,a equivalent concentrated mass dynamics model of the planetary transmission mechanism is established.The natural frequency of the planetary gear train at a specific gear is calculated and extracted.The relationship between the meshing stiffness of each row and the natural frequency of the system is analyzed,thereby avoiding possible resonance behavior by changing the meshing stiffness.These results show that the meshing stiffness,in its range of possible values,has nearly no effect on the low order natural frequency(<4.000.Hz),and that the time-varying meshing stiffness mainly affects the natural frequencies of the higher-and middle-order parts of the system.Changes of the natural frequencies lead to the change of the system's corresponding vibration mode,which will change the vibration situation of the system.展开更多
BACKGROUND Hourglass-like constriction neuropathy is a rare neurological disorder.The main clinical manifestation is peripheral nerve injury with no apparent cause,and the pathomorphological change is an unexplained n...BACKGROUND Hourglass-like constriction neuropathy is a rare neurological disorder.The main clinical manifestation is peripheral nerve injury with no apparent cause,and the pathomorphological change is an unexplained narrowing of the diseased nerve.The diagnosis and treatment of the disease are challenging and there is no accepted diagnostic or therapeutic approach.CASE SUMMARY This report describes a rare hourglass constriction of the anterior interosseous nerve in the left forearm in a 47-year-old healthy male who was treated surgically and gradually recovered function over a 6-mo follow-up period.CONCLUSION Hourglass-like constriction neuropathy is a rare disorder.With the development of medical technology,more examinations are now available for diagnosis.This case aims to highlight the rare manifestations of Hourglass-like constriction neuropathy and provides a reference for enriching the clinical diagnosis and treatment experience.展开更多
The char combustion mechanisms were analyzed and a comprehensive fractal char combustion model was developed to give a better understanding and better predictions of the char combustion characteristics. Most of the co...The char combustion mechanisms were analyzed and a comprehensive fractal char combustion model was developed to give a better understanding and better predictions of the char combustion characteristics. Most of the complex factors affecting the char combustion were included, such as the coupling effects between the pore diffusion and the chemical reactions, the evolution of the char pore structures and the variation of the apparent reaction order during combustion, the CO/CO_2 ratio in the combustion products and the correction for oxy-char combustion. Eleven different chars were then combusted in two drop tube furnaces with the conversions of the partly burned char samples measured by thermogravimetric analysis. The combustion processes of these chars were simulated with the predicted char conversions matching very well with the measured data which shows that this char combustion model has good accuracy. The apparent reaction order of the char combustion decreases, stabilizes and then increases during the combustion process. The combustion rates in the oxy-mode are generally slower than in the air-mode and the effect of the char-CO_2 gasification reaction becomes obvious only when the temperature is relatively high and the O_2 concentration is relatively low.展开更多
Ternary multifunctional A<sub>1</sub>Zn<sub>y</sub>Zr<sub>z</sub>O<sub>n</sub> catalysts are prepared by introducing A-site transition metals with the redox capability i...Ternary multifunctional A<sub>1</sub>Zn<sub>y</sub>Zr<sub>z</sub>O<sub>n</sub> catalysts are prepared by introducing A-site transition metals with the redox capability into binary Zn<sub>1</sub>Zr<sub>8</sub>O<sub>n</sub>. Structure and morphology were investigated by means of XRD, BET and FESEM, respectively. Activity data showed that Cr addition exhibited obvious beneficial effect to promote isobutene production from direct conversion of bio-ethanol compared to other A-site metal dopants. A significant higher yield of isobutene over Cr-promoted Zn<sub>1</sub>Zr<sub>8</sub>O<sub>n</sub> catalyst was also observed with respect to its binary Zn<sub>1</sub>Zr<sub>8</sub>O<sub>n</sub> counterpart. The choice of A-site metal is of prime importance in the isobutene production, catalyzing mainly the ethanol dehydrogenation, meanwhile the appropriate addition of zinc on the catalyst surface is also essential for good isobutene yield.展开更多
Objective:To study the clinical effect of the Huagai Pingchuan decoction combined with Seretide in the treatment of asthma.Methods:138 cases of asthma patients in our hospital were separated into the control group and...Objective:To study the clinical effect of the Huagai Pingchuan decoction combined with Seretide in the treatment of asthma.Methods:138 cases of asthma patients in our hospital were separated into the control group and the experimental group.The control group was given Seretide alone,while the experimental group was treated with Huagai Pingchuan decoction combined with Seretide.Results:After treatment,the wheezing symptoms remission time of the experimental group was shorter than control group,the performance of serum inflammatory factors and lung function indexes were better than control group,P<0.05 with significant difference.Conclusion:Huagai Pingchuan decoction combined with Seretide is more effec-tive in the treatment of asthma.展开更多
Nasopharyngeal carcinoma(NPC),a malignant tumor originating from the nasopharynx,is one of the common malignant tumors of the head and neck.There are significant geographical differences in the incidence of nasopharyn...Nasopharyngeal carcinoma(NPC),a malignant tumor originating from the nasopharynx,is one of the common malignant tumors of the head and neck.There are significant geographical differences in the incidence of nasopharyngeal carcinoma,with a high incidence in China and Southeast Asian countries.Herein,we designed and synthesized a novel near-infrared fluorescent(NIRF)probe to detect glutathione(GSH)in cellular and tumor environments using semi-naphthofluorescein(SNAFL)as the fluorescent molecular backbone and 2-fluoro-4-nitrobenzenesulfonate as the recognition moiety.Upon reaction with GSH,SNAFL-GSH emitted a fluorescence signal,and its emission wavelength at 650 nm was remarkably enhanced.The results of selectivity experiments indicated that SNAFL-GSH was able to discriminate GSH from Cys,Hcy,and H_(2) S.Moreover,SNAFL-GSH could image both endogenous and exogenous GSH and distinguish normal and cancer cells by fluorescence signal difference.At the cellular level,cisplatin(DDP)-induced ferroptosis and inhibition of proliferation of various NPC cell lines(CNE2,CNE1,5-8F cells)by erastin combined with DDP were visualized with the help of SNAFL-GSH.In a mouse tumor xenograft model,we successfully employed SNAFL-GSH for the evaluation of the efficacy of erastin combined with DDP in the treatment of NPC.More importantly,the probe could image cancerous tissue sections from NPC patients with an imaging depth of approximately 80µm.It was foreseen that SNAFL-GSH offered great potential for application in the diagnosis and evaluation of the therapeutic efficacy of NPC,and these results would also provide new ideas for the clinical treatment of NPC.展开更多
<strong>Objective:</strong> To assess and compare the clinical application value of nursing risk management in the diagnosis and treatment of severe peptic ulcer bleeding. <strong>Methods:</strong...<strong>Objective:</strong> To assess and compare the clinical application value of nursing risk management in the diagnosis and treatment of severe peptic ulcer bleeding. <strong>Methods:</strong> A total of 70 patients with severe peptic ulcer bleeding were selected as the research objects, randomly divided into observation group and control group, 35 cases for each. The nursing risk management and conventional nursing management were implemented for the two groups, respectively. The success rate of hemostasis, average length of stay, cure rate, complication rate, dyspnea rate, nursing dispute rate, SAS score, and SDS score were compared between the two groups. Patients’ satisfaction with nursing quality was also compared. <strong>Results:</strong> After the implementation of two different nursing management methods, all the above-mentioned metrics were better in the observation group than in the control group, and the differences were statistically significant (P < 0.01 or P < 0.05). <strong>Conclusion:</strong> The application of nursing risk management in the nursing intervention process of patients with severe peptic ulcer bleeding can effectively reduce the probability of nursing risk events, increase the cure rate, shorten the patient’s hospital stay, but also improve the patients’ psychological state and increase the patient’s satisfaction with nursing quality, which is worth clinical promotion.展开更多
Background: The prevalence of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, is projected to increase twofold by 2030. Leucine-rich repeat kinase 2 (LRRK2) is the most commonly observ...Background: The prevalence of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, is projected to increase twofold by 2030. Leucine-rich repeat kinase 2 (LRRK2) is the most commonly observed gene in both familial and sporadic PD cases. Notably, there is a substantial augmentation in motor activity during both larval and adult stages of zebrafish lacking the lrrk2 gene. Nevertheless, the precise genetic abnormalities accountable for eliciting these phenotypes in zebrafish are yet to be elucidated. Methods: Real-time polymerase chain reaction (PCR) was conducted on zebrafish larvae at 6 days post fertilization (dpf) belonging to both the wild-type and lrk2(-/-) groups. Guide RNA was designed and subsequently employed in the PCR process. Electrophoresis was performed to facilitate identification. Results: The expression of CNTF mRNA was significantly diminished in lrrk2(-/-), in comparison to the wildtype zebrafish larvae. This finding implies that CNTF may have crucial implications in the regulated functioning of lrrk2, which is widely acknowledged as the predominant genetic factor contributing to hereditary PD. The primers for CNTF DNA were meticulously designed, and the electrophoresis results of the PCR product were subsequently presented. The wild type zebrafish embryos were meticulously prepared for micro-injection, and the resulting efficiency identification displayed the presence of the mutant PCR product, which exhibited the presence of several debris. Conclusions: The present study demonstrates the successful generation of CNTF mutant zebrafish using the CRISPR/Cas9 genome editing technique. Further investigations are necessary to deepen our understanding of the exogenous CNTF gene’s functionality.展开更多
泰思肯集成矿物分析仪(TESCAN Integrated Mineral Analyzer,简称TIMA)是基于扫描电子显微镜、加载多个X射线能谱仪和其他探测器、自动识别矿物并成像的分析系统。TIMA已广泛应用到岩石学、矿物学、地球化学、石油、古生物等地球科学领...泰思肯集成矿物分析仪(TESCAN Integrated Mineral Analyzer,简称TIMA)是基于扫描电子显微镜、加载多个X射线能谱仪和其他探测器、自动识别矿物并成像的分析系统。TIMA已广泛应用到岩石学、矿物学、地球化学、石油、古生物等地球科学领域中,特别是在针对矿物成分和结构复杂、粒径细小的地质样品以及数量大且样品重复性高的实验需求时,它具备分析快速并且能获得统计学数据的优势。为了达到分析测试目的,同时节约成本,选择最佳的实验条件至关重要,但相关研究往往被忽视。因此,本文以陕西省略阳县铧厂沟金矿床中的含金矿化黄铁绢英岩样品为例,使用TIMA在不同扫描模式和分析类型以及多种实验参数设置条件下,对样品进行了分析测试,比较了测试结果的矿物相组成数据、小区域矿物相图和元素分布图的图像质量以及矿物颗粒粒径等统计数据。研究结果表明,影响TIMA分析质量的主要因素为背散射像素间距、能谱测试点间距以及X射线采集计数;实验条件的选择主要取决于样品的矿物成分、粒径和测试分析的目的。展开更多
Various combinations of diamond, moissanite, zircon, corundum, rutile and titanitehave been recovered from the Bulqiza chromitites. More than 10 grains of diamond have been recovered, most of which are pale yellow to ...Various combinations of diamond, moissanite, zircon, corundum, rutile and titanitehave been recovered from the Bulqiza chromitites. More than 10 grains of diamond have been recovered, most of which are pale yellow to reddish–orange to colorless. The grains are all 100–300 μm in size and mostly anhedral, but with a range of morphologies including elongated, octahedral and subhedral varieties. Their identification was confirmed by a characteristic shift in the Raman spectra between 1325 cm-1 and 1333 cm-1, mostly at 1331.51 cm-1 or 1326.96 cm-1. This investigation extends the occurrence of diamond and moissanite to the Bulqiza chromitites in the Eastern Mirdita Ophiolite. Integration of the mineralogical, petrological and geochemical data of the Bulqiza chromitites suggests their multi–stage formation. Magnesiochromite grains and perhaps small bodies of chromitite formed at various depths in the upper mantle, and encapsulated the ultra–high pressure, highly reduced and crustal minerals. Some oceanic crustal slabs containing the magnesiochromite and their inclusion were later trapped in suprasubduction zones, where they were modified by tholeiitic and boninitic arc magmas, thus changing the magnesiochromite compositions and depositing chromitite ores in melt channels.展开更多
A group of mantle minerals including about 70-80 subtypes of minerals are discovered from a podiform chromitite in Xizang,China.Recovered minerals include diamond,coesite,moissanite,wustite,Fe-silides and a new minera...A group of mantle minerals including about 70-80 subtypes of minerals are discovered from a podiform chromitite in Xizang,China.Recovered minerals include diamond,coesite,moissanite,wustite,Fe-silides and a new mineral,luobusaite.All of these minerals were hand-picked from heavymineral separates of the podiform chromitite in the mantle peridotite of an ophiolite.The grains of luobusaite are as host mineral with inclusions of native silicon or as an intergrowth with native silicon and Fe-Si phase.Luobusaite occurs as irregular grains,with 0.1-0.2 mm in size,consisting of very finegrained aggregates.The mineral is steel-grey in color,metallic luster,and opaque.The empirical formula(based on 2 for Si)is Fe_(0.83)Si_(2),according to the chemical compositions of luobusaite.X-ray powder-diffraction data:orthorhombic system,space group Cmca,a=9.874(14)A,b=7.784(5)A,c=7.829(7)A,Z=16.展开更多
We describe the new mineral species titanium, ideally Ti, found in the podiform chromitites of the Luobusha ophiolite in Tibet, People＇s Republic of China. The irregular crystals range from 0.1 to 0.6 mm in diameter ...We describe the new mineral species titanium, ideally Ti, found in the podiform chromitites of the Luobusha ophiolite in Tibet, People＇s Republic of China. The irregular crystals range from 0.1 to 0.6 mm in diameter and form an intergrowth with coesite and kyanite. Titanium is silver grey in colour, the luster is metallic, it is opaque, the streak is grayish black, and it is non-fluorescent. The mineral is malleable, has a rough to hackly fracture and has no apparent cleavage. The estimated Mohs hardness is 4, and the calculated density is 4.503 g/cm3. The composition is Ti 99.23-100.00 wt%. The mineral is hexagonal, space group P6flmmc. Unit-cell parameters are a 2.950 （2） ~, c 4.686 （1） A,V 35.32 （5） A3, Z = 2. The five strongest powder diffraction lines [d in A （hkl） （I/I0）] are： 2.569 （010） （32）, 2.254（011） （100）, 1.730 （012） （16）, 1.478 （110） （21）, and 0.9464 （121） （8）. The species and name were approved by the CNMNC （IMA 2010-044）.展开更多
Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334...Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334 consecutive patients with SAP who underwent first PCI following multi-slice computer tomography （MSCT） were enrolled from our institution between January 2007 and June 2012. The CAC score was calculated according to the standard Agatston calcium scoring algorithm. Complex PCI was defined as use of high pressure bal-loon, kissing balloon and/or rotablator. Procedure-related complications included dissection, occlusion, perforation, no/slow flow and emer-gency coronary artery bypass grafting. Main adverse cardiac events （MACE） were defined as a combined end point of death, non-fatal myo-cardial infarction, target lesion revascularization and rehospitalization for cardiac ischemic events. Results Patients with a CAC score〉300 （n=145） had significantly higher PCI complexity （13.1%vs. 5.8%, P=0.017） and rate of procedure-related complications （17.2%vs. 7.4%, P=0.005） than patients with a CAC score≤300 （n=189）. After a median follow-up of 22.5 months （4-72 months）, patients with a CAC score≤300 differ greatly than those patients with CAC score＆gt;300 in cumulative non-events survival rates （88.9 vs. 79.0%, Log rank 4.577, P=0.032）. After adjusted for other factors, the risk of MACE was significantly higher [hazard ratio （HR）：4.3, 95%confidence inter-val （95%CI）：2.4-8.2, P=0.038] in patients with a CAC score〉300 compared to patients with a lower CAC score. Conclusions The CAC score is an independent predictor for MACE in SAP patients who underwent PCI and indicates complexity of PCI and proce-dure-related complications.展开更多
文摘BACKGROUND Endoscopic colon polypectomy is a common procedure used to remove polyps that may develop into colorectal cancer if left untreated.Despite these advantages,patients frequently experience anxiety and other adverse reactions.Standardized evidence-based nursing practices are essential for enhancing patient care by addressing both physical and psychological health issues.AIM To analyze the impact of standardized evidence-based nursing on psychological status and adverse reactions of patients undergoing endoscopic colonic polypectomy.METHODS Data from 200 patients who underwent endoscopic colonic polypectomy at the authors’hospital between January and June 2024 were randomly assigned to two groups:Control[received routine nursing care(n=100)]and study[received standardized evidence-based nursing intervention(s)(n=100)].Psychological status,visual analog scale,and Short-Form 36 Health Survey scores,adverse events,and satisfaction with nursing were compared between the two groups.RESULTS After the interventions,the study group exhibited significantly lower scores on the Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale,along with a reduced incidence of adverse events compared with the control group(P<0.05).Short-Form 36 Health Survey scores and overall satisfaction with nursing care were also significantly higher in the intervention group(P<0.05).CONCLUSION Standardized evidence-based nursing interventions effectively reduced negative patient emotions and enhanced quality of life and satisfaction,demonstrating high safety.
基金This work has been supported by the Liaoning Province Natural Science Foundation(Grant Nos.:2020-ZLLH-47,2020-MS-065,2021-YGJC-02,and 2017225054).Figures in the paper were drawn using Figdraw,and we sincerely thank the free drawing support provided by the Figdraw platform(www.fgdraw.com).We also would like to thank Editage(www.editage.cn)for English language editing.
文摘Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory process.NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling.However,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction.Additionally,it plays a complex role in various physiological processes and mediates several diseases.Sivelestat,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.
基金funded by grants from Sinoprobe-05-02 from the Ministry of Science and Technology of China,the NSF China(Nos.41502062,40930313,40921001,41202036)the China Geological Survey(Nos.12120115027201,12120114061801,2014DFR2127C)from the Institute of Geology,Chinese Academy of Geological Sciences(J1526)
文摘Various combinations of diamond, moissanite, zircon, quartz, corundum, rutile, titanite, almandine garnet, kyanite, and andalusite have been recovered from the Dangqiong peridotites. More than 80 grains of diamond have been recovered, most of which are pale yellow to reddish-orange to colorless. The grains are all 100-200 μm in size and mostly anhedral, but with a range of morphologies including elongated, octahedral and subhedral varieties. Their identification was confirmed by a characteristic shift in the Raman spectra between 1325 cm^-1 and 1333 cm^-1, mostly at 1331.51 cm^-1 or 1326.96 cm^-1. Integration of the mineralogical, petrological and geochemical data for the Dongqiong peridotites suggests a multi-stage formation for this body and similar ophiolites in the Yarlung-Zangbo suture zone. Chromian spinel grains and perhaps small bodies of chromitite crystallized at various depths in the upper mantle, and encapsulated the UHP, highly reduced and crustal minerals. Some oceanic crustal slabs containing the chromian spinel and their inclusion were later trapped in suprasubduction zones（SSZ）, where they were modified by island arc tholeiitic and boninitic magmas, thus changing the chromian spinel compositions and depositing chromitite ores in melt channels.
基金supported in part by the National Natural Science Foundation of China under Grant No.61931011in part by the Primary Research & Developement Plan of Jiangsu Province No. BE2021013-4+2 种基金in part by the National Natural Science Foundation of China under Grant No. 62072303in part by the National Postdoctoral Program for Innovative Talents of China No. BX20190202in part by the Open Project Program of the Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space No. KF20202105。
文摘This paper establishes a new layered flying ad hoc networks(FANETs) system of mobile edge computing(MEC) supported by multiple UAVs,where the first layer of user UAVs can perform tasks such as area coverage, and the second layer of MEC UAVs are deployed as flying MEC sever for user UAVs with computing-intensive tasks. In this system, we first divide the user UAVs into multiple clusters, and transmit the tasks of the cluster members(CMs) within a cluster to its cluster head(CH). Then, we need to determine whether each CH’ tasks are executed locally or offloaded to one of the MEC UAVs for remote execution(i.e., task scheduling), and how much resources should be allocated to each CH(i.e., resource allocation), as well as the trajectories of all MEC UAVs.We formulate an optimization problem with the aim of minimizing the overall energy consumption of all user UAVs, under the constraints of task completion deadline and computing resource, which is a mixed integer non-convex problem and hard to solve. We propose an iterative algorithm by applying block coordinate descent methods. To be specific, the task scheduling between CH UAVs and MEC UAVs, computing resource allocation, and MEC UAV trajectory are alternately optimized in each iteration. For the joint task scheduling and computing resource allocation subproblem and MEC UAV trajectory subproblem, we employ branch and bound method and continuous convex approximation technique to solve them,respectively. Extensive simulation results validate the superiority of our proposed approach to several benchmarks.
基金supported by the National Key Research and Development Program of China(2016YFC0102700)National Natural Science Foundation of China(21171117,21271181,21473240,and 81270209)+1 种基金Medical-Engineering Crossover Fund of Shanghai Jiao Tong University(YG2015MS51 and YG2014MS66)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning
文摘Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy.
基金National Natural Science Foundation of China(51375043)。
文摘According to the relationship between the meshing stiffness and the inherent characteristics of a seven-speed three-row coupled planetary transmission mechanism,a equivalent concentrated mass dynamics model of the planetary transmission mechanism is established.The natural frequency of the planetary gear train at a specific gear is calculated and extracted.The relationship between the meshing stiffness of each row and the natural frequency of the system is analyzed,thereby avoiding possible resonance behavior by changing the meshing stiffness.These results show that the meshing stiffness,in its range of possible values,has nearly no effect on the low order natural frequency(<4.000.Hz),and that the time-varying meshing stiffness mainly affects the natural frequencies of the higher-and middle-order parts of the system.Changes of the natural frequencies lead to the change of the system's corresponding vibration mode,which will change the vibration situation of the system.
文摘BACKGROUND Hourglass-like constriction neuropathy is a rare neurological disorder.The main clinical manifestation is peripheral nerve injury with no apparent cause,and the pathomorphological change is an unexplained narrowing of the diseased nerve.The diagnosis and treatment of the disease are challenging and there is no accepted diagnostic or therapeutic approach.CASE SUMMARY This report describes a rare hourglass constriction of the anterior interosseous nerve in the left forearm in a 47-year-old healthy male who was treated surgically and gradually recovered function over a 6-mo follow-up period.CONCLUSION Hourglass-like constriction neuropathy is a rare disorder.With the development of medical technology,more examinations are now available for diagnosis.This case aims to highlight the rare manifestations of Hourglass-like constriction neuropathy and provides a reference for enriching the clinical diagnosis and treatment experience.
基金Supported by the National Natural Science Foundation of China(No.51176096)
文摘The char combustion mechanisms were analyzed and a comprehensive fractal char combustion model was developed to give a better understanding and better predictions of the char combustion characteristics. Most of the complex factors affecting the char combustion were included, such as the coupling effects between the pore diffusion and the chemical reactions, the evolution of the char pore structures and the variation of the apparent reaction order during combustion, the CO/CO_2 ratio in the combustion products and the correction for oxy-char combustion. Eleven different chars were then combusted in two drop tube furnaces with the conversions of the partly burned char samples measured by thermogravimetric analysis. The combustion processes of these chars were simulated with the predicted char conversions matching very well with the measured data which shows that this char combustion model has good accuracy. The apparent reaction order of the char combustion decreases, stabilizes and then increases during the combustion process. The combustion rates in the oxy-mode are generally slower than in the air-mode and the effect of the char-CO_2 gasification reaction becomes obvious only when the temperature is relatively high and the O_2 concentration is relatively low.
文摘Ternary multifunctional A<sub>1</sub>Zn<sub>y</sub>Zr<sub>z</sub>O<sub>n</sub> catalysts are prepared by introducing A-site transition metals with the redox capability into binary Zn<sub>1</sub>Zr<sub>8</sub>O<sub>n</sub>. Structure and morphology were investigated by means of XRD, BET and FESEM, respectively. Activity data showed that Cr addition exhibited obvious beneficial effect to promote isobutene production from direct conversion of bio-ethanol compared to other A-site metal dopants. A significant higher yield of isobutene over Cr-promoted Zn<sub>1</sub>Zr<sub>8</sub>O<sub>n</sub> catalyst was also observed with respect to its binary Zn<sub>1</sub>Zr<sub>8</sub>O<sub>n</sub> counterpart. The choice of A-site metal is of prime importance in the isobutene production, catalyzing mainly the ethanol dehydrogenation, meanwhile the appropriate addition of zinc on the catalyst surface is also essential for good isobutene yield.
基金The Sixth Batch of national old TCM experts’academic experience inheritance project。
文摘Objective:To study the clinical effect of the Huagai Pingchuan decoction combined with Seretide in the treatment of asthma.Methods:138 cases of asthma patients in our hospital were separated into the control group and the experimental group.The control group was given Seretide alone,while the experimental group was treated with Huagai Pingchuan decoction combined with Seretide.Results:After treatment,the wheezing symptoms remission time of the experimental group was shorter than control group,the performance of serum inflammatory factors and lung function indexes were better than control group,P<0.05 with significant difference.Conclusion:Huagai Pingchuan decoction combined with Seretide is more effec-tive in the treatment of asthma.
基金supported by the Hainan Province Science and Technology Special Fund(Nos.ZDYF2021SHFZ219,ZDYF2022SHFZ288)National Natural Science Foundation of China(Nos.21961010,22264013,22204037)+3 种基金Hainan Provincial Natural Science Foundation of China(No.822RC831)Natural Science Research Talent Project of Hainan Medical University(No.JBGS202101)Project for Functional Materials and Molecular Imaging Science Innovation Group of Hainan Medical UniversityHainan Province Clinical Medical Center(2021).
文摘Nasopharyngeal carcinoma(NPC),a malignant tumor originating from the nasopharynx,is one of the common malignant tumors of the head and neck.There are significant geographical differences in the incidence of nasopharyngeal carcinoma,with a high incidence in China and Southeast Asian countries.Herein,we designed and synthesized a novel near-infrared fluorescent(NIRF)probe to detect glutathione(GSH)in cellular and tumor environments using semi-naphthofluorescein(SNAFL)as the fluorescent molecular backbone and 2-fluoro-4-nitrobenzenesulfonate as the recognition moiety.Upon reaction with GSH,SNAFL-GSH emitted a fluorescence signal,and its emission wavelength at 650 nm was remarkably enhanced.The results of selectivity experiments indicated that SNAFL-GSH was able to discriminate GSH from Cys,Hcy,and H_(2) S.Moreover,SNAFL-GSH could image both endogenous and exogenous GSH and distinguish normal and cancer cells by fluorescence signal difference.At the cellular level,cisplatin(DDP)-induced ferroptosis and inhibition of proliferation of various NPC cell lines(CNE2,CNE1,5-8F cells)by erastin combined with DDP were visualized with the help of SNAFL-GSH.In a mouse tumor xenograft model,we successfully employed SNAFL-GSH for the evaluation of the efficacy of erastin combined with DDP in the treatment of NPC.More importantly,the probe could image cancerous tissue sections from NPC patients with an imaging depth of approximately 80µm.It was foreseen that SNAFL-GSH offered great potential for application in the diagnosis and evaluation of the therapeutic efficacy of NPC,and these results would also provide new ideas for the clinical treatment of NPC.
文摘<strong>Objective:</strong> To assess and compare the clinical application value of nursing risk management in the diagnosis and treatment of severe peptic ulcer bleeding. <strong>Methods:</strong> A total of 70 patients with severe peptic ulcer bleeding were selected as the research objects, randomly divided into observation group and control group, 35 cases for each. The nursing risk management and conventional nursing management were implemented for the two groups, respectively. The success rate of hemostasis, average length of stay, cure rate, complication rate, dyspnea rate, nursing dispute rate, SAS score, and SDS score were compared between the two groups. Patients’ satisfaction with nursing quality was also compared. <strong>Results:</strong> After the implementation of two different nursing management methods, all the above-mentioned metrics were better in the observation group than in the control group, and the differences were statistically significant (P < 0.01 or P < 0.05). <strong>Conclusion:</strong> The application of nursing risk management in the nursing intervention process of patients with severe peptic ulcer bleeding can effectively reduce the probability of nursing risk events, increase the cure rate, shorten the patient’s hospital stay, but also improve the patients’ psychological state and increase the patient’s satisfaction with nursing quality, which is worth clinical promotion.
文摘Background: The prevalence of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, is projected to increase twofold by 2030. Leucine-rich repeat kinase 2 (LRRK2) is the most commonly observed gene in both familial and sporadic PD cases. Notably, there is a substantial augmentation in motor activity during both larval and adult stages of zebrafish lacking the lrrk2 gene. Nevertheless, the precise genetic abnormalities accountable for eliciting these phenotypes in zebrafish are yet to be elucidated. Methods: Real-time polymerase chain reaction (PCR) was conducted on zebrafish larvae at 6 days post fertilization (dpf) belonging to both the wild-type and lrk2(-/-) groups. Guide RNA was designed and subsequently employed in the PCR process. Electrophoresis was performed to facilitate identification. Results: The expression of CNTF mRNA was significantly diminished in lrrk2(-/-), in comparison to the wildtype zebrafish larvae. This finding implies that CNTF may have crucial implications in the regulated functioning of lrrk2, which is widely acknowledged as the predominant genetic factor contributing to hereditary PD. The primers for CNTF DNA were meticulously designed, and the electrophoresis results of the PCR product were subsequently presented. The wild type zebrafish embryos were meticulously prepared for micro-injection, and the resulting efficiency identification displayed the presence of the mutant PCR product, which exhibited the presence of several debris. Conclusions: The present study demonstrates the successful generation of CNTF mutant zebrafish using the CRISPR/Cas9 genome editing technique. Further investigations are necessary to deepen our understanding of the exogenous CNTF gene’s functionality.
文摘泰思肯集成矿物分析仪(TESCAN Integrated Mineral Analyzer,简称TIMA)是基于扫描电子显微镜、加载多个X射线能谱仪和其他探测器、自动识别矿物并成像的分析系统。TIMA已广泛应用到岩石学、矿物学、地球化学、石油、古生物等地球科学领域中,特别是在针对矿物成分和结构复杂、粒径细小的地质样品以及数量大且样品重复性高的实验需求时,它具备分析快速并且能获得统计学数据的优势。为了达到分析测试目的,同时节约成本,选择最佳的实验条件至关重要,但相关研究往往被忽视。因此,本文以陕西省略阳县铧厂沟金矿床中的含金矿化黄铁绢英岩样品为例,使用TIMA在不同扫描模式和分析类型以及多种实验参数设置条件下,对样品进行了分析测试,比较了测试结果的矿物相组成数据、小区域矿物相图和元素分布图的图像质量以及矿物颗粒粒径等统计数据。研究结果表明,影响TIMA分析质量的主要因素为背散射像素间距、能谱测试点间距以及X射线采集计数;实验条件的选择主要取决于样品的矿物成分、粒径和测试分析的目的。
基金funded by grants from the NSF China(Nos.41502062,41672046,41541017,41641015)the China Geological Survey(Nos.DD20160023-01,201511022)+2 种基金National Key Research and Development Project of China(2016YFC0600310)from the Institute of Geology,Chinese Academy of Geological Sciences(J1526)IGCP–649
文摘Various combinations of diamond, moissanite, zircon, corundum, rutile and titanitehave been recovered from the Bulqiza chromitites. More than 10 grains of diamond have been recovered, most of which are pale yellow to reddish–orange to colorless. The grains are all 100–300 μm in size and mostly anhedral, but with a range of morphologies including elongated, octahedral and subhedral varieties. Their identification was confirmed by a characteristic shift in the Raman spectra between 1325 cm-1 and 1333 cm-1, mostly at 1331.51 cm-1 or 1326.96 cm-1. This investigation extends the occurrence of diamond and moissanite to the Bulqiza chromitites in the Eastern Mirdita Ophiolite. Integration of the mineralogical, petrological and geochemical data of the Bulqiza chromitites suggests their multi–stage formation. Magnesiochromite grains and perhaps small bodies of chromitite formed at various depths in the upper mantle, and encapsulated the ultra–high pressure, highly reduced and crustal minerals. Some oceanic crustal slabs containing the magnesiochromite and their inclusion were later trapped in suprasubduction zones, where they were modified by tholeiitic and boninitic arc magmas, thus changing the magnesiochromite compositions and depositing chromitite ores in melt channels.
基金supported by the National Natural Science Foundation of China(Grant 40620120098 and 40472025).
文摘A group of mantle minerals including about 70-80 subtypes of minerals are discovered from a podiform chromitite in Xizang,China.Recovered minerals include diamond,coesite,moissanite,wustite,Fe-silides and a new mineral,luobusaite.All of these minerals were hand-picked from heavymineral separates of the podiform chromitite in the mantle peridotite of an ophiolite.The grains of luobusaite are as host mineral with inclusions of native silicon or as an intergrowth with native silicon and Fe-Si phase.Luobusaite occurs as irregular grains,with 0.1-0.2 mm in size,consisting of very finegrained aggregates.The mineral is steel-grey in color,metallic luster,and opaque.The empirical formula(based on 2 for Si)is Fe_(0.83)Si_(2),according to the chemical compositions of luobusaite.X-ray powder-diffraction data:orthorhombic system,space group Cmca,a=9.874(14)A,b=7.784(5)A,c=7.829(7)A,Z=16.
基金supported by the National Natural Science Foundation of China (40472025, 40620120098,40872043)
文摘We describe the new mineral species titanium, ideally Ti, found in the podiform chromitites of the Luobusha ophiolite in Tibet, People＇s Republic of China. The irregular crystals range from 0.1 to 0.6 mm in diameter and form an intergrowth with coesite and kyanite. Titanium is silver grey in colour, the luster is metallic, it is opaque, the streak is grayish black, and it is non-fluorescent. The mineral is malleable, has a rough to hackly fracture and has no apparent cleavage. The estimated Mohs hardness is 4, and the calculated density is 4.503 g/cm3. The composition is Ti 99.23-100.00 wt%. The mineral is hexagonal, space group P6flmmc. Unit-cell parameters are a 2.950 （2） ~, c 4.686 （1） A,V 35.32 （5） A3, Z = 2. The five strongest powder diffraction lines [d in A （hkl） （I/I0）] are： 2.569 （010） （32）, 2.254（011） （100）, 1.730 （012） （16）, 1.478 （110） （21）, and 0.9464 （121） （8）. The species and name were approved by the CNMNC （IMA 2010-044）.
文摘Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334 consecutive patients with SAP who underwent first PCI following multi-slice computer tomography （MSCT） were enrolled from our institution between January 2007 and June 2012. The CAC score was calculated according to the standard Agatston calcium scoring algorithm. Complex PCI was defined as use of high pressure bal-loon, kissing balloon and/or rotablator. Procedure-related complications included dissection, occlusion, perforation, no/slow flow and emer-gency coronary artery bypass grafting. Main adverse cardiac events （MACE） were defined as a combined end point of death, non-fatal myo-cardial infarction, target lesion revascularization and rehospitalization for cardiac ischemic events. Results Patients with a CAC score〉300 （n=145） had significantly higher PCI complexity （13.1%vs. 5.8%, P=0.017） and rate of procedure-related complications （17.2%vs. 7.4%, P=0.005） than patients with a CAC score≤300 （n=189）. After a median follow-up of 22.5 months （4-72 months）, patients with a CAC score≤300 differ greatly than those patients with CAC score＆gt;300 in cumulative non-events survival rates （88.9 vs. 79.0%, Log rank 4.577, P=0.032）. After adjusted for other factors, the risk of MACE was significantly higher [hazard ratio （HR）：4.3, 95%confidence inter-val （95%CI）：2.4-8.2, P=0.038] in patients with a CAC score〉300 compared to patients with a lower CAC score. Conclusions The CAC score is an independent predictor for MACE in SAP patients who underwent PCI and indicates complexity of PCI and proce-dure-related complications.
