Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apop...Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha/nuclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs.展开更多
Ultrafine metal nanoparticles are crucial for various applications,such as energy storage,catalysis,electronics,and biomedicine,owing to their high surfaceto-volume ratio and unique electronic properties.However,conve...Ultrafine metal nanoparticles are crucial for various applications,such as energy storage,catalysis,electronics,and biomedicine,owing to their high surfaceto-volume ratio and unique electronic properties.However,conventional nanoparticle synthesis methods often face challenges like irregular shapes and agglomeration,leading to compromised functionality.To address these challenges,this paper introduces a novel,rapid,high-temperature thermal radiation heating for the ultrafast synthesis and dispersion of metal nanoparticles.Utilizing the heating properties of carbon materials,the direct Joule heating generated by them rises to 1800-2000 K within~200 ms,followed by cooling to room temperature at a rate of 2×10^(3)K s^(-1).展开更多
The co-utilization of silicon(Si) and graphite(G) has been considered as the preferred strategy to achieve high energy density anode materials,but the effective synergistic integration of Si and graphite is still a ch...The co-utilization of silicon(Si) and graphite(G) has been considered as the preferred strategy to achieve high energy density anode materials,but the effective synergistic integration of Si and graphite is still a challenge and it is necessary to find a scheme to accommodate the large-scale production of Si/graphite anodes.In this work,silicon cutting waste from the photovoltaic industry was used as raw material,mixed with graphite,pitch,and polyvinylpyrrolidone,and subjected to high-energy ball milling.The mixture was then heated in an Ar atmosphere for the carbon coating,and the resulting Si/graphite/carbon(Si/G/C) composite was etched to remove the thicker SiOx layer formed on the Si surface to allow the pores between the Si and the carbon matrix to obtain Si@voids/G@C.Benefiting from the integrated structural design and the significantly enhanced electronic conductivity,the Si/G@voids@C composite exhibited the first dischargespecific capacity of 2530 mAh·g^(-1) with an initial coulombic efficiency(ICE) of 86.7%,and the remaining capacity exceeded 1000 mAh·g^(-1) after 550 cycles at 1.5A·g^(-1).Notably,full lithium-ion batteries with a Si/G@voids@C anode and LiFePO_4 cathode delivered a stable capacity of 140 mAh·g^(-1).The synthesis method is facile and cost-effective,providing an integration strategy for Si and G with a potential scheme for large-scale commercial applications.展开更多
A biopolymer-inorganic hybrid system(MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles(MSNs) and folic acid(FA)-terminated temperature-sensitive synthetic polypeptide,i.e.,poly(γ-benzyl-L-glu...A biopolymer-inorganic hybrid system(MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles(MSNs) and folic acid(FA)-terminated temperature-sensitive synthetic polypeptide,i.e.,poly(γ-benzyl-L-glutamate)(PBLG) derivative,through a thiol-disulfide exchange reaction,where MSNs with high drug loading capacity serve as drug nanocarriers and the biocompatible PBLG biopolymer brushes installed on MSN surface through disulfide bonds endow the system with tumor-specific recognition ability and GSH/temperature dual-stimuli responsiveness.Controlled drug release experiments indicate that DOX can be tightly hosted in the system with limited premature release,but efficiently released in response to an increased concentration of GSH and/or an elevated temperature.Intracellular experiments demonstrate that the DOX-loaded MSN@PBLGF nanohybrid shows outstanding cellular uptake and cell-growth inhibition effects on human lung cancer cell line A549 in comparison with healthy human cells such as hepatocyte cells LO2.展开更多
A simple and effective method has been developed to reflect the growth of bacteria CH-1via the potential of the solution.The results indicate that during the bacterial cultivation,the biomass increases and the potenti...A simple and effective method has been developed to reflect the growth of bacteria CH-1via the potential of the solution.The results indicate that during the bacterial cultivation,the biomass increases and the potential of the solution decreases over time.The relationship between biomass and potential of the solution could be expressed by the equation with constants of a and b whichare all related to species,batch,number,and growth environment of bacterial.When the initial pH value is10and the initial biomassis6.55×107cell/mL,the correlated equation of the biomass and the potential of the solution could be divided into two segments.Thegrowth of bacteria CH-1is different under various experimental conditions,but the biomass is directly related to the potential of thesolution regardless of the conditions of different initial pH values and bacteria number.展开更多
Two strategies for the design of new pillar[5]arene-based mechanically self-interlocked molecules (MSMs) are reported here. The first strategy is based on the construction of an intermediate pseudo[1]rotaxane followed...Two strategies for the design of new pillar[5]arene-based mechanically self-interlocked molecules (MSMs) are reported here. The first strategy is based on the construction of an intermediate pseudo[1]rotaxane followed by the desired bis-[l]rotaxane. The other one is based on the construction of the desired bis-[1]rotaxane directly via a condensation reaction through host-vip interactions between a mono-functionalized pillar[5]arene and the axle. The newly synthesized bis-[1]rotaxane BR was characterized by ~1H NMR, ^(13)C NMR, 2D NMRs (~1H-^(13)C HSQC,~1H-~1H COSY and NOESY) and LC-ESI-MS,which indicated compound BR displayed an self-interlocked structure in CDCl_3. Surprisingly, the results of SEM, TEM and DLS showed that the compound BR could assemble into spherical nanoparticles in MeOH.展开更多
Objectives:Early identification of sarcopenia in patients with chronic liver disease is crucial for patient management and prevention of severe complications.We aimed to assess the effectiveness of Ishii score,Strengt...Objectives:Early identification of sarcopenia in patients with chronic liver disease is crucial for patient management and prevention of severe complications.We aimed to assess the effectiveness of Ishii score,Strength,Assistance with Walking,Rise from a Chair,Climb Stairs and Falls(SARC-F),SARC-F and Calf Circumference(SARC-CalF),and Mini Sarcopenia Risk Assessment-7(MSRA-7)to screen sarcopenia in patients with chronic liver disease.Methods:This prospective study included patients with chronic liver disease in the infectious department of a tertiary hospital in Sichuan,China.Ishii score,SARC-F,SARC-CalF,and MSRA-7 were used to screen for sarcopenia risk.Sarcopenia was diagnosed according to the Asian Myometriosis Working Group(AWGS)2019,which was used as the gold standard to compare the performance of the four screening tools.We completed clinical registration on the Chinese Clinical Trial Registration website(ChiCTR2100043910).Results:A total of 366 patients with chronic liver disease(22.4%women,mean age 48.96±11.88 years)were evaluated.Based on the AWGS 2019 standard,the prevalence of sarcopenia in patients with chronic liver disease was 17.5%.Among all participants,receiver operating characteristic(ROC)produced an area under the curve(AUC)of 0.82 for Ishii score(sensitivity 85.94%,specificity 78.15%),0.53 for SARC-F(sensitivity 6.25%,specificity 99.34%),0.64 for SARC-CalF(sensitivity 45.31%,specificity 83.11%),and 0.55 for MSRA-7(sensitivity 87.50%,specificity 22.85%).Based on AUC,decision curve analysis,and calibration curves,we concluded that Ishii score was the most accurate screening tool and was superior to the other tools.Conclusions:Ishii score is more suitable for screening sarcopenia in patients with chronic liver disease than the SARC-F,SARC-CalF,and MSRA-7,based on the AWGS 2019 criteria.Nursing professionals can use Ishii score as a clinical tool to screen for sarcopenia in patients with chronic liver disease,providing an indication cue for the final diagnosis of sarcopenia,improving diagnostic efficiency,and enabling early identification and prevention of complications resulting from sarcopenia.展开更多
SINCE 2015,17 Sustainable Development Goals(SDGs)have been understood as more promising blueprints for a peaceful,prosperous,and sustainable future[1]which are formulated to seek a framework to address global challeng...SINCE 2015,17 Sustainable Development Goals(SDGs)have been understood as more promising blueprints for a peaceful,prosperous,and sustainable future[1]which are formulated to seek a framework to address global challenging issues such as poverty,inequality,and pollution.展开更多
Micro-nanostructured materials exhibit unique physical and chemical properties,making them valuable for both scientific research and technological applications.Particularly,these materials significantly improve the el...Micro-nanostructured materials exhibit unique physical and chemical properties,making them valuable for both scientific research and technological applications.Particularly,these materials significantly improve the electrochemical performance of lithium-ion batteries(LIBs).Spray drying(SD),a facile and scalable synthesis method,provides an effective strategy for the precise design and fabrication of functional nano structured materials with tailored compositions and morphologies.This review provides a comprehensive overview of recent advances in the application of SD for fabricating key micro-nanomaterials for LIBs.The paper examines the fundamental principles of SD,its historical development in the LIB field,and its current industrial status.The review systematically evaluates strategies for applying SD to enhance the performance of typical LIB cathode and anode materials.Additionally,the inherent advantages and current challenges of SD are comprehensively analyzed.This paper provides valuable theoretical and practical guidance for the advancement of SD in the fabrication of high-performance micro-nano structured materials for LIBs.展开更多
Met tyrosine kinase,a receptor for a hepatocyte growth factor(HGF),plays a critical role in tumor growth,metastasis,and drug resistance.Mitochondria are highly dynamic and undergo fission and fusion to maintain a func...Met tyrosine kinase,a receptor for a hepatocyte growth factor(HGF),plays a critical role in tumor growth,metastasis,and drug resistance.Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network.Dysregulated mitochondrial dynamics are responsible for the progression and metastasis of many cancers.Here,using structured illumination microscopy(SIM)and high spatial and temporal resolution live cell imaging,we identified mitochondrial trafficking of receptor tyrosine kinase Met.The ton tacts betwee n activated Met kinase and mitochondria formed dramatically,and an intact HGF/Met axis was necessary for dysregulated mitochondrial fission and cancer cell movements.Mechanically,we found that Met directly phosphorylated outer mitochondrial membrane protein Fis1 at Tyr38(Fisl pY38).Fisl pY38 promoted mitochondrial fission by recruiting the mitochondrial fission GTPase dynamin-related protein・1(Drp1)to mitochondria.Fragmented mitochondria fueled actin filament remodeling and lamellipodia or invadopodia formation to facilitate cell metastasis in hepatocellular carcinoma(HCC)cells both in vitro and in vivo.These findings reveal a novel and noncanonical pathway of Met receptor tyrosine kinase in the regulation of mitochondrial activities,which may provide a therapeutic target for metastatic HCC.展开更多
Three nanostructured photosensitizers with aggregation-induced emission(AIE) characteristics based on2,3-bis(4?-(diphenylamino)-[1,1?-biphenyl]-4-yl) fumaronitrile(BDBF) were prepared for image-guided photodynamic the...Three nanostructured photosensitizers with aggregation-induced emission(AIE) characteristics based on2,3-bis(4?-(diphenylamino)-[1,1?-biphenyl]-4-yl) fumaronitrile(BDBF) were prepared for image-guided photodynamic therapy(PDT). BDBF was encapsulated with Pluronic F-127(F127) to form usual spherical nanoparticles(F127@BDBF NPs) with a red fluorescence emission and 9.8% fluorescence quantum yield(FQY). Moreover, BDBF self-assembled into nanorods(BDBF NRs) in water. Compared with F127@BDBF NPs, BDBF NRs exhibited stronger orange fluorescence with a higher FQY of 23.3% and similar singlet oxygen(1O2) generation capability. BDBF NRs were further modified with F127 to form BDBF@F127 NRs with the same 1O2 generation ability as BDBF NRs. The three nanostructures exhibited a higher 1O2 production capacity than BDBF molecule in dissolved state and favorable stability in an aqueous solution as well as under physiological condition. In vitro photocytotoxicity experiments indicated that the three nanostructures inhibited tumor cell proliferation effectively.Therefore, to construct eligible nanostructures with a high FQY and 1O2 generation ability, simple self-assembly can serve as a valuable method to prepare photosensitizers with enhanced PDT.展开更多
基金supported by the National Natural Science Foundation of China,No.82204663(to TZ)the Natural Science Foundation of Shandong Province,No.ZR2022QH058(to TZ).
文摘Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha/nuclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs.
基金financially supported by the National Natural Science Foundation of China(Nos.22468029,52274408,52204314)the Major Science and Technology Projects in Yunnan Province(No.202402AF080005)+1 种基金Yunnan Fundamental Research Projects(No.202201AW070014)the Program for Innovative Research Team in the University of ministry of Education of China(No.IRT_17R48)
文摘Ultrafine metal nanoparticles are crucial for various applications,such as energy storage,catalysis,electronics,and biomedicine,owing to their high surfaceto-volume ratio and unique electronic properties.However,conventional nanoparticle synthesis methods often face challenges like irregular shapes and agglomeration,leading to compromised functionality.To address these challenges,this paper introduces a novel,rapid,high-temperature thermal radiation heating for the ultrafast synthesis and dispersion of metal nanoparticles.Utilizing the heating properties of carbon materials,the direct Joule heating generated by them rises to 1800-2000 K within~200 ms,followed by cooling to room temperature at a rate of 2×10^(3)K s^(-1).
基金financially supported by the National Natural Science Foundation of China (Nos.51974143,52274408,5220041313,52164050 and 51904134)Major Science and Technology Projects in Yunnan Province (Nos.202102AB080016,202103AA080004 and 202202AB080010)+3 种基金Yunnan Fundamental Research Projects (No.202201AW070014)Yunnan Ten Thousand Talents Project (No.YNWR-QNBJ-2018-111)Yunnan High-level Talent Project (No.YNQR-GCC-2019-010)the Program for Innovative Research Team in University of Ministry of Education of China (No.IRT_17R48)。
文摘The co-utilization of silicon(Si) and graphite(G) has been considered as the preferred strategy to achieve high energy density anode materials,but the effective synergistic integration of Si and graphite is still a challenge and it is necessary to find a scheme to accommodate the large-scale production of Si/graphite anodes.In this work,silicon cutting waste from the photovoltaic industry was used as raw material,mixed with graphite,pitch,and polyvinylpyrrolidone,and subjected to high-energy ball milling.The mixture was then heated in an Ar atmosphere for the carbon coating,and the resulting Si/graphite/carbon(Si/G/C) composite was etched to remove the thicker SiOx layer formed on the Si surface to allow the pores between the Si and the carbon matrix to obtain Si@voids/G@C.Benefiting from the integrated structural design and the significantly enhanced electronic conductivity,the Si/G@voids@C composite exhibited the first dischargespecific capacity of 2530 mAh·g^(-1) with an initial coulombic efficiency(ICE) of 86.7%,and the remaining capacity exceeded 1000 mAh·g^(-1) after 550 cycles at 1.5A·g^(-1).Notably,full lithium-ion batteries with a Si/G@voids@C anode and LiFePO_4 cathode delivered a stable capacity of 140 mAh·g^(-1).The synthesis method is facile and cost-effective,providing an integration strategy for Si and G with a potential scheme for large-scale commercial applications.
基金supported by the Nursing Project of Jiangsu Cancer Hospital(ZH202001)General program of Jiangsu Provincial Health Commission Medical Research(M2021114)Project of Jiangsu Provincial Hospital Management Association(JSYGY-3-2021-284)。
基金the Jilin Province-University Cooperative Construction Project-Special Funds for New Materials (No. SXGJSF2017-3) for financial support
文摘A biopolymer-inorganic hybrid system(MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles(MSNs) and folic acid(FA)-terminated temperature-sensitive synthetic polypeptide,i.e.,poly(γ-benzyl-L-glutamate)(PBLG) derivative,through a thiol-disulfide exchange reaction,where MSNs with high drug loading capacity serve as drug nanocarriers and the biocompatible PBLG biopolymer brushes installed on MSN surface through disulfide bonds endow the system with tumor-specific recognition ability and GSH/temperature dual-stimuli responsiveness.Controlled drug release experiments indicate that DOX can be tightly hosted in the system with limited premature release,but efficiently released in response to an increased concentration of GSH and/or an elevated temperature.Intracellular experiments demonstrate that the DOX-loaded MSN@PBLGF nanohybrid shows outstanding cellular uptake and cell-growth inhibition effects on human lung cancer cell line A549 in comparison with healthy human cells such as hepatocyte cells LO2.
基金Projects(51304251,51504299)supported by the National Natural Science Foundation of ChinaProject(201509050)supported by Special Program on Environmental Protection for Public Welfare,China
文摘A simple and effective method has been developed to reflect the growth of bacteria CH-1via the potential of the solution.The results indicate that during the bacterial cultivation,the biomass increases and the potential of the solution decreases over time.The relationship between biomass and potential of the solution could be expressed by the equation with constants of a and b whichare all related to species,batch,number,and growth environment of bacterial.When the initial pH value is10and the initial biomassis6.55×107cell/mL,the correlated equation of the biomass and the potential of the solution could be divided into two segments.Thegrowth of bacteria CH-1is different under various experimental conditions,but the biomass is directly related to the potential of thesolution regardless of the conditions of different initial pH values and bacteria number.
文摘Two strategies for the design of new pillar[5]arene-based mechanically self-interlocked molecules (MSMs) are reported here. The first strategy is based on the construction of an intermediate pseudo[1]rotaxane followed by the desired bis-[l]rotaxane. The other one is based on the construction of the desired bis-[1]rotaxane directly via a condensation reaction through host-vip interactions between a mono-functionalized pillar[5]arene and the axle. The newly synthesized bis-[1]rotaxane BR was characterized by ~1H NMR, ^(13)C NMR, 2D NMRs (~1H-^(13)C HSQC,~1H-~1H COSY and NOESY) and LC-ESI-MS,which indicated compound BR displayed an self-interlocked structure in CDCl_3. Surprisingly, the results of SEM, TEM and DLS showed that the compound BR could assemble into spherical nanoparticles in MeOH.
文摘Objectives:Early identification of sarcopenia in patients with chronic liver disease is crucial for patient management and prevention of severe complications.We aimed to assess the effectiveness of Ishii score,Strength,Assistance with Walking,Rise from a Chair,Climb Stairs and Falls(SARC-F),SARC-F and Calf Circumference(SARC-CalF),and Mini Sarcopenia Risk Assessment-7(MSRA-7)to screen sarcopenia in patients with chronic liver disease.Methods:This prospective study included patients with chronic liver disease in the infectious department of a tertiary hospital in Sichuan,China.Ishii score,SARC-F,SARC-CalF,and MSRA-7 were used to screen for sarcopenia risk.Sarcopenia was diagnosed according to the Asian Myometriosis Working Group(AWGS)2019,which was used as the gold standard to compare the performance of the four screening tools.We completed clinical registration on the Chinese Clinical Trial Registration website(ChiCTR2100043910).Results:A total of 366 patients with chronic liver disease(22.4%women,mean age 48.96±11.88 years)were evaluated.Based on the AWGS 2019 standard,the prevalence of sarcopenia in patients with chronic liver disease was 17.5%.Among all participants,receiver operating characteristic(ROC)produced an area under the curve(AUC)of 0.82 for Ishii score(sensitivity 85.94%,specificity 78.15%),0.53 for SARC-F(sensitivity 6.25%,specificity 99.34%),0.64 for SARC-CalF(sensitivity 45.31%,specificity 83.11%),and 0.55 for MSRA-7(sensitivity 87.50%,specificity 22.85%).Based on AUC,decision curve analysis,and calibration curves,we concluded that Ishii score was the most accurate screening tool and was superior to the other tools.Conclusions:Ishii score is more suitable for screening sarcopenia in patients with chronic liver disease than the SARC-F,SARC-CalF,and MSRA-7,based on the AWGS 2019 criteria.Nursing professionals can use Ishii score as a clinical tool to screen for sarcopenia in patients with chronic liver disease,providing an indication cue for the final diagnosis of sarcopenia,improving diagnostic efficiency,and enabling early identification and prevention of complications resulting from sarcopenia.
基金supported by the Australian Research Council(DE210100274)。
文摘SINCE 2015,17 Sustainable Development Goals(SDGs)have been understood as more promising blueprints for a peaceful,prosperous,and sustainable future[1]which are formulated to seek a framework to address global challenging issues such as poverty,inequality,and pollution.
基金financially supported by the National Key R&D Program of China(No.2024YFC3907605)the National Natural Science Foundation of China(Nos.52474440,52204314,52274408)+3 种基金Major Science and Technology Projects in Yunnan Province(No.202402AF080005)Yunnan Fundamental Research Projects(Nos.202201BE070001-002,202201AW070014,202201AT070442)Yunnan Xingdian Talents Support Plan(No.XDYC-QNRC-2022-0596)the Program for Innovative Research Team in the University of Ministry of Education of China(No.IRT_17R48)
文摘Micro-nanostructured materials exhibit unique physical and chemical properties,making them valuable for both scientific research and technological applications.Particularly,these materials significantly improve the electrochemical performance of lithium-ion batteries(LIBs).Spray drying(SD),a facile and scalable synthesis method,provides an effective strategy for the precise design and fabrication of functional nano structured materials with tailored compositions and morphologies.This review provides a comprehensive overview of recent advances in the application of SD for fabricating key micro-nanomaterials for LIBs.The paper examines the fundamental principles of SD,its historical development in the LIB field,and its current industrial status.The review systematically evaluates strategies for applying SD to enhance the performance of typical LIB cathode and anode materials.Additionally,the inherent advantages and current challenges of SD are comprehensively analyzed.This paper provides valuable theoretical and practical guidance for the advancement of SD in the fabrication of high-performance micro-nano structured materials for LIBs.
基金This study was supported by the Natural Science Foundation of China(81772624,81972855,81630079,and 81972442)the Science and Technology Project of Guangzhou(201803010007)+4 种基金the Natural Science Foundation of Guangdong Province(2017A030313481,2021 Al 515010092)the National Postdoctoral Program for Innovative Talents(BX2021391)the Fundamental Research Funds for the Central Universities(17ykjc25)the National Key R&D Program of China(2017YFC0908501)the Open Funds of State Key Laboratory of Oncology in South China(KY013714).
文摘Met tyrosine kinase,a receptor for a hepatocyte growth factor(HGF),plays a critical role in tumor growth,metastasis,and drug resistance.Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network.Dysregulated mitochondrial dynamics are responsible for the progression and metastasis of many cancers.Here,using structured illumination microscopy(SIM)and high spatial and temporal resolution live cell imaging,we identified mitochondrial trafficking of receptor tyrosine kinase Met.The ton tacts betwee n activated Met kinase and mitochondria formed dramatically,and an intact HGF/Met axis was necessary for dysregulated mitochondrial fission and cancer cell movements.Mechanically,we found that Met directly phosphorylated outer mitochondrial membrane protein Fis1 at Tyr38(Fisl pY38).Fisl pY38 promoted mitochondrial fission by recruiting the mitochondrial fission GTPase dynamin-related protein・1(Drp1)to mitochondria.Fragmented mitochondria fueled actin filament remodeling and lamellipodia or invadopodia formation to facilitate cell metastasis in hepatocellular carcinoma(HCC)cells both in vitro and in vivo.These findings reveal a novel and noncanonical pathway of Met receptor tyrosine kinase in the regulation of mitochondrial activities,which may provide a therapeutic target for metastatic HCC.
基金financially supported by the National Natural Science Foundation of China (21835001, 51773080, 21674041, 51573068, 21221063, and 81870117)the Program for Changbaishan Scholars of Jilin Province, Jilin Province project (20160101305JC)+1 种基金Jilin Province Science and Technology Development Plan (20190201252JC)“Talents Cultivation Program” of Jilin University
文摘Three nanostructured photosensitizers with aggregation-induced emission(AIE) characteristics based on2,3-bis(4?-(diphenylamino)-[1,1?-biphenyl]-4-yl) fumaronitrile(BDBF) were prepared for image-guided photodynamic therapy(PDT). BDBF was encapsulated with Pluronic F-127(F127) to form usual spherical nanoparticles(F127@BDBF NPs) with a red fluorescence emission and 9.8% fluorescence quantum yield(FQY). Moreover, BDBF self-assembled into nanorods(BDBF NRs) in water. Compared with F127@BDBF NPs, BDBF NRs exhibited stronger orange fluorescence with a higher FQY of 23.3% and similar singlet oxygen(1O2) generation capability. BDBF NRs were further modified with F127 to form BDBF@F127 NRs with the same 1O2 generation ability as BDBF NRs. The three nanostructures exhibited a higher 1O2 production capacity than BDBF molecule in dissolved state and favorable stability in an aqueous solution as well as under physiological condition. In vitro photocytotoxicity experiments indicated that the three nanostructures inhibited tumor cell proliferation effectively.Therefore, to construct eligible nanostructures with a high FQY and 1O2 generation ability, simple self-assembly can serve as a valuable method to prepare photosensitizers with enhanced PDT.
