The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders:Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulat...The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders:Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances.In this regard,gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients,but also produces metabolites,fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells,which considerably affects the physiology of the host and contribute to maintaining homeostasis(Lyte,2013).展开更多
Some years ago,the infiltration of T-cells into the central nervous system(CNS)was considered a pathological condition exclusively.However,during the last two decades,a growing body of studies has shown that T-cells a...Some years ago,the infiltration of T-cells into the central nervous system(CNS)was considered a pathological condition exclusively.However,during the last two decades,a growing body of studies has shown that T-cells are essential players regulating several physiological processes exerted by the CNS,including stress resilience,social behavior.展开更多
基金supported by Programa de Apoyo a Centros con Financiamiento Basal AFB-170004(to Fundación Ciencia&Vida)from“Comisión Nacional de Investigación Científica y Tecnológica de Chile(CONICYT)”by grants FONDECYT-1170093 from Fondo Nacional de Desarrollo Científico y Tecnológico de ChileMJFF-10332.01 and MJFF-15076 from Michael J.Fox Foundation for Parkinson Research
文摘The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders:Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances.In this regard,gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients,but also produces metabolites,fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells,which considerably affects the physiology of the host and contribute to maintaining homeostasis(Lyte,2013).
基金supported by"Financiamiento Basal para Centros Cientificos y Tecnológicos de Excelencia de ANID"Centro Ciencia&VidaFB210008(to Fundocion Ciencia&Vida)funded by FONDECYT-1210013(to RP)from"Agencia Nacional de Investigación y Desarrollo de Chile(ANID)"。
文摘Some years ago,the infiltration of T-cells into the central nervous system(CNS)was considered a pathological condition exclusively.However,during the last two decades,a growing body of studies has shown that T-cells are essential players regulating several physiological processes exerted by the CNS,including stress resilience,social behavior.
