背景:研究已证明循环炎症蛋白和免疫细胞与类风湿关节炎之间的关联性,但因果关系尚不明确。目的:探究免疫细胞介导下循环炎症蛋白与类风湿关节炎的因果关系。方法:从GWAS Catalog数据库(由美国国家人类基因组研究所与欧洲生物信息学研...背景:研究已证明循环炎症蛋白和免疫细胞与类风湿关节炎之间的关联性,但因果关系尚不明确。目的:探究免疫细胞介导下循环炎症蛋白与类风湿关节炎的因果关系。方法:从GWAS Catalog数据库(由美国国家人类基因组研究所与欧洲生物信息学研究所联合创建并维护,为开放数据库)下载循环炎症蛋白和免疫细胞表型数据,从FinnGen数据库(是芬兰国内研究机构和生物样本库与国际行业伙伴合作的基因组学项目,为开放数据库)下载类风湿关节炎全基因组关联研究数据,进行两步孟德尔随机化分析:使用逆方差加权法评估91种循环炎症蛋白和731种免疫细胞对类风湿关节炎风险的因果影响,并辅助以MR-Egger、加权中位数、加权模式、简单模式和敏感性分析;评估已识别免疫细胞对循环炎症蛋白与类风湿关节炎之间关系的介导作用。结果与结论:①逆方差加权法分析结果表明,4种循环炎症蛋白与类风湿关节炎风险存在显著相关性,其中1种循环炎症蛋白是类风湿关节炎的危险因素,3种循环炎症蛋白是类风湿关节炎的保护因素;46种免疫细胞与类风湿关节炎存在显著相关性,其中20种免疫细胞是类风湿关节炎的危险因素,26种免疫细胞是是类风湿关节炎的保护因素。反向孟德尔随机化分析未发现类风湿关节炎与已识别的4种循环炎症蛋白存在因果关联。敏感性分析未发现显著的异质性和水平多效性。进一步中介分析结果显示,CD19 on IgD-CD38br在一定程度上介导了白细胞介素18(β=0.064,OR=1.066,P=0.044)与类风湿关节炎的因果效应,中介效应为0.004,中介占比为5.7%,直接效应为0.060。②研究结果揭示了循环炎症蛋白和免疫细胞与类风湿关节炎之间的因果关联,发现CD19 on IgD-CD38br在白细胞介素18与类风湿关节炎的因果关联中起部分介导作用。针对中国生物医学科研领域,可参考国际多组学研究平台与跨种族队列数据的整合分析框架,构建中国人群专属的表观基因组、蛋白质组及代谢组联合数据库,揭示复杂疾病发生发展的分子调控网络,助力疾病分型与早期诊断标志物开发;通过学习跨国协作研究机制,建立中国多民族、多地域的自然人群队列,系统解析环境暴露与基因交互作用对健康的影响,为制定本土化疾病预防策略提供科学依据。展开更多
Cycloaddition of carbon dioxide and propylene oxide to propylene carbonate catalyzed by tetra-tert-butyl metal phthalocyanine in the presence of tributylamine (TBA) shows higher yield than catalyzed by unsubstituted m...Cycloaddition of carbon dioxide and propylene oxide to propylene carbonate catalyzed by tetra-tert-butyl metal phthalocyanine in the presence of tributylamine (TBA) shows higher yield than catalyzed by unsubstituted metal phthalocyanine. Comparing different catalysts of diverse metals, (t-Bu)4PcMg is more active than (t-Bu)4PcFe. But (t-Bu)4PcCo and (t-Bu)4PcNi only have low catalytic activities towards the reaction. Moreover, the yield will increase as the temperature increases.展开更多
The catalytic properties of a series of cobalt complexes containing bidenated nitrogen ligand for displacement reaction of trialkylaluminum with ethylene is reported. Effect of different reaction time, temperature an...The catalytic properties of a series of cobalt complexes containing bidenated nitrogen ligand for displacement reaction of trialkylaluminum with ethylene is reported. Effect of different reaction time, temperature and cobalt complexes containing different ligand on catalyst performance has been investigated.展开更多
A kinetic study of two ruthenium carbene catalysts, （PCy3）2Cl2Ru=CHPh 1 （Grubbs catalyst） and a new catalyst [1,3-bis（2,6-dimethylphenyl）4,5-dihydroimidazol-2-ylidene]（PPh3） （Cl）2Ru-CHPh 3, were conducted in...A kinetic study of two ruthenium carbene catalysts, （PCy3）2Cl2Ru=CHPh 1 （Grubbs catalyst） and a new catalyst [1,3-bis（2,6-dimethylphenyl）4,5-dihydroimidazol-2-ylidene]（PPh3） （Cl）2Ru-CHPh 3, were conducted in metathesis of 1-hexene. The kinetic behavior of these catalysts at 40, 50, 60 and 70℃ was compared. Complex 3 has the more active catalytic effect at temperatures 40-70℃.展开更多
随着我国山区高速公路建设的不断推进,弃渣场地的稳定性及致灾机制成为工程建设评估的重要因素之一。为了实现弃渣场的稳定性、失稳灾害动力学全过程的分析,基于面向GPU并行高性能计算软件CoSim中的物质点法(material point method,简称...随着我国山区高速公路建设的不断推进,弃渣场地的稳定性及致灾机制成为工程建设评估的重要因素之一。为了实现弃渣场的稳定性、失稳灾害动力学全过程的分析,基于面向GPU并行高性能计算软件CoSim中的物质点法(material point method,简称MPM),引入强度折减法(strength reduction method,简称SRM)开展相关研究工作。为了验证算法的合理性,以典型均质边坡为例,采用基于MPM的强度折减法与极限平衡法(limit equilibrium method,简称LEM)进行了对比,表明两者无论在稳定系数Fs还是在潜在滑动面上均具有良好的一致性。在此基础上,以云南某高速公路弃渣场降雨诱发失稳灾害为例,对其在天然工况和暴雨工况下稳定性和失稳过程进行了分析。结果表明,该弃渣场边坡在天然状态下处于稳定状态,而在暴雨工况下会发生失稳和大变形滑动;数值模拟和现场调查结果吻合较好,表明了提出的方法在弃渣场边坡稳定性与大变形失稳动力学分析中有强大的优势,可以实现斜坡的“稳定性→大变形→流动→堆积”的全过程分析。展开更多
随着山区高速公路建设的迅速推进,弃渣场的稳定性及潜在失稳灾害评估日益受到重视。具有巨大能量的滑坡体,可能会冲击破坏沿途的结构物进而威胁生命财产安全。充分发挥利用物质点法(material point method,MPM)可以对连续介质大变形过...随着山区高速公路建设的迅速推进,弃渣场的稳定性及潜在失稳灾害评估日益受到重视。具有巨大能量的滑坡体,可能会冲击破坏沿途的结构物进而威胁生命财产安全。充分发挥利用物质点法(material point method,MPM)可以对连续介质大变形过程模拟和离散元法(digital elevation model,DEM)能够精准的接触判断优势,MPM-DEM耦合算法可有效解决滑坡体与复杂地形、沿线结构物之间的相互作用问题。文章基于GPU并行高性能计算软件CoSim中的MPM-DEM耦合算法,实现了对弃渣场边坡稳定性、潜在失稳灾害的动力学分析。研究首先以散粒体冲击结构物的算例,验证了该算法的合理性与准确性;在此基础上,以云南某高速公路弃渣场为研究案例,进一步计算其稳定性系数,并预测潜在失稳灾害的影响范围与危害程度。结果表明,该弃渣场边坡目前处于稳定状态;若发生失稳,滑坡体将对下游高速公路桥桩产生巨大冲击力。该耦合算法在弃渣场边坡稳定性与失稳灾害动力学分析中具备显著优势,能够实现边坡“稳定性→大变形→流动→堆积”的全过程分析。展开更多
In this work,ultrasonic energy field assistance combined with tempering treatment is proposed to improve the microstructure and mechanical properties of A517Q alloy steel fabricated by laser directed energy deposition...In this work,ultrasonic energy field assistance combined with tempering treatment is proposed to improve the microstructure and mechanical properties of A517Q alloy steel fabricated by laser directed energy deposition(LDED).The effects of ultrasonic vibration(UV)and tempering treatment on microstructure evolution,microhardness distribution and mechanical properties of deposition layer were studied in detail.The microstructure of UV assisted LDED sample after tempering is mainly composed of tempered sorbite(TS).Due to the improvement of microstructure inhomogeneity and grains refinement,UV assisted LDED sample with tempering treatment obtains excellent mechanical properties.The ultimate tensile strength(UTS),yield strength(YS)and elongation after breaking(EL)reach 765 MPa,657 MPa and 19.5%,the increase ratios of UTS and YS are 14.5%and 33.8%while maintaining plasticity compared to original LDED sample,respectively.It is obvious that ultrasonic vibration combined with tempering is a potential and effective method to obtain uniform microstructure and excellent mechanical properties in metal laser directed energy deposition field.展开更多
文摘背景:研究已证明循环炎症蛋白和免疫细胞与类风湿关节炎之间的关联性,但因果关系尚不明确。目的:探究免疫细胞介导下循环炎症蛋白与类风湿关节炎的因果关系。方法:从GWAS Catalog数据库(由美国国家人类基因组研究所与欧洲生物信息学研究所联合创建并维护,为开放数据库)下载循环炎症蛋白和免疫细胞表型数据,从FinnGen数据库(是芬兰国内研究机构和生物样本库与国际行业伙伴合作的基因组学项目,为开放数据库)下载类风湿关节炎全基因组关联研究数据,进行两步孟德尔随机化分析:使用逆方差加权法评估91种循环炎症蛋白和731种免疫细胞对类风湿关节炎风险的因果影响,并辅助以MR-Egger、加权中位数、加权模式、简单模式和敏感性分析;评估已识别免疫细胞对循环炎症蛋白与类风湿关节炎之间关系的介导作用。结果与结论:①逆方差加权法分析结果表明,4种循环炎症蛋白与类风湿关节炎风险存在显著相关性,其中1种循环炎症蛋白是类风湿关节炎的危险因素,3种循环炎症蛋白是类风湿关节炎的保护因素;46种免疫细胞与类风湿关节炎存在显著相关性,其中20种免疫细胞是类风湿关节炎的危险因素,26种免疫细胞是是类风湿关节炎的保护因素。反向孟德尔随机化分析未发现类风湿关节炎与已识别的4种循环炎症蛋白存在因果关联。敏感性分析未发现显著的异质性和水平多效性。进一步中介分析结果显示,CD19 on IgD-CD38br在一定程度上介导了白细胞介素18(β=0.064,OR=1.066,P=0.044)与类风湿关节炎的因果效应,中介效应为0.004,中介占比为5.7%,直接效应为0.060。②研究结果揭示了循环炎症蛋白和免疫细胞与类风湿关节炎之间的因果关联,发现CD19 on IgD-CD38br在白细胞介素18与类风湿关节炎的因果关联中起部分介导作用。针对中国生物医学科研领域,可参考国际多组学研究平台与跨种族队列数据的整合分析框架,构建中国人群专属的表观基因组、蛋白质组及代谢组联合数据库,揭示复杂疾病发生发展的分子调控网络,助力疾病分型与早期诊断标志物开发;通过学习跨国协作研究机制,建立中国多民族、多地域的自然人群队列,系统解析环境暴露与基因交互作用对健康的影响,为制定本土化疾病预防策略提供科学依据。
文摘Cycloaddition of carbon dioxide and propylene oxide to propylene carbonate catalyzed by tetra-tert-butyl metal phthalocyanine in the presence of tributylamine (TBA) shows higher yield than catalyzed by unsubstituted metal phthalocyanine. Comparing different catalysts of diverse metals, (t-Bu)4PcMg is more active than (t-Bu)4PcFe. But (t-Bu)4PcCo and (t-Bu)4PcNi only have low catalytic activities towards the reaction. Moreover, the yield will increase as the temperature increases.
文摘The catalytic properties of a series of cobalt complexes containing bidenated nitrogen ligand for displacement reaction of trialkylaluminum with ethylene is reported. Effect of different reaction time, temperature and cobalt complexes containing different ligand on catalyst performance has been investigated.
文摘A kinetic study of two ruthenium carbene catalysts, （PCy3）2Cl2Ru=CHPh 1 （Grubbs catalyst） and a new catalyst [1,3-bis（2,6-dimethylphenyl）4,5-dihydroimidazol-2-ylidene]（PPh3） （Cl）2Ru-CHPh 3, were conducted in metathesis of 1-hexene. The kinetic behavior of these catalysts at 40, 50, 60 and 70℃ was compared. Complex 3 has the more active catalytic effect at temperatures 40-70℃.
文摘随着山区高速公路建设的迅速推进,弃渣场的稳定性及潜在失稳灾害评估日益受到重视。具有巨大能量的滑坡体,可能会冲击破坏沿途的结构物进而威胁生命财产安全。充分发挥利用物质点法(material point method,MPM)可以对连续介质大变形过程模拟和离散元法(digital elevation model,DEM)能够精准的接触判断优势,MPM-DEM耦合算法可有效解决滑坡体与复杂地形、沿线结构物之间的相互作用问题。文章基于GPU并行高性能计算软件CoSim中的MPM-DEM耦合算法,实现了对弃渣场边坡稳定性、潜在失稳灾害的动力学分析。研究首先以散粒体冲击结构物的算例,验证了该算法的合理性与准确性;在此基础上,以云南某高速公路弃渣场为研究案例,进一步计算其稳定性系数,并预测潜在失稳灾害的影响范围与危害程度。结果表明,该弃渣场边坡目前处于稳定状态;若发生失稳,滑坡体将对下游高速公路桥桩产生巨大冲击力。该耦合算法在弃渣场边坡稳定性与失稳灾害动力学分析中具备显著优势,能够实现边坡“稳定性→大变形→流动→堆积”的全过程分析。
基金Project(2021YFC2801904) supported by the National Key R&D Program of ChinaProject(KY10100230067) supported by the Basic Product Innovation Research Project,China+3 种基金Projects(52271130,52305344) supported by the National Natural Science Foundation of ChinaProject(ZR2022QE073) supported by the Natural Science Foundation of Shandong Province,ChinaProject(AMGM2021F01) supported by the Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai,ChinaProject(KY90200210015) supported by Leading Scientific Research Project of CNNC,China。
文摘In this work,ultrasonic energy field assistance combined with tempering treatment is proposed to improve the microstructure and mechanical properties of A517Q alloy steel fabricated by laser directed energy deposition(LDED).The effects of ultrasonic vibration(UV)and tempering treatment on microstructure evolution,microhardness distribution and mechanical properties of deposition layer were studied in detail.The microstructure of UV assisted LDED sample after tempering is mainly composed of tempered sorbite(TS).Due to the improvement of microstructure inhomogeneity and grains refinement,UV assisted LDED sample with tempering treatment obtains excellent mechanical properties.The ultimate tensile strength(UTS),yield strength(YS)and elongation after breaking(EL)reach 765 MPa,657 MPa and 19.5%,the increase ratios of UTS and YS are 14.5%and 33.8%while maintaining plasticity compared to original LDED sample,respectively.It is obvious that ultrasonic vibration combined with tempering is a potential and effective method to obtain uniform microstructure and excellent mechanical properties in metal laser directed energy deposition field.
