Taji et al . have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue （MALT） lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I pat...Taji et al . have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue （MALT） lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alphasatellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas .展开更多
The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being ...The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and thrombocytopenia.It is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic agents.Notably,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.展开更多
Dear Editor,Significant progress has been made in understanding the genetics of amyotrophic lateral sclerosis(ALS),particularly in European populations.However,a substantial proportion of familial ALS(fALS)cases remai...Dear Editor,Significant progress has been made in understanding the genetics of amyotrophic lateral sclerosis(ALS),particularly in European populations.However,a substantial proportion of familial ALS(fALS)cases remaingenetically unexplained.Emerging evidence suggests that ALS phenotypes and genetic risk factors may vary across ethnicities and regions.Investigating the genetic architecture of ALS in understudied populations could uncover new pathwaysand mechanisms contributing to motor neuron degeneration.展开更多
文摘Taji et al . have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue （MALT） lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alphasatellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas .
基金supported by the Deutsche Forschungsgemeinschaft(DFG)through the Cluster of Excellence“Inflammation-at-Interfaces”EXC306-PN and EXC306-PM(D.K.,O.A.and C.K.)the Werner-und-Klara-Kreitz Foundation(JB).
文摘The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and thrombocytopenia.It is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic agents.Notably,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.
文摘Dear Editor,Significant progress has been made in understanding the genetics of amyotrophic lateral sclerosis(ALS),particularly in European populations.However,a substantial proportion of familial ALS(fALS)cases remaingenetically unexplained.Emerging evidence suggests that ALS phenotypes and genetic risk factors may vary across ethnicities and regions.Investigating the genetic architecture of ALS in understudied populations could uncover new pathwaysand mechanisms contributing to motor neuron degeneration.
