In this paper, we focus on the intermediate nodes of network and quantification of level of commodity and its cost on each node because intermediate nodes have stocking capacities which we generally see in the supply ...In this paper, we focus on the intermediate nodes of network and quantification of level of commodity and its cost on each node because intermediate nodes have stocking capacities which we generally see in the supply chain network. The commodity is supplied from a node to node in response to the power form of demand at a particular time. Since the traffic intensity of the demand of commodity also affects the flow of the commodity in the network, hence study of flow of commodity in the network is believed to be a significant contribution in this area. Several cases of quantifying the level of commodity in different situations as well as the cost analysis of incoming and outgoing commodity at a particular node have been thoroughly discussed in the paper. The present problem, presumably seeks to contribute to managerial decision making in supply chain network.展开更多
This study investigates the potential of methyl eugenol(ME),a compound found in the essential oils of various plants,to inhibit oxidative stress and its impact on diseases associated with this process.ME has been show...This study investigates the potential of methyl eugenol(ME),a compound found in the essential oils of various plants,to inhibit oxidative stress and its impact on diseases associated with this process.ME has been shown to possess antioxidant properties and antiproliferative activity in several cancers.It also demonstrates neuroprotective potential in conditions such as Alzheimer’s disease and ischemic brain injury.The mechanism of action involves the activation of the nuclear factor erythroid 2-related factor 2,which facilitates the transcription of antioxidant genes and modulation of pathways such as AMP-activated protein kinase/glycogen synthase kinase 3 beta,thereby reducing the production of reactive oxygen species and pro-inflammatory cytokines.However,research has identified potential toxicological risks associated with ME,including hepatotoxicity and changes in the gut microbiota.These findings highlight the need for caution when considering prolonged exposure to this compound.展开更多
文摘In this paper, we focus on the intermediate nodes of network and quantification of level of commodity and its cost on each node because intermediate nodes have stocking capacities which we generally see in the supply chain network. The commodity is supplied from a node to node in response to the power form of demand at a particular time. Since the traffic intensity of the demand of commodity also affects the flow of the commodity in the network, hence study of flow of commodity in the network is believed to be a significant contribution in this area. Several cases of quantifying the level of commodity in different situations as well as the cost analysis of incoming and outgoing commodity at a particular node have been thoroughly discussed in the paper. The present problem, presumably seeks to contribute to managerial decision making in supply chain network.
基金The author Mozaniel Santana de Oliveira thanks PDPG-POSDOC-Programa de Desenvolvimento da Pós-Graduação Pós-Doutorado Estratégico,as well as CAPES for the scholarship(process number:88887.852405/2023-00).
文摘This study investigates the potential of methyl eugenol(ME),a compound found in the essential oils of various plants,to inhibit oxidative stress and its impact on diseases associated with this process.ME has been shown to possess antioxidant properties and antiproliferative activity in several cancers.It also demonstrates neuroprotective potential in conditions such as Alzheimer’s disease and ischemic brain injury.The mechanism of action involves the activation of the nuclear factor erythroid 2-related factor 2,which facilitates the transcription of antioxidant genes and modulation of pathways such as AMP-activated protein kinase/glycogen synthase kinase 3 beta,thereby reducing the production of reactive oxygen species and pro-inflammatory cytokines.However,research has identified potential toxicological risks associated with ME,including hepatotoxicity and changes in the gut microbiota.These findings highlight the need for caution when considering prolonged exposure to this compound.
