The extent and aggression of colorectal cancer is a worldwide public health threat.Extensive research has been conducted on the pre-requisites leading to this fatal cancer.An array of genes along with their mutations ...The extent and aggression of colorectal cancer is a worldwide public health threat.Extensive research has been conducted on the pre-requisites leading to this fatal cancer.An array of genes along with their mutations and the signal transduction pathways leading to the cellular transformation into the cancerous cells have been investigated.Based on the knowledge gained so far,present review shortly discussed the role of the major genes especially those are involved in instigating abnormalities in the cellular cycles,cellular proliferation and differentiation.A simple but novel molecular scheme of the colorectal cancer development has also been plotted.展开更多
Quorum sensing is the biochemical communication system within bacterial cells which may instigate their virulence factors,and hence,is imperative for pathogenesis.Such a system optimizes metabolic and behavioral activ...Quorum sensing is the biochemical communication system within bacterial cells which may instigate their virulence factors,and hence,is imperative for pathogenesis.Such a system optimizes metabolic and behavioral activities played by the densely populated bacterial community as well as the production of the concomitant response against diffusible or secreted signals.Thus,the multi-layered signal transduction networks of quorum sensing help bacteria acclimatize to the disadvantages by increasing their confrontation ability aided by biofilm formation.Previous studies unraveled the impact of quorum sensing in the microbial interactions both within a single species and between several species.The development of the synthetic ecological models has added advantages in the studies of microbial sociability in natural habitats as well as aided in drug designing.Current review highlighted the up-to-date knowledge on the basic mechanisms of quorum sensing and its influence to accelerate the bacterial resistance against different environmental stimuli or synthetic drugs along with the factors affecting the quorum sensing system,and the harmful role of quorum sensing in food spoilage.The information gathered in this review would be beneficial to understand the metabolic cross talk as well as the virulence traits of the pathogenic microorganisms in course of their pathogenesis augmented by quorum sensing.展开更多
Study of bacterial stress response against an array of stress signals like heat shock and oxidative stress has been well accomplished so far.Several stress factors cause microorganisms to go under the viable but noncu...Study of bacterial stress response against an array of stress signals like heat shock and oxidative stress has been well accomplished so far.Several stress factors cause microorganisms to go under the viable but nonculturable state.However,the growth resuscitation of bacterial cells from such viable but nonculturable state is still obscure.Current review briefly focused on the growth revival of the viable but nonculturable cells and placed the possible model of growth resuscitation.The significance of such type of study on the viable but nonculturable cells principally relies upon clinical sectors whereby some pathogens are found to be latent for many days and thereby imparting the false negative results as well as in the food industries whereby the viable but nonculturable cells may cause massive damage in the public health upon their resuscitation.展开更多
Along with the running COVID-19 pandemic by the severe acute respiratory syndrome coronavirus 2,the Chikungunya virus is already known as the causative agent of re-emerging Chikungunya fever in many countries after se...Along with the running COVID-19 pandemic by the severe acute respiratory syndrome coronavirus 2,the Chikungunya virus is already known as the causative agent of re-emerging Chikungunya fever in many countries after several years of latency;and it’s certainly one of the most important clinical issues possibly due to the lack of appropriate vaccination.Therefore,continuous study and monitoring of this disease outbreak demand attention by the relevant health professionals.Present review has been written in the light of the recently available reports on the Chikungunya virus infection.The genomic structure and its impact on the viral epidemiology,the possible protective immunity,and the infection mitigation strategies have been discussed.It’s already well known that the Chikungunya virus can start infection after getting entrance into the blood circulation through the mosquito bites followed by the dissemination into the major organs like liver,brain,eye,joints and lymph nodes in order to inaugurate the infectivity.Apparently,the occurrence of death is very rare but the extreme fatality and morbidity may occur if the patient has other underlying disease conditions.The molecular aspects of the virus,the site-specific damages caused by the viral infection,and finally,the public awareness of such viral infection as discussed in the current review would help to maintain the public health sustainability especially in the developing countries whereby the knowledge on the required hygiene is poor.展开更多
文摘The extent and aggression of colorectal cancer is a worldwide public health threat.Extensive research has been conducted on the pre-requisites leading to this fatal cancer.An array of genes along with their mutations and the signal transduction pathways leading to the cellular transformation into the cancerous cells have been investigated.Based on the knowledge gained so far,present review shortly discussed the role of the major genes especially those are involved in instigating abnormalities in the cellular cycles,cellular proliferation and differentiation.A simple but novel molecular scheme of the colorectal cancer development has also been plotted.
文摘Quorum sensing is the biochemical communication system within bacterial cells which may instigate their virulence factors,and hence,is imperative for pathogenesis.Such a system optimizes metabolic and behavioral activities played by the densely populated bacterial community as well as the production of the concomitant response against diffusible or secreted signals.Thus,the multi-layered signal transduction networks of quorum sensing help bacteria acclimatize to the disadvantages by increasing their confrontation ability aided by biofilm formation.Previous studies unraveled the impact of quorum sensing in the microbial interactions both within a single species and between several species.The development of the synthetic ecological models has added advantages in the studies of microbial sociability in natural habitats as well as aided in drug designing.Current review highlighted the up-to-date knowledge on the basic mechanisms of quorum sensing and its influence to accelerate the bacterial resistance against different environmental stimuli or synthetic drugs along with the factors affecting the quorum sensing system,and the harmful role of quorum sensing in food spoilage.The information gathered in this review would be beneficial to understand the metabolic cross talk as well as the virulence traits of the pathogenic microorganisms in course of their pathogenesis augmented by quorum sensing.
文摘Study of bacterial stress response against an array of stress signals like heat shock and oxidative stress has been well accomplished so far.Several stress factors cause microorganisms to go under the viable but nonculturable state.However,the growth resuscitation of bacterial cells from such viable but nonculturable state is still obscure.Current review briefly focused on the growth revival of the viable but nonculturable cells and placed the possible model of growth resuscitation.The significance of such type of study on the viable but nonculturable cells principally relies upon clinical sectors whereby some pathogens are found to be latent for many days and thereby imparting the false negative results as well as in the food industries whereby the viable but nonculturable cells may cause massive damage in the public health upon their resuscitation.
文摘Along with the running COVID-19 pandemic by the severe acute respiratory syndrome coronavirus 2,the Chikungunya virus is already known as the causative agent of re-emerging Chikungunya fever in many countries after several years of latency;and it’s certainly one of the most important clinical issues possibly due to the lack of appropriate vaccination.Therefore,continuous study and monitoring of this disease outbreak demand attention by the relevant health professionals.Present review has been written in the light of the recently available reports on the Chikungunya virus infection.The genomic structure and its impact on the viral epidemiology,the possible protective immunity,and the infection mitigation strategies have been discussed.It’s already well known that the Chikungunya virus can start infection after getting entrance into the blood circulation through the mosquito bites followed by the dissemination into the major organs like liver,brain,eye,joints and lymph nodes in order to inaugurate the infectivity.Apparently,the occurrence of death is very rare but the extreme fatality and morbidity may occur if the patient has other underlying disease conditions.The molecular aspects of the virus,the site-specific damages caused by the viral infection,and finally,the public awareness of such viral infection as discussed in the current review would help to maintain the public health sustainability especially in the developing countries whereby the knowledge on the required hygiene is poor.
