Herein,we report a highly efficient versatile synthetic route to Chiraphos derivatives through Rh/Ph-bod catalyzed asymmetric addition of aryl boronic acids to phosphinyl dienes.Various substituted phosphinyl dienes,b...Herein,we report a highly efficient versatile synthetic route to Chiraphos derivatives through Rh/Ph-bod catalyzed asymmetric addition of aryl boronic acids to phosphinyl dienes.Various substituted phosphinyl dienes,both on the parent skeleton and the phosphine atoms,were well tolerated with this method and provided chiral phosphine oxides in satisfied yield and up to 95%ee.The corresponding Chiraphos derivative displayed an advantage over Chiraphos in the representative Pd-catalyzed asymmetric 1,4-addition reaction.展开更多
基金support from the National Natural Science Foundation of China (Nos. 21901235 and 22071224)the USTC Research Funds of the Double First-Class Initiative (No. YD20600002010)+1 种基金the Anhui Provincial Natural Science-Foundation (No. 1908085MB34)the Science, Technology and Innovation Commission of Shenzhen (No. JCYJ20190807155201669)
文摘Herein,we report a highly efficient versatile synthetic route to Chiraphos derivatives through Rh/Ph-bod catalyzed asymmetric addition of aryl boronic acids to phosphinyl dienes.Various substituted phosphinyl dienes,both on the parent skeleton and the phosphine atoms,were well tolerated with this method and provided chiral phosphine oxides in satisfied yield and up to 95%ee.The corresponding Chiraphos derivative displayed an advantage over Chiraphos in the representative Pd-catalyzed asymmetric 1,4-addition reaction.
