AIM:To determine the risk of second primary malignancy(SPM)and survival of patients with essential thrombocythemia(ET).METHODS:We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance,Epi...AIM:To determine the risk of second primary malignancy(SPM)and survival of patients with essential thrombocythemia(ET).METHODS:We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance,Epidemiology and End Results(SEER)18 database.Actuarial and relative survival methods were used to calculate the survival statistics.We utilized the SEER 13 database to calculate SPM.We used multiple primary standardized incidence ratio(SIR)session of the SEER*Stat software(version 8.1.5)to calculate SIR and excess risk of SPM for ET patients.RESULTS:Age standardized five-year cause-specific survival was greater for patients<50 years vs those≥50 years(99.4%vs 93.5%,P<0.01).Five-year causespecific survival was lower for men vs women(70.2%vs 79.7%).A total of 201 patients(2.46%)developed SPM at a median age of 75 years.SPMs occurred at an observed/expected(O/E)ratio of 1.26(95%CI:1.09-1.45,P=0.002)with an absolute excess risk(AER)of 37.44 per 10000 population.A significantly higher risk was noted for leukemia(O/E 3.78;95%CI:2.20-6.05,P<0.001;AER 11.28/10000).CONCLUSION:ET patients have an excellent causespecific five-year survival but are at an increased risk of SPM,particularly leukemia,which may contribute to excess deaths.展开更多
Toxocariasis is a zoonotic infection caused by Toxocara canis,or less commonly,Toxocara cati,which is one of the most common zoonotic infections worldwide.It commonly affects the pediatric and immunocompromised popula...Toxocariasis is a zoonotic infection caused by Toxocara canis,or less commonly,Toxocara cati,which is one of the most common zoonotic infections worldwide.It commonly affects the pediatric and immunocompromised population;however,it has rarely been reported in the immunocompetent adults.Two of the well-recognized syndromes in children are visceral larva migrans and ocular larva migrans.Infection in adults usually ranges from asymptomatic to nonspecific symptoms which makes the diagnosis challenging.A case of 36 year-old male was presented with disseminated toxocariasis with pulmonary and hepatic involvement and striking peripheral eosinophilia.展开更多
Diarrhea is a common complication of allogeneic hematopoietic stem cell transplant(HSCT),with an average incidence of approximately 40%-50%.A wide variety of etiologies can contribute to diarrhea in HSCT patients,incl...Diarrhea is a common complication of allogeneic hematopoietic stem cell transplant(HSCT),with an average incidence of approximately 40%-50%.A wide variety of etiologies can contribute to diarrhea in HSCT patients,including medication-induced mucosal inflammation,infections,graft-vs-host disease and cord colitis syndrome in umbilical cord blood transplant.Clinical manifestations can vary from isolated diarrheal episodes,to other organ involvement including pneumonia or myocarditis,and rarely multiorgan failure.The approach for diagnosis of diarrheal disorders in HSCT patients depends on the most likely cause.Given the risk of life-threatening conditions,the development of clinically significant diarrhea requires prompt evaluation,supportive care and specific therapy,as indicated.Serious metabolic and nutritional disturbances can happen in HSCT patients,and may even lead to mortality.In this review,we aim to provide a practical approach to diagnosis and management of diarrhea in the post-transplant period.展开更多
基金Supported by The University of Nebraska Medical Center,College of Medicine,Physician-Scientist Training Program Grant 2015-2016(to Bhatt VR).
文摘AIM:To determine the risk of second primary malignancy(SPM)and survival of patients with essential thrombocythemia(ET).METHODS:We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance,Epidemiology and End Results(SEER)18 database.Actuarial and relative survival methods were used to calculate the survival statistics.We utilized the SEER 13 database to calculate SPM.We used multiple primary standardized incidence ratio(SIR)session of the SEER*Stat software(version 8.1.5)to calculate SIR and excess risk of SPM for ET patients.RESULTS:Age standardized five-year cause-specific survival was greater for patients<50 years vs those≥50 years(99.4%vs 93.5%,P<0.01).Five-year causespecific survival was lower for men vs women(70.2%vs 79.7%).A total of 201 patients(2.46%)developed SPM at a median age of 75 years.SPMs occurred at an observed/expected(O/E)ratio of 1.26(95%CI:1.09-1.45,P=0.002)with an absolute excess risk(AER)of 37.44 per 10000 population.A significantly higher risk was noted for leukemia(O/E 3.78;95%CI:2.20-6.05,P<0.001;AER 11.28/10000).CONCLUSION:ET patients have an excellent causespecific five-year survival but are at an increased risk of SPM,particularly leukemia,which may contribute to excess deaths.
文摘Toxocariasis is a zoonotic infection caused by Toxocara canis,or less commonly,Toxocara cati,which is one of the most common zoonotic infections worldwide.It commonly affects the pediatric and immunocompromised population;however,it has rarely been reported in the immunocompetent adults.Two of the well-recognized syndromes in children are visceral larva migrans and ocular larva migrans.Infection in adults usually ranges from asymptomatic to nonspecific symptoms which makes the diagnosis challenging.A case of 36 year-old male was presented with disseminated toxocariasis with pulmonary and hepatic involvement and striking peripheral eosinophilia.
文摘Diarrhea is a common complication of allogeneic hematopoietic stem cell transplant(HSCT),with an average incidence of approximately 40%-50%.A wide variety of etiologies can contribute to diarrhea in HSCT patients,including medication-induced mucosal inflammation,infections,graft-vs-host disease and cord colitis syndrome in umbilical cord blood transplant.Clinical manifestations can vary from isolated diarrheal episodes,to other organ involvement including pneumonia or myocarditis,and rarely multiorgan failure.The approach for diagnosis of diarrheal disorders in HSCT patients depends on the most likely cause.Given the risk of life-threatening conditions,the development of clinically significant diarrhea requires prompt evaluation,supportive care and specific therapy,as indicated.Serious metabolic and nutritional disturbances can happen in HSCT patients,and may even lead to mortality.In this review,we aim to provide a practical approach to diagnosis and management of diarrhea in the post-transplant period.
