BACKGROUND Currently,only tumors classified as LR-5 are considered definitive hepatocellular carcinoma(HCC),and no further pathologic confirmation is required to initiate therapy.Previous studies have shown that the s...BACKGROUND Currently,only tumors classified as LR-5 are considered definitive hepatocellular carcinoma(HCC),and no further pathologic confirmation is required to initiate therapy.Previous studies have shown that the sensitivity of LR-5 is modest,and lesions enhanced by gadoxetic acid(Gd-EOB-DTPA)may exhibit lower sensitivity than those enhanced by Gd-DTPA.AIM To identify malignant ancillary features(AFs)that can independently and significantly predict HCC in Liver Imaging Reporting and Data System version 2018,and to develop modified LR-5 criteria to improve diagnostic performance on Gd-EOB-DTPA-enhanced magnetic resonance imaging.METHODS Imaging data from patients with HCC risk factors who underwent abdominal Gd-EOB-DTPA-enhanced magnetic resonance imaging were collected.Univariate and multivariate logistic regression analyses were performed to determine AFs that could independently and significantly predict HCC.The modified LR-5 criteria involved reclassifying LR-4/LR-3 lesions based on major features combined with independently significant AFs for HCC,or by substituting threshold growth with significant AFs.McNemar's test was used to compare the diagnostic performance of the modified LR-5 criteria.RESULTS A total of 244 lesions from 216 patients were included.Transitional phase hypointensity,mild-moderate T2 hyperintensity,and fat in mass(more than adjacent liver)were identified as significant independent predictors of HCC.Using the modified LR-5 criteria(e.g.,LR-5-M1:LR-4+transitional phase hypointensity;LR-5-M4:LR-5 by transitional phase hypointensity instead of threshold growth;LR-5-M5:LR-5 by mild-moderate T2 hyperintensity instead of threshold growth;LR-5-M8:LR-3/LR-4+any two features of transitional phase hypointensity/mild-moderate T2 hyperintensity/fat in mass),sensitivities were significantly increased(88.5%-89.1%)compared to the standard LR-5(60.6%;all P values<0.05),while specificities(84.8%-89.9%)remained largely unchanged(93.7%;all P values>0.05).The LR-5-M8 criterion achieved the highest sensitivity.CONCLUSION Mild-moderate T2 hyperintensity,transitional phase hypointensity,and fat in mass are independent and significant predictors of HCC malignant AFs.The modified LR-5 criteria can improve sensitivity without significantly reducing specificity.展开更多
This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar ...This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system.展开更多
Vesicles of lipid bilayer can adopt a variety of shapes due to different coating proteins.The ability of proteins to reshape membrane is typically characterized by inducing spontaneous curvature of the membrane at the...Vesicles of lipid bilayer can adopt a variety of shapes due to different coating proteins.The ability of proteins to reshape membrane is typically characterized by inducing spontaneous curvature of the membrane at the coated area.BAR family proteins are known to have a crescent shape and can induce membrane curvature along their concaved body axis but not in the perpendicular direction.We model this type of proteins as a rod-shaped molecule with an orientation and induce normal curvature along its orientation in the tangential plane of the membrane surface.We show how a ring of these proteins reshapes an axisymmetric vesicle when the protein curvature or orientation is varied.A discontinuous shape transformation from a protrusion shape without a neck to a one with a neck is found.Increasing the rigidity of the protein ring is able to smooth out the transition.Furthermore,we show that varying the protein orientation is able to induce an hourglass-shaped neck,which is significantly narrower than the reciprocal of the protein curvature.Our results offer a new angle to rationalize the helical structure formed by many proteins that carry out membrane fission functions.展开更多
new species in the genus Amauromyza Hendel,1931,Amauromyza(Cephalomyza)wuyuanensis Fu&Shi sp.nov.,is described and illustrated.A.(Cephalomyza)karli(Hendel,1927)is newly discovered from China.So far,five species in...new species in the genus Amauromyza Hendel,1931,Amauromyza(Cephalomyza)wuyuanensis Fu&Shi sp.nov.,is described and illustrated.A.(Cephalomyza)karli(Hendel,1927)is newly discovered from China.So far,five species in the genus Amauromyza have been reported from China.A key to these species and a checklist with host plants and distributions are presented.展开更多
Alzheimer’s disease(AD)is a complex neurodegenerative condition.5α-epoxyalantolactone(5α-EAL),a eudesmane-type sesquiterpene isolated from the herb of Inula macrophylla,has various pharmacological effects.This work...Alzheimer’s disease(AD)is a complex neurodegenerative condition.5α-epoxyalantolactone(5α-EAL),a eudesmane-type sesquiterpene isolated from the herb of Inula macrophylla,has various pharmacological effects.This work supposed to investigate the improved impact of 5α-EAL on cognitive impairment.5α-EAL inhibited the generation of nitric oxide(NO)in BV-2 cells stimulated with lipopolysaccharide(LPS)with an EC50 of 6.2μM.5α-EAL significantly reduced the production of prostaglandin E2(PGE2)and tumor necrosis factor-α(TNF-α),while also inhibiting the production of cyclooxygenase-2(COX-2)and inducible nitric oxide synthase(iNOS)proteins.The ability of 5α-EAL to penetrate the blood-brain barrier(BBB)was confirmed via a parallel artificial membrane permeation assay.Scopolamine(SCOP)-induced AD mice model was employed to assess the improved impacts of 5α-EAL on cognitive impairment in vivo.After the mice were pretreated with 5α-EAL(10 and 30 mg/kg per day,i.p.)for 21 days,the behavioral experiments indicated that the administration of the 5α-EAL could alleviate the cognitive and memory impairments.5α-EAL significantly reduced the AChE activity in the brain of SCOP-induced AD mice.In summary,these findings highlight the beneficial effects of the natural product 5α-EAL as a potential bioactive compound for attenuating cognitive deficits in AD due to its pharmacological profile.展开更多
[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-RA).[Methods]To confirm that baicalin alleviated the...[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-RA).[Methods]To confirm that baicalin alleviated the activation of NLRP3 inflammasome in HFLS-RA,the expression of NLRP3 before and after baicalin treatment was observed by immunofluorescence.Western blot was used to detect the protein expression of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1 after baicalin treatment for 48 h,and the contents of IL-1 and IL-18 in the supernatents were detected by ELISA.In order to explore the mechanism of baicalin alleviating the activation of NLRP3 inflammasome,the corresponding relationship between let-7i-3p and PIK3CA was verified by double luciferin and Westen blot analysis.The expression of let-7i-3p and PI3K before and after baicalin intervention was detected by RT-qPCR.let-7i-3p interference was used to verify whether baicalin mitigated the activation of enhanced NLRP3 inflammasome.[Results]Baicalin(50 and 100 mg/L)significantly reduced the activation of NLRP3 inflammasome,inhibited the protein expressions of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1,and the secretion of IL-1 and IL-18.let-7i-3p and PIK3CA had a targeted correspondence,and baicalin up-regulated the expression of let-7i-3p and down-regulated the expression of PIK3CA.Baicalin attenuated the activation of NLRP3 inflammasome enhanced by let-7i-3p interference.[Conclusions]Baicalin can up-regulate let-7i-3p expression,inhibit PI3K/Akt/NF-κB signal transduction,and thus reduce the activation of NLRP3 inflammasome in HFLS-RA.展开更多
As the most important irradiation-induced defects,dislocation loop and copper-rich nanocluster are the major contributors to the embrittlement of the neutron-irradiated reactor pressure vessel steels.In this study,suc...As the most important irradiation-induced defects,dislocation loop and copper-rich nanocluster are the major contributors to the embrittlement of the neutron-irradiated reactor pressure vessel steels.In this study,such nano-defects were introduced into the material by 3 MeV Fe ions up to the dose of 1 dpa at high temperature(290℃)to simulate neutron irradiation.It was found that pulsed electric current can effectively reduce 95%of irradiation-induced hardening.Correspondingly,the characterization results showed that almost all the dislocation loops disappeared and the quantity of copper-rich nanoclusters also reduced greatly at relatively low temperature(450℃),and the process took only 20 min.Mean-while,it was qualitatively proved by positron annihilation spectroscopy that the number of irradiation-induced vacancy-type defects and solute-enriched clusters was significantly decreased after electropuls-ing.Furthermore,under the pulsed electric field,the rapid annihilation of the dislocation loops due to their accelerated collision with vacancies can remove the nucleation sites of the copper-rich nanoclusters and make them become dispersed,further promoting the nanoclusters that lack nucleation sites dissolv-ing faster.Therefore,this electropulsing treatment provides a practical“in-situ”performance repair tech-nology to extend the service life of reactor pressure vessel steels by regulating the interaction between vacancies,interstitial atoms and irradiation-induced defects.展开更多
With the rapid development of information technology,Building Information Modeling(BIM)technology has gradually occupied an important position in the construction industry.With the introduction of BIM technology,the c...With the rapid development of information technology,Building Information Modeling(BIM)technology has gradually occupied an important position in the construction industry.With the introduction of BIM technology,the cost control of construction projects can be greatly improved[1].The use of this technology can not only reduce the project approval time but also improve the quality of the project.In addition,it can also help the construction personnel to solve the project changes,maintenance costs,insurance rates,and other related issues,so that the operation of the project is more efficient and economical.This paper will discuss the role of BIM technology in depth,and explore the advantages and disadvantages of each link through the research of the project,to provide a reference for the promotion of this new project.By constantly adjusting the application strategy,the goal is to meet the current market demand.展开更多
Definite emission colorfrom rare-earth Eu^(2+)cannot be guaranteed in distinct hosts because its spectrum behavior is strongly dependent on surrounding microenvironment.Herein,we propose a strategy of heterostructure ...Definite emission colorfrom rare-earth Eu^(2+)cannot be guaranteed in distinct hosts because its spectrum behavior is strongly dependent on surrounding microenvironment.Herein,we propose a strategy of heterostructure polyhedron BO3-PO4 substitution that can realize customizable and even predictable Eu^(2+)emission.Taking Sr_(3)La(PO_(4))_(3):Eu^(2+)blue phosphor as host,we prepared a series of BO3-PO4 substitution-designed Sr_(3)La(PO_(4))_(3):Eu^(2+)(SLP_(3-x)B_(x):Eu^(2+))phosphors via solid-state reaction.Structural and spectral analyses demonstrate that substitution of PO_(4)with BO_(3)unit drives Eu^(2+)to migrate from original occupied Sr sites to unoccupied six-coordinated La sites,bringing out a brand-new broadband yellow-emitting peak at 530 nm,enabling an efficient spectrum tailoring from initial blue emission at 420 nm to white-light and then yellow.Strikingly,we find that the resultant Eu^(2+)spectrum behavior in as-prepared SLP_(3-x)B_(x):Eu^(2+)and Eu^(2+)-doped other borophosphate phosphors is highly similar(although they have different microenvironments).Such exciting findings indicate that proposed BO3-PO4 substitution-strategy possesses an ability of predicting emission by modulating Eu^(2+)site-selective occupation.Utilizing SLP_(3-x)B_(x):Eu^(2+)(x=0.1 and 0.4)phosphors,we fabricated optical temperature sensor and white LED prototypes,showcasing remarkable temperature sensitivity of S_(r)=1.1%/K and good color rendering index(CRI)of 83.This work may aid the discovery of novel functional materials with specific,desirablephysicochemical properties.展开更多
Reducing the cost of RuO_(2)/TiO_(2)catalysts is still one of the urgent challenges in catalytic HCl oxidation.In the present work,a Ce-doped TiO_(2)supported RuO_(2)catalyst with a low Ru loading was developed,showin...Reducing the cost of RuO_(2)/TiO_(2)catalysts is still one of the urgent challenges in catalytic HCl oxidation.In the present work,a Ce-doped TiO_(2)supported RuO_(2)catalyst with a low Ru loading was developed,showing a high activity in the catalytic oxidation of HCl to Cl_(2).The results on some extensive characterizations of both Ce-doped TiO_(2)carriers and their supported RuO_(2)catalysts show that the doping of Ce into TiO_(2)can effectively change the lattice parameters of TiO_(2)to improve the dispersion of the active RuO_(2)species on the carrier,which facilitates the production of surface Ru species to expose more active sites for boosting the catalytic performance even under some harsh reaction conditions.This work provides some scientific basis and technical support for chlorine recycling.展开更多
Bridged bicyclic cores have been recognized as valuable bioisosteres of benzene ring,which are of great value in medicinal chemistry.However,the development of fluorinated bicyclic skeletons,which encompass two privil...Bridged bicyclic cores have been recognized as valuable bioisosteres of benzene ring,which are of great value in medicinal chemistry.However,the development of fluorinated bicyclic skeletons,which encompass two privileged elements widely acknowledged for fine tuning the working effect of target molecules,are far less common.Herein,we present a general and practical synthesis of gem-difluorobicyclo[2.1.1]hexanes(diF-BCHs)from readily available difluorinated hexa-1,5-dienes through energy transfer photocatalysis.By taking advantage of an efficient Cope rearrangement,the preparation of both constitutional isomers of diF-BCHs is readily achieved under identical conditions.The operational simplicity,mild conditions and wide scope further highlight the potential application of this protocol.Moreover,computational studies indicated a positive effect of fluorine atoms in lowering either the triplet or FMO energies of the hexa-1,5-diene substrates,thus promoting the present photoinduced[2+2]cycloaddition.展开更多
By analyzing the successful case of meteorological support services for the navigation ceremony of Langzhong Airport,the practice experience,existing problems and future improvement directions of aviation meteorologic...By analyzing the successful case of meteorological support services for the navigation ceremony of Langzhong Airport,the practice experience,existing problems and future improvement directions of aviation meteorological support services were analyzed and summarized to provide reference for the airport and its subsequent aviation meteorological support services in the future.展开更多
Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane...Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane,plays a critical role in ensuring proper cell division.In this study,we apply a hydrodynamic model to describe the actin cortex as an active nematic surface,incorporating orientational order arising from actin filament alignment and anisotropic active stress produced by myosin motors.By analyzing the linearized dynamics,we investigate how shape,flow,and stress regulators evolve over time when the surface deviates slightly from a sphere.Our findings reveal that the active alignment of actin filaments,often overlooked in previous studies,is crucial for successful division.Furthermore,we demonstrate that a cortical chiral flow naturally emerges as a consequence of this active alignment.Overall,our results provide a mechanistic explanation for key phenomena observed during cell division,offering new insights into the role of active stress and filament alignment in cortical dynamics.展开更多
Non-chemical CO_(2) microbubbles as a mobility control technology in enhanced oil recovery(EOR)and carbon sequestration are becoming attractive.In this study,the EOR mechanisms of non-chemical CO_(2) microbubble(MB)in...Non-chemical CO_(2) microbubbles as a mobility control technology in enhanced oil recovery(EOR)and carbon sequestration are becoming attractive.In this study,the EOR mechanisms of non-chemical CO_(2) microbubble(MB)in low permeability reservoirs are experimentally investigated by the nuclear magnetic resonance(NMR)technology.This study reveals,for the first time,the EOR mechanisms of MB in a heterogeneous reservoir and its effect on pore structure.First,mobility reduction factors of MB with various gas–liquid ratios were determined,with MB at a gas–liquid ratio of 1 exhibiting the best performance under experimental conditions.Second,the coreflood experiments with NMR scanning were performed to reveal the EOR mechanisms of MB.It was observed that MB achieved an incremental oil recovery of 13.49% and 22.80%in the core sample with a permeability of 9.51×10^(−3) and 2.23×10^(−3)μm^(2),respectively.Benefiting from MB's conformance control,the total oil recovery was increased from 38.34%to 54.57% of original oil in place by MB in parallel core flood experiments.Third,the NMR tests demonstrated that MB significantly reduced residual oil in core samples,especially in small pore areas,which highlights the improvement of sweep efficiency by MB.Lastly,the effect of MB on pore structure was studied.The NMR tests indicated a significant increase in pore space after 1 pore volume of MB flooding.Minerals in the core sample were dissolved,leading to an increase in permeability and porosity of the core sample by 17.01%and 0.31%,respectively.Overall,the results of this study provide valuable insights into the EOR mechanisms of MB at the pore scale and offer implications for EOR and carbon sequestration in low-permeability reservoirs.展开更多
The elastic properties of membranes are typically characterized by a few phenomenological parameters,including bending and Gaussian curvature moduli measuring the membrane rigidity against its deformation and topologi...The elastic properties of membranes are typically characterized by a few phenomenological parameters,including bending and Gaussian curvature moduli measuring the membrane rigidity against its deformation and topological change,as well as spontaneous curvature arising from the asymmetry between the two leaflets in the lipid bilayers.Though tether-based and fluctuationbased experiments are commonly utilized to measure the bending modulus,measuring the Gaussian curvature modulus and the spontaneous curvature of the membrane is considered to be much more difficult.In this paper,we study the buckling process of a circular membrane with nonzero spontaneous curvature under compressive stresses.It is found that when the stress exceeds a critical value,the circular membrane will transform from a spherical cap to a buckled shape,with its buckling degree enhanced with the increase of stress until its base is constricted to almost zero.As the stress-strain relationship of the buckled membrane strongly depends on the Gaussian curvature modulus and the spontaneous curvature,we therefore propose a method to determine the Gaussian curvature modulus and the spontaneous curvature simultaneously by measuring its stress-strain relationship during a buckling process.展开更多
In the Homoneura(Homoneura)beckeri group,a species H.(H.)annulata Liu&Shi sp.nov.is described as new to science.Morphological descriptions and photos of this new species are provided.A list of 29 species of the Ho...In the Homoneura(Homoneura)beckeri group,a species H.(H.)annulata Liu&Shi sp.nov.is described as new to science.Morphological descriptions and photos of this new species are provided.A list of 29 species of the Homoneura(Homoneura)beckeri group in Oriental Region and a key to separate them are provided.展开更多
Parkinson’s disease(PD),a neurodegenerative disease that shows a high incidence in older individuals,is becoming increasingly prevalent.Unfortunately,there is no clinical cure for PD,and novel anti-PD drugs are there...Parkinson’s disease(PD),a neurodegenerative disease that shows a high incidence in older individuals,is becoming increasingly prevalent.Unfortunately,there is no clinical cure for PD,and novel anti-PD drugs are therefore urgently required.However,the selective permeability of the blood–brain barrier(BBB)poses a huge challenge in the development of such drugs.Fortunately,through strategies based on the physiological characteristics of the BBB and other modifications,including enhancement of BBB permeability,nanotechnology can offer a solution to this problem and facilitate drug delivery across the BBB.Although nanomaterials are often used as carriers for PD treatment,their biological activity is ignored.Several studies in recent years have shown that nanomaterials can improve PD symptoms via their own nano-bio effects.In this review,we first summarize the physiological features of the BBB and then discuss the design of appropriate brain-targeted delivery nanoplatforms for PD treatment.Subsequently,we highlight the emerging strategies for crossing the BBB and the development of novel nanomaterials with anti-PD nano-biological effects.Finally,we discuss the current challenges in nanomaterial-based PD treatment and the future trends in this field.Our review emphasizes the clinical value of nanotechnology in PD treatment based on recent patents and could guide researchers working in this area in the future.展开更多
Edge-computing-enabled smart greenhouses are a representative application of the Internet of Things(IoT)technology,which can monitor the environmental information in real-time and employ the information to contribute ...Edge-computing-enabled smart greenhouses are a representative application of the Internet of Things(IoT)technology,which can monitor the environmental information in real-time and employ the information to contribute to intelligent decision-making.In the process,anomaly detection for wireless sensor data plays an important role.However,the traditional anomaly detection algorithms originally designed for anomaly detection in static data do not properly consider the inherent characteristics of the data stream produced by wireless sensors such as infiniteness,correlations,and concept drift,which may pose a considerable challenge to anomaly detection based on data stream and lead to low detection accuracy and efficiency.First,the data stream is usually generated quickly,which means that the data stream is infinite and enormous.Hence,any traditional off-line anomaly detection algorithm that attempts to store the whole dataset or to scan the dataset multiple times for anomaly detection will run out of memory space.Second,there exist correlations among different data streams,and traditional algorithms hardly consider these correlations.Third,the underlying data generation process or distribution may change over time.Thus,traditional anomaly detection algorithms with no model update will lose their effects.Considering these issues,a novel method(called DLSHiForest)based on Locality-Sensitive Hashing and the time window technique is proposed to solve these problems while achieving accurate and efficient detection.Comprehensive experiments are executed using a real-world agricultural greenhouse dataset to demonstrate the feasibility of our approach.Experimental results show that our proposal is practical for addressing the challenges of traditional anomaly detection while ensuring accuracy and efficiency.展开更多
Sports matches are very popular all over the world.The prediction of a sports match is helpful to grasp the team's state in time and adjust the strategy in the process of the match.It's a challenging effort to...Sports matches are very popular all over the world.The prediction of a sports match is helpful to grasp the team's state in time and adjust the strategy in the process of the match.It's a challenging effort to predict a sports match.Therefore,a method is proposed to predict the result of the next match by using teams'historical match data.We combined the Long Short-Term Memory(LSTM)model with the attention mechanism and put forward an ASLSTM model for predicting match results.Furthermore,to ensure the timeliness of the prediction,we add the time sliding window to make the prediction have better timeliness.Taking the football match as an example,we carried out a case study and proposed the feasibility of this method.展开更多
基金This study was approved by the Medical Ethics Committee of Jieshou City People's Hospital,approval No.[2022]21.
文摘BACKGROUND Currently,only tumors classified as LR-5 are considered definitive hepatocellular carcinoma(HCC),and no further pathologic confirmation is required to initiate therapy.Previous studies have shown that the sensitivity of LR-5 is modest,and lesions enhanced by gadoxetic acid(Gd-EOB-DTPA)may exhibit lower sensitivity than those enhanced by Gd-DTPA.AIM To identify malignant ancillary features(AFs)that can independently and significantly predict HCC in Liver Imaging Reporting and Data System version 2018,and to develop modified LR-5 criteria to improve diagnostic performance on Gd-EOB-DTPA-enhanced magnetic resonance imaging.METHODS Imaging data from patients with HCC risk factors who underwent abdominal Gd-EOB-DTPA-enhanced magnetic resonance imaging were collected.Univariate and multivariate logistic regression analyses were performed to determine AFs that could independently and significantly predict HCC.The modified LR-5 criteria involved reclassifying LR-4/LR-3 lesions based on major features combined with independently significant AFs for HCC,or by substituting threshold growth with significant AFs.McNemar's test was used to compare the diagnostic performance of the modified LR-5 criteria.RESULTS A total of 244 lesions from 216 patients were included.Transitional phase hypointensity,mild-moderate T2 hyperintensity,and fat in mass(more than adjacent liver)were identified as significant independent predictors of HCC.Using the modified LR-5 criteria(e.g.,LR-5-M1:LR-4+transitional phase hypointensity;LR-5-M4:LR-5 by transitional phase hypointensity instead of threshold growth;LR-5-M5:LR-5 by mild-moderate T2 hyperintensity instead of threshold growth;LR-5-M8:LR-3/LR-4+any two features of transitional phase hypointensity/mild-moderate T2 hyperintensity/fat in mass),sensitivities were significantly increased(88.5%-89.1%)compared to the standard LR-5(60.6%;all P values<0.05),while specificities(84.8%-89.9%)remained largely unchanged(93.7%;all P values>0.05).The LR-5-M8 criterion achieved the highest sensitivity.CONCLUSION Mild-moderate T2 hyperintensity,transitional phase hypointensity,and fat in mass are independent and significant predictors of HCC malignant AFs.The modified LR-5 criteria can improve sensitivity without significantly reducing specificity.
基金supported in part by the National Nat-ural Science Foundation of China(No.51977012,No.52307080).
文摘This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system.
基金support from the the National Natural Science Foundation of China(Grant Nos.12474199(RM)and 12374213(YC))Fundamental Research Funds for Central Universities of China(Grant No.20720240144(RM))111 Project(Grant No.B16029).
文摘Vesicles of lipid bilayer can adopt a variety of shapes due to different coating proteins.The ability of proteins to reshape membrane is typically characterized by inducing spontaneous curvature of the membrane at the coated area.BAR family proteins are known to have a crescent shape and can induce membrane curvature along their concaved body axis but not in the perpendicular direction.We model this type of proteins as a rod-shaped molecule with an orientation and induce normal curvature along its orientation in the tangential plane of the membrane surface.We show how a ring of these proteins reshapes an axisymmetric vesicle when the protein curvature or orientation is varied.A discontinuous shape transformation from a protrusion shape without a neck to a one with a neck is found.Increasing the rigidity of the protein ring is able to smooth out the transition.Furthermore,we show that varying the protein orientation is able to induce an hourglass-shaped neck,which is significantly narrower than the reciprocal of the protein curvature.Our results offer a new angle to rationalize the helical structure formed by many proteins that carry out membrane fission functions.
基金supported by the National Natural Science Foundation of China(32160128).
文摘new species in the genus Amauromyza Hendel,1931,Amauromyza(Cephalomyza)wuyuanensis Fu&Shi sp.nov.,is described and illustrated.A.(Cephalomyza)karli(Hendel,1927)is newly discovered from China.So far,five species in the genus Amauromyza have been reported from China.A key to these species and a checklist with host plants and distributions are presented.
基金supported by the National Key Research and Development Program of China(No.2021YFE0103700)the National Natural Science Foundation of China(U21A20407,22274163,and 22374160)Shaanxi Fundamental Science Research Project for Chemistry and Biology(No.23JHQ054).
文摘Alzheimer’s disease(AD)is a complex neurodegenerative condition.5α-epoxyalantolactone(5α-EAL),a eudesmane-type sesquiterpene isolated from the herb of Inula macrophylla,has various pharmacological effects.This work supposed to investigate the improved impact of 5α-EAL on cognitive impairment.5α-EAL inhibited the generation of nitric oxide(NO)in BV-2 cells stimulated with lipopolysaccharide(LPS)with an EC50 of 6.2μM.5α-EAL significantly reduced the production of prostaglandin E2(PGE2)and tumor necrosis factor-α(TNF-α),while also inhibiting the production of cyclooxygenase-2(COX-2)and inducible nitric oxide synthase(iNOS)proteins.The ability of 5α-EAL to penetrate the blood-brain barrier(BBB)was confirmed via a parallel artificial membrane permeation assay.Scopolamine(SCOP)-induced AD mice model was employed to assess the improved impacts of 5α-EAL on cognitive impairment in vivo.After the mice were pretreated with 5α-EAL(10 and 30 mg/kg per day,i.p.)for 21 days,the behavioral experiments indicated that the administration of the 5α-EAL could alleviate the cognitive and memory impairments.5α-EAL significantly reduced the AChE activity in the brain of SCOP-induced AD mice.In summary,these findings highlight the beneficial effects of the natural product 5α-EAL as a potential bioactive compound for attenuating cognitive deficits in AD due to its pharmacological profile.
基金Supported by the National Natural Science Foundation of China(82360802):the Natural Science Foundation of Ningxia Province,China(2022AAC 03152).
文摘[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-RA).[Methods]To confirm that baicalin alleviated the activation of NLRP3 inflammasome in HFLS-RA,the expression of NLRP3 before and after baicalin treatment was observed by immunofluorescence.Western blot was used to detect the protein expression of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1 after baicalin treatment for 48 h,and the contents of IL-1 and IL-18 in the supernatents were detected by ELISA.In order to explore the mechanism of baicalin alleviating the activation of NLRP3 inflammasome,the corresponding relationship between let-7i-3p and PIK3CA was verified by double luciferin and Westen blot analysis.The expression of let-7i-3p and PI3K before and after baicalin intervention was detected by RT-qPCR.let-7i-3p interference was used to verify whether baicalin mitigated the activation of enhanced NLRP3 inflammasome.[Results]Baicalin(50 and 100 mg/L)significantly reduced the activation of NLRP3 inflammasome,inhibited the protein expressions of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1,and the secretion of IL-1 and IL-18.let-7i-3p and PIK3CA had a targeted correspondence,and baicalin up-regulated the expression of let-7i-3p and down-regulated the expression of PIK3CA.Baicalin attenuated the activation of NLRP3 inflammasome enhanced by let-7i-3p interference.[Conclusions]Baicalin can up-regulate let-7i-3p expression,inhibit PI3K/Akt/NF-κB signal transduction,and thus reduce the activation of NLRP3 inflammasome in HFLS-RA.
基金supported by the National Natural Science Foundation of China(No.U21B2082)the Beijing Municipal Natural Science Foundation(No.2222065)the Fundamental Research Funds for the Central Universities(No.FRF-TP-22-02C2).
文摘As the most important irradiation-induced defects,dislocation loop and copper-rich nanocluster are the major contributors to the embrittlement of the neutron-irradiated reactor pressure vessel steels.In this study,such nano-defects were introduced into the material by 3 MeV Fe ions up to the dose of 1 dpa at high temperature(290℃)to simulate neutron irradiation.It was found that pulsed electric current can effectively reduce 95%of irradiation-induced hardening.Correspondingly,the characterization results showed that almost all the dislocation loops disappeared and the quantity of copper-rich nanoclusters also reduced greatly at relatively low temperature(450℃),and the process took only 20 min.Mean-while,it was qualitatively proved by positron annihilation spectroscopy that the number of irradiation-induced vacancy-type defects and solute-enriched clusters was significantly decreased after electropuls-ing.Furthermore,under the pulsed electric field,the rapid annihilation of the dislocation loops due to their accelerated collision with vacancies can remove the nucleation sites of the copper-rich nanoclusters and make them become dispersed,further promoting the nanoclusters that lack nucleation sites dissolv-ing faster.Therefore,this electropulsing treatment provides a practical“in-situ”performance repair tech-nology to extend the service life of reactor pressure vessel steels by regulating the interaction between vacancies,interstitial atoms and irradiation-induced defects.
文摘With the rapid development of information technology,Building Information Modeling(BIM)technology has gradually occupied an important position in the construction industry.With the introduction of BIM technology,the cost control of construction projects can be greatly improved[1].The use of this technology can not only reduce the project approval time but also improve the quality of the project.In addition,it can also help the construction personnel to solve the project changes,maintenance costs,insurance rates,and other related issues,so that the operation of the project is more efficient and economical.This paper will discuss the role of BIM technology in depth,and explore the advantages and disadvantages of each link through the research of the project,to provide a reference for the promotion of this new project.By constantly adjusting the application strategy,the goal is to meet the current market demand.
基金the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2021D01E19,2022TSYCXC0016)the Project of youth science and technology innovation talent project of Xinjiang Normal University(XJNUQB2022-15)+1 种基金the National Natural Science Foundations of China(52262029,51762040)Postgraduate Research and the Research Fund of Xinjiang Normal University Research Platform Student Project(XSY202201013).
文摘Definite emission colorfrom rare-earth Eu^(2+)cannot be guaranteed in distinct hosts because its spectrum behavior is strongly dependent on surrounding microenvironment.Herein,we propose a strategy of heterostructure polyhedron BO3-PO4 substitution that can realize customizable and even predictable Eu^(2+)emission.Taking Sr_(3)La(PO_(4))_(3):Eu^(2+)blue phosphor as host,we prepared a series of BO3-PO4 substitution-designed Sr_(3)La(PO_(4))_(3):Eu^(2+)(SLP_(3-x)B_(x):Eu^(2+))phosphors via solid-state reaction.Structural and spectral analyses demonstrate that substitution of PO_(4)with BO_(3)unit drives Eu^(2+)to migrate from original occupied Sr sites to unoccupied six-coordinated La sites,bringing out a brand-new broadband yellow-emitting peak at 530 nm,enabling an efficient spectrum tailoring from initial blue emission at 420 nm to white-light and then yellow.Strikingly,we find that the resultant Eu^(2+)spectrum behavior in as-prepared SLP_(3-x)B_(x):Eu^(2+)and Eu^(2+)-doped other borophosphate phosphors is highly similar(although they have different microenvironments).Such exciting findings indicate that proposed BO3-PO4 substitution-strategy possesses an ability of predicting emission by modulating Eu^(2+)site-selective occupation.Utilizing SLP_(3-x)B_(x):Eu^(2+)(x=0.1 and 0.4)phosphors,we fabricated optical temperature sensor and white LED prototypes,showcasing remarkable temperature sensitivity of S_(r)=1.1%/K and good color rendering index(CRI)of 83.This work may aid the discovery of novel functional materials with specific,desirablephysicochemical properties.
基金supported by Zhejiang Provincial Key R&D Project(No.2021C01056)the Programme of Introducing Talents of Discipline to Universities(No.D17008).
文摘Reducing the cost of RuO_(2)/TiO_(2)catalysts is still one of the urgent challenges in catalytic HCl oxidation.In the present work,a Ce-doped TiO_(2)supported RuO_(2)catalyst with a low Ru loading was developed,showing a high activity in the catalytic oxidation of HCl to Cl_(2).The results on some extensive characterizations of both Ce-doped TiO_(2)carriers and their supported RuO_(2)catalysts show that the doping of Ce into TiO_(2)can effectively change the lattice parameters of TiO_(2)to improve the dispersion of the active RuO_(2)species on the carrier,which facilitates the production of surface Ru species to expose more active sites for boosting the catalytic performance even under some harsh reaction conditions.This work provides some scientific basis and technical support for chlorine recycling.
基金the National Natural Science Foundation of China(No.22271151)the Distinguished Youth Foundation of Jiangsu Province.
文摘Bridged bicyclic cores have been recognized as valuable bioisosteres of benzene ring,which are of great value in medicinal chemistry.However,the development of fluorinated bicyclic skeletons,which encompass two privileged elements widely acknowledged for fine tuning the working effect of target molecules,are far less common.Herein,we present a general and practical synthesis of gem-difluorobicyclo[2.1.1]hexanes(diF-BCHs)from readily available difluorinated hexa-1,5-dienes through energy transfer photocatalysis.By taking advantage of an efficient Cope rearrangement,the preparation of both constitutional isomers of diF-BCHs is readily achieved under identical conditions.The operational simplicity,mild conditions and wide scope further highlight the potential application of this protocol.Moreover,computational studies indicated a positive effect of fluorine atoms in lowering either the triplet or FMO energies of the hexa-1,5-diene substrates,thus promoting the present photoinduced[2+2]cycloaddition.
文摘By analyzing the successful case of meteorological support services for the navigation ceremony of Langzhong Airport,the practice experience,existing problems and future improvement directions of aviation meteorological support services were analyzed and summarized to provide reference for the airport and its subsequent aviation meteorological support services in the future.
基金support from the National Nat-ural Science Foundation of China(Grant No.12474199)the Fundamental Research Funds for Central Universities of China(Grant No.20720240144),and 111 Project(B16029).
文摘Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane,plays a critical role in ensuring proper cell division.In this study,we apply a hydrodynamic model to describe the actin cortex as an active nematic surface,incorporating orientational order arising from actin filament alignment and anisotropic active stress produced by myosin motors.By analyzing the linearized dynamics,we investigate how shape,flow,and stress regulators evolve over time when the surface deviates slightly from a sphere.Our findings reveal that the active alignment of actin filaments,often overlooked in previous studies,is crucial for successful division.Furthermore,we demonstrate that a cortical chiral flow naturally emerges as a consequence of this active alignment.Overall,our results provide a mechanistic explanation for key phenomena observed during cell division,offering new insights into the role of active stress and filament alignment in cortical dynamics.
基金supported by the National Natural Science Foundation of China(52074317)the PetroChina Group Major Special Project(2021ZZ01-03)the National Key Research and Development Program(2023YFF0614100).
文摘Non-chemical CO_(2) microbubbles as a mobility control technology in enhanced oil recovery(EOR)and carbon sequestration are becoming attractive.In this study,the EOR mechanisms of non-chemical CO_(2) microbubble(MB)in low permeability reservoirs are experimentally investigated by the nuclear magnetic resonance(NMR)technology.This study reveals,for the first time,the EOR mechanisms of MB in a heterogeneous reservoir and its effect on pore structure.First,mobility reduction factors of MB with various gas–liquid ratios were determined,with MB at a gas–liquid ratio of 1 exhibiting the best performance under experimental conditions.Second,the coreflood experiments with NMR scanning were performed to reveal the EOR mechanisms of MB.It was observed that MB achieved an incremental oil recovery of 13.49% and 22.80%in the core sample with a permeability of 9.51×10^(−3) and 2.23×10^(−3)μm^(2),respectively.Benefiting from MB's conformance control,the total oil recovery was increased from 38.34%to 54.57% of original oil in place by MB in parallel core flood experiments.Third,the NMR tests demonstrated that MB significantly reduced residual oil in core samples,especially in small pore areas,which highlights the improvement of sweep efficiency by MB.Lastly,the effect of MB on pore structure was studied.The NMR tests indicated a significant increase in pore space after 1 pore volume of MB flooding.Minerals in the core sample were dissolved,leading to an increase in permeability and porosity of the core sample by 17.01%and 0.31%,respectively.Overall,the results of this study provide valuable insights into the EOR mechanisms of MB at the pore scale and offer implications for EOR and carbon sequestration in low-permeability reservoirs.
基金the financial support from the National Natural Science Foundation of China under Grant Nos.12174323 and 12474199Fundamental Research Funds for Central Universities of China under Grant No.20720240144(RM)111 project B16029。
文摘The elastic properties of membranes are typically characterized by a few phenomenological parameters,including bending and Gaussian curvature moduli measuring the membrane rigidity against its deformation and topological change,as well as spontaneous curvature arising from the asymmetry between the two leaflets in the lipid bilayers.Though tether-based and fluctuationbased experiments are commonly utilized to measure the bending modulus,measuring the Gaussian curvature modulus and the spontaneous curvature of the membrane is considered to be much more difficult.In this paper,we study the buckling process of a circular membrane with nonzero spontaneous curvature under compressive stresses.It is found that when the stress exceeds a critical value,the circular membrane will transform from a spherical cap to a buckled shape,with its buckling degree enhanced with the increase of stress until its base is constricted to almost zero.As the stress-strain relationship of the buckled membrane strongly depends on the Gaussian curvature modulus and the spontaneous curvature,we therefore propose a method to determine the Gaussian curvature modulus and the spontaneous curvature simultaneously by measuring its stress-strain relationship during a buckling process.
基金funded by the National Natural Science Foundation of China(32160128).
文摘In the Homoneura(Homoneura)beckeri group,a species H.(H.)annulata Liu&Shi sp.nov.is described as new to science.Morphological descriptions and photos of this new species are provided.A list of 29 species of the Homoneura(Homoneura)beckeri group in Oriental Region and a key to separate them are provided.
基金This work was financially supported through grants from the Guangdong Basic and Applied Basic Research Foundation(2019B1515120043)National Natural Science Foundation of China(File No.82104354)+2 种基金the Science and Technology Development Fund,Macao SAR(File No.0016/2021/A)and the Open Project of Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine(zdsys-202101)Open access funding provided by Shanghai Jiao Tong University
文摘Parkinson’s disease(PD),a neurodegenerative disease that shows a high incidence in older individuals,is becoming increasingly prevalent.Unfortunately,there is no clinical cure for PD,and novel anti-PD drugs are therefore urgently required.However,the selective permeability of the blood–brain barrier(BBB)poses a huge challenge in the development of such drugs.Fortunately,through strategies based on the physiological characteristics of the BBB and other modifications,including enhancement of BBB permeability,nanotechnology can offer a solution to this problem and facilitate drug delivery across the BBB.Although nanomaterials are often used as carriers for PD treatment,their biological activity is ignored.Several studies in recent years have shown that nanomaterials can improve PD symptoms via their own nano-bio effects.In this review,we first summarize the physiological features of the BBB and then discuss the design of appropriate brain-targeted delivery nanoplatforms for PD treatment.Subsequently,we highlight the emerging strategies for crossing the BBB and the development of novel nanomaterials with anti-PD nano-biological effects.Finally,we discuss the current challenges in nanomaterial-based PD treatment and the future trends in this field.Our review emphasizes the clinical value of nanotechnology in PD treatment based on recent patents and could guide researchers working in this area in the future.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant No.30919011282.
文摘Edge-computing-enabled smart greenhouses are a representative application of the Internet of Things(IoT)technology,which can monitor the environmental information in real-time and employ the information to contribute to intelligent decision-making.In the process,anomaly detection for wireless sensor data plays an important role.However,the traditional anomaly detection algorithms originally designed for anomaly detection in static data do not properly consider the inherent characteristics of the data stream produced by wireless sensors such as infiniteness,correlations,and concept drift,which may pose a considerable challenge to anomaly detection based on data stream and lead to low detection accuracy and efficiency.First,the data stream is usually generated quickly,which means that the data stream is infinite and enormous.Hence,any traditional off-line anomaly detection algorithm that attempts to store the whole dataset or to scan the dataset multiple times for anomaly detection will run out of memory space.Second,there exist correlations among different data streams,and traditional algorithms hardly consider these correlations.Third,the underlying data generation process or distribution may change over time.Thus,traditional anomaly detection algorithms with no model update will lose their effects.Considering these issues,a novel method(called DLSHiForest)based on Locality-Sensitive Hashing and the time window technique is proposed to solve these problems while achieving accurate and efficient detection.Comprehensive experiments are executed using a real-world agricultural greenhouse dataset to demonstrate the feasibility of our approach.Experimental results show that our proposal is practical for addressing the challenges of traditional anomaly detection while ensuring accuracy and efficiency.
文摘Sports matches are very popular all over the world.The prediction of a sports match is helpful to grasp the team's state in time and adjust the strategy in the process of the match.It's a challenging effort to predict a sports match.Therefore,a method is proposed to predict the result of the next match by using teams'historical match data.We combined the Long Short-Term Memory(LSTM)model with the attention mechanism and put forward an ASLSTM model for predicting match results.Furthermore,to ensure the timeliness of the prediction,we add the time sliding window to make the prediction have better timeliness.Taking the football match as an example,we carried out a case study and proposed the feasibility of this method.
