<abstract>Aim: The testicular inhibitory effect of the aqueous fraction of methanol extract of Stephania hernandifolia leaf was studied in male Wistar rats. Methods: The supernatent and the precipitate part of a...<abstract>Aim: The testicular inhibitory effect of the aqueous fraction of methanol extract of Stephania hernandifolia leaf was studied in male Wistar rats. Methods: The supernatent and the precipitate part of aqueous fractions of the methanol extract of the leaf were gavaged separately to rat at a similar dose of 200 mg/mL per 100 g body weight per day for 28 days. After cessation of treatment, various observations were conducted. Results: In both treated groups, there were significant decreases in the relative weights of the sex organs, the testicular key androgenic enzymes activities, the plasma level of testosterone, the number of different germ cells at stage VII of seminiferous epithelial cell cycle and the seminiferous tubular diameter in comparison to the controls. Neither of the parts had somatic, renal and hepatic toxicity. This study suggested that the active molecules present in the aqueous fraction of methanol extract of Stephania hemandifolia leaves might be steroids as indicated by thin layer chromatography using specific staining substance for steroid molecules. Conclusion: In rats, the aqueous fraction of methanol extract of the 5. hemandifolia leaves possesses certain testis-inhibitory substances, which may be steroid-like agents.展开更多
series of data samples was collected with the Belle Ⅱ detector at the SuperKEKB collider from March 2019 to June 2022.We determine the integrated luminosities of these data samples using three distinct methodologies ...series of data samples was collected with the Belle Ⅱ detector at the SuperKEKB collider from March 2019 to June 2022.We determine the integrated luminosities of these data samples using three distinct methodologies involving Bhabha(e^(+)e^(-)→e^(+)e^(-)(ny),digamma(e^(+)e^(-)→γγ(nγ),and dimuon(e^(+)e^(-)→μ^(+)μ^(-)(nγ)events.The total integrated luminosity obtained with Bhabha,digamma,and dimuon events is(426.88±0.03±2.61)fb^(-1),(429.28±0.03±2.62)fb^(-1),and(423.99±0.04±3.83)fb^(-1),where the first uncertainties are statistical and the second are systematic.The resulting total integrated luminosity obtained from the combination of the three methods is(427.87±2.01)fb^(-1).展开更多
文摘<abstract>Aim: The testicular inhibitory effect of the aqueous fraction of methanol extract of Stephania hernandifolia leaf was studied in male Wistar rats. Methods: The supernatent and the precipitate part of aqueous fractions of the methanol extract of the leaf were gavaged separately to rat at a similar dose of 200 mg/mL per 100 g body weight per day for 28 days. After cessation of treatment, various observations were conducted. Results: In both treated groups, there were significant decreases in the relative weights of the sex organs, the testicular key androgenic enzymes activities, the plasma level of testosterone, the number of different germ cells at stage VII of seminiferous epithelial cell cycle and the seminiferous tubular diameter in comparison to the controls. Neither of the parts had somatic, renal and hepatic toxicity. This study suggested that the active molecules present in the aqueous fraction of methanol extract of Stephania hemandifolia leaves might be steroids as indicated by thin layer chromatography using specific staining substance for steroid molecules. Conclusion: In rats, the aqueous fraction of methanol extract of the 5. hemandifolia leaves possesses certain testis-inhibitory substances, which may be steroid-like agents.
基金supported by Higher Education and Science Committee of the Republic of Armenia(23LCG-1C011)Australian Research Council and Research(DP200101792,DP210101900,DP210102831,DE220100462,LE210100098,LE230100085)+41 种基金Austrian Federal Ministry of Education,Science and Research,Austrian Science Fund(P 34529,J 4731,J 4625,M 3153)Horizon 2020 ERC Starting(947006)“InterLeptons”Natural Sciences and Engineering Research Council of Canada,Compute Canada and CANARIENational Key R&D Program of China(2022YFA1601903)National Natural Science Foundation of China(11575017,11761141009,11705209,11975076,12135005,12150004,12161141008,12175041)Natural Science Foundation Project of Shandong Province,China(ZR2022JQ02)the Czech Science Foundation(22-18469S)and Charles University Grant Agency(246122)European Research Council,Seventh Framework(PIEF-GA-2013-622527)Horizon 2020 ERC-Advanced(Grant Nos.267104 and 884719)Horizon 2020 ERC-Consolidator(819127)Horizon 2020 Marie Sklodowska-Curie Grant Agreement(700525)“NIOBE”and(101026516)Horizon 2020 Marie Sklodowska-Curie RISE project JENNIFER2 Grant Agreement(822070)(European grants)L'Institut National de Physique Nucléaire et de Physique des Particules(IN2P3)du CNRS and L'Agence Nationale de la Recherche(ANR)(ANR-21-CE31-0009)(France)BMBF,DFG,HGF,MPG,and AvH Foundation(Germany)Department of Atomic Energy under Project Identification(RTI 4002)Department of Science and Technology,and UPES SEED funding programs(UPES/R&D-SEED-INFRA/17052023/01,UPES/R&D-SOE/20062022/06)(India)Israel Science Foundation(2476/17)U.S.-Israel Binational Science Foundation(2016113)Israel Ministry of Science(3-16543)Istituto Nazionale di Fisica Nucleare and the Research Grants BELLE2Japan Society for the Promotion of Science,Grant-in-Aid for Scientific Research(16H03968,16H03993,16H06492,16K05323,17H01133,17H05405,18K03621,18H03710,18H05226,19H00682,20H05850,20H05858,22H00144,22K14056,22K21347,23H05433,26220706,26400255)the Ministry of Education,Culture,Sports,Science,and Technology(MEXT)of JapanNational Research Foundation(NRF)of Korea(2016R1D1A1B02012900,2018R1A2B3003643,2018R1A6A1A06024970,2019R1I1A3A01058933,2021R1A6A1A03043957,2021R1F1A1060423,2021R1F1A1064008,2022R1A2C1003993,RS-2022-00197659)Radiation Science Research Institute,Foreign Large-Size Research Facility Application Supporting project,the Global Science Experimental Data Hub Center of the Korea Institute of Science and Technology Information and KREONET/GLORIADUniversiti Malaya RU grant,Akademi Sains Malaysia,and Ministry of Education MalaysiaFrontiers of Science Program(FOINS-296,CB-221329,CB-236394,CB-254409,CB-180023)SEP-CINVESTAV Research(237)(Mexico)the Polish Ministry of Science and Higher Education and the National Science Centerthe Ministry of Science and Higher Education of the Russian Federation and the HSE University Basic Research Program,MoscowUniversity of Tabuk Research(S-0256-1438,S-0280-1439)(Saudi Arabia)Slovenian Research Agency and Research(J1-9124,P1-0135)Agencia Estatal de Investigacion,Spain(RYC2020-029875-I)Generalitat Valenciana,Spain(CIDEGENT/2018/020)The Knut and Alice Wallenberg Foundation(Sweden),(2021.0174,2021.0299)National Science and Technology Council,and Ministry of EducationThailand Center of Excellence in PhysicsTUBITAK ULAKBIM(Turkey)National Research Foundation of Ukraine,(2020.02/0257)Ministry of Education and Science of Ukrainethe U.S.National Science Foundation and Research(PHY-1913789,PHY-2111604)the U.S.Department of Energy and Research Awards(DE-AC06-76RLO1830,DE-SC0007983,DESC0009824,DE-SC0009973,DE-SC0010007,DE-SC0010073,DE-SC0010118,DE-SC0010504,DE-SC0011784,DE-SC0012704,DE-SC0019230,DESC0021274,DE-SC0021616,DE-SC0022350,DE-SC0023470)the Vietnam Academy of Science and Technology(VAST)(NVCC.05.12/22-23,DL0000.02/24-25)。
文摘series of data samples was collected with the Belle Ⅱ detector at the SuperKEKB collider from March 2019 to June 2022.We determine the integrated luminosities of these data samples using three distinct methodologies involving Bhabha(e^(+)e^(-)→e^(+)e^(-)(ny),digamma(e^(+)e^(-)→γγ(nγ),and dimuon(e^(+)e^(-)→μ^(+)μ^(-)(nγ)events.The total integrated luminosity obtained with Bhabha,digamma,and dimuon events is(426.88±0.03±2.61)fb^(-1),(429.28±0.03±2.62)fb^(-1),and(423.99±0.04±3.83)fb^(-1),where the first uncertainties are statistical and the second are systematic.The resulting total integrated luminosity obtained from the combination of the three methods is(427.87±2.01)fb^(-1).
