Chitosan based nanocomposite scaffolds have attracted wider applications in medicine,in the area of drug delivery,tissue engineering and wound healing.Chitosan matrix incorporated with nanometallic components has imme...Chitosan based nanocomposite scaffolds have attracted wider applications in medicine,in the area of drug delivery,tissue engineering and wound healing.Chitosan matrix incorporated with nanometallic components has immense potential in the area of wound dressings due to its antimicrobial properties.This review focuses on the different combinations of Chitosan metal nanocomposites such as Chitosan/nAg,Chitosan/nAu,Chitosan/nCu,Chitosan/nZnO and Chitosan/nTiO2 towards enhancement of healing or infection control with special reference to the antimicrobial mechanism of action and toxicity.展开更多
Hydrogels are a class of materials that has the property of injectability and in situ gel formation.This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of al...Hydrogels are a class of materials that has the property of injectability and in situ gel formation.This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin network.Alginate nanobeads developed by calcium cross-linking yielded a size of 200e500 nm.The alginate nanobeads fibrin hydrogel was formed using dual syringe apparatus.Characterization of the in situ injectable hydrogel was done by SEM,FTIR and Rheometer.The developed hydrogel showed mechanical strength of 19 kPa which provides the suitable compliance for soft tissue engineering.Cytocompatibility studies using human umbilical cord blood derived mesenchymal stem cells showed good attachment,proliferation and infiltration within the hydrogel similar to fibrin gel.The developed in situ forming hydrogel could be a suitable delivery carrier of stem cells for soft tissue regeneration.展开更多
基金Authors are grateful to the Department of Biotechnology(DBT),India,for providing funding(BT/PR6758/NNT/28/620/2012 dated 23-08-2013)Annapoorna Mohandas acknowledges the University Grants Commission(UGC,India)for Five year Fellowship(EU-IV dtd 31/07/2010 SRNo.2120930570)One of the author S.Deepthi is thankful to the Council of Scientific and Industrial Research for supporting financially under the CSIR-SRF award no:9/963(0034)2K13-EMR-I.
文摘Chitosan based nanocomposite scaffolds have attracted wider applications in medicine,in the area of drug delivery,tissue engineering and wound healing.Chitosan matrix incorporated with nanometallic components has immense potential in the area of wound dressings due to its antimicrobial properties.This review focuses on the different combinations of Chitosan metal nanocomposites such as Chitosan/nAg,Chitosan/nAu,Chitosan/nCu,Chitosan/nZnO and Chitosan/nTiO2 towards enhancement of healing or infection control with special reference to the antimicrobial mechanism of action and toxicity.
基金One of the authors R.Jayakumar is grateful to the Department of Biotechnology(DBT),India,for providing fund under the scheme of Nanoscience and Nanotechnology Program(Ref.No.BT/PR 13585/NNT/28/474/2010)One of the author S.Deepthi is thankful to the Council of Scientific and Industrial Research for supporting financially under the CSIR-SRF award no:9/963(0034)2K13-EMR-I.
文摘Hydrogels are a class of materials that has the property of injectability and in situ gel formation.This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin network.Alginate nanobeads developed by calcium cross-linking yielded a size of 200e500 nm.The alginate nanobeads fibrin hydrogel was formed using dual syringe apparatus.Characterization of the in situ injectable hydrogel was done by SEM,FTIR and Rheometer.The developed hydrogel showed mechanical strength of 19 kPa which provides the suitable compliance for soft tissue engineering.Cytocompatibility studies using human umbilical cord blood derived mesenchymal stem cells showed good attachment,proliferation and infiltration within the hydrogel similar to fibrin gel.The developed in situ forming hydrogel could be a suitable delivery carrier of stem cells for soft tissue regeneration.
