Implantation is an essential issue in orthopedic surgery.Bulk metallic glasses(BMGs),as a kind of novel materials,attract lots of attentions in biological field owing to their comprehensive excellent properties.Here,w...Implantation is an essential issue in orthopedic surgery.Bulk metallic glasses(BMGs),as a kind of novel materials,attract lots of attentions in biological field owing to their comprehensive excellent properties.Here,we show that a Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%)BMG(Zr-based BMG)displays the best cytocompatibility,pronounced positive effects on cellular migration,and tube formation from in-vitro tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone.The in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation.Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based BMG.Accordingly,the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based BMG.Dynamic gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery,simultaneously,without abnormal ionic accumulation and inflammatory reactions.Considering suitable mechanical properties,we provide a realistic candidate of the Zr61Ti2Cu25Al12 BMG for biomedical applications.展开更多
基金The financial supports from the NSFC[Nos.51801027,51925103,51827801,81972121]the 111 project[No.D16002]are all appreciated.
文摘Implantation is an essential issue in orthopedic surgery.Bulk metallic glasses(BMGs),as a kind of novel materials,attract lots of attentions in biological field owing to their comprehensive excellent properties.Here,we show that a Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%)BMG(Zr-based BMG)displays the best cytocompatibility,pronounced positive effects on cellular migration,and tube formation from in-vitro tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone.The in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation.Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based BMG.Accordingly,the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based BMG.Dynamic gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery,simultaneously,without abnormal ionic accumulation and inflammatory reactions.Considering suitable mechanical properties,we provide a realistic candidate of the Zr61Ti2Cu25Al12 BMG for biomedical applications.
