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Cytokines IL-6,IL-10,and CCL5 Secreted by Infiltrating B Cells Promote Cell Migration of Human Prostate Cancer Cell Lines
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作者 Crystal J.Byrd Monasia Evans +2 位作者 Woojung Kim quintera knight Geou-Yarh Liou 《Oncology Research》 2026年第4期413-425,共13页
Objective:The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment.Within this microenvironment,infiltrating immune cells,such as B cells,can be either anti-tumorigenic or pr... Objective:The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment.Within this microenvironment,infiltrating immune cells,such as B cells,can be either anti-tumorigenic or pro-tumorigenic.Our preliminary data showed that a higher density of the infiltrating B cells was found near prostate cancer cells in human cancer tissues,as compared to the benign prostate tissue regions,thus suggesting that infiltrating B cells would promote the progression of prostate cancer cells.In this study,we aim to investigate the role of infiltrating B cells in enhancing the migratory ability of human prostate cancer cells.Methods:We utilized Transwell©R assays to evaluate the migratory ability of human prostate cancer cells in the presence or absence of B cells,B cell-secreted cytokines,and neutralizing antibodies of B cell-secreted cytokines.We also used Western blot and immunofluorescence staining to evaluate the effects of epithelial-mesenchymal transition on the human prostate cancer cells in response to the B cell cytokines.Results:Our findings showed an increase in migration of human prostate cancer cells in response to co-cultured B cells as well as the identified B cell cytokines:IL-6,IL-10,and CCL5.Neutralization of these cytokines through their specific neutralizing antibodies decreased B cell-induced prostate cancer cell migration.Results from Western blot and immunocytochemistry showed an increase in expression of N-cadherin and Slug,as well as disorganization of ZO-1,amongst the LNCaP cells treated with B cell cytokines.Conclusion:These results revealed that infiltrating B cells through their secretion factors enhanced prostate cancer cell migratory ability,which may lead to metastasis. 展开更多
关键词 CYTOKINES B cells human prostate cancer cells cell migration tumor microenvironment(TME)
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