Liver cancer is one of the most common malignant tumors worldwide.Currently,the available treatment methods cannot fully control its recurrence and mortality rate.Establishing appropriate animal models for liver cance...Liver cancer is one of the most common malignant tumors worldwide.Currently,the available treatment methods cannot fully control its recurrence and mortality rate.Establishing appropriate animal models for liver cancer is crucial for developing new treatment technologies and strategies.The patient-derived xenograft(PDX)model preserves the tumor’s microenvironment and heterogeneity,which makes it advantageous for biological research,drug evaluation,personalized medicine,and other purposes.This article reviews the development,preparation techniques,application fields,and challenges of PDX models in liver cancer,providing insights for the research and exploration of PDX models in diagnostic and therapeutic strategies of liver cancer.展开更多
基金This work was supported by grants from the Capital Health Research and Development of Special(No.2020-2-1152)National Science and Technology Major Special Program of the 13th Five-Year Plan for the Prevention and Control of Major Infectious Diseases(No.2018ZX10302205-005)Beijing Municipal Institute of Public Medical Research Development and Reform Pilot Project(No.Jingyiyan-2021-10).
文摘Liver cancer is one of the most common malignant tumors worldwide.Currently,the available treatment methods cannot fully control its recurrence and mortality rate.Establishing appropriate animal models for liver cancer is crucial for developing new treatment technologies and strategies.The patient-derived xenograft(PDX)model preserves the tumor’s microenvironment and heterogeneity,which makes it advantageous for biological research,drug evaluation,personalized medicine,and other purposes.This article reviews the development,preparation techniques,application fields,and challenges of PDX models in liver cancer,providing insights for the research and exploration of PDX models in diagnostic and therapeutic strategies of liver cancer.
