OBJECTIVE:To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS:A Franz diffusion cell was used in v...OBJECTIVE:To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS:A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux(Q_(tot)),cumulative transmission(T_(tot)),and mean penetration rate(Kp)of pseudoephedrine and amygdalin in majiepingchuan.Linear regression analyses of Q_(tot)over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS:At 1,2,4,6,and 8 h,the Q_(tot),T_(tot)and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION:There was a small difference in theratios of Q_(tot),T_(tot)and Kp between pseudoephedrine and amygdalin,and a correlation between them.展开更多
基金Supported by the Science and Technology Major Projects for Major New Drugs(Research on innovation of Majiepingchuan effective components cataplasm of transdermal drug delivery system),No.2012ZX09103201-007
文摘OBJECTIVE:To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS:A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux(Q_(tot)),cumulative transmission(T_(tot)),and mean penetration rate(Kp)of pseudoephedrine and amygdalin in majiepingchuan.Linear regression analyses of Q_(tot)over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS:At 1,2,4,6,and 8 h,the Q_(tot),T_(tot)and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION:There was a small difference in theratios of Q_(tot),T_(tot)and Kp between pseudoephedrine and amygdalin,and a correlation between them.
