Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A t...Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A total of 27 patients with pancreatic cancer undergoing chemotherapy at two medical institutions were recruited between November 2023 and August 2024.Semi-structured interviews were conducted in person or over the phone.Data were analyzed using traditional content and thematic analyses.Results:Three themes were identified:symptom experience,self-coping patterns,and existing obstacles.During the early stages of chemotherapy,patients reported a higher frequency of unpleasant symptoms and recognized these symptoms earlier in the treatment course.Patients in the early stages primarily relied on external support to cope with symptoms,while those in the later stages adopted self-care strategies.Several challenges related to unpleasant symptoms were observed,which appeared to correlate with the self-coping patterns employed.Conclusion:Patients with pancreatic cancer undergoing chemotherapy experience a complex and diverse range of symptoms,with varying coping patterns at different stages of treatment.Symptom management during chemotherapy presents significant challenges.Healthcare providers should improve the ongoing monitoring of symptoms post-chemotherapy.By linking patients’symptom experiences and self-coping patterns at different stages of chemotherapy to their specific challenges,personalized symptom management strategies can be developed to enhance care quality.展开更多
背景与目的肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确,本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料,采用欧洲癌症研...背景与目的肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确,本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料,采用欧洲癌症研究与治疗组织生活质量核心量表C30 (European Organization for Research and Treatment of Cancer quality of life core 30,EORTC QLQ-C30)和肺癌生活质量量表29 (Quality of Life QuestionnaireLung Cancer 29,QLQ-LC29)收集患者的生活质量资料。将基线资料中潜在混杂因素纳入多因素回归模型中校正,比较两组患者术后3个月的生活质量与传统临床结局。结果共纳入130例肺癌患者,男性57例(43.8%),女性73例(56.2%),平均年龄(57.1±9.5)岁。两组患者基线资料中,放置引流管数量具有统计学差异(P<0.001)。经回归模型校正后,在术后3个月时,两组患者全部症状及功能状态评分无明显差异(P均>0.05)。多孔组的手术时间(120.0 min vs 85.0 min,P=0.001)、术后住院时间(6.0 d vs 4.0 d,P=0.020)比单孔组更长,早期>2级并发症发生率(39.0%vs 10.1%,P=0.011)比单孔组更高。结论单孔与多孔胸腔镜肺叶切除术患者在术后3个月时具有相似的生活质量。单孔组在手术时间、术后住院时间及术后早期并发症等传统临床结局指标上可能具有一定的优势。展开更多
Purpose This study aims to identify symptoms and concerns experienced by patients at different treatment stages through qualitative research,develop quality-of-life measurement domains,and understand the age-specific ...Purpose This study aims to identify symptoms and concerns experienced by patients at different treatment stages through qualitative research,develop quality-of-life measurement domains,and understand the age-specific status and needs for health care services.Methods Purposive sampling was employed to select 38 breast cancer patients from a tertiary hospital for semistructured interviews conducted between August and October 2024.The interview recordings were transcribed and analyzed by two researchers.The traditional content analysis and thematic analysis were used to identify the common codes,subthemes,and themes.The number of patients affected by each theme and their corresponding proportions were calculated to reflect the concerns and needs of patients across different age stages.Results Five key themes were identified:physical symptoms,psychological symptoms,activities of daily living,family functioning,and social functioning.Within physiological symptoms,specific symptoms related to surgery,chemotherapy,and endocrine therapy were distinguished,leading to the construction of quality-of-life measurement modules.Compared with their younger counterparts elderly patients demonstrated more surgical incision numbness(62.5% vs.20.7%),Peripheral neuropathy(77.8% vs.55.2%),and limited walking and exercise capacity(66.7% vs.34.5%).Conclusion This study highlights the symptom-related distress and quality-of-life issues faced by breast cancer patients at various treatment stages.The differences identified between age groups will support personalized patient care strategies.展开更多
Purpose This multicenter qualitative study aimed to explore the perceptions of clinicians and research ethics boards(REBs)regarding ethical issues in Investigator Initiated Trials(IITs).Methods Between February and Ap...Purpose This multicenter qualitative study aimed to explore the perceptions of clinicians and research ethics boards(REBs)regarding ethical issues in Investigator Initiated Trials(IITs).Methods Between February and April 2024,semi-structured interviews were conducted with 27 participants from 15 tertiary hospitals,including clinical doctors and members of REBs.Responses were grouped and analyzed using a descriptive phenomenological approach.Results Clinicians expressed challenges in navigating the formal review process due to limited access to information and unclear guidelines.Academic review highlighted a deficiency in research literacy among clinical investigators,leading to flawed study design.Ethical review revealed concerns about inadequate ethical awareness among clini-cians,resulting in failed ethical approvals.Moreover,delays in review processes and resource shortages were noted,hindering the efficient conduct of IITs.Conclusion The findings underscore the need for comprehensive training programs to enhance clinicians’research literacy and ethical awareness.Establishing a comprehensive system to support IITs,including enhanced guidance and support from REBs,is essential to ensure the quality and integrity of IITs in China.展开更多
SARS-CoV-2 has evolved dramatically since the COVID-19 pandemic in Dec 2019,acquiring mutations that enhance transmissibility,infectivity,and immune evasion.1 Unlike other variants targeting lungs,Omicron altered entr...SARS-CoV-2 has evolved dramatically since the COVID-19 pandemic in Dec 2019,acquiring mutations that enhance transmissibility,infectivity,and immune evasion.1 Unlike other variants targeting lungs,Omicron altered entry pathways and promoted replication in the upper respiratory tract,resulting in more asymptomatic cases.This facilitated its spread and posed challenges to infection prevention.展开更多
基金supported by the State Key Laboratory of Ultrasonic Medical Engineering/the Chongqing Science and Technology Bureau(Project No.2022KFKT7011)the Postdoctoral Fellowship Program of CPSF(GZC20233357)+1 种基金the Health Commission of Sichuan Province Medical Science and Technology Program(24QNMP007)the Medical Research Program of Health Commission of Chengdu(2023535).
文摘Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A total of 27 patients with pancreatic cancer undergoing chemotherapy at two medical institutions were recruited between November 2023 and August 2024.Semi-structured interviews were conducted in person or over the phone.Data were analyzed using traditional content and thematic analyses.Results:Three themes were identified:symptom experience,self-coping patterns,and existing obstacles.During the early stages of chemotherapy,patients reported a higher frequency of unpleasant symptoms and recognized these symptoms earlier in the treatment course.Patients in the early stages primarily relied on external support to cope with symptoms,while those in the later stages adopted self-care strategies.Several challenges related to unpleasant symptoms were observed,which appeared to correlate with the self-coping patterns employed.Conclusion:Patients with pancreatic cancer undergoing chemotherapy experience a complex and diverse range of symptoms,with varying coping patterns at different stages of treatment.Symptom management during chemotherapy presents significant challenges.Healthcare providers should improve the ongoing monitoring of symptoms post-chemotherapy.By linking patients’symptom experiences and self-coping patterns at different stages of chemotherapy to their specific challenges,personalized symptom management strategies can be developed to enhance care quality.
文摘背景与目的肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确,本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料,采用欧洲癌症研究与治疗组织生活质量核心量表C30 (European Organization for Research and Treatment of Cancer quality of life core 30,EORTC QLQ-C30)和肺癌生活质量量表29 (Quality of Life QuestionnaireLung Cancer 29,QLQ-LC29)收集患者的生活质量资料。将基线资料中潜在混杂因素纳入多因素回归模型中校正,比较两组患者术后3个月的生活质量与传统临床结局。结果共纳入130例肺癌患者,男性57例(43.8%),女性73例(56.2%),平均年龄(57.1±9.5)岁。两组患者基线资料中,放置引流管数量具有统计学差异(P<0.001)。经回归模型校正后,在术后3个月时,两组患者全部症状及功能状态评分无明显差异(P均>0.05)。多孔组的手术时间(120.0 min vs 85.0 min,P=0.001)、术后住院时间(6.0 d vs 4.0 d,P=0.020)比单孔组更长,早期>2级并发症发生率(39.0%vs 10.1%,P=0.011)比单孔组更高。结论单孔与多孔胸腔镜肺叶切除术患者在术后3个月时具有相似的生活质量。单孔组在手术时间、术后住院时间及术后早期并发症等传统临床结局指标上可能具有一定的优势。
基金supported by grants from the State Key Laboratory of Ultrasound in Medicine and Engineering(2020KFKT011)the Natural Science Foundation of Chongqing(CSTB2023NSCQ-BHX0027).
文摘Purpose This study aims to identify symptoms and concerns experienced by patients at different treatment stages through qualitative research,develop quality-of-life measurement domains,and understand the age-specific status and needs for health care services.Methods Purposive sampling was employed to select 38 breast cancer patients from a tertiary hospital for semistructured interviews conducted between August and October 2024.The interview recordings were transcribed and analyzed by two researchers.The traditional content analysis and thematic analysis were used to identify the common codes,subthemes,and themes.The number of patients affected by each theme and their corresponding proportions were calculated to reflect the concerns and needs of patients across different age stages.Results Five key themes were identified:physical symptoms,psychological symptoms,activities of daily living,family functioning,and social functioning.Within physiological symptoms,specific symptoms related to surgery,chemotherapy,and endocrine therapy were distinguished,leading to the construction of quality-of-life measurement modules.Compared with their younger counterparts elderly patients demonstrated more surgical incision numbness(62.5% vs.20.7%),Peripheral neuropathy(77.8% vs.55.2%),and limited walking and exercise capacity(66.7% vs.34.5%).Conclusion This study highlights the symptom-related distress and quality-of-life issues faced by breast cancer patients at various treatment stages.The differences identified between age groups will support personalized patient care strategies.
基金supported by grants from the National Key R&D Program of China(2022YFE0133100)the Natural Science Foundation Project of Chongqing(CSTB2022NSCQ-MSX0118)。
文摘Purpose This multicenter qualitative study aimed to explore the perceptions of clinicians and research ethics boards(REBs)regarding ethical issues in Investigator Initiated Trials(IITs).Methods Between February and April 2024,semi-structured interviews were conducted with 27 participants from 15 tertiary hospitals,including clinical doctors and members of REBs.Responses were grouped and analyzed using a descriptive phenomenological approach.Results Clinicians expressed challenges in navigating the formal review process due to limited access to information and unclear guidelines.Academic review highlighted a deficiency in research literacy among clinical investigators,leading to flawed study design.Ethical review revealed concerns about inadequate ethical awareness among clini-cians,resulting in failed ethical approvals.Moreover,delays in review processes and resource shortages were noted,hindering the efficient conduct of IITs.Conclusion The findings underscore the need for comprehensive training programs to enhance clinicians’research literacy and ethical awareness.Establishing a comprehensive system to support IITs,including enhanced guidance and support from REBs,is essential to ensure the quality and integrity of IITs in China.
基金supported by the Science and Technology Innovation Key R&D Program of Chongqing,China(No.CSTB2022TIAD-STX0013).
文摘SARS-CoV-2 has evolved dramatically since the COVID-19 pandemic in Dec 2019,acquiring mutations that enhance transmissibility,infectivity,and immune evasion.1 Unlike other variants targeting lungs,Omicron altered entry pathways and promoted replication in the upper respiratory tract,resulting in more asymptomatic cases.This facilitated its spread and posed challenges to infection prevention.
