Direct ink writing(DIW)holds enormous potential in fabricating multiscale and multi-functional architectures by virtue of its wide range of printable materials,simple operation,and ease of rapid prototyping.Although i...Direct ink writing(DIW)holds enormous potential in fabricating multiscale and multi-functional architectures by virtue of its wide range of printable materials,simple operation,and ease of rapid prototyping.Although it is well known that ink rheology and processing parameters have a direct impact on the resolution and shape of the printed objects,the underlying mechanisms of these key factors on the printability and quality of DIW technique remain poorly understood.To tackle this issue,we systematically analyzed the printability and quality through extrusion mechanism modeling and experimental validating.Hybrid non-Newtonian fluid inks were first prepared,and their rheological properties were measured.Then,finite element analysis of the whole DIW process was conducted to reveal the flow dynamics of these inks.The obtained optimal process parameters(ink rheology,applied pressure,printing speed,etc)were also validated by experiments where high-resolution(<100μm)patterns were fabricated rapidly(>70 mm s^(-1)).Finally,as a process research demonstration,we printed a series of microstructures and circuit systems with hybrid inks and silver inks,showing the suitability of the printable process parameters.This study provides a strong quantitative illustration of the use of DIW for the high-speed preparation of high-resolution,high-precision samples.展开更多
Considering the aircraft and its external components are subjected to complex and variable aerodynamic loads during the working process,the missile-frame clearance system of the airborne external missile is investigat...Considering the aircraft and its external components are subjected to complex and variable aerodynamic loads during the working process,the missile-frame clearance system of the airborne external missile is investigated.The random vibration characteristics of the airborne external components are analyzed by finite element method.The finite element model is optimized with reference to the test results,and the effects of different clearance on the dynamic response of the missile-frame system are compared.The result shows that the frequency response curves of the same position and the resonant peak frequencies are consistent under different clearances.The acceleration response at both ends of the missile is large and the amplitude near the center of mass is gentle.The results can be used to predict reasonable missile-frame clearance and make guidance to the structural design and reliability analysis of the missile-frame system.展开更多
The non-destructive operation of intelligent underwater robotics with human-like sensory capabilities is essential for deep-sea resource exploration.However,extreme deep-sea hydrostatic pressure easily distorts sensor...The non-destructive operation of intelligent underwater robotics with human-like sensory capabilities is essential for deep-sea resource exploration.However,extreme deep-sea hydrostatic pressure easily distorts sensor signals or damages devices,and detecting hundred-pascal-level contact forces under tens-of-megapascal hydrostatic pressures presents a critical challenge that hinders the advancement of underwater tactile sensing technology.Inspired by deep-sea sponges’hydrostatic skeletal supporting mechanisms,we developed a fully open-pore hydrophobic ionogel as the sensing layer to construct a biomimetic deep-sea tactile sensor.The contact force is converted into electrical signals for object classification and non-destructive manipulation of marine organisms.This innovative sensing layer features aquatic stability and a pore structure balancing internal-external hydrostatic pressure,reducing environmental disturbances.The sensor maintains stable contact force detection under 50 MPa hydrostatic pressure,and accurately classify objects of varying hardness with an overall recognition accuracy of 95.5%,holding great potential for deep-sea exploration and sustainable resource exploitation.展开更多
Background:Colorectal cancer is the third-most common type of cancer.When peritoneal metastasis(PM)develops,diagnosing metastatic lesions is difficult and the prognosis is poor.This study aimed to compare the value of...Background:Colorectal cancer is the third-most common type of cancer.When peritoneal metastasis(PM)develops,diagnosing metastatic lesions is difficult and the prognosis is poor.This study aimed to compare the value of fluorine-18 fibroblast activation protein-specific inhibitor(^(18)F-FAPI-42)and fluorine-18 fluorodeoxyglucose(^(18)F-FDG)positron emission tomography/computed tomography(PET/CT)for detecting PM of colorectal cancer and to guide clinical decision-making.Methods:Forty-eight patients with PM who underwent both^(18)F-FAPI-42 and^(18)F-FDG PET/CT examinations were studied.The maximum standardized uptake value(SUV max),tumor-to-background ratios(TBRs)and peritoneal cancer index(PCI)of the PM were compared between the two imaging techniques.The intraclass correlation coefficient(ICC)was used to compare the consistency between the PET/CT PCI score and the intraoperative PCI.A receiver-operating characteristic curve was used to predict the accuracy of CC-0 cytoreduction(complete cytoreduction with no visible disease).Results:The sensitivity and accuracy of^(18)F-FAPI-42 PET/CT for detecting PM were higher than those of^(18)F-FDG PET/CT(82.1%vs 61.1%,P<0.01;84.6%vs 74.5%,P<0.01).The median SUV max and TBR of PM was greater in^(18)F-FAPI-42 than in^(18)F-FDG PET/CT[4.8(1.9-20.1)vs 4.7(1.0-11.0),P=0.02;4.3(1.4-14.6)vs 2.9(0.6-8.0),P<0.01,respectively].The median PCI of PM based on^(18)F-FAPI-42 PET/CT was greater than that based on^(18)F-FDG PET/CT(15 vs 9,P<0.01).The ICC for^(18)F-FAPI-42 PCI was greater than that for^(18)F-FDG PCI(0.915 vs 0.724,P<0.01).The cut-off values of the PCI of the PM for^(18)F-FAPI-42 and^(18)F-FDG PET/CT to predict CC-0 were<18 and<10,with areas under the curve of 0.80 and 0.79,respectively.Conclusions:^(18)F-FAPI-42 PET/CT has superior diagnostic efficacy for PM,particularly in the right upper epigastrium and small intestine.The PCI score of^(18)F-FAPI-42 PET/CT is very close to the intraoperative PCI score and has a high value for predicting CC-0.The individualized management of PM based on the^(18)F-FAPI-42 PET/CT PCI score is pivotal.展开更多
To make sense of physical clogging during Yellow River water spreading in the strong leakage zone of the Yufuhe River,a laboratory sand column experiment was undertaken and the heterogeneous sand gravel with a uniform...To make sense of physical clogging during Yellow River water spreading in the strong leakage zone of the Yufuhe River,a laboratory sand column experiment was undertaken and the heterogeneous sand gravel with a uniformity coefficient of 25.2 from the Yufuhe River was used as an infiltration medium.Under either the condition of raw sand or washed sand,physical clogging tests were conducted with constant hydraulic heads of 10 cm and 30 cm and inflow suspension concentrations of 200 mg/L,500 mg/L,and 1000 mg/L.The fine particles in the suspension and in the raw sand were considered exogenous and endogenous particles,respectively.Rapid clogging was observed in the porous medium when the inflow concentrations of the exogenous particles were high,and increased hydraulic head led to serious clogging.This result indicated that the Yufuhe River has a strong recharge capability with respect to clogging.The analysis of particle content shows that endogenous fine particles(diameter 1–10 mm and 50–74 mm)had less mobility and generally accumulated in the sand column,whereas particles with diameter 10–50 mm had greater mobility in the sand column.And the distribution of exogenous fine particles size after movement is relatively uniform in the sand column.Field observations indicated that the filtration effect of the aquifers have greatly improved the water quality of recharge water in the strong leakage zone of the Yufuhe River,and test data of turbidity also verified the results of the sand column experiments.展开更多
基金supported by National Natural Science Foundation of China(Nos.52188102,U2013213,51820105008)the Technology Innovation Project of Hubei Province of China under Grant No.2019AEA171+1 种基金The project of introducing innovative leading talents in Songshan Lake High-tech Zone,Dongguan City,Guangdong Province(No.2019342101RSFJ-G)the support from Flexible Electronics Research Center of HUST for providing experiment facility。
文摘Direct ink writing(DIW)holds enormous potential in fabricating multiscale and multi-functional architectures by virtue of its wide range of printable materials,simple operation,and ease of rapid prototyping.Although it is well known that ink rheology and processing parameters have a direct impact on the resolution and shape of the printed objects,the underlying mechanisms of these key factors on the printability and quality of DIW technique remain poorly understood.To tackle this issue,we systematically analyzed the printability and quality through extrusion mechanism modeling and experimental validating.Hybrid non-Newtonian fluid inks were first prepared,and their rheological properties were measured.Then,finite element analysis of the whole DIW process was conducted to reveal the flow dynamics of these inks.The obtained optimal process parameters(ink rheology,applied pressure,printing speed,etc)were also validated by experiments where high-resolution(<100μm)patterns were fabricated rapidly(>70 mm s^(-1)).Finally,as a process research demonstration,we printed a series of microstructures and circuit systems with hybrid inks and silver inks,showing the suitability of the printable process parameters.This study provides a strong quantitative illustration of the use of DIW for the high-speed preparation of high-resolution,high-precision samples.
基金funded by National Natural Science Foundation of China(No.11972295)the Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of Education,Northeastern University(No.VCAME201803)+1 种基金Aeronautical Science Foundation of China(Nos.20182953025,2016ZD12032)Graduate Innovation Fund of Northwestern Polytechnical University(No.ZZ2019126)。
文摘Considering the aircraft and its external components are subjected to complex and variable aerodynamic loads during the working process,the missile-frame clearance system of the airborne external missile is investigated.The random vibration characteristics of the airborne external components are analyzed by finite element method.The finite element model is optimized with reference to the test results,and the effects of different clearance on the dynamic response of the missile-frame system are compared.The result shows that the frequency response curves of the same position and the resonant peak frequencies are consistent under different clearances.The acceleration response at both ends of the missile is large and the amplitude near the center of mass is gentle.The results can be used to predict reasonable missile-frame clearance and make guidance to the structural design and reliability analysis of the missile-frame system.
基金support from the National Key R&D Program of China(No.2024YFB4707300)the National Natural Science Foundation of China(No.52550004,52188102,52475018)+3 种基金the Fundamental Research Funds for the Central Universities(HUST:YCJJ20242101)the STAR Project by the School of Mechanical Science and Engineering of Huazhong University of Science and Technologysupport from Flexible Electronics Research Center and Analytical and Testing Center of HUST for providing experiment facilitysupport from the National University of Singapore Presidential Young Professorship.
文摘The non-destructive operation of intelligent underwater robotics with human-like sensory capabilities is essential for deep-sea resource exploration.However,extreme deep-sea hydrostatic pressure easily distorts sensor signals or damages devices,and detecting hundred-pascal-level contact forces under tens-of-megapascal hydrostatic pressures presents a critical challenge that hinders the advancement of underwater tactile sensing technology.Inspired by deep-sea sponges’hydrostatic skeletal supporting mechanisms,we developed a fully open-pore hydrophobic ionogel as the sensing layer to construct a biomimetic deep-sea tactile sensor.The contact force is converted into electrical signals for object classification and non-destructive manipulation of marine organisms.This innovative sensing layer features aquatic stability and a pore structure balancing internal-external hydrostatic pressure,reducing environmental disturbances.The sensor maintains stable contact force detection under 50 MPa hydrostatic pressure,and accurately classify objects of varying hardness with an overall recognition accuracy of 95.5%,holding great potential for deep-sea exploration and sustainable resource exploitation.
基金the National Natural Science Foundation of China[grant no.82103084]the Dongguan Science and Technology of Social Development Program[grant no.20231800904303]+6 种基金Z.Z.has received grants from the National Natural Science Foundation of China[no.81901772]the Natural Science Foundation of Guangdong Province[nos 2019A1515011893,2023A1515011300]the State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia&The First People’s Hospital of Kashi Fund[no.SKL-HIDCA-2020-KS2]H.W.has received grants from the Xinjiang Autonomous Region Technology Plan[grant no.2022E02125]The Sixth Affiliated Hospital of Sun Yat-Sen University Clinical Research-1010 Program:1010CG(2022)-08K.Y.has received grants from the National Natural Science Foundation of China[grant no.82300619]the Science and Technology Projects in Guangzhou[grant no.2023A04J2245].
文摘Background:Colorectal cancer is the third-most common type of cancer.When peritoneal metastasis(PM)develops,diagnosing metastatic lesions is difficult and the prognosis is poor.This study aimed to compare the value of fluorine-18 fibroblast activation protein-specific inhibitor(^(18)F-FAPI-42)and fluorine-18 fluorodeoxyglucose(^(18)F-FDG)positron emission tomography/computed tomography(PET/CT)for detecting PM of colorectal cancer and to guide clinical decision-making.Methods:Forty-eight patients with PM who underwent both^(18)F-FAPI-42 and^(18)F-FDG PET/CT examinations were studied.The maximum standardized uptake value(SUV max),tumor-to-background ratios(TBRs)and peritoneal cancer index(PCI)of the PM were compared between the two imaging techniques.The intraclass correlation coefficient(ICC)was used to compare the consistency between the PET/CT PCI score and the intraoperative PCI.A receiver-operating characteristic curve was used to predict the accuracy of CC-0 cytoreduction(complete cytoreduction with no visible disease).Results:The sensitivity and accuracy of^(18)F-FAPI-42 PET/CT for detecting PM were higher than those of^(18)F-FDG PET/CT(82.1%vs 61.1%,P<0.01;84.6%vs 74.5%,P<0.01).The median SUV max and TBR of PM was greater in^(18)F-FAPI-42 than in^(18)F-FDG PET/CT[4.8(1.9-20.1)vs 4.7(1.0-11.0),P=0.02;4.3(1.4-14.6)vs 2.9(0.6-8.0),P<0.01,respectively].The median PCI of PM based on^(18)F-FAPI-42 PET/CT was greater than that based on^(18)F-FDG PET/CT(15 vs 9,P<0.01).The ICC for^(18)F-FAPI-42 PCI was greater than that for^(18)F-FDG PCI(0.915 vs 0.724,P<0.01).The cut-off values of the PCI of the PM for^(18)F-FAPI-42 and^(18)F-FDG PET/CT to predict CC-0 were<18 and<10,with areas under the curve of 0.80 and 0.79,respectively.Conclusions:^(18)F-FAPI-42 PET/CT has superior diagnostic efficacy for PM,particularly in the right upper epigastrium and small intestine.The PCI score of^(18)F-FAPI-42 PET/CT is very close to the intraoperative PCI score and has a high value for predicting CC-0.The individualized management of PM based on the^(18)F-FAPI-42 PET/CT PCI score is pivotal.
基金This study was supported by Shandong Provincial Key Research and Development Project(No.2017GSF17121)the Danish Development agency(DANIDA)coordinated by the DANIDA Fellowship center(DFC)(No.17-M08-GEU)Confucius Institute at Colorado State University.
文摘To make sense of physical clogging during Yellow River water spreading in the strong leakage zone of the Yufuhe River,a laboratory sand column experiment was undertaken and the heterogeneous sand gravel with a uniformity coefficient of 25.2 from the Yufuhe River was used as an infiltration medium.Under either the condition of raw sand or washed sand,physical clogging tests were conducted with constant hydraulic heads of 10 cm and 30 cm and inflow suspension concentrations of 200 mg/L,500 mg/L,and 1000 mg/L.The fine particles in the suspension and in the raw sand were considered exogenous and endogenous particles,respectively.Rapid clogging was observed in the porous medium when the inflow concentrations of the exogenous particles were high,and increased hydraulic head led to serious clogging.This result indicated that the Yufuhe River has a strong recharge capability with respect to clogging.The analysis of particle content shows that endogenous fine particles(diameter 1–10 mm and 50–74 mm)had less mobility and generally accumulated in the sand column,whereas particles with diameter 10–50 mm had greater mobility in the sand column.And the distribution of exogenous fine particles size after movement is relatively uniform in the sand column.Field observations indicated that the filtration effect of the aquifers have greatly improved the water quality of recharge water in the strong leakage zone of the Yufuhe River,and test data of turbidity also verified the results of the sand column experiments.
