Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensi...Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensitizers, or dose intensifiers for phototherma! therapy （PTT）, photodynamic therapy （PDT）, or radiation therapy （RT）. In this study, ultrathin tungsten oxide nanowires （W18O49） were synthesized using a solvothermal approach and examined as a multifunctional theranostic nanoplatform. In vitro and in vivo analyses demonstrated that these nanowires could induce extensive heat- and singlet oxygen-mediated damage to cancer cells under 980 nm near infrared （NIR）-laser excitation. They were also shown to function as radiation dose intensifying agents that enhance irradiative energy deposition locally and selectively during radiation therapy. Compared to NIR-induced PTT/PDT and RT alone, W18O49 - based synergistic tri-modal therapy eradicated xenograft tumors and no recurrence was observed within a 9-month follow up. Moreover, the strong X-ray attenuation ability of the tungsten element （Z = 74, 4.438 cm^2·g^-1, 100 KeV） qualified these nanowires as excellent contrast agents in X-ray-based imaging, such as diagnostic computed tomography （CT） and cone-beam CT for image-guided radiation therapy. Toxicity studies demonstrated minimal adverse effects on the hematologic system and major organs of mice within one month. In conclusion, these nanowires have shown significant potential for cancer therapy with inherent image guidance and synergistic effects from phototherapy and radiation therapy, which warrants further investigation.展开更多
To enhance the interface bonding of polyimide(PI)/carbon fiber(CF)composites,CFs were functionalized by introducing a polydopamine(PDA)transition layer,whose active groups provide absorption sites for the growth of mo...To enhance the interface bonding of polyimide(PI)/carbon fiber(CF)composites,CFs were functionalized by introducing a polydopamine(PDA)transition layer,whose active groups provide absorption sites for the growth of molybdenum disulfide(MoS_(2))nanosheets and improve the bonding strength with PI.Uniform and dense MoS_(2) nanosheets with thicknesses of 30–40 nm on the surface of the PDA@CF were obtained via a subsequent hydrothermal method.As a result,the interface between the CF and the PI matrix becomes more compact with the help of the PDA transition layer and MoS_(2) nanosheets.This is beneficial in forming PI/CF–MoS_(2) composites with better thermal stability,higher tensile strength,and enhanced tribological properties.The lubricating and reinforcing effects of the hybrid CF–MoS_(2) in the PI composite are discussed in detail.The tensile strength of the PI/CF–MoS_(2) composite increases by 43%,and the friction coefficient and the wear rate reduce by 57%and 77%,respectively,compared to those of the pure PI.These values are higher than those of the PI/CF composites without MoS_(2) nanosheets.These results indicate that the CF–MoS_(2) hybrid material can be used as an additive to improve the mechanical and tribological properties of polymers.展开更多
基金Acknowledgements This work has been financially supported by the National Natural Science Foundation of China （Nos. 51372260, 51132009, and 21172043）, the Shanghai Rising-Star Program （No. 12QH1402500）, the Science and Technology Commission of Shanghai （No. 11nm0505000 and 124119a0400）, the Shanghai Municipal Commission of Health （No. 20134360）, the Development Foundation for Talents of Shanghai （No. 2012035）.
文摘Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensitizers, or dose intensifiers for phototherma! therapy （PTT）, photodynamic therapy （PDT）, or radiation therapy （RT）. In this study, ultrathin tungsten oxide nanowires （W18O49） were synthesized using a solvothermal approach and examined as a multifunctional theranostic nanoplatform. In vitro and in vivo analyses demonstrated that these nanowires could induce extensive heat- and singlet oxygen-mediated damage to cancer cells under 980 nm near infrared （NIR）-laser excitation. They were also shown to function as radiation dose intensifying agents that enhance irradiative energy deposition locally and selectively during radiation therapy. Compared to NIR-induced PTT/PDT and RT alone, W18O49 - based synergistic tri-modal therapy eradicated xenograft tumors and no recurrence was observed within a 9-month follow up. Moreover, the strong X-ray attenuation ability of the tungsten element （Z = 74, 4.438 cm^2·g^-1, 100 KeV） qualified these nanowires as excellent contrast agents in X-ray-based imaging, such as diagnostic computed tomography （CT） and cone-beam CT for image-guided radiation therapy. Toxicity studies demonstrated minimal adverse effects on the hematologic system and major organs of mice within one month. In conclusion, these nanowires have shown significant potential for cancer therapy with inherent image guidance and synergistic effects from phototherapy and radiation therapy, which warrants further investigation.
基金This work is supported by the National Natural Science Foundation of China(51875330 and 51975342)the National Science Foundation of Shaanxi Province(2018JZ5003 and 2019JZ‐24).
文摘To enhance the interface bonding of polyimide(PI)/carbon fiber(CF)composites,CFs were functionalized by introducing a polydopamine(PDA)transition layer,whose active groups provide absorption sites for the growth of molybdenum disulfide(MoS_(2))nanosheets and improve the bonding strength with PI.Uniform and dense MoS_(2) nanosheets with thicknesses of 30–40 nm on the surface of the PDA@CF were obtained via a subsequent hydrothermal method.As a result,the interface between the CF and the PI matrix becomes more compact with the help of the PDA transition layer and MoS_(2) nanosheets.This is beneficial in forming PI/CF–MoS_(2) composites with better thermal stability,higher tensile strength,and enhanced tribological properties.The lubricating and reinforcing effects of the hybrid CF–MoS_(2) in the PI composite are discussed in detail.The tensile strength of the PI/CF–MoS_(2) composite increases by 43%,and the friction coefficient and the wear rate reduce by 57%and 77%,respectively,compared to those of the pure PI.These values are higher than those of the PI/CF composites without MoS_(2) nanosheets.These results indicate that the CF–MoS_(2) hybrid material can be used as an additive to improve the mechanical and tribological properties of polymers.
