This paper investigates interfacial heat transfer characteristics in amulti-layer structure under ultra-high heat flux conditions,focusing on thermal contact resistance(TCR)between adjacent layers.Athree-layer computa...This paper investigates interfacial heat transfer characteristics in amulti-layer structure under ultra-high heat flux conditions,focusing on thermal contact resistance(TCR)between adjacent layers.Athree-layer computational model with dual rough interfaces was developed to systematically analyze the synergistic effects of interfacial pressure,surface emissivity,and thermal interface materials(TIMs).Surface reconstruction using experimental measurement data generated two representative roughness models to quantify the impact of surface roughness on heat dissipation.Numerical simulations demonstrate that the absence of TIMs leads to insufficient thermal dissipation capacity under ultra-high heat flux conditions.Compared to TIMapplication,merely increasing the convective heat transfer coefficient shows limited effectiveness in enhancing heat dissipation efficiency.展开更多
The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon cancer.Our previous studies highlighted the potent anti-cancer properties of the princ...The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon cancer.Our previous studies highlighted the potent anti-cancer properties of the principal compounds found in Garcinia yunnanensis(YTE-17),attributing these effects to the regu-lation of multiple signaling pathways.However,knowledge regarding the mechanism and effect of YTE-17 in the prevention of colorectal cancer is limited.In this study,we conducted isobaric tags for relative and absolute quantification(iTRAQ)analysis on intestinal epithelial cells(IECs)exposed YTE-17,both in vitro and in vivo,revealing a significant inhibition of the Wnt family member 5a(Wnt5a)/c-Jun N-terminal kinase(JNK)signaling pathway.Subsequently,we elucidated the influence and mechanism of YTE-17 on the tumor microenvironment(TME),specifically focusing on macrophage-mediated T helper 17(Th17)cell induction in a colitis-associated cancer(CAC)model with Wnt5a deletion.Additionally,we performed the single-cell RNA sequencing(scRNA-seq)on the colonic tissue from the Wnt5a-deleted CAC model to characterize the composition,lineage,and functional status of immune mesenchymal cells during different stages of colorectal cancer(CRC)progression.Remarkably,our findings demon-strate a significant reduction in M2 macrophage polarization and Th17 cell phenotype upon treatment with YTE-17,leading to the restoration of regulatory T(Treg)/Th17 cell balance in azoxymethane(AOM)/dextran sodium sulfate(DSS)model.Furthermore,we also confirmed that YTE-17 effectively inhibited the glycolysis of Th17 cells in both direct and indirect co-culture systems with M2 macrophages.Notably,our study shed light on potential mechanisms linking the non-canonical Wnt5a/JNK signaling pathway and well-established canonical b-catenin oncogenic pathway in vivo.Specifically,we proposed that Wnt5a/JNK signaling activity in IECs promotes the development of cancer stem cells with b-catenin activity within the TME,involving macrophages and T cells.In summary,our study undergoes the po-tential of YTE-17 as a preventive strategy against CRC development by addressing the imbalance with the immune microenvironment,thereby mitigating the risk of malignancies.展开更多
The teaching mode of the Computer Composition Principles includes theoretical and practical teaching.At present,there is a problem of inconsistency in the teaching content of the two methods in our school.To this end,...The teaching mode of the Computer Composition Principles includes theoretical and practical teaching.At present,there is a problem of inconsistency in the teaching content of the two methods in our school.To this end,this paper conducts online and offline hybrid teaching based on the learning platform and the virtual simulation experiment platform,and cleverly applies ideological and political elements to theoretical and practical teaching to practice ideological and political education.Finally,the combination of theoretical and practical teaching modes can further help students firmly grasp the core knowledge points and improve the teaching quality and level of this course.展开更多
The transport of colloids and radionuclides is sophisticated because of the variety of charge properties between colloidal particles and host subsurface media, which causes great difficulty in establishing a reliable ...The transport of colloids and radionuclides is sophisticated because of the variety of charge properties between colloidal particles and host subsurface media, which causes great difficulty in establishing a reliable model of radionuclides migration by taking the colloid phase into consideration. In this work,the co-transport of illite colloids(IC) and Eu(Ⅲ) in the quartz sand and iron-coated sand porous media was investigated by column experiments to address the predominant mechanism of charge properties on co-transport. Results showed that Eu(Ⅲ) transport was driven by the illite colloids and electrostatic interaction was critical in governing the co-transport patterns. The promotion of Eu(Ⅲ) transport by IC was attenuated in the iron-coated sand systems;more IC-Eu(Ⅲ) complexes were retained uniformly in the column. The pore throat shrinkage caused by electrostatic attachment between aggregated IC and iron oxides exacerbated the physical straining and size exclusion effect of IC-Eu(Ⅲ) complexes. An aggravated irreversible retention of IC-Eu(Ⅲ) was detected in iron-coated sand column due to the electrostatic attraction of IC-Eu(Ⅲ) to host media. The findings are essential for improving the understanding on the potential transport, retention and release risk of colloids associated radionuclides, and imply that the positively charged permeable reactive barrier is an effective strategy to reduce the transport risk of colloid associated radionuclides.展开更多
The contradiction between id and ego is the root cause of various problems in the growth process of students.On the basis of understanding the functions of different psychological defense mechanisms,teachers can assis...The contradiction between id and ego is the root cause of various problems in the growth process of students.On the basis of understanding the functions of different psychological defense mechanisms,teachers can assist students in dealing with all areas of inner conflict and thus achieve a balanced state.Psychological defense mechanism is one of the means for individuals to deal with setbacks and anxiety.It plays an important role in preserving an individual's mental health.This paper mainly analyzes the impact of different types of psychological defense mechanisms in the growth process of students and discusses its importance as well as its significance.Finally,by analyzing its influencing factors,this paper also proposes strategies for adjusting the psychological defense mechanism,so as to provide reference for teachers in the practical education process.展开更多
基金by the Natural Science Foundation of Shandong Province,China(No.ZR2023QE159).
文摘This paper investigates interfacial heat transfer characteristics in amulti-layer structure under ultra-high heat flux conditions,focusing on thermal contact resistance(TCR)between adjacent layers.Athree-layer computational model with dual rough interfaces was developed to systematically analyze the synergistic effects of interfacial pressure,surface emissivity,and thermal interface materials(TIMs).Surface reconstruction using experimental measurement data generated two representative roughness models to quantify the impact of surface roughness on heat dissipation.Numerical simulations demonstrate that the absence of TIMs leads to insufficient thermal dissipation capacity under ultra-high heat flux conditions.Compared to TIMapplication,merely increasing the convective heat transfer coefficient shows limited effectiveness in enhancing heat dissipation efficiency.
基金supported by“Jiaotong University Star”Program,China(Grant No.:YG2022QN082)the National Natural Science Foundation of China(Grant No.:82204887)+1 种基金the Science Foundation for Shanghai Committee of Science Project,China(Grant Nos.:21S21901400,23S21901200)the Natural Science Research Foundation of Jiading District,China(Grant No.:JDKW-2021-0023).
文摘The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon cancer.Our previous studies highlighted the potent anti-cancer properties of the principal compounds found in Garcinia yunnanensis(YTE-17),attributing these effects to the regu-lation of multiple signaling pathways.However,knowledge regarding the mechanism and effect of YTE-17 in the prevention of colorectal cancer is limited.In this study,we conducted isobaric tags for relative and absolute quantification(iTRAQ)analysis on intestinal epithelial cells(IECs)exposed YTE-17,both in vitro and in vivo,revealing a significant inhibition of the Wnt family member 5a(Wnt5a)/c-Jun N-terminal kinase(JNK)signaling pathway.Subsequently,we elucidated the influence and mechanism of YTE-17 on the tumor microenvironment(TME),specifically focusing on macrophage-mediated T helper 17(Th17)cell induction in a colitis-associated cancer(CAC)model with Wnt5a deletion.Additionally,we performed the single-cell RNA sequencing(scRNA-seq)on the colonic tissue from the Wnt5a-deleted CAC model to characterize the composition,lineage,and functional status of immune mesenchymal cells during different stages of colorectal cancer(CRC)progression.Remarkably,our findings demon-strate a significant reduction in M2 macrophage polarization and Th17 cell phenotype upon treatment with YTE-17,leading to the restoration of regulatory T(Treg)/Th17 cell balance in azoxymethane(AOM)/dextran sodium sulfate(DSS)model.Furthermore,we also confirmed that YTE-17 effectively inhibited the glycolysis of Th17 cells in both direct and indirect co-culture systems with M2 macrophages.Notably,our study shed light on potential mechanisms linking the non-canonical Wnt5a/JNK signaling pathway and well-established canonical b-catenin oncogenic pathway in vivo.Specifically,we proposed that Wnt5a/JNK signaling activity in IECs promotes the development of cancer stem cells with b-catenin activity within the TME,involving macrophages and T cells.In summary,our study undergoes the po-tential of YTE-17 as a preventive strategy against CRC development by addressing the imbalance with the immune microenvironment,thereby mitigating the risk of malignancies.
基金National Natural Science Foundation of China(62302014)Key Project of Science Research in Universities of Anhui Province of China(2023AH050492,2023AH050497)+2 种基金Anhui Province Graduate Education Teaching Key Project(2023jyjxggyjY193)Anqing Normal University Undergraduate Education Teaching Key Project(2023aqnujyxm15,2023aqnujyxm12)Anqing Normal University Undergraduate Education Teaching General Project(2023aqnujyxm34)。
文摘The teaching mode of the Computer Composition Principles includes theoretical and practical teaching.At present,there is a problem of inconsistency in the teaching content of the two methods in our school.To this end,this paper conducts online and offline hybrid teaching based on the learning platform and the virtual simulation experiment platform,and cleverly applies ideological and political elements to theoretical and practical teaching to practice ideological and political education.Finally,the combination of theoretical and practical teaching modes can further help students firmly grasp the core knowledge points and improve the teaching quality and level of this course.
基金supported by the National Natural Science Foundation of China(Nos.22176077,22006060)the Fundamental Research Funds for the Central Universities(No.lzujbky-2022-sp04)Science and Technology Program of Gansu Province,China(No.20JR10RA615).
文摘The transport of colloids and radionuclides is sophisticated because of the variety of charge properties between colloidal particles and host subsurface media, which causes great difficulty in establishing a reliable model of radionuclides migration by taking the colloid phase into consideration. In this work,the co-transport of illite colloids(IC) and Eu(Ⅲ) in the quartz sand and iron-coated sand porous media was investigated by column experiments to address the predominant mechanism of charge properties on co-transport. Results showed that Eu(Ⅲ) transport was driven by the illite colloids and electrostatic interaction was critical in governing the co-transport patterns. The promotion of Eu(Ⅲ) transport by IC was attenuated in the iron-coated sand systems;more IC-Eu(Ⅲ) complexes were retained uniformly in the column. The pore throat shrinkage caused by electrostatic attachment between aggregated IC and iron oxides exacerbated the physical straining and size exclusion effect of IC-Eu(Ⅲ) complexes. An aggravated irreversible retention of IC-Eu(Ⅲ) was detected in iron-coated sand column due to the electrostatic attraction of IC-Eu(Ⅲ) to host media. The findings are essential for improving the understanding on the potential transport, retention and release risk of colloids associated radionuclides, and imply that the positively charged permeable reactive barrier is an effective strategy to reduce the transport risk of colloid associated radionuclides.
基金Anhui Provincial Natural Science Foundation(Grant Number:2108085QF269)Project of Quality Engineering of Anqing Normal University(Grant Number:2020aqnujyxm45)。
文摘The contradiction between id and ego is the root cause of various problems in the growth process of students.On the basis of understanding the functions of different psychological defense mechanisms,teachers can assist students in dealing with all areas of inner conflict and thus achieve a balanced state.Psychological defense mechanism is one of the means for individuals to deal with setbacks and anxiety.It plays an important role in preserving an individual's mental health.This paper mainly analyzes the impact of different types of psychological defense mechanisms in the growth process of students and discusses its importance as well as its significance.Finally,by analyzing its influencing factors,this paper also proposes strategies for adjusting the psychological defense mechanism,so as to provide reference for teachers in the practical education process.
