Objective： In the present study, we have examined the safety and efficacy of recombinant adenovirus encoding human p53 tumor suppressor gene （rAd-p53） injection in patients with advanced non-small-cell lung cancer ...Objective： In the present study, we have examined the safety and efficacy of recombinant adenovirus encoding human p53 tumor suppressor gene （rAd-p53） injection in patients with advanced non-small-cell lung cancer （NSCLC） in the combination with the therapy of bronchial arterial infusion （BAI）. Methods： A total of 58 patients with advanced NSCLC were enrolled in a non-randomized, two-armed clinical trial. Of which, 19 received a combination treatment of BAI and rAd-p53 （the combo group）, while the remaining 39 were treated with only BAI （the control group）. Patients were followed up for 12 months, with safety and local response evaluated by the National Cancer lnstitute＇s Common Toxicity Criteria and response evaluation criteria in solid tumor （RECIST）, respectively. Time to progression （TTP） and survival rates were also analyzed by Kaplan-Meier method. Results In the combo group, 19 patients received a total of 49 injections ofrAd-p53 and 46 times of BAI, respectively, while 39 patients in the control group received a total of 113 times of BAI. The combination treatment was found to have less adverse events such as anorexia, nausea and emesis, pain, and leucopenia （P〈0.05） but more arthralgia, fever, influenza-like symptom, and myalgia （P〈0.05）, compared with the control group. The overall response rates （complete response （CR）＋partial response （PR）） were 47.3% and 38.4% for the combo group and the control group, respectively （P〉0.05）. Patients in the combo group had a longer TTP than those in the control group （a median 7.75 vs 5.5 months, P-0.018）. However, the combination treatment did not lead to better survival, with survival rates at 3, 6, and 12 months in the combo group being 94.74%, 89.47%, and 52.63%, respectively, com- pared with 92.31%, 69.23%, and 38.83% in the control group （P=0.224）. Conclusion： Our results show that the combination of rAd-p53 and BAI was well tolerated in patients with NSCLC and may have improved the quality of life and delayed the disease progression. A further study to better determine the efficacy of this combination therapy is warranted.展开更多
The extraction chromatography–electrodeposition(EC–ED) process was proposed for the quantitative recovery of palladium from high-level liquid waste(HLLW) in this study. The process coupled the extraction chromatogra...The extraction chromatography–electrodeposition(EC–ED) process was proposed for the quantitative recovery of palladium from high-level liquid waste(HLLW) in this study. The process coupled the extraction chromatography method to obtain the decontamination of Pd(II) from HLLW with the electrochemical method to recover metallic palladium from the concentrated solution.Separation of Pd(II) from a nitric acid medium by extraction chromatography using iso Bu-BTP/SiO_2-P adsorbent and the electrochemical behavior of Pd(II) in nitric acid solution in the presence of thiourea(TU) were investigated.iso Bu-BTP/SiO_2-P exhibited a high selectivity for Pd(II)over other fission products(FPs), and Pd(II) could be desorbed by TU from loaded BTP/SiO_2-P. The adsorbent performed good stability against HNO_3 because the adsorption performance kept Pd(II) after extended contact with HNO_3 solution. The column experiment achieved the separation of Pd(II) from simulated HLLW successfully.The electrochemical behavior of Pd(II) in palladium desorption solution containing TU and nitric acid was investigated at a platinum electrode by cyclic voltammetry. A weak reduction wave at-0.4 V was due to the reduction in Pd(II) to Pd(0), and the deposition process wasirreversible. In electrowinning experiments, a maximum of92% palladium could be obtained.展开更多
Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer(omHSPC).Methods The basic characteristics,treatment strategies and long-term follow-up of 18...Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer(omHSPC).Methods The basic characteristics,treatment strategies and long-term follow-up of 181 patients with omHSPC were retrospectively analyzed.All patients were divided into cytoreductive surgery group and no local therapy group according to the administration of cytoreductive surgery before progression to metastatic castration-resistant prostate cancer(mCRPC).Subsequently,our study explored the effect of cytoreductive surgery on CRPC-free survival in omHSPC patients.Results A total of 181 patients were enrolled in the study,including 48 patients who received cytoreductive surgery and 133 patients who did not receive local therapy.No significant differences were detected between the two groups regarding prostate-specific antigen(PSA)at the initial diagnosis(P=0.194),the International Society of Urological Pathology(ISUP)grade group(P=0.158),the treatment options during omHSPC(P=0.090),common comorbidities(P=0.649)and the number of metastases(P=0.291).The proportions of patients with Tx stage(P=0.027)and Nx stage(P=0.027)in the no local therapy group were significantly higher than that in the cytoreductive group.After propensity score matching(PSM),it was found that cytoreductive surgery could significantly improve the CRPC-free survival of omHSPC patients(hazard ratio(HR)=0.537,95%confidence interval(CI)=0.317-0.909,P=0.016).Conclusion Cytoreductive surgery can significantly improve the CRPC-free survival of omHSPC patients.Additionally,large sample-size,prospective and randomized controlled studies are needed to validate the results of our study in the future.展开更多
The randomized phase 3 CHART trial(NCT03520478)revealed that rezvilutamide(REZ)plus androgen deprivation therapy(ADT)in high-volume,metastatic,hormone-sensitive prostate cancer(mHSPC)significantly enhanced radiographi...The randomized phase 3 CHART trial(NCT03520478)revealed that rezvilutamide(REZ)plus androgen deprivation therapy(ADT)in high-volume,metastatic,hormone-sensitive prostate cancer(mHSPC)significantly enhanced radiographic progression-free and overall survival than bicalutamide(BIC)-ADT.Accordingly,we examined patient-reported outcomes(PROs)results,which were exploratory endpoints in the CHART trial.The patients were randomly allocated to receive REZ-ADT or BIC-ADT in a 1:1 ratio.The PROs were evaluated with the Brief Pain Inventory-Short Form(BPI-SF)and the Functional Assessment of Cancer Therapy-Prostate(FACT-P)questionnaires.Both study groups displayed comparable baseline pain scores and functional status.Patients administered REZ-ADT had an extended time to progression of worst pain intensity in comparison to those treated with BIC-ADT(25th percentile,9.2[95%CI 7.4-16.6]vs.6.4 months[95%CI 5.5-8.3];HR 0.75[95%CI 0.57-0.97];p=0.026).Similarly,patients received REZ-ADT exhibited a delayed time to progression of pain interference in comparison to those receiving BIC-ADT(25th percentile,20.2[95%CI 12.9-31.3]vs.10.2 months[95%CI 7.4-11.1];HR 0.70[95%CI 0.52-0.93];p=0.015).Additionally,the REZ-ADT group demonstrated a prolonged delay in the deterioration of the total score on the FACT-P questionnaire(25th percentile,12.8[95%CI 7.4-20.3]vs.6.0 months[95%CI 4.6-9.2];HR 0.66[95%CI 0.50-0.86];p=0.002),as well as most of the FACT-P subscale scores,in comparison to the BIC-ADT group.In conclusion,REZ-ADT is superior to BIC-ADT regarding the pain alleviation and enhancement of functional scales for high-volume mHSPC.展开更多
A porous Me2-CA-BTP/SiO2-P adsorbent was prepared to separate MA（III） from Ln（III） in high level liquid waste （HLLW）. The adsorption behavior of Me2-CA-BTP/SiO2-P toward 241Am（III） and Ln（III） in 0.01 M HNO3...A porous Me2-CA-BTP/SiO2-P adsorbent was prepared to separate MA（III） from Ln（III） in high level liquid waste （HLLW）. The adsorption behavior of Me2-CA-BTP/SiO2-P toward 241Am（III） and Ln（III） in 0.01 M HNO3-NaNO3 solution was studied. Me2-CA-BTP/SiO2-P showed high adsorption and selectivity toward 241Am（III） over Ln（III） fission products with the separation factor （SF） reaching to 557, 2355, 1952, 1082, 214, 105, 86, 14 for Y, La, Ce, Nd, Sm, Eu, Gd and Dy respectively in 0.01 M HNO3-0.99 M NaNO3 solution. The adsorption kinetics of both Dy（III） and Eu（III） on Me2-CA-BTP/SiO2-P was studied and followed pseudo-second-order rate equation indicating chemical sorption as the rate-limiting step of the adsorption, and the adsorption isotherm of Dy（III） and Eu（III） matched better with the Langmuir isotherm than the Freundlich isotherm with the adsorption amount around 0.22 and 0.20 mmol/g respectively. Thermodynamic study revealed that the adsorption of both Dy（III） and Eu（III） on Me2-CA-BTP/SiO2-P was spontaneous and endothermic processes with a positive entropy at 298, 308, 313 K.展开更多
Prostate cancer(PC)is an epithelial malignancy occurring in the prostate.PC ranks second in incidence among all male malignancies globally by the latest statistics from the World Health Organization.Notably,China has ...Prostate cancer(PC)is an epithelial malignancy occurring in the prostate.PC ranks second in incidence among all male malignancies globally by the latest statistics from the World Health Organization.Notably,China has seen a more rapid increase in PC incidence compared to developed European and American nations.By 2022,the newly reported cases and deaths due to PC in China increased to 134,200 and 47,500,respectively.Thus,early diagnosis and stand-ardized treatment for prostate cancer in China remain far-reaching objectives.Burgeoning research on advanced PC and castration-resistant prostate cancer in recent years have paved the way for a new era of integrated treatment methods including novel endocrine drugs,chemotherapy,targeted therapy,and immunotherapy.Future therapies involve precision treatment guided by genetic testing and individualized integrated treatment as part of a multi-disciplinary integrated diagnosis and treatment model for PC.The Genitourinary Oncology Committee of theCACA guidelines for holistic integrative management of prostate cancer China Anti-Cancer Association(CACA-GU)has invited multidisciplinary experts across fields including surgery,oncology,pathology,radiology,herbal medicine,physiatry,and psychology to collaboratively write,discuss,and revise guide-lines on managing PC.The CACA Guidelines for Holistic Integrative Management of Prostate Cancer includes epide-miology,screening and diagnosis,treatment for localized PC,diagnosis and treatment of PC recurrence after radical prostatectomy,management of metastatic PC,traditional Chinese medicine diagnosis and treatment of PC,and reha-bilitation from PC.This guideline aims to standardize the clinical diagnosis and treatment management of PC in China.It is more aligned with China’s clinical practice,highlights Chinese characteristics,and bears significant clinical importance.展开更多
Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing not...Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical benefits.However,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of life.In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients.Additionally,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management.展开更多
With the initiation of the National Virtual Simulation Experimental Teaching Project in 2018,educational institutions in China have recognized the significance of virtual simulation technology in reforming traditional...With the initiation of the National Virtual Simulation Experimental Teaching Project in 2018,educational institutions in China have recognized the significance of virtual simulation technology in reforming traditional teaching methods and fostering innovative talent cultivation models.Within the realm of higher education in China,motivating students to sustain their utilization of Virtual Simulation Learning Systems(VSLSs)has become a significant challenge.This article builds upon an assessment of the development status of VSLSs in Chinese higher education and draws upon previous studies to construct a model comprising three dimensions:perceived quality,perceived value,and social influence,with the aim of predicting students’enduring willingness to engage with VSLSs.To achieve this objective,a structural modeling analysis approach is employed to explore the interrelationships among the constructs under investigation,while a survey questionnaire is utilized to collect relevant data.The sample population consists of 274 college students from diverse disciplinary fields in China,including Science,Technology,Engineering,and Mathematics(STEM)and Humanities,Arts,and Social Sciences(HASS).The findings reveal that perceived value significantly influences students’willingness to participate,with perceived benefits exerting a greater impact than perceived costs.Furthermore,the overall quality of the VSLSs,encompassing aspects such as software quality,instructional design quality,and virtual simulation quality,holds substantial influence over students’perceived value.Additionally,societal factors such as course scheduling and recommendations from teachers exhibit a positive impact on students’intention to continue using VSLSs.Building upon these findings,the article presents relevant recommendations aimed at enhancing students’sustained utilization of VSLSs.展开更多
文摘Objective： In the present study, we have examined the safety and efficacy of recombinant adenovirus encoding human p53 tumor suppressor gene （rAd-p53） injection in patients with advanced non-small-cell lung cancer （NSCLC） in the combination with the therapy of bronchial arterial infusion （BAI）. Methods： A total of 58 patients with advanced NSCLC were enrolled in a non-randomized, two-armed clinical trial. Of which, 19 received a combination treatment of BAI and rAd-p53 （the combo group）, while the remaining 39 were treated with only BAI （the control group）. Patients were followed up for 12 months, with safety and local response evaluated by the National Cancer lnstitute＇s Common Toxicity Criteria and response evaluation criteria in solid tumor （RECIST）, respectively. Time to progression （TTP） and survival rates were also analyzed by Kaplan-Meier method. Results In the combo group, 19 patients received a total of 49 injections ofrAd-p53 and 46 times of BAI, respectively, while 39 patients in the control group received a total of 113 times of BAI. The combination treatment was found to have less adverse events such as anorexia, nausea and emesis, pain, and leucopenia （P〈0.05） but more arthralgia, fever, influenza-like symptom, and myalgia （P〈0.05）, compared with the control group. The overall response rates （complete response （CR）＋partial response （PR）） were 47.3% and 38.4% for the combo group and the control group, respectively （P〉0.05）. Patients in the combo group had a longer TTP than those in the control group （a median 7.75 vs 5.5 months, P-0.018）. However, the combination treatment did not lead to better survival, with survival rates at 3, 6, and 12 months in the combo group being 94.74%, 89.47%, and 52.63%, respectively, com- pared with 92.31%, 69.23%, and 38.83% in the control group （P=0.224）. Conclusion： Our results show that the combination of rAd-p53 and BAI was well tolerated in patients with NSCLC and may have improved the quality of life and delayed the disease progression. A further study to better determine the efficacy of this combination therapy is warranted.
基金supported by the National Natural Science Foundation of China(Nos.11305102,91126006,and 21261140335)
文摘The extraction chromatography–electrodeposition(EC–ED) process was proposed for the quantitative recovery of palladium from high-level liquid waste(HLLW) in this study. The process coupled the extraction chromatography method to obtain the decontamination of Pd(II) from HLLW with the electrochemical method to recover metallic palladium from the concentrated solution.Separation of Pd(II) from a nitric acid medium by extraction chromatography using iso Bu-BTP/SiO_2-P adsorbent and the electrochemical behavior of Pd(II) in nitric acid solution in the presence of thiourea(TU) were investigated.iso Bu-BTP/SiO_2-P exhibited a high selectivity for Pd(II)over other fission products(FPs), and Pd(II) could be desorbed by TU from loaded BTP/SiO_2-P. The adsorbent performed good stability against HNO_3 because the adsorption performance kept Pd(II) after extended contact with HNO_3 solution. The column experiment achieved the separation of Pd(II) from simulated HLLW successfully.The electrochemical behavior of Pd(II) in palladium desorption solution containing TU and nitric acid was investigated at a platinum electrode by cyclic voltammetry. A weak reduction wave at-0.4 V was due to the reduction in Pd(II) to Pd(0), and the deposition process wasirreversible. In electrowinning experiments, a maximum of92% palladium could be obtained.
基金supported by the Research Project of Jiangsu Cancer Hospital(ZM202015).
文摘Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer(omHSPC).Methods The basic characteristics,treatment strategies and long-term follow-up of 181 patients with omHSPC were retrospectively analyzed.All patients were divided into cytoreductive surgery group and no local therapy group according to the administration of cytoreductive surgery before progression to metastatic castration-resistant prostate cancer(mCRPC).Subsequently,our study explored the effect of cytoreductive surgery on CRPC-free survival in omHSPC patients.Results A total of 181 patients were enrolled in the study,including 48 patients who received cytoreductive surgery and 133 patients who did not receive local therapy.No significant differences were detected between the two groups regarding prostate-specific antigen(PSA)at the initial diagnosis(P=0.194),the International Society of Urological Pathology(ISUP)grade group(P=0.158),the treatment options during omHSPC(P=0.090),common comorbidities(P=0.649)and the number of metastases(P=0.291).The proportions of patients with Tx stage(P=0.027)and Nx stage(P=0.027)in the no local therapy group were significantly higher than that in the cytoreductive group.After propensity score matching(PSM),it was found that cytoreductive surgery could significantly improve the CRPC-free survival of omHSPC patients(hazard ratio(HR)=0.537,95%confidence interval(CI)=0.317-0.909,P=0.016).Conclusion Cytoreductive surgery can significantly improve the CRPC-free survival of omHSPC patients.Additionally,large sample-size,prospective and randomized controlled studies are needed to validate the results of our study in the future.
文摘The randomized phase 3 CHART trial(NCT03520478)revealed that rezvilutamide(REZ)plus androgen deprivation therapy(ADT)in high-volume,metastatic,hormone-sensitive prostate cancer(mHSPC)significantly enhanced radiographic progression-free and overall survival than bicalutamide(BIC)-ADT.Accordingly,we examined patient-reported outcomes(PROs)results,which were exploratory endpoints in the CHART trial.The patients were randomly allocated to receive REZ-ADT or BIC-ADT in a 1:1 ratio.The PROs were evaluated with the Brief Pain Inventory-Short Form(BPI-SF)and the Functional Assessment of Cancer Therapy-Prostate(FACT-P)questionnaires.Both study groups displayed comparable baseline pain scores and functional status.Patients administered REZ-ADT had an extended time to progression of worst pain intensity in comparison to those treated with BIC-ADT(25th percentile,9.2[95%CI 7.4-16.6]vs.6.4 months[95%CI 5.5-8.3];HR 0.75[95%CI 0.57-0.97];p=0.026).Similarly,patients received REZ-ADT exhibited a delayed time to progression of pain interference in comparison to those receiving BIC-ADT(25th percentile,20.2[95%CI 12.9-31.3]vs.10.2 months[95%CI 7.4-11.1];HR 0.70[95%CI 0.52-0.93];p=0.015).Additionally,the REZ-ADT group demonstrated a prolonged delay in the deterioration of the total score on the FACT-P questionnaire(25th percentile,12.8[95%CI 7.4-20.3]vs.6.0 months[95%CI 4.6-9.2];HR 0.66[95%CI 0.50-0.86];p=0.002),as well as most of the FACT-P subscale scores,in comparison to the BIC-ADT group.In conclusion,REZ-ADT is superior to BIC-ADT regarding the pain alleviation and enhancement of functional scales for high-volume mHSPC.
基金supported by the National Natural Science of China(91126006,11305102)the Ministry of Education of Specialized Research Fund for the Doctoral Program of Higher Education (20130073110046)
文摘A porous Me2-CA-BTP/SiO2-P adsorbent was prepared to separate MA（III） from Ln（III） in high level liquid waste （HLLW）. The adsorption behavior of Me2-CA-BTP/SiO2-P toward 241Am（III） and Ln（III） in 0.01 M HNO3-NaNO3 solution was studied. Me2-CA-BTP/SiO2-P showed high adsorption and selectivity toward 241Am（III） over Ln（III） fission products with the separation factor （SF） reaching to 557, 2355, 1952, 1082, 214, 105, 86, 14 for Y, La, Ce, Nd, Sm, Eu, Gd and Dy respectively in 0.01 M HNO3-0.99 M NaNO3 solution. The adsorption kinetics of both Dy（III） and Eu（III） on Me2-CA-BTP/SiO2-P was studied and followed pseudo-second-order rate equation indicating chemical sorption as the rate-limiting step of the adsorption, and the adsorption isotherm of Dy（III） and Eu（III） matched better with the Langmuir isotherm than the Freundlich isotherm with the adsorption amount around 0.22 and 0.20 mmol/g respectively. Thermodynamic study revealed that the adsorption of both Dy（III） and Eu（III） on Me2-CA-BTP/SiO2-P was spontaneous and endothermic processes with a positive entropy at 298, 308, 313 K.
基金supported by China Anti-Cancer Association(CACA).
文摘Prostate cancer(PC)is an epithelial malignancy occurring in the prostate.PC ranks second in incidence among all male malignancies globally by the latest statistics from the World Health Organization.Notably,China has seen a more rapid increase in PC incidence compared to developed European and American nations.By 2022,the newly reported cases and deaths due to PC in China increased to 134,200 and 47,500,respectively.Thus,early diagnosis and stand-ardized treatment for prostate cancer in China remain far-reaching objectives.Burgeoning research on advanced PC and castration-resistant prostate cancer in recent years have paved the way for a new era of integrated treatment methods including novel endocrine drugs,chemotherapy,targeted therapy,and immunotherapy.Future therapies involve precision treatment guided by genetic testing and individualized integrated treatment as part of a multi-disciplinary integrated diagnosis and treatment model for PC.The Genitourinary Oncology Committee of theCACA guidelines for holistic integrative management of prostate cancer China Anti-Cancer Association(CACA-GU)has invited multidisciplinary experts across fields including surgery,oncology,pathology,radiology,herbal medicine,physiatry,and psychology to collaboratively write,discuss,and revise guide-lines on managing PC.The CACA Guidelines for Holistic Integrative Management of Prostate Cancer includes epide-miology,screening and diagnosis,treatment for localized PC,diagnosis and treatment of PC recurrence after radical prostatectomy,management of metastatic PC,traditional Chinese medicine diagnosis and treatment of PC,and reha-bilitation from PC.This guideline aims to standardize the clinical diagnosis and treatment management of PC in China.It is more aligned with China’s clinical practice,highlights Chinese characteristics,and bears significant clinical importance.
文摘Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical benefits.However,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of life.In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients.Additionally,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management.
基金the National Social Sciences Found of China’s Major Program“Research on Virtual Reality Media Narrative”(No.21&ZD326).
文摘With the initiation of the National Virtual Simulation Experimental Teaching Project in 2018,educational institutions in China have recognized the significance of virtual simulation technology in reforming traditional teaching methods and fostering innovative talent cultivation models.Within the realm of higher education in China,motivating students to sustain their utilization of Virtual Simulation Learning Systems(VSLSs)has become a significant challenge.This article builds upon an assessment of the development status of VSLSs in Chinese higher education and draws upon previous studies to construct a model comprising three dimensions:perceived quality,perceived value,and social influence,with the aim of predicting students’enduring willingness to engage with VSLSs.To achieve this objective,a structural modeling analysis approach is employed to explore the interrelationships among the constructs under investigation,while a survey questionnaire is utilized to collect relevant data.The sample population consists of 274 college students from diverse disciplinary fields in China,including Science,Technology,Engineering,and Mathematics(STEM)and Humanities,Arts,and Social Sciences(HASS).The findings reveal that perceived value significantly influences students’willingness to participate,with perceived benefits exerting a greater impact than perceived costs.Furthermore,the overall quality of the VSLSs,encompassing aspects such as software quality,instructional design quality,and virtual simulation quality,holds substantial influence over students’perceived value.Additionally,societal factors such as course scheduling and recommendations from teachers exhibit a positive impact on students’intention to continue using VSLSs.Building upon these findings,the article presents relevant recommendations aimed at enhancing students’sustained utilization of VSLSs.
