As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to pr...As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDLC)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesityassociated decline in cardiac systolic function among routine metabolic/inflammatory markers.展开更多
目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)患者新辅助治疗后行电视辅助胸腔镜手术(video-assisted thoracoscopic surgery,VATS)和开胸手术的围手术期疗效差异。方法回顾性收集2020年6月—2022年5月上海市肺科医院新辅...目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)患者新辅助治疗后行电视辅助胸腔镜手术(video-assisted thoracoscopic surgery,VATS)和开胸手术的围手术期疗效差异。方法回顾性收集2020年6月—2022年5月上海市肺科医院新辅助治疗后行VATS或开胸手术NSCLC患者的临床资料,比较两组围手术期结果。结果共纳入260例患者,其中184例(70.8%)行VATS,76例(29.2%)行开胸手术。经倾向性评分匹配后VATS组113例(62.4%),开胸组68例(37.6%)。VATS具有与开胸相似的淋巴结清扫能力与术后并发症发生率(P>0.05),优点是手术时间更短(146.00 min vs.165.00 min,P=0.006)、术中失血量更少(50.00 mL vs.100.00 mL,P<0.001)、术中输血率更低(0.0%vs.7.4%,P=0.003)、术后3 d引流量更少(250.00 mL vs.350.00 mL,P=0.011;180.00 mL vs.250.00 mL,P=0.002;150.00 mL vs.235.00 mL,P<0.001)、术后引流时间(9.34 d vs.13.84 d,P<0.001)和术后住院时间(6.19 d vs.7.94 d,P=0.006)更短。结论NSCLC新辅助治疗后行VATS手术安全性高于开胸手术,并且术后恢复更好。展开更多
基于模型诊断(MBD)方法在不同的环境中有越来越多的用途,包括软件故障定位、电子表格的调试、Web服务和硬件设计,以及生物系统的分析等.受这些不同用途的启发,近年来MBD算法改进成效显著.然而,对体系庞大、结构复杂的系统,需要对现有方...基于模型诊断(MBD)方法在不同的环境中有越来越多的用途,包括软件故障定位、电子表格的调试、Web服务和硬件设计,以及生物系统的分析等.受这些不同用途的启发,近年来MBD算法改进成效显著.然而,对体系庞大、结构复杂的系统,需要对现有方法进一步改进.由于求解诊断解在计算上具有挑战性,因此相继提出了一些通过压缩模型的MBD算法来提高诊断效率,如基于统治的多观测压缩模型(dominated-based compacted model with multiple observations,D-CMMO)算法.对于给定多个观测值且注入1个以上错误需要大量时间的诊断问题,提出了一个新的诊断模型CCM(cardinality-constrained compacted model)来解决.基于基数约束的压缩模型算法使用2种方法对求解过程进行优化:首先,利用系统观测的故障输出和故障组件数量之间的约束关系来限制目标解的范围;其次,通过对假设集采用单次入队方法,进而有效提升MaxSAT(maximum satisfiability)求解器的性能.此外,在ISCAS85和ITC99基准测试用例上的实验结果表明,与目前最新的MBD求解方法D-CMMO相比,上述2种优化方法有效缩小了MBD问题的求解范围,降低MaxSAT求解器搜索目标解的难度,进而能在更短的时间内返回一个诊断解.在平均状况下,CCM方法相比D-CMMO方法求解效率分别提升64.5%和92.8%.展开更多
Chitin is an abundant aminopolysaccharide found in insect pests and phytopathogenic microorganisms but absent in higher plants and vertebrates. It is crucial for mitigating threats posed by chitin-containing organisms...Chitin is an abundant aminopolysaccharide found in insect pests and phytopathogenic microorganisms but absent in higher plants and vertebrates. It is crucial for mitigating threats posed by chitin-containing organisms to human health, food safety, and agriculture. Therefore, targeting the chitin biosynthesisassociated bioprocess holds a promise for developing human-safe and eco-friendly antifungal agents or pesticides. Chitin biosynthesis requires chitin synthase and associated factors, which are involved in the modification, regulation, organization or turnover of chitin during its biosynthesis. A number of enzymes such as chitinases, hexosaminidases, chitin deacetylases are closely related and therefore are promising targets for designing novel agrochemicals that target at chitin biosynthesis. This review summarizes the advances in understanding chitin biology over the past decade by our research group and collaborates,specifically regarding essential proteins linked to chitin biosynthesis that can be exploited as promising pesticide targets. Examples of small bioactive molecules that against the activity of these targets are given.展开更多
Transparent materials utilized as underwater optical windows are highly vulnerable to various forms of pollution or abrasion due to their intrinsic hydrophilic properties.This susceptibility is particularly pronounced...Transparent materials utilized as underwater optical windows are highly vulnerable to various forms of pollution or abrasion due to their intrinsic hydrophilic properties.This susceptibility is particularly pronounced in underwater environments where pollutants can impede the operation of these optical devices,significantly degrading or even compromising their optical properties.The glass catfish,known for its remarkable transparency in water,maintains surface cleanliness and clarity despite exposure to contaminants,impurities abrasion,and hydraulic pressure.Inspired by the glass catfish’s natural attributes,this study introduces a new solution named subaquatic abrasion-resistant and anti-fouling window(SAAW).Utilizing femtosecond laser ablation and electrodeposition,the SAAW is engineered by embedding fine metal bone structures into a transparent substrate and anti-fouling sliding layer,akin to the sturdy bones among catfish’s body.This approach significantly bolsters the window’s abrasion resistance and anti-fouling performance while maintaining high light transmittance.The sliding layer on the SAAW’s surface remarkably reduces the friction of various liquids,which is the reason that SAAW owns the great anti-fouling property.The SAAW demonstrates outstanding optical clarity even after enduring hundreds of sandpaper abrasions,attributing to the fine metal bone structures bearing all external forces and protecting the sliding layer of SAAW.Furthermore,it exhibits exceptional resistance to biological adhesion and underwater pressure.In a green algae environment,the window remains clean with minimal change in transmittance over one month.Moreover,it retains its wettability and anti-fouling properties when subjected to a depth of 30 m of underwater pressure for 30 d.Hence,the SAAW prepared by femtosecond laser ablation and electrodeposition presents a promising strategy for developing stable optical windows in liquid environments.展开更多
BACKGROUND Fistula-in-ano is an abnormal tunnel formation linking the anal canal with the perineum and perianal skin.Multiple imagining methods are available to evaluate it,among which magnetic resonance imaging(MRI)i...BACKGROUND Fistula-in-ano is an abnormal tunnel formation linking the anal canal with the perineum and perianal skin.Multiple imagining methods are available to evaluate it,among which magnetic resonance imaging(MRI)is the most advanced nonin-vasive preoperative method.However,it is limited in its visualization function.AIM To investigate the use of intraluminal MRI for perianal fistulas via a novel direct MRI fistulography method.METHODS We mixed 3%hydrogen peroxide(HP)with gadolinium for HPMRI fistulogra-phy,retrospectively analyzing 60 cases of complex/recurrent fistula-in-ano using physical examination,trans-perineal ultrasonography(TPUS),low-spatial-reso-lution MRI,and high-resolution direct HPMRI fistulography.We assessed detec-tion rates of fistula tracks,internal openings,their relationship with anal sphinc-ters,and perianal abscesses using statistical analyses,including interobserver agreement(Kappa statistic),and compared results with intraoperative findings.RESULTS Surgical confirmation in 60 cases showed that high-resolution direct HPMRI fis-tulography provided superior detection rates for internal openings(153)and fistula tracks(162)compared to physical exams,TPUS,and low-spatial-resolution MRI(Z>5.7,P<0.05).The effectiveness of physical examination and TPUS was also inferior to that of our method for detecting perianal abscesses(54)(Z=6.773,3.694,P<0.05),whereas that of low-spatial-resolution MRI was not significantly different(Z=1.851,P=0.06).High-resolution direct HPMRI fistulography also achieved the highest interobserver agreement(Kappa:0.89,0.85,and 0.80),while low-spatial-resolution MRI showed moderate agreement(Kappa:0.78,0.74,and 0.69).TPUS and physical examination had lower agreement(Kappa range:0.33-0.63).CONCLUSION High-resolution direct HPMRI fistulography enhances the visualization of recurrent and complex fistula-in-ano,including branched fistulas,allowing for precise planning and improved surgical outcomes.展开更多
Credit risk assessment is a crucial task in bank risk management.By making lending decisions based on credit risk assessment results,banks can reduce the probability of non-performing loans.However,class imbalance in ...Credit risk assessment is a crucial task in bank risk management.By making lending decisions based on credit risk assessment results,banks can reduce the probability of non-performing loans.However,class imbalance in bank credit default datasets limits the predictive performance of traditional machine learning and deep learning models.To address this issue,this study employs the conditional variational autoencoder-Wasserstein generative adversarial network with gradient penalty(CVAE-WGAN-gp)model for oversampling,generating samples similar to the original default customer data to enhance model prediction performance.To evaluate the quality of the data generated by the CVAE-WGAN-gp model,we selected several bank loan datasets for experimentation.The experimental results demonstrate that using the CVAE-WGAN-gp model for oversampling can significantly improve the predictive performance in credit risk assessment problems.展开更多
Gastric cancer(GC)remains a major global health challenge,because of its poor prognosis and limited treatment options in advanced stages1,2.Recent advancements in immunotherapy,highlighted by the findings of the CHECK...Gastric cancer(GC)remains a major global health challenge,because of its poor prognosis and limited treatment options in advanced stages1,2.Recent advancements in immunotherapy,highlighted by the findings of the CHECKMATE-649,ORIENT-16,and KEYNOTE-859 trials,have markedly transformed the treatment paradigm for advanced gastric cancer(AGC)3-5.展开更多
Establishing power systems with a high share of renewable energy sources is a pivotal step toward achieving a globally sustainable transition to green and low-carbon energy.This study focuses on low-output wind power ...Establishing power systems with a high share of renewable energy sources is a pivotal step toward achieving a globally sustainable transition to green and low-carbon energy.This study focuses on low-output wind power that affects the generation capacity of power systems with a high share of renewable energy sources.Utilizing the Coupled Model Intercomparison Project Phase 6 datasets,a predictive model for low-output wind power was employed to investigate regional trends worldwide.The frequency and duration of low-output wind-power events exhibited increasing trends globally,particularly in East Asia and South America,but not in North America.By 2060,the annual total days with low-output wind power in East Asia and South America could rise to 13 and 5 d,and the maximum continuous duration of low-output wind power could reach 5 and 2 d,respectively.As wind power becomes a primary elec-tricity source,such low output could lead to shortages in energy supply within the power system,trig-gering large-scale power outages.This issue calls for critical attention when establishing power systems with a high share of renewable energy sources.The conclusions provide a basis for analyzing power supply risks and configuring flexible power sources for scenarios with a high share of renewable energy.展开更多
Introducing the inherent genetic diversity of wild species into cultivars has become one of the hot topics in crop genetic breeding and genetic resource research.Fiber-and seed-related traits,which are critical to the...Introducing the inherent genetic diversity of wild species into cultivars has become one of the hot topics in crop genetic breeding and genetic resource research.Fiber-and seed-related traits,which are critical to the global economy and people's livelihoods,are the principal focus of cotton breeding.Here,the wild cotton species Gossypium tomentosum was used to broaden the genetic basis of G.hirsutum and identify QTLs for fiber-and seed-related traits.A population of 559 chromosome segment substitution lines(CSSLs)was established with various chromosome segments from G.tomentosum in a G.hirsutum cultivar background.Totals of 72,89,and 76 QTLs were identified for three yield traits,five fiber quality traits,and six cottonseed nutrient quality traits,respectively.Favorable alleles of 104 QTLs were contributed by G.tomentosum.Sixty-four QTLs were identified in two or more environments,and candidate genes for three of them were further identified.The results of this study contribute to further studies on the genetic basis of the morphogenesis of these economic traits,and indicate the great breeding potential of G.tomentosum for improving the fiber-and seed-related traits in G.hirsutum.展开更多
It is fundamental and useful to investigate how deep learning forecasting models(DLMs)perform compared to operational oceanography forecast systems(OFSs).However,few studies have intercompared their performances using...It is fundamental and useful to investigate how deep learning forecasting models(DLMs)perform compared to operational oceanography forecast systems(OFSs).However,few studies have intercompared their performances using an identical reference.In this study,three physically reasonable DLMs are implemented for the forecasting of the sea surface temperature(SST),sea level anomaly(SLA),and sea surface velocity in the South China Sea.The DLMs are validated against both the testing dataset and the“OceanPredict”Class 4 dataset.Results show that the DLMs'RMSEs against the latter increase by 44%,245%,302%,and 109%for SST,SLA,current speed,and direction,respectively,compared to those against the former.Therefore,different references have significant influences on the validation,and it is necessary to use an identical and independent reference to intercompare the DLMs and OFSs.Against the Class 4 dataset,the DLMs present significantly better performance for SLA than the OFSs,and slightly better performances for other variables.The error patterns of the DLMs and OFSs show a high degree of similarity,which is reasonable from the viewpoint of predictability,facilitating further applications of the DLMs.For extreme events,the DLMs and OFSs both present large but similar forecast errors for SLA and current speed,while the DLMs are likely to give larger errors for SST and current direction.This study provides an evaluation of the forecast skills of commonly used DLMs and provides an example to objectively intercompare different DLMs.展开更多
Microcystin-LR(MC-LR)is a highly toxic category of biotoxins that can damage eye development and retinal structure in zebrafish,while probiotics can largely benefit the function of the retina.Although they both act on...Microcystin-LR(MC-LR)is a highly toxic category of biotoxins that can damage eye development and retinal structure in zebrafish,while probiotics can largely benefit the function of the retina.Although they both act on the visual system,whether probiotics can alleviate the visual damage caused by MC-LR in fish and the underlying mechanisms remains unclear.In this study,we exposed adult zebrafish for 28 days at MC-LR concentrations of 0,2.20,and 22.00μg/L with or without the probiotic Lactobacillus rhamnosus in the diet.MC-LR exposure alone resulted in structural damage to the retina and abnormal phototropic behavior,whereas L.rhamnosus could alleviate these damages.Biochemical analyses showed thatMCLR-induced abnormalities in apoptosis of ocular cells,retinal inflammatory responses,neurotransmission,and phototransduction were restored in the L.rhamnosus treatment group,indicating L.rhamnosus alleviated MC-LR-induced defects in the visual system and dysfunctions.This study underlines the defensive role of probiotics in protecting the host from environmental pollutants,which may provide guidance for the application of probiotics in aquaculture.展开更多
Diaphragma juglandis(D.juglandis)Fructus is a brownish lamellar structure located between walnut kernels.As a traditional Chinese herbal medicine,it exhibits therapeutic effects including spleen-strengthening,kidney c...Diaphragma juglandis(D.juglandis)Fructus is a brownish lamellar structure located between walnut kernels.As a traditional Chinese herbal medicine,it exhibits therapeutic effects including spleen-strengthening,kidney consolidation,astringency,diuresis,and heat-clearing.In this study,the polyphenolic constituents of D.juglandis and its functional instant tea were investigated in this study.Three polyphenolic compounds were isolated from 70%ethanol extract of D.juglandis Fructus as 2-methoxy juglone,regiolone and quercetin.The HPLC method was established for determination of the content of quercetin in the instant tea samples under the premise that the methodology was verifi ed to meet the standard requirements.The preparation process of D.juglandis Fructus instant tea was optimized through single factor experiments and Box-Behnken design-response surface methodology and the optimal conditions were determined as follows:feed rate of 10 mL/min,inlet temperature of 151℃,andβ-cyclodextrin addition of 9%.Then the antioxidant activity of each sample was evaluated using DPPH and ABTS radical scavenging assays.The results showed that the quercetin had significant antioxidant activity.The instant tea group demonstrated superior antioxidant effects compared to the extracts group at 50,200,and 800μg/mL(P<0.001),likely due to the optimized spray-drying process,which might have enhanced the solubility,stability,and bioavailability of the active compounds.The results provided critical foundational data for the deep processing and comprehensive utilization of D.juglandis Fructus.展开更多
Chitin is an abundant natural biopolymer that plays a crucial role in insect growth and development as a fundamental structural component of the exoskeleton.The membrane-integralβ-glycosyltransferase,chitin synthase,...Chitin is an abundant natural biopolymer that plays a crucial role in insect growth and development as a fundamental structural component of the exoskeleton.The membrane-integralβ-glycosyltransferase,chitin synthase,has been identified as the central component in chitin biosynthesis.However,the precise roles of other proteins in facilitating chitin synthase in chitin biosynthesis remain unclear.In this study,we employed split-ubiquitin membrane yeast two-hybrid(MYTH)and pull-down assays to demonstrate the physical interaction between Twinstar(Tsr),a small molecular protein in the actin-depolymerizing factor ADF/Cofilin protein family,and chitin synthase Krotzkopf verkehrt(Kkv)in Drosophila melanogaster in vitro.The RNA interference(RNAi)-mediated global knockdown of Tsr in D.melanogaster resulted in larval lethality.Furthermore,targeted suppression of Tsr in the tracheal and epidermal tissues also led to larval mortality,while knocking down Tsr in the wing tissues led to wrinkled wings.Additionally,silencing Tsr not only reduced the chitin content in the first longitudinal vein of the wings but also led to the absence of the chitin lamellar structure.To validate the functional conservation of Tsr in other insect orders,the two agricultural pests Ostrinia furnacalis and Tribolium castaneum,representing lepidoptera and coleoptera insects,respectively,were investigated.Knockdown experiments targeting the Drosophila Tsr orthologues OfTsr in O.furnacalis and TcTsr in T.castaneum produced abnormal larvae during molting or pupation in O.furnacalis and lethality in T.castaneum.Our findings not only improve ourknowledge of the chitin biosynthesis machinery in insect cuticles but also provide new potential targets for the control of major agricultural pests.展开更多
Purpose–This study solves the key problem that the static level monitoring is susceptible to temperature interference and affects the accuracy in slope instability/deformation monitoring.The purpose is to develop a r...Purpose–This study solves the key problem that the static level monitoring is susceptible to temperature interference and affects the accuracy in slope instability/deformation monitoring.The purpose is to develop a reliable temperature compensation method for the system,improve the accuracy of slope stability monitoring and provide support for improving the safety and safety monitoring of engineering spoil slope and other projects.Design/methodology/approach–Combined with theoretical analysis and experimental verification,the temperature compensation method is explored.The working principle of the hydrostatic leveling monitoring system is analyzed and the data processing formula,the temperature error calculation formula and the calculation formula for eliminating the error settlement value are derived.The temperature compensation method is established and verified by the field test of the engineering spoil slope which is disturbed by a debris flow.Findings–The experimental results show that this method can reduce the error of the static level monitoring system by about 40%.The field test shows that the fluctuation of slope settlement monitoring value is reduced after temperature compensation and the monitoring value is consistent with the actual situation,which has certain practicability.Originality/value–The originality of this study is to derive a theoretical formula for quantifying/eliminating temperature errors in static leveling and to establish a practical temperature compensation method.The accuracy of the system is improved,which provides a reference for slope stability monitoring under complex environment(especially railway geotechnical engineering)and promotes the development of precision monitoring technology.展开更多
Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the ra...Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame reconstruction.Here,a high-frequency enhanced compressed active photography(H-CAP)is proposed.By uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling mode.This sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image enhanced.The superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,respectively.We applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames.展开更多
This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanis...This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.展开更多
High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human...High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human-machine interactions.However,despite the recent advances,the development of three-dimensional(3D)soft electronics with both high resolution and high integration is still challenging because of the lack of efficient manufacturing methods to guarantee interlayer alignment of the high-density vias and reliable interlayer electrical conductivity.Here,an advanced 3D laser printing pathway,based on femtosecond laser direct writing(FLDW),is demonstrated for preparing liquid metal(LM)-based any layer HDI soft electronics.FLDW technology,with the characteristics of high spatial resolution and high precision,allows the maskless fabrication of high-resolution embedded LM microchannels and high-density vertical interconnect accesses for 3D integrated circuits.High-aspect-ratio blind/through LM microstructures are formed inside the elastomer due to the supermetalphobicity induced during laser ablation.The LM-based HDI circuit featuring high resolution(~1.5μm)and high integration(10-layer electrical interconnection)is achieved for customized soft electronics,including various customized multilayer passive electric components,soft multilayer circuit,and cross-scale multimode sensors.The 3D laser printing method provides a versatile approach for developing chip-level soft electronics.展开更多
The organic matter inmunicipal wastewater can be recovered by anaerobic biological treatment,making further resource utilization of municipal wastewater,which meets the requirements of sustainable development.An upflo...The organic matter inmunicipal wastewater can be recovered by anaerobic biological treatment,making further resource utilization of municipal wastewater,which meets the requirements of sustainable development.An upflow anaerobic biofilter(UAF)treating municipal wastewater was established.The performances of stable operation and recovery operation of UAF after long-term starvation(234 days)and the changes of microbial community structure were researched.By gradually reducing HRT from 10 h to 4 h,the UAF achieved the treatment performance of pre-starvation after only 50 days recovery operation,in which total COD and soluble COD removal efficiencies reached 66%and 69%,respectively,and the CH_(4) production rate was 0.21 L CH_(4)/g CODremoval.The recovery performance of UAF after long term starvation showed that the recovery sequence of three main anaerobic processes was hydrolytic acidification,hydrogen-acetate production and methanogenesis.High-throughput sequencing results indicated that dominant bacteria associated with hydrolytic acidification process changed from Moduliflexaceae and Trichococcus in stable operation stage to Trichococcus and Romboutsia in recovery stage.Besides,the dominant archaea changed from Methanosaeta(hydrotrophic methanogens)to Methanobacterium(acetotrophic methanogens),showing Methanobacterium was more resistant to starvation environment.Therefore,by using UAF for biological treatment of organic matter,even after a long period of starvation,the system would not be completely destroyed.Once it resumed operation,the treatment performance could be restored in a short period of time.展开更多
Hard scales in scaly fish species ensure the structural and functional integrity of the inner skin and body,even when subjected to various types of external forces.Mucus and oil secreted from the inner layer of the fi...Hard scales in scaly fish species ensure the structural and functional integrity of the inner skin and body,even when subjected to various types of external forces.Mucus and oil secreted from the inner layer of the fish skin to the surface exhibit resistance to a wide range of liquids,maintaining the antifouling properties of the fish skin surface.Inspired by these biological structures,ultra-sturdy and durable scale-armored-sliding surfaces(SASSs)were fabricated in this study using femtosecond laser electrodeposition(FED).In the FED method,a scaly structure is grown from the substrate across a sliding layer to form an SASS.The unique scale-armored structure offers protection against impact and abrasion while maintaining the performance and integrity of the structure.The mechanical sturdiness of the SASS improved by four orders of magnitude compared to that of the conventional antifouling surface.In addition,the SASS exhibited remarkable chemical durability,excellent hydraulic pressure resistance,liquid repellency,and good corrosion resistance based on characterization using various methods.FED enables the preparation of SASS on several materials,including Cu and Al and more.SASS fabricated using FED has great potential for the application of antifouling surfaces in extremely harsh environments.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82430018 to Q.C.,82270361 and 82570402 to H.Z.)the Nanjing Medical University Undergraduate Innovation and Entrepreneurship Training Program Fund(Grant No.202410312138Y to C.Z.)the Basic Sciences of Jiangsu Higher Education Institutions(Grant No.22KJA310002 to H.Z.)。
文摘As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDLC)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesityassociated decline in cardiac systolic function among routine metabolic/inflammatory markers.
文摘目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)患者新辅助治疗后行电视辅助胸腔镜手术(video-assisted thoracoscopic surgery,VATS)和开胸手术的围手术期疗效差异。方法回顾性收集2020年6月—2022年5月上海市肺科医院新辅助治疗后行VATS或开胸手术NSCLC患者的临床资料,比较两组围手术期结果。结果共纳入260例患者,其中184例(70.8%)行VATS,76例(29.2%)行开胸手术。经倾向性评分匹配后VATS组113例(62.4%),开胸组68例(37.6%)。VATS具有与开胸相似的淋巴结清扫能力与术后并发症发生率(P>0.05),优点是手术时间更短(146.00 min vs.165.00 min,P=0.006)、术中失血量更少(50.00 mL vs.100.00 mL,P<0.001)、术中输血率更低(0.0%vs.7.4%,P=0.003)、术后3 d引流量更少(250.00 mL vs.350.00 mL,P=0.011;180.00 mL vs.250.00 mL,P=0.002;150.00 mL vs.235.00 mL,P<0.001)、术后引流时间(9.34 d vs.13.84 d,P<0.001)和术后住院时间(6.19 d vs.7.94 d,P=0.006)更短。结论NSCLC新辅助治疗后行VATS手术安全性高于开胸手术,并且术后恢复更好。
文摘基于模型诊断(MBD)方法在不同的环境中有越来越多的用途,包括软件故障定位、电子表格的调试、Web服务和硬件设计,以及生物系统的分析等.受这些不同用途的启发,近年来MBD算法改进成效显著.然而,对体系庞大、结构复杂的系统,需要对现有方法进一步改进.由于求解诊断解在计算上具有挑战性,因此相继提出了一些通过压缩模型的MBD算法来提高诊断效率,如基于统治的多观测压缩模型(dominated-based compacted model with multiple observations,D-CMMO)算法.对于给定多个观测值且注入1个以上错误需要大量时间的诊断问题,提出了一个新的诊断模型CCM(cardinality-constrained compacted model)来解决.基于基数约束的压缩模型算法使用2种方法对求解过程进行优化:首先,利用系统观测的故障输出和故障组件数量之间的约束关系来限制目标解的范围;其次,通过对假设集采用单次入队方法,进而有效提升MaxSAT(maximum satisfiability)求解器的性能.此外,在ISCAS85和ITC99基准测试用例上的实验结果表明,与目前最新的MBD求解方法D-CMMO相比,上述2种优化方法有效缩小了MBD问题的求解范围,降低MaxSAT求解器搜索目标解的难度,进而能在更短的时间内返回一个诊断解.在平均状况下,CCM方法相比D-CMMO方法求解效率分别提升64.5%和92.8%.
基金supported by the National Key Research and Development Program of China (No. 2022YFD1700200)the National Natural Science Foundation of China (Nos. 32161133010, 3230170969)+1 种基金the Innovation Program of Chinese Academy of Agricultural Sciences, the Shenzhen Science and Technology Program (No. KQTD20180411143628272)the Special Funds for Science Technology Innovation and Industrial Development of Shenzhen Dapeng New District (No. PT202101–02)。
文摘Chitin is an abundant aminopolysaccharide found in insect pests and phytopathogenic microorganisms but absent in higher plants and vertebrates. It is crucial for mitigating threats posed by chitin-containing organisms to human health, food safety, and agriculture. Therefore, targeting the chitin biosynthesisassociated bioprocess holds a promise for developing human-safe and eco-friendly antifungal agents or pesticides. Chitin biosynthesis requires chitin synthase and associated factors, which are involved in the modification, regulation, organization or turnover of chitin during its biosynthesis. A number of enzymes such as chitinases, hexosaminidases, chitin deacetylases are closely related and therefore are promising targets for designing novel agrochemicals that target at chitin biosynthesis. This review summarizes the advances in understanding chitin biology over the past decade by our research group and collaborates,specifically regarding essential proteins linked to chitin biosynthesis that can be exploited as promising pesticide targets. Examples of small bioactive molecules that against the activity of these targets are given.
基金supported by the National Science Foundation of China under Grant Nos(Nos.12127806,62175195)the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies。
文摘Transparent materials utilized as underwater optical windows are highly vulnerable to various forms of pollution or abrasion due to their intrinsic hydrophilic properties.This susceptibility is particularly pronounced in underwater environments where pollutants can impede the operation of these optical devices,significantly degrading or even compromising their optical properties.The glass catfish,known for its remarkable transparency in water,maintains surface cleanliness and clarity despite exposure to contaminants,impurities abrasion,and hydraulic pressure.Inspired by the glass catfish’s natural attributes,this study introduces a new solution named subaquatic abrasion-resistant and anti-fouling window(SAAW).Utilizing femtosecond laser ablation and electrodeposition,the SAAW is engineered by embedding fine metal bone structures into a transparent substrate and anti-fouling sliding layer,akin to the sturdy bones among catfish’s body.This approach significantly bolsters the window’s abrasion resistance and anti-fouling performance while maintaining high light transmittance.The sliding layer on the SAAW’s surface remarkably reduces the friction of various liquids,which is the reason that SAAW owns the great anti-fouling property.The SAAW demonstrates outstanding optical clarity even after enduring hundreds of sandpaper abrasions,attributing to the fine metal bone structures bearing all external forces and protecting the sliding layer of SAAW.Furthermore,it exhibits exceptional resistance to biological adhesion and underwater pressure.In a green algae environment,the window remains clean with minimal change in transmittance over one month.Moreover,it retains its wettability and anti-fouling properties when subjected to a depth of 30 m of underwater pressure for 30 d.Hence,the SAAW prepared by femtosecond laser ablation and electrodeposition presents a promising strategy for developing stable optical windows in liquid environments.
基金Supported by Bozhou Key Research and Development Project,No.bzzc2020031.
文摘BACKGROUND Fistula-in-ano is an abnormal tunnel formation linking the anal canal with the perineum and perianal skin.Multiple imagining methods are available to evaluate it,among which magnetic resonance imaging(MRI)is the most advanced nonin-vasive preoperative method.However,it is limited in its visualization function.AIM To investigate the use of intraluminal MRI for perianal fistulas via a novel direct MRI fistulography method.METHODS We mixed 3%hydrogen peroxide(HP)with gadolinium for HPMRI fistulogra-phy,retrospectively analyzing 60 cases of complex/recurrent fistula-in-ano using physical examination,trans-perineal ultrasonography(TPUS),low-spatial-reso-lution MRI,and high-resolution direct HPMRI fistulography.We assessed detec-tion rates of fistula tracks,internal openings,their relationship with anal sphinc-ters,and perianal abscesses using statistical analyses,including interobserver agreement(Kappa statistic),and compared results with intraoperative findings.RESULTS Surgical confirmation in 60 cases showed that high-resolution direct HPMRI fis-tulography provided superior detection rates for internal openings(153)and fistula tracks(162)compared to physical exams,TPUS,and low-spatial-resolution MRI(Z>5.7,P<0.05).The effectiveness of physical examination and TPUS was also inferior to that of our method for detecting perianal abscesses(54)(Z=6.773,3.694,P<0.05),whereas that of low-spatial-resolution MRI was not significantly different(Z=1.851,P=0.06).High-resolution direct HPMRI fistulography also achieved the highest interobserver agreement(Kappa:0.89,0.85,and 0.80),while low-spatial-resolution MRI showed moderate agreement(Kappa:0.78,0.74,and 0.69).TPUS and physical examination had lower agreement(Kappa range:0.33-0.63).CONCLUSION High-resolution direct HPMRI fistulography enhances the visualization of recurrent and complex fistula-in-ano,including branched fistulas,allowing for precise planning and improved surgical outcomes.
基金supported by National Key R&D Program of China(2022YFA1008000)the National Natural Science Foundation of China(12571297,12101585)+1 种基金the CAS Talent Introduction Program(Category B)the Young Elite Scientist Sponsorship Program by CAST(YESS20220125).
文摘Credit risk assessment is a crucial task in bank risk management.By making lending decisions based on credit risk assessment results,banks can reduce the probability of non-performing loans.However,class imbalance in bank credit default datasets limits the predictive performance of traditional machine learning and deep learning models.To address this issue,this study employs the conditional variational autoencoder-Wasserstein generative adversarial network with gradient penalty(CVAE-WGAN-gp)model for oversampling,generating samples similar to the original default customer data to enhance model prediction performance.To evaluate the quality of the data generated by the CVAE-WGAN-gp model,we selected several bank loan datasets for experimentation.The experimental results demonstrate that using the CVAE-WGAN-gp model for oversampling can significantly improve the predictive performance in credit risk assessment problems.
基金supported by The National Key Research and Development Program of China(Grant no.2021YFA0910100)Healthy Zhejiang One Million People Cohort(Grant no.K-20230085)+5 种基金Post-doctoral Innovative Talent Support Program(Grant no.BX2023375)Lingyan Project of Zhejiang Provincial Department of Science and Technology(Grant no.2025C02059)the National Natural Science Foundation of China(Grant nos.82304946,82473489,and 82403546)Natural Science Foundation of Zhejiang Province(Grant nos.LR21H280001,LGF22H160056,ZCLQN25H1602,and LMS25H160006)Medicine and Health Science Fund of Zhejiang Province Health Commission(Grant nos.2025KY047 and 2022KY658)Traditional Chinese Medicine Science and Technology Project of Zhejiang Provincial Health Commission(Grant no.2022ZA023).
文摘Gastric cancer(GC)remains a major global health challenge,because of its poor prognosis and limited treatment options in advanced stages1,2.Recent advancements in immunotherapy,highlighted by the findings of the CHECKMATE-649,ORIENT-16,and KEYNOTE-859 trials,have markedly transformed the treatment paradigm for advanced gastric cancer(AGC)3-5.
基金supported by the Joint Research Fund in Smart Grid(U1966601)under cooperative agreement between the National Natural Science Foundation of China(NSFC)and the State Grid Cor-poration of China(SGCC).
文摘Establishing power systems with a high share of renewable energy sources is a pivotal step toward achieving a globally sustainable transition to green and low-carbon energy.This study focuses on low-output wind power that affects the generation capacity of power systems with a high share of renewable energy sources.Utilizing the Coupled Model Intercomparison Project Phase 6 datasets,a predictive model for low-output wind power was employed to investigate regional trends worldwide.The frequency and duration of low-output wind-power events exhibited increasing trends globally,particularly in East Asia and South America,but not in North America.By 2060,the annual total days with low-output wind power in East Asia and South America could rise to 13 and 5 d,and the maximum continuous duration of low-output wind power could reach 5 and 2 d,respectively.As wind power becomes a primary elec-tricity source,such low output could lead to shortages in energy supply within the power system,trig-gering large-scale power outages.This issue calls for critical attention when establishing power systems with a high share of renewable energy sources.The conclusions provide a basis for analyzing power supply risks and configuring flexible power sources for scenarios with a high share of renewable energy.
基金supported by the National Natural Science Foundation of China(32172064)。
文摘Introducing the inherent genetic diversity of wild species into cultivars has become one of the hot topics in crop genetic breeding and genetic resource research.Fiber-and seed-related traits,which are critical to the global economy and people's livelihoods,are the principal focus of cotton breeding.Here,the wild cotton species Gossypium tomentosum was used to broaden the genetic basis of G.hirsutum and identify QTLs for fiber-and seed-related traits.A population of 559 chromosome segment substitution lines(CSSLs)was established with various chromosome segments from G.tomentosum in a G.hirsutum cultivar background.Totals of 72,89,and 76 QTLs were identified for three yield traits,five fiber quality traits,and six cottonseed nutrient quality traits,respectively.Favorable alleles of 104 QTLs were contributed by G.tomentosum.Sixty-four QTLs were identified in two or more environments,and candidate genes for three of them were further identified.The results of this study contribute to further studies on the genetic basis of the morphogenesis of these economic traits,and indicate the great breeding potential of G.tomentosum for improving the fiber-and seed-related traits in G.hirsutum.
基金supported by the National Natural Science Foundation of China(Grant Nos.42375062 and 42275158)the National Key Scientific and Technological Infrastructure project“Earth System Science Numerical Simulator Facility”(EarthLab)the Natural Science Foundation of Gansu Province(Grant No.22JR5RF1080)。
文摘It is fundamental and useful to investigate how deep learning forecasting models(DLMs)perform compared to operational oceanography forecast systems(OFSs).However,few studies have intercompared their performances using an identical reference.In this study,three physically reasonable DLMs are implemented for the forecasting of the sea surface temperature(SST),sea level anomaly(SLA),and sea surface velocity in the South China Sea.The DLMs are validated against both the testing dataset and the“OceanPredict”Class 4 dataset.Results show that the DLMs'RMSEs against the latter increase by 44%,245%,302%,and 109%for SST,SLA,current speed,and direction,respectively,compared to those against the former.Therefore,different references have significant influences on the validation,and it is necessary to use an identical and independent reference to intercompare the DLMs and OFSs.Against the Class 4 dataset,the DLMs present significantly better performance for SLA than the OFSs,and slightly better performances for other variables.The error patterns of the DLMs and OFSs show a high degree of similarity,which is reasonable from the viewpoint of predictability,facilitating further applications of the DLMs.For extreme events,the DLMs and OFSs both present large but similar forecast errors for SLA and current speed,while the DLMs are likely to give larger errors for SST and current direction.This study provides an evaluation of the forecast skills of commonly used DLMs and provides an example to objectively intercompare different DLMs.
基金supported by the National Key Research and Development Program of China(No.2023YFD2400900)the National Natural Science Foundation of China(Nos.32171619 and 32201388)+2 种基金the Youth project of the Natural Science Foundation of Hubei Province(No.2021CFB243)Hubei Province Excellent Young and Middle aged Science and Technology Innovation Team Project(No.T2022028)the Youth Talent Project of Science and Technology Research Program of Hubei Provincial Department of Education(No.Q20212503)。
文摘Microcystin-LR(MC-LR)is a highly toxic category of biotoxins that can damage eye development and retinal structure in zebrafish,while probiotics can largely benefit the function of the retina.Although they both act on the visual system,whether probiotics can alleviate the visual damage caused by MC-LR in fish and the underlying mechanisms remains unclear.In this study,we exposed adult zebrafish for 28 days at MC-LR concentrations of 0,2.20,and 22.00μg/L with or without the probiotic Lactobacillus rhamnosus in the diet.MC-LR exposure alone resulted in structural damage to the retina and abnormal phototropic behavior,whereas L.rhamnosus could alleviate these damages.Biochemical analyses showed thatMCLR-induced abnormalities in apoptosis of ocular cells,retinal inflammatory responses,neurotransmission,and phototransduction were restored in the L.rhamnosus treatment group,indicating L.rhamnosus alleviated MC-LR-induced defects in the visual system and dysfunctions.This study underlines the defensive role of probiotics in protecting the host from environmental pollutants,which may provide guidance for the application of probiotics in aquaculture.
文摘Diaphragma juglandis(D.juglandis)Fructus is a brownish lamellar structure located between walnut kernels.As a traditional Chinese herbal medicine,it exhibits therapeutic effects including spleen-strengthening,kidney consolidation,astringency,diuresis,and heat-clearing.In this study,the polyphenolic constituents of D.juglandis and its functional instant tea were investigated in this study.Three polyphenolic compounds were isolated from 70%ethanol extract of D.juglandis Fructus as 2-methoxy juglone,regiolone and quercetin.The HPLC method was established for determination of the content of quercetin in the instant tea samples under the premise that the methodology was verifi ed to meet the standard requirements.The preparation process of D.juglandis Fructus instant tea was optimized through single factor experiments and Box-Behnken design-response surface methodology and the optimal conditions were determined as follows:feed rate of 10 mL/min,inlet temperature of 151℃,andβ-cyclodextrin addition of 9%.Then the antioxidant activity of each sample was evaluated using DPPH and ABTS radical scavenging assays.The results showed that the quercetin had significant antioxidant activity.The instant tea group demonstrated superior antioxidant effects compared to the extracts group at 50,200,and 800μg/mL(P<0.001),likely due to the optimized spray-drying process,which might have enhanced the solubility,stability,and bioavailability of the active compounds.The results provided critical foundational data for the deep processing and comprehensive utilization of D.juglandis Fructus.
基金supported by the National Natural Science Foundation of China(32161133010)the National Key Research and Development Program of China(2022YFD1700200)+2 种基金the Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-CSCB-202302)the Shenzhen Science and Technology Program,China(KQTD20180411143628272)the Special Funds for Science Technology Innovation and Industrial Development of Shenzhen Dapeng New District,China(PT202101-02).
文摘Chitin is an abundant natural biopolymer that plays a crucial role in insect growth and development as a fundamental structural component of the exoskeleton.The membrane-integralβ-glycosyltransferase,chitin synthase,has been identified as the central component in chitin biosynthesis.However,the precise roles of other proteins in facilitating chitin synthase in chitin biosynthesis remain unclear.In this study,we employed split-ubiquitin membrane yeast two-hybrid(MYTH)and pull-down assays to demonstrate the physical interaction between Twinstar(Tsr),a small molecular protein in the actin-depolymerizing factor ADF/Cofilin protein family,and chitin synthase Krotzkopf verkehrt(Kkv)in Drosophila melanogaster in vitro.The RNA interference(RNAi)-mediated global knockdown of Tsr in D.melanogaster resulted in larval lethality.Furthermore,targeted suppression of Tsr in the tracheal and epidermal tissues also led to larval mortality,while knocking down Tsr in the wing tissues led to wrinkled wings.Additionally,silencing Tsr not only reduced the chitin content in the first longitudinal vein of the wings but also led to the absence of the chitin lamellar structure.To validate the functional conservation of Tsr in other insect orders,the two agricultural pests Ostrinia furnacalis and Tribolium castaneum,representing lepidoptera and coleoptera insects,respectively,were investigated.Knockdown experiments targeting the Drosophila Tsr orthologues OfTsr in O.furnacalis and TcTsr in T.castaneum produced abnormal larvae during molting or pupation in O.furnacalis and lethality in T.castaneum.Our findings not only improve ourknowledge of the chitin biosynthesis machinery in insect cuticles but also provide new potential targets for the control of major agricultural pests.
基金funded by the Scientific Research Project of China Academy of Railway Sciences Group Co.,Ltd(No.2024YJ332 and No.2024QT005)Scientific Research Special Project of China State Railway Group Co.,Ltd(No.TICSTR-2024-Ⅳ-007).
文摘Purpose–This study solves the key problem that the static level monitoring is susceptible to temperature interference and affects the accuracy in slope instability/deformation monitoring.The purpose is to develop a reliable temperature compensation method for the system,improve the accuracy of slope stability monitoring and provide support for improving the safety and safety monitoring of engineering spoil slope and other projects.Design/methodology/approach–Combined with theoretical analysis and experimental verification,the temperature compensation method is explored.The working principle of the hydrostatic leveling monitoring system is analyzed and the data processing formula,the temperature error calculation formula and the calculation formula for eliminating the error settlement value are derived.The temperature compensation method is established and verified by the field test of the engineering spoil slope which is disturbed by a debris flow.Findings–The experimental results show that this method can reduce the error of the static level monitoring system by about 40%.The field test shows that the fluctuation of slope settlement monitoring value is reduced after temperature compensation and the monitoring value is consistent with the actual situation,which has certain practicability.Originality/value–The originality of this study is to derive a theoretical formula for quantifying/eliminating temperature errors in static leveling and to establish a practical temperature compensation method.The accuracy of the system is improved,which provides a reference for slope stability monitoring under complex environment(especially railway geotechnical engineering)and promotes the development of precision monitoring technology.
基金supported by the National Science Foundation of China(No.12127806,No.62175195 and No.12304382)the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies.
文摘Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame reconstruction.Here,a high-frequency enhanced compressed active photography(H-CAP)is proposed.By uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling mode.This sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image enhanced.The superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,respectively.We applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames.
基金supported by the National Natural Science Foundation under Grant 62273189the Shandong Province Natural Science Foundation under Grant ZR2021MF005Systems Science Plus Joint Research Program of Qingdao University under Grant XT2024201 of China supporting this research work.
文摘This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.
基金supported by the National Science Foundation of China under the Grant Nos.12127806 and 62175195the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies。
文摘High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human-machine interactions.However,despite the recent advances,the development of three-dimensional(3D)soft electronics with both high resolution and high integration is still challenging because of the lack of efficient manufacturing methods to guarantee interlayer alignment of the high-density vias and reliable interlayer electrical conductivity.Here,an advanced 3D laser printing pathway,based on femtosecond laser direct writing(FLDW),is demonstrated for preparing liquid metal(LM)-based any layer HDI soft electronics.FLDW technology,with the characteristics of high spatial resolution and high precision,allows the maskless fabrication of high-resolution embedded LM microchannels and high-density vertical interconnect accesses for 3D integrated circuits.High-aspect-ratio blind/through LM microstructures are formed inside the elastomer due to the supermetalphobicity induced during laser ablation.The LM-based HDI circuit featuring high resolution(~1.5μm)and high integration(10-layer electrical interconnection)is achieved for customized soft electronics,including various customized multilayer passive electric components,soft multilayer circuit,and cross-scale multimode sensors.The 3D laser printing method provides a versatile approach for developing chip-level soft electronics.
基金supported by the National Natural Science Foundation of China(No.52270018).
文摘The organic matter inmunicipal wastewater can be recovered by anaerobic biological treatment,making further resource utilization of municipal wastewater,which meets the requirements of sustainable development.An upflow anaerobic biofilter(UAF)treating municipal wastewater was established.The performances of stable operation and recovery operation of UAF after long-term starvation(234 days)and the changes of microbial community structure were researched.By gradually reducing HRT from 10 h to 4 h,the UAF achieved the treatment performance of pre-starvation after only 50 days recovery operation,in which total COD and soluble COD removal efficiencies reached 66%and 69%,respectively,and the CH_(4) production rate was 0.21 L CH_(4)/g CODremoval.The recovery performance of UAF after long term starvation showed that the recovery sequence of three main anaerobic processes was hydrolytic acidification,hydrogen-acetate production and methanogenesis.High-throughput sequencing results indicated that dominant bacteria associated with hydrolytic acidification process changed from Moduliflexaceae and Trichococcus in stable operation stage to Trichococcus and Romboutsia in recovery stage.Besides,the dominant archaea changed from Methanosaeta(hydrotrophic methanogens)to Methanobacterium(acetotrophic methanogens),showing Methanobacterium was more resistant to starvation environment.Therefore,by using UAF for biological treatment of organic matter,even after a long period of starvation,the system would not be completely destroyed.Once it resumed operation,the treatment performance could be restored in a short period of time.
基金supported by the National Science Foundation of China(12127806 and 62175195)the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies.
文摘Hard scales in scaly fish species ensure the structural and functional integrity of the inner skin and body,even when subjected to various types of external forces.Mucus and oil secreted from the inner layer of the fish skin to the surface exhibit resistance to a wide range of liquids,maintaining the antifouling properties of the fish skin surface.Inspired by these biological structures,ultra-sturdy and durable scale-armored-sliding surfaces(SASSs)were fabricated in this study using femtosecond laser electrodeposition(FED).In the FED method,a scaly structure is grown from the substrate across a sliding layer to form an SASS.The unique scale-armored structure offers protection against impact and abrasion while maintaining the performance and integrity of the structure.The mechanical sturdiness of the SASS improved by four orders of magnitude compared to that of the conventional antifouling surface.In addition,the SASS exhibited remarkable chemical durability,excellent hydraulic pressure resistance,liquid repellency,and good corrosion resistance based on characterization using various methods.FED enables the preparation of SASS on several materials,including Cu and Al and more.SASS fabricated using FED has great potential for the application of antifouling surfaces in extremely harsh environments.
