The transition energies, E1 transitional oscillator strengths of the spin-allowed as well as the spin-forbidden and the corresponding transition rates, and complete M1, E2, M2 forbidden transition rates for 1s^(2), 1s...The transition energies, E1 transitional oscillator strengths of the spin-allowed as well as the spin-forbidden and the corresponding transition rates, and complete M1, E2, M2 forbidden transition rates for 1s^(2), 1s2s, and 1s2p states of He I, are investigated using the multi-configuration Dirac–Hartree–Fock method. In the subsequent relativistic configuration interaction computations, the Breit interaction and the QED effect are considered as perturbation, separately. Our transition energies, oscillator strengths, and transition rates are in good agreement with the experimental and other theoretical results. As a result, the QED effect is not important for helium atoms, however, the effect of the Breit interaction plays a significant role in the transition energies, the oscillator strengths and transition rates.展开更多
Although magnesium-aluminum alloys,such as AZ80 and AZ91 have promising application potential in automotive,high-speed train and aerospace fields,their age-hardening response is generally not very appreciable.In this ...Although magnesium-aluminum alloys,such as AZ80 and AZ91 have promising application potential in automotive,high-speed train and aerospace fields,their age-hardening response is generally not very appreciable.In this work,the aging-hardening response of AZ80 alloy was effectively enhanced by applying cold-rolling deformation before conducting conventional aging treatment at 200°C.Compared to the directly aged sample,the yield strength of the pre-rolling and aged sample was increased by 35 MPa.Electron microscope examination confirmed that profuse{10¯11}and{10¯11}-{10¯12}twins,consisting of high density of dislocations and stacking faults,were generated by cold rolling.Blocky or ellipsoidal Mg_(17)Al_(12)precipitates formed at the twin boundaries(TBs)during subsequent aging treatment.Crystallographic analysis indicated that the precipitates at{10¯11}TBs always held an identical Potter OR with both the matrix and twin,while the precipitates at{10¯11}-{10¯12}TBs exhibited three different ORs:Burgers OR,Potter OR and P-S OR with either the matrix or the twin.Moreover,recrystallized grains were found inside{10¯11}-{10¯12}double twins after peak-aging at 200°C,implying that precipitation and recrystallization might occur concurrently along TBs at a relatively low temperature.It was speculated that the highly stored energy inside twins and the high elastic energy between the precipitates and twins were driving factors for the occurrence of recrystallization.展开更多
Viruses are significant pathogens causing severe plant infections and crop losses globally.The resistance mechanisms of rice to viral diseases,particularly Southern rice black-streaked dwarf virus(SRBSDV),remain poorl...Viruses are significant pathogens causing severe plant infections and crop losses globally.The resistance mechanisms of rice to viral diseases,particularly Southern rice black-streaked dwarf virus(SRBSDV),remain poorly understood.In this study,we assessed SRBSDV susceptibility in 20 Xian/indica(XI)and 20 Geng/japonica(GJ)rice varieties.XI-1B accessions in the Xian subgroup displayed higher resistance than GJ accessions.Comparative transcriptome analysis revealed changes in processes like oxidoreductase activity,jasmonic acid(JA)metabolism,and stress response.JA sensitivity assays further linked antiviral defense to the JA pathway.These findings highlight a JA-mediated resistance mechanism in rice and offer insights for breeding SRBSDV-resistant varieties.展开更多
目的:比较LY01011(重组全人源抗RANKL单克隆抗体注射液)与地舒单抗注射液治疗实体瘤骨转移的有效性和安全性。方法:开展了一项随机、双盲、阳性药物平行对照、多中心临床试验。共850名受试者被随机分配(1:1比例)至试验组(424名受试者)...目的:比较LY01011(重组全人源抗RANKL单克隆抗体注射液)与地舒单抗注射液治疗实体瘤骨转移的有效性和安全性。方法:开展了一项随机、双盲、阳性药物平行对照、多中心临床试验。共850名受试者被随机分配(1:1比例)至试验组(424名受试者)或对照组(426名受试者)。试验组接受13剂LY01011治疗,对照组先接受3剂地舒单抗治疗,随后再接受10剂LY01011治疗。结果:主要疗效指标第13周尿肌酐校正的尿I型胶原交联N端肽(urinary N-terminal telopeptide of type I collagen corrected by urinary creatinine,uNTX/uCr)相对于基线的自然对数变化值。试验组的变化值为−1.740(0.0420),对照组为−1.745(0.0421)。组间最小二乘均值差为0.005(90%置信区间:−0.088~0.097),表明无统计学显著差异(P>0.05)。安全性方面,包括治疗期间出现的不良事件、实验室检查、生命体征、体格检查和心电图结果,两组间具有可比性(P>0.05)。结论:LY01011是地舒单抗注射液的生物类似药,整体安全耐受性良好,安全性较高,临床可继续推广运用。展开更多
The water conservancy construction and soil and water conservation projects in New China have reshaped the tea industry landscape in Xinyang City of Henan Province from multiple dimensions.In terms of hydraulic techno...The water conservancy construction and soil and water conservation projects in New China have reshaped the tea industry landscape in Xinyang City of Henan Province from multiple dimensions.In terms of hydraulic technology,engineering systems represented by the Nanwan Irrigation District redefined the watershed irrigation pattern,while the application of modern agricultural technologies such as sprinkler and electric irrigation accelerated the shift from traditional experience to scientific management in tea garden practices.Ecologically,systematic soil and water management significantly improved growing conditions,making it possible for tea cultivation to break through the traditional geographical limitation of"tea does not grow north of the Huai River."This integrated governance model not only laid the foundation for the northward expansion of Xinyang's tea industry across the Huai River but also facilitated the transition toward scale and intensification through improved irrigation infrastructure and the breeding of cold-resistant tea varieties.Ultimately,driven by the tripartite interactive mechanism of"engineering governance-ecological improvement-spatial expansion,"the tea industry in Xinyang achieved a historic leap from traditional production to modern intensive development.展开更多
Postoperative bleeding(POB)is a major complication following pancreaticoduodenectomy(PD),leading to significant morbidity and potential mortality.This minireview focuses on the prevention and management strategies for...Postoperative bleeding(POB)is a major complication following pancreaticoduodenectomy(PD),leading to significant morbidity and potential mortality.This minireview focuses on the prevention and management strategies for POB,synthesizing current evidence on surgical techniques,perioperative management,and postoperative interventions.Effective prevention strategies include the use of regional vessel wrapping,optimal pancreatic anastomosis,and meticulous intraoperative hemostasis.Postoperative management strategies,such as early detection using predictive models and advanced imaging,along with endovascular interventions like angiographic embolization and stent graft placement,are essential for timely intervention.Risk factors,including pancreatic texture,anticoagulation therapy,and patient comorbidities,further influence bleeding outcomes.The minireview also identifies gaps in current research and emphasizes the need for prospective randomized controlled trials to establish standardized protocols.Overall,a multidisciplinary approach combining surgical expertise,predictive analytics,and personalized care is essential to improving patient out comes and minimizing the risk of POB following PD.展开更多
Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affe...Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment.To date,differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties,which has increased the uncertainty of treatment effects.On the basis of current research evidence,this expert consensus outlines risk factors,clinical manifestations,clinical grading,ancillary examinations,diagnostic basis,prevention and treatment strategies and efficacy indicators for OM.In addition to strategies such as basic oral care,antiinflammatory and analgesic agents,anti-infective agents,pro-healing agents,and photobiotherapy recommended in previous guidelines,we also emphasize the role of traditional Chinese medicine in OM prevention and treatment.This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention,diagnosis,and treatment,standardizing clinical practice,reducing OM occurrence,promoting healing,and improving the quality of life of patients.展开更多
Reactive oxygen species(ROS),including singlet oxygen(^(1)O_(2)),hydroxyl radicals(·OH),and superoxide anions(O_(2)^(·-)),are highly reactive molecules that play central roles in many chemical,biological,and...Reactive oxygen species(ROS),including singlet oxygen(^(1)O_(2)),hydroxyl radicals(·OH),and superoxide anions(O_(2)^(·-)),are highly reactive molecules that play central roles in many chemical,biological,and environmental processes due to their strong oxidative power[1].Generating ROS in a controlled manner under mild conditions is essential for achieving selective oxidation reactions.Light-driven methods are especially appealing for this purpose,as they offer precise control over where and when ROS are produced.展开更多
Hearing relies on the structural and functional integrity of cochlear hair cells,particularly their apical F-actin-filled stereocilia.Phospholipid scramblases are important for maintaining membrane asymmetry,but their...Hearing relies on the structural and functional integrity of cochlear hair cells,particularly their apical F-actin-filled stereocilia.Phospholipid scramblases are important for maintaining membrane asymmetry,but their roles in the stereocilia and auditory functions are not fully understood.Here,we identify Plscr5 as a downstream target of the transcription factor POU4F3 essential for hair cell function,whose mutation causes human DFNA15 deafness.Plscr5 knockout mice exhibit progressive hearing loss due to stereocilia degeneration and hair cell loss.Functional analyses reveal that PLSCR5 contributes to phosphatidylserine externalization in hair cell apical membranes,particularly in inner hair cells,and is important for outer hair cell and stereocilia maintenance.Our findings highlight PLSCR5 as an important downstream effector of POU4F3 and regulator of phosphatidylserine externalization and membrane dynamics required for auditory functions.展开更多
0 INTRODUCTION Rock masses are inherently discontinuous,with fractures and joints governing their mechanical behavior and stability(Liu et al.,2024;Shang et al.,2018;Lisjak and Grasselli,2014;Scholtès and Donz...0 INTRODUCTION Rock masses are inherently discontinuous,with fractures and joints governing their mechanical behavior and stability(Liu et al.,2024;Shang et al.,2018;Lisjak and Grasselli,2014;Scholtès and Donzé,2012;Jiang et al.,2009;Pine et al.,2006;Aydan et al.,1989).展开更多
This work develops a protein imprinted nanosphere with varied recognition specificity for bovine serum albumin(BSA)and lysozyme(Lyz)under different UV light through a gradient dual crosslinked imprinting strategy(i.e....This work develops a protein imprinted nanosphere with varied recognition specificity for bovine serum albumin(BSA)and lysozyme(Lyz)under different UV light through a gradient dual crosslinked imprinting strategy(i.e.,covalent crosslinking and dynamic reversible crosslinking).The imprinting cavities are initially constructed using irreversible covalent crosslinking to specifically recognize BSA,and then the coumarin residues in the imprinting cavities are crosslinked under 365 nm UV light to further imprint Lyz,because Lyz has smaller size than BSA.Since the photo-crosslinking of coumarin is a reversible reaction,the imprinting cavities of Lyz can be de-crosslinked under 254 nm UV light and restore the imprinting cavities of BSA.Moreover,the N-isopropyl acrylamide(NIPAM)and pyrrolidine residues copolymerized in the polymeric surface of the nanospheres are temperature-and p H-responsive respectively.Therefore,the protein rebinding and release behaviors of the nanospheres are controlled by external temperature and p H.As a result,the materials can selectively separate BSA from real bovine whole blood and Lyz from egg white under different UV light.This study may provide a new strategy for construction of protein imprinted materials with tunable specificity for different proteins.展开更多
Electrocatalytic conversion of nitrate to ammonia(NITRR)can simultaneously achieve the removal of nitrate and the synthesis of value-added ammonia,a promising candidate to replace Haber-Bosch process with low carbon d...Electrocatalytic conversion of nitrate to ammonia(NITRR)can simultaneously achieve the removal of nitrate and the synthesis of value-added ammonia,a promising candidate to replace Haber-Bosch process with low carbon dioxide emissions.However,high hydrogenation energy barrier for*NO intermediates and insufficient supply of active hydrogen cause slow hydrogenation process,and further result in low efficiency of nitrate conversion and ammonia synthesis.Herein,a series of tandem catalysts,one-dimensional coordination polymers(1D CCPs)with dual sites are synthesized and obtained 190.4 mg h^(-1)mgcat^(-1)ammonia production rate with Faradaic efficiency of 97.16%,outperforming to the most of recent reported catalysts.The catalytic performances are well-maintained even after a long-term stability test of 1200 h,laying the foundation for practical applications.Density functional theory results reveal that the stationary adsorbed*NO on Ni site induced proximity electronic effect could reduce the energy barrier for hydrogenation of*NO intermediates over Cu site.In addition,the Ni site in the dual sites 1D CCPs is conducive to generating active hydrogen,providing rich proton source to boost the hydrogenation of*NO,and further enhancing the compatibility of deoxygenation and hydrogenation process.Our work paves a new insight into the mechanism of NITRR process and will inspire more research interests in exploring the proximity electronic effect in catalytic process.展开更多
Hydrogen peroxide(H_(2)O_(2)),an environmentally friendly chemical with high value,is extensively used in industrial production and daily life.However,the traditional anthraquinone method for H_(2)O_(2) production is ...Hydrogen peroxide(H_(2)O_(2)),an environmentally friendly chemical with high value,is extensively used in industrial production and daily life.However,the traditional anthraquinone method for H_(2)O_(2) production is associated with a highly energy-consuming and heavily polluting process.Solor-driven photocatalytic evolution of H_(2)O_(2) is a promising,eco-friendly,and energy-efficient strategy that holds great potential to substitute the traditional approach.Here,a ternary photocatalyst,NiS/CdS/Halloysite nanotubes(NiS/CdS/HNTs)is designed and prepared with an earth-abundant clay mineral HNTs as the support and NiS as a co-catalyst.The pivotal roles of HNTs and NiS in the photocatalytic process are elucidated by experiments and theoretical calculations.HNTs serve as the carrier,which allows CdS to be uniformly dispersed onto its surface as small particles,increasing effective contact with H_(2)O and O_(2) for H_(2)O_(2) formation.Simultaneously,it resulted in the formation of a Schottky junction between NiS and CdS,which not only favors photogenerated charges separating efficiently but also provides a unidirectional path to transfer electrons.Consequently,the optimized NiS/CdS/HNTs composite demonstrates an H_(2)O_(2) evolution rate of 380.5μmol·g^(-1)·h^(-1) without adding any sacrificial agent or extra O_(2),nearly 5.0 times that of pure CdS.This work suggests a feasible idea for designing and developing highly active and low-cost solar energy catalytic composite materials.展开更多
Viral hepatitis,including hepatitis B and hepatitis C(HCV),remains a significant global health burden,leading to liver fibrosis,cirrhosis,and hepatocellular car-cinoma.Traditional diagnostic methods,while effective,of...Viral hepatitis,including hepatitis B and hepatitis C(HCV),remains a significant global health burden,leading to liver fibrosis,cirrhosis,and hepatocellular car-cinoma.Traditional diagnostic methods,while effective,often face limitations in accuracy,accessibility,and timeliness.Artificial intelligence(AI)has emerged as a transformative tool in healthcare,enhancing the detection,diagnosis,and treat-ment of viral hepatitis.This review explores the role of AI in viral hepatitis mana-gement,focusing on early detection through image analysis,digital pathology,and machine learning algorithms.AI-driven image analysis tools,such as con-volutional neural networks,have demonstrated high accuracy in detecting HCV-related liver lesions from computed tomography scans.Supervised learning models such as support vector machines and hybrid quantum neural networks further enhance early risk stratification.AI also facilitates personalized treatment by predicting treatment responses,accelerating drug discovery,and advancing precision medicine.Furthermore,AI contributes to epidemiological surveillance by predicting disease spread and tracking treatment adherence.Despite its po-tential,challenges such as data privacy,algorithmic bias,and regulatory comp-liance must be addressed to ensure equitable and effective AI implementation.Future directions include integrating AI into clinical workflows and expanding AI applications in low-resource settings.AI-assisted diagnosis and management have the potential to revolutionize viral hepatitis care,improving patient outcomes and reducing the global disease burden.展开更多
基金Supported by the National Key Research and Development Program of China (Grant No. 2017YFA0402300)the National Natural Science Foundation of China (Grant Nos. 11774344 and 11474033)。
文摘The transition energies, E1 transitional oscillator strengths of the spin-allowed as well as the spin-forbidden and the corresponding transition rates, and complete M1, E2, M2 forbidden transition rates for 1s^(2), 1s2s, and 1s2p states of He I, are investigated using the multi-configuration Dirac–Hartree–Fock method. In the subsequent relativistic configuration interaction computations, the Breit interaction and the QED effect are considered as perturbation, separately. Our transition energies, oscillator strengths, and transition rates are in good agreement with the experimental and other theoretical results. As a result, the QED effect is not important for helium atoms, however, the effect of the Breit interaction plays a significant role in the transition energies, the oscillator strengths and transition rates.
基金financially supported by the National Natural Science Foundation of China(No.52071040 and 51871036)Natural Science Foundation of Shandong Province,China(No.ZR2022QE008)China Postdoctoral Science Foundation(No.2022M712984)。
文摘Although magnesium-aluminum alloys,such as AZ80 and AZ91 have promising application potential in automotive,high-speed train and aerospace fields,their age-hardening response is generally not very appreciable.In this work,the aging-hardening response of AZ80 alloy was effectively enhanced by applying cold-rolling deformation before conducting conventional aging treatment at 200°C.Compared to the directly aged sample,the yield strength of the pre-rolling and aged sample was increased by 35 MPa.Electron microscope examination confirmed that profuse{10¯11}and{10¯11}-{10¯12}twins,consisting of high density of dislocations and stacking faults,were generated by cold rolling.Blocky or ellipsoidal Mg_(17)Al_(12)precipitates formed at the twin boundaries(TBs)during subsequent aging treatment.Crystallographic analysis indicated that the precipitates at{10¯11}TBs always held an identical Potter OR with both the matrix and twin,while the precipitates at{10¯11}-{10¯12}TBs exhibited three different ORs:Burgers OR,Potter OR and P-S OR with either the matrix or the twin.Moreover,recrystallized grains were found inside{10¯11}-{10¯12}double twins after peak-aging at 200°C,implying that precipitation and recrystallization might occur concurrently along TBs at a relatively low temperature.It was speculated that the highly stored energy inside twins and the high elastic energy between the precipitates and twins were driving factors for the occurrence of recrystallization.
基金funded by the National Key Research and Development Plan of China(2023YFD1400300)National Natural Science Foundation of China(U23A6006,32270149,32272555)+1 种基金Zhejiang Provincial Natural Science Foundation(LZ22C140001)the Ningbo Major Research and Development Plan Project(2023Z124).
文摘Viruses are significant pathogens causing severe plant infections and crop losses globally.The resistance mechanisms of rice to viral diseases,particularly Southern rice black-streaked dwarf virus(SRBSDV),remain poorly understood.In this study,we assessed SRBSDV susceptibility in 20 Xian/indica(XI)and 20 Geng/japonica(GJ)rice varieties.XI-1B accessions in the Xian subgroup displayed higher resistance than GJ accessions.Comparative transcriptome analysis revealed changes in processes like oxidoreductase activity,jasmonic acid(JA)metabolism,and stress response.JA sensitivity assays further linked antiviral defense to the JA pathway.These findings highlight a JA-mediated resistance mechanism in rice and offer insights for breeding SRBSDV-resistant varieties.
文摘目的:比较LY01011(重组全人源抗RANKL单克隆抗体注射液)与地舒单抗注射液治疗实体瘤骨转移的有效性和安全性。方法:开展了一项随机、双盲、阳性药物平行对照、多中心临床试验。共850名受试者被随机分配(1:1比例)至试验组(424名受试者)或对照组(426名受试者)。试验组接受13剂LY01011治疗,对照组先接受3剂地舒单抗治疗,随后再接受10剂LY01011治疗。结果:主要疗效指标第13周尿肌酐校正的尿I型胶原交联N端肽(urinary N-terminal telopeptide of type I collagen corrected by urinary creatinine,uNTX/uCr)相对于基线的自然对数变化值。试验组的变化值为−1.740(0.0420),对照组为−1.745(0.0421)。组间最小二乘均值差为0.005(90%置信区间:−0.088~0.097),表明无统计学显著差异(P>0.05)。安全性方面,包括治疗期间出现的不良事件、实验室检查、生命体征、体格检查和心电图结果,两组间具有可比性(P>0.05)。结论:LY01011是地舒单抗注射液的生物类似药,整体安全耐受性良好,安全性较高,临床可继续推广运用。
文摘The water conservancy construction and soil and water conservation projects in New China have reshaped the tea industry landscape in Xinyang City of Henan Province from multiple dimensions.In terms of hydraulic technology,engineering systems represented by the Nanwan Irrigation District redefined the watershed irrigation pattern,while the application of modern agricultural technologies such as sprinkler and electric irrigation accelerated the shift from traditional experience to scientific management in tea garden practices.Ecologically,systematic soil and water management significantly improved growing conditions,making it possible for tea cultivation to break through the traditional geographical limitation of"tea does not grow north of the Huai River."This integrated governance model not only laid the foundation for the northward expansion of Xinyang's tea industry across the Huai River but also facilitated the transition toward scale and intensification through improved irrigation infrastructure and the breeding of cold-resistant tea varieties.Ultimately,driven by the tripartite interactive mechanism of"engineering governance-ecological improvement-spatial expansion,"the tea industry in Xinyang achieved a historic leap from traditional production to modern intensive development.
文摘Postoperative bleeding(POB)is a major complication following pancreaticoduodenectomy(PD),leading to significant morbidity and potential mortality.This minireview focuses on the prevention and management strategies for POB,synthesizing current evidence on surgical techniques,perioperative management,and postoperative interventions.Effective prevention strategies include the use of regional vessel wrapping,optimal pancreatic anastomosis,and meticulous intraoperative hemostasis.Postoperative management strategies,such as early detection using predictive models and advanced imaging,along with endovascular interventions like angiographic embolization and stent graft placement,are essential for timely intervention.Risk factors,including pancreatic texture,anticoagulation therapy,and patient comorbidities,further influence bleeding outcomes.The minireview also identifies gaps in current research and emphasizes the need for prospective randomized controlled trials to establish standardized protocols.Overall,a multidisciplinary approach combining surgical expertise,predictive analytics,and personalized care is essential to improving patient out comes and minimizing the risk of POB following PD.
基金supported by the National Natural Science Foundation of China(U23A20445)the Science and Technology Program of Guangzhou(202206080009)。
文摘Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment.To date,differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties,which has increased the uncertainty of treatment effects.On the basis of current research evidence,this expert consensus outlines risk factors,clinical manifestations,clinical grading,ancillary examinations,diagnostic basis,prevention and treatment strategies and efficacy indicators for OM.In addition to strategies such as basic oral care,antiinflammatory and analgesic agents,anti-infective agents,pro-healing agents,and photobiotherapy recommended in previous guidelines,we also emphasize the role of traditional Chinese medicine in OM prevention and treatment.This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention,diagnosis,and treatment,standardizing clinical practice,reducing OM occurrence,promoting healing,and improving the quality of life of patients.
文摘Reactive oxygen species(ROS),including singlet oxygen(^(1)O_(2)),hydroxyl radicals(·OH),and superoxide anions(O_(2)^(·-)),are highly reactive molecules that play central roles in many chemical,biological,and environmental processes due to their strong oxidative power[1].Generating ROS in a controlled manner under mild conditions is essential for achieving selective oxidation reactions.Light-driven methods are especially appealing for this purpose,as they offer precise control over where and when ROS are produced.
基金supported by the National Natural Science Foundation of China(82171136 and 92368110 to G.W.,82201291 to G.-J.Z.,82192861 to Z.X.,81970884 and 82192862 to X.G.)the Natural Science Foundation of Jiangsu Province(BK20220188 to Q.L.,BK20220189 to G.-J.Z.)the Fundamental Research Funds for the Central Universities(021414380533 to G.W.).
文摘Hearing relies on the structural and functional integrity of cochlear hair cells,particularly their apical F-actin-filled stereocilia.Phospholipid scramblases are important for maintaining membrane asymmetry,but their roles in the stereocilia and auditory functions are not fully understood.Here,we identify Plscr5 as a downstream target of the transcription factor POU4F3 essential for hair cell function,whose mutation causes human DFNA15 deafness.Plscr5 knockout mice exhibit progressive hearing loss due to stereocilia degeneration and hair cell loss.Functional analyses reveal that PLSCR5 contributes to phosphatidylserine externalization in hair cell apical membranes,particularly in inner hair cells,and is important for outer hair cell and stereocilia maintenance.Our findings highlight PLSCR5 as an important downstream effector of POU4F3 and regulator of phosphatidylserine externalization and membrane dynamics required for auditory functions.
基金supported by the National Key R&D Program of China(No.2022YFC3080200)。
文摘0 INTRODUCTION Rock masses are inherently discontinuous,with fractures and joints governing their mechanical behavior and stability(Liu et al.,2024;Shang et al.,2018;Lisjak and Grasselli,2014;Scholtès and Donzé,2012;Jiang et al.,2009;Pine et al.,2006;Aydan et al.,1989).
基金financial support from the National Natural Science Foundation of China(No.22275148)National Key R&D Program of China(No.2018YFB1900201)for Qiuyu Zhang+2 种基金the National Natural Science Foundation of China(No.22271232)Fundamental Research Funds for the Central Universities(No.D5000230114)for Shixin Fathe Fundamental Research Funds for the Central Universities(No.D5000220339)for Qing Liu。
文摘This work develops a protein imprinted nanosphere with varied recognition specificity for bovine serum albumin(BSA)and lysozyme(Lyz)under different UV light through a gradient dual crosslinked imprinting strategy(i.e.,covalent crosslinking and dynamic reversible crosslinking).The imprinting cavities are initially constructed using irreversible covalent crosslinking to specifically recognize BSA,and then the coumarin residues in the imprinting cavities are crosslinked under 365 nm UV light to further imprint Lyz,because Lyz has smaller size than BSA.Since the photo-crosslinking of coumarin is a reversible reaction,the imprinting cavities of Lyz can be de-crosslinked under 254 nm UV light and restore the imprinting cavities of BSA.Moreover,the N-isopropyl acrylamide(NIPAM)and pyrrolidine residues copolymerized in the polymeric surface of the nanospheres are temperature-and p H-responsive respectively.Therefore,the protein rebinding and release behaviors of the nanospheres are controlled by external temperature and p H.As a result,the materials can selectively separate BSA from real bovine whole blood and Lyz from egg white under different UV light.This study may provide a new strategy for construction of protein imprinted materials with tunable specificity for different proteins.
文摘Electrocatalytic conversion of nitrate to ammonia(NITRR)can simultaneously achieve the removal of nitrate and the synthesis of value-added ammonia,a promising candidate to replace Haber-Bosch process with low carbon dioxide emissions.However,high hydrogenation energy barrier for*NO intermediates and insufficient supply of active hydrogen cause slow hydrogenation process,and further result in low efficiency of nitrate conversion and ammonia synthesis.Herein,a series of tandem catalysts,one-dimensional coordination polymers(1D CCPs)with dual sites are synthesized and obtained 190.4 mg h^(-1)mgcat^(-1)ammonia production rate with Faradaic efficiency of 97.16%,outperforming to the most of recent reported catalysts.The catalytic performances are well-maintained even after a long-term stability test of 1200 h,laying the foundation for practical applications.Density functional theory results reveal that the stationary adsorbed*NO on Ni site induced proximity electronic effect could reduce the energy barrier for hydrogenation of*NO intermediates over Cu site.In addition,the Ni site in the dual sites 1D CCPs is conducive to generating active hydrogen,providing rich proton source to boost the hydrogenation of*NO,and further enhancing the compatibility of deoxygenation and hydrogenation process.Our work paves a new insight into the mechanism of NITRR process and will inspire more research interests in exploring the proximity electronic effect in catalytic process.
文摘Hydrogen peroxide(H_(2)O_(2)),an environmentally friendly chemical with high value,is extensively used in industrial production and daily life.However,the traditional anthraquinone method for H_(2)O_(2) production is associated with a highly energy-consuming and heavily polluting process.Solor-driven photocatalytic evolution of H_(2)O_(2) is a promising,eco-friendly,and energy-efficient strategy that holds great potential to substitute the traditional approach.Here,a ternary photocatalyst,NiS/CdS/Halloysite nanotubes(NiS/CdS/HNTs)is designed and prepared with an earth-abundant clay mineral HNTs as the support and NiS as a co-catalyst.The pivotal roles of HNTs and NiS in the photocatalytic process are elucidated by experiments and theoretical calculations.HNTs serve as the carrier,which allows CdS to be uniformly dispersed onto its surface as small particles,increasing effective contact with H_(2)O and O_(2) for H_(2)O_(2) formation.Simultaneously,it resulted in the formation of a Schottky junction between NiS and CdS,which not only favors photogenerated charges separating efficiently but also provides a unidirectional path to transfer electrons.Consequently,the optimized NiS/CdS/HNTs composite demonstrates an H_(2)O_(2) evolution rate of 380.5μmol·g^(-1)·h^(-1) without adding any sacrificial agent or extra O_(2),nearly 5.0 times that of pure CdS.This work suggests a feasible idea for designing and developing highly active and low-cost solar energy catalytic composite materials.
文摘Viral hepatitis,including hepatitis B and hepatitis C(HCV),remains a significant global health burden,leading to liver fibrosis,cirrhosis,and hepatocellular car-cinoma.Traditional diagnostic methods,while effective,often face limitations in accuracy,accessibility,and timeliness.Artificial intelligence(AI)has emerged as a transformative tool in healthcare,enhancing the detection,diagnosis,and treat-ment of viral hepatitis.This review explores the role of AI in viral hepatitis mana-gement,focusing on early detection through image analysis,digital pathology,and machine learning algorithms.AI-driven image analysis tools,such as con-volutional neural networks,have demonstrated high accuracy in detecting HCV-related liver lesions from computed tomography scans.Supervised learning models such as support vector machines and hybrid quantum neural networks further enhance early risk stratification.AI also facilitates personalized treatment by predicting treatment responses,accelerating drug discovery,and advancing precision medicine.Furthermore,AI contributes to epidemiological surveillance by predicting disease spread and tracking treatment adherence.Despite its po-tential,challenges such as data privacy,algorithmic bias,and regulatory comp-liance must be addressed to ensure equitable and effective AI implementation.Future directions include integrating AI into clinical workflows and expanding AI applications in low-resource settings.AI-assisted diagnosis and management have the potential to revolutionize viral hepatitis care,improving patient outcomes and reducing the global disease burden.
