BACKGROUND:Patients suffering from hemorrhagic shock(HS)complicated by severe trauma are at high risk of developing acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).The underlying pathophysiology is...BACKGROUND:Patients suffering from hemorrhagic shock(HS)complicated by severe trauma are at high risk of developing acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).The underlying pathophysiology is complex,and the lack of targeted therapeutic strategies remains a major clinical challenge.METHODS:In this narrative review,a literature search was conducted in the PubMed to identify articles published from 2006 to August 2025 concerning trauma,HS,traumatic HS(THS),biomarkers related to ALI,ARDS and HS,as well as their treatment.Through its multifactorial pathogenesis,we discuss the diagnostic and prognostic values of biomarkers,their potential role in treatment,and therapeutic advancements and perspectives.RESULTS:ALI and ARDS are serious complications in severe trauma patients with HS.Hypoperfusion,hypoxia,endothelial cell activation,inflammation,ischemia/reperfusion injury and the intestinal response,as well as chest trauma and transfusion-related events are potential causes of lung injury.The pulmonary epithelial biomarkers soluble receptor for advanced glycation end products(sRAGE)and surfactant protein-D provide indicators for evaluating the severity of lung contusion and injury,whereas Clara cell protein 16 may have clinical value for trauma patients with ALI complicated by pneumonia.Elevated endothelial biomarkers angiopoietin-2 and syndecan-1 are correlated with injury severity,transfusion,coagulopathy,the onset of ARDS,and patient outcomes.The role of biomarkers in therapeutic benefit is reviewed.CONCLUSIONS:Preventive and therapeutic strategies for THS-induced ALI/ARDS rely on the implementation of multi-target,multi-mechanism interventions that address the complex pathophysiology.Targeted phenotypic therapy guided by biomarkers would be of interest for future research aimed at improving clinical outcomes.展开更多
A monolithic integrated full-wave bridge rectifier consisted of horizontal Schottky-barrier diodes(SBD)is prepared based on 100 nm ultra-thinβ-Ga_(2)O_(3)and demonstrated the solar-blind UV(SUV)light-modulated charac...A monolithic integrated full-wave bridge rectifier consisted of horizontal Schottky-barrier diodes(SBD)is prepared based on 100 nm ultra-thinβ-Ga_(2)O_(3)and demonstrated the solar-blind UV(SUV)light-modulated characteristics.Under SUV light illumination,the rectifier has the excellent full-wave rectification characteristics for the AC input signals of 5,12,and 24 V with different frequencies.Further,experimental results confirmed the feasibility of continuously tuning the rectified output through SUV light-encoding.This work provides valuable insights for the development of optically programmable Ga_(2)O_(3)ACDC converters.展开更多
Fat embolism syndrome(FES)is a fatal complication of long bone fractures and multiple traumas.Severe FES can lead to potentially fatal respiratory failure in the form of rapidly developing acute respiratory distress s...Fat embolism syndrome(FES)is a fatal complication of long bone fractures and multiple traumas.Severe FES can lead to potentially fatal respiratory failure in the form of rapidly developing acute respiratory distress syndrome(ARDS).Here,we report a case of venousarterial extracorporeal membrane oxygenation(VAECMO)treatment of a patient with near-fatal pulmonary fat emboli caused by severe trauma.展开更多
The aqueous solution of tetrabutyl ether derivatives of p-sulfonatocalix[4]arene (SC4Bu) and ascorbic acid (AA) complex has been studied based on fluorescence and 1H NMR spectroscopic results. It was found that the fl...The aqueous solution of tetrabutyl ether derivatives of p-sulfonatocalix[4]arene (SC4Bu) and ascorbic acid (AA) complex has been studied based on fluorescence and 1H NMR spectroscopic results. It was found that the fluorescence intensity of SC4Bu quenched regularly upon the addition of AA. A 1:1 stoichiometry for the complexation was established and was verified by Job’s plot. The temperature-dependent inclusion constants were calculated, form which Δ H and ΔS values were calculated. Meanwhile the proposed interaction mechanism of the inclusion complex was discussed based on 1H NMR results. The various factors (ionic strength, and surfactants) effecting the inclusion process were examined in detail.展开更多
目的探讨心力衰竭(HF)患者外周血可溶性生长刺激表达基因2蛋白(sST2)、单核细胞/高密度脂蛋白胆固醇比值(MHR)、同型半胱氨酸(Hcy)与射血分数(LVEF)的相关性,并分析其对预后不良的预测价值。方法选取2023年1月至2024年1月该院收治的100...目的探讨心力衰竭(HF)患者外周血可溶性生长刺激表达基因2蛋白(sST2)、单核细胞/高密度脂蛋白胆固醇比值(MHR)、同型半胱氨酸(Hcy)与射血分数(LVEF)的相关性,并分析其对预后不良的预测价值。方法选取2023年1月至2024年1月该院收治的100例HF患者作为研究对象,根据美国纽约心脏病学会(NYHA)分级分为NYHAⅠ级组21例、NYHAⅡ级组29例、NYHAⅢ级组40例、NYHAⅣ级组10例。比较不同NYHA分级HF患者血清sST2、MHR、Hcy水平及心功能指标[LVEF、左心室舒张末期内径(LVEDD)];采用Pearson相关分析血清sST2、MHR、Hcy与LVEF、LVEDD的相关性。随访6个月,根据HF患者是否发生不良预后事件(再发HF入院、心血管不良事件、全因死亡)分为预后良好组、预后不良组。比较不同预后HF患者血清sST2、MHR、Hcy水平,分析三者对HF患者预后不良的预测价值。结果不同NYHA分级患者血清sST2、MHR、Hcy及LVEF、LVEDD比较,差异均有统计学意义(P<0.05)。血清sST2、Hcy水平及MHR与LVEF呈负相关(P<0.05),与LVEDD均呈正相关(P<0.05)。预后良好组72例,预后不良组28例。预后良好组入院24、72 h血清sST2、Hcy水平及MHR均低于预后不良组(P<0.05),ΔsST2、ΔMHR、ΔHcy均大于预后不良组(P<0.05)。入院24 h sST2、入院72 h sST2、ΔsST2、入院24 h MHR、入院72 h MHR、ΔMHR、入院24 h Hcy、入院72 h Hcy、ΔHcy预测HF患者预后不良的曲线下面积(AUC)分别为0.765、0.805、0.821、0.749、0.769、0.803、0.756、0.826、0.739。结论HF患者血清sST2、MHR、Hcy与LVEF密切相关,对预后不良有较高预测价值,可作为HF临床治疗、病情及预后评估的有效血清学指标。展开更多
基金supported by grants from the Zhejiang Provincial Key Research and Development Program of China(2023C03085).
文摘BACKGROUND:Patients suffering from hemorrhagic shock(HS)complicated by severe trauma are at high risk of developing acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).The underlying pathophysiology is complex,and the lack of targeted therapeutic strategies remains a major clinical challenge.METHODS:In this narrative review,a literature search was conducted in the PubMed to identify articles published from 2006 to August 2025 concerning trauma,HS,traumatic HS(THS),biomarkers related to ALI,ARDS and HS,as well as their treatment.Through its multifactorial pathogenesis,we discuss the diagnostic and prognostic values of biomarkers,their potential role in treatment,and therapeutic advancements and perspectives.RESULTS:ALI and ARDS are serious complications in severe trauma patients with HS.Hypoperfusion,hypoxia,endothelial cell activation,inflammation,ischemia/reperfusion injury and the intestinal response,as well as chest trauma and transfusion-related events are potential causes of lung injury.The pulmonary epithelial biomarkers soluble receptor for advanced glycation end products(sRAGE)and surfactant protein-D provide indicators for evaluating the severity of lung contusion and injury,whereas Clara cell protein 16 may have clinical value for trauma patients with ALI complicated by pneumonia.Elevated endothelial biomarkers angiopoietin-2 and syndecan-1 are correlated with injury severity,transfusion,coagulopathy,the onset of ARDS,and patient outcomes.The role of biomarkers in therapeutic benefit is reviewed.CONCLUSIONS:Preventive and therapeutic strategies for THS-induced ALI/ARDS rely on the implementation of multi-target,multi-mechanism interventions that address the complex pathophysiology.Targeted phenotypic therapy guided by biomarkers would be of interest for future research aimed at improving clinical outcomes.
基金supported by Natural Science Basic Research Program of Shaanxi Province of China(Grant No.2023JCYB574)National Natural Science Foundation of China(Grant No.62204203)。
文摘A monolithic integrated full-wave bridge rectifier consisted of horizontal Schottky-barrier diodes(SBD)is prepared based on 100 nm ultra-thinβ-Ga_(2)O_(3)and demonstrated the solar-blind UV(SUV)light-modulated characteristics.Under SUV light illumination,the rectifier has the excellent full-wave rectification characteristics for the AC input signals of 5,12,and 24 V with different frequencies.Further,experimental results confirmed the feasibility of continuously tuning the rectified output through SUV light-encoding.This work provides valuable insights for the development of optically programmable Ga_(2)O_(3)ACDC converters.
文摘Fat embolism syndrome(FES)is a fatal complication of long bone fractures and multiple traumas.Severe FES can lead to potentially fatal respiratory failure in the form of rapidly developing acute respiratory distress syndrome(ARDS).Here,we report a case of venousarterial extracorporeal membrane oxygenation(VAECMO)treatment of a patient with near-fatal pulmonary fat emboli caused by severe trauma.
文摘The aqueous solution of tetrabutyl ether derivatives of p-sulfonatocalix[4]arene (SC4Bu) and ascorbic acid (AA) complex has been studied based on fluorescence and 1H NMR spectroscopic results. It was found that the fluorescence intensity of SC4Bu quenched regularly upon the addition of AA. A 1:1 stoichiometry for the complexation was established and was verified by Job’s plot. The temperature-dependent inclusion constants were calculated, form which Δ H and ΔS values were calculated. Meanwhile the proposed interaction mechanism of the inclusion complex was discussed based on 1H NMR results. The various factors (ionic strength, and surfactants) effecting the inclusion process were examined in detail.
文摘目的探讨心力衰竭(HF)患者外周血可溶性生长刺激表达基因2蛋白(sST2)、单核细胞/高密度脂蛋白胆固醇比值(MHR)、同型半胱氨酸(Hcy)与射血分数(LVEF)的相关性,并分析其对预后不良的预测价值。方法选取2023年1月至2024年1月该院收治的100例HF患者作为研究对象,根据美国纽约心脏病学会(NYHA)分级分为NYHAⅠ级组21例、NYHAⅡ级组29例、NYHAⅢ级组40例、NYHAⅣ级组10例。比较不同NYHA分级HF患者血清sST2、MHR、Hcy水平及心功能指标[LVEF、左心室舒张末期内径(LVEDD)];采用Pearson相关分析血清sST2、MHR、Hcy与LVEF、LVEDD的相关性。随访6个月,根据HF患者是否发生不良预后事件(再发HF入院、心血管不良事件、全因死亡)分为预后良好组、预后不良组。比较不同预后HF患者血清sST2、MHR、Hcy水平,分析三者对HF患者预后不良的预测价值。结果不同NYHA分级患者血清sST2、MHR、Hcy及LVEF、LVEDD比较,差异均有统计学意义(P<0.05)。血清sST2、Hcy水平及MHR与LVEF呈负相关(P<0.05),与LVEDD均呈正相关(P<0.05)。预后良好组72例,预后不良组28例。预后良好组入院24、72 h血清sST2、Hcy水平及MHR均低于预后不良组(P<0.05),ΔsST2、ΔMHR、ΔHcy均大于预后不良组(P<0.05)。入院24 h sST2、入院72 h sST2、ΔsST2、入院24 h MHR、入院72 h MHR、ΔMHR、入院24 h Hcy、入院72 h Hcy、ΔHcy预测HF患者预后不良的曲线下面积(AUC)分别为0.765、0.805、0.821、0.749、0.769、0.803、0.756、0.826、0.739。结论HF患者血清sST2、MHR、Hcy与LVEF密切相关,对预后不良有较高预测价值,可作为HF临床治疗、病情及预后评估的有效血清学指标。
