[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single fac...[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material.展开更多
Take-home message:This Chinese expert consensus focuses on the hematoporphyrin derivative (HpD) photodynamic therapy(PDT) in cervical high-grade squamous intraepithelial lesion (HSIL).It aims to provide systematic gui...Take-home message:This Chinese expert consensus focuses on the hematoporphyrin derivative (HpD) photodynamic therapy(PDT) in cervical high-grade squamous intraepithelial lesion (HSIL).It aims to provide systematic guidance for gynaecologists,oncologists,nursing professionals and PDT practitioners at all levels in the clinical application of HpD-PDT for the treatment of cervical HSIL.展开更多
基金Supported by Guilin Scientific Research and Technology Development Program(20210202-1,2020011203-1,2020011203-2)Open Project of Guangxi Key Laboratory of Cancer Immunology and Microenvironment Regulation(2022KF005)+1 种基金Guangxi Science and Technology Major Project(Guike AA22096020)Fund for Central Guiding Local Science and Technology Development(ZY20230102).
文摘[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material.
基金supported by the National Key R&D Program of China (2024YFC2707503)Sanming Project of Medicine in Shenzhen (SZSM202011016)+2 种基金Shenzhen Public Platform for Preservation of Fertility and Reproduction (XMHT20220104049)Shenzhen Key Medical Discipline Construction Fund (SZXK027)the specific research fund of The Innovation Platform for Academicians of Hainan Province (YSPTZX202202)。
文摘Take-home message:This Chinese expert consensus focuses on the hematoporphyrin derivative (HpD) photodynamic therapy(PDT) in cervical high-grade squamous intraepithelial lesion (HSIL).It aims to provide systematic guidance for gynaecologists,oncologists,nursing professionals and PDT practitioners at all levels in the clinical application of HpD-PDT for the treatment of cervical HSIL.
