The construction of a barrier-free environment is an important measure that guarantees the safety,right-of-way,and interests of the disabled,the elderly,and other mobility disadvantaged groups.It is also an indispensa...The construction of a barrier-free environment is an important measure that guarantees the safety,right-of-way,and interests of the disabled,the elderly,and other mobility disadvantaged groups.It is also an indispensable part of the low-carbon urban transportation and a necessary way to protect the rights of mobility disadvantaged groups in green travel.In this paper,the researchers conducted life log surveys on the travels of 10 wheelchair users residing in Beijing with IoT Inspector,a self-developed,wheelchairmountable intelligent sensing device.Wheelchair users’travel preferences and reasons were then analyzed using the image and textual data from the surveys.Combined with a mapping workshop,a comparative analysis was performed on the bumpiness of sidewalk paving materials.The study found that wheelchair travelers’preferred non-motor lanes over sidewalks;substandard curb ramps,unleveled tree pools,limited access widths,and bumpy pavement were the main problems faced by wheelchair users in sidewalk accessibility.In addition,the study explores the inclusive needs and challenges of non-motorized right-of-way for new transportation means at urban planning and traffic management levels.Based on multi-sourced data,this paper discusses the possibility of assessing urban barrier-free environment and representing a narrative of the needs of mobility disadvantaged groups,so as to provide practical experience and technical support to the improvement strategies of adaptive roads.展开更多
Multidrug-resistance(MDR)featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the clinic.Compound nanoparticles comprising multiple cytostatics with differen...Multidrug-resistance(MDR)featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the clinic.Compound nanoparticles comprising multiple cytostatics with different mechanisms of action are commonly developed to tackle the multifaceted nature of clinical MDR.However,the different pharmacokinetics and release profiles of various drugs result in inconsistent drug internalization and suboptimal drug synergy at the tumor sites.In the present study,a type of self-targeting hyaluronate(HA)nanogels((CDDPH)^ANG/DOX)to reverse drug resistance through the synchronized pharmacokinetics,intratumoral distribution,and intracellular release of topoisomerase II inhibitor doxorubicin(DOX)and DNA-crosslinking agent cisplatin(CDDP)is developed.With prolonged circulation time and enhanced intratumoral accumulation in vivo,(CDDP)^HANG/DOX shows efficient drug delivery into the drug-resistant MCF-7/ADR breast cancer cells and enhanced antitumor activity.Besides,fluorescence imaging of DOX combined with the micro-computed tomography(micro-CT)imaging of CDDP facilitates the visualization of this combination tumor chemotherapy.With visualizable synchronized drug delivery,the self-targeting in situ crosslinked nanoplatform may hold good potential in future clinical therapy of advanced cancers.展开更多
文摘The construction of a barrier-free environment is an important measure that guarantees the safety,right-of-way,and interests of the disabled,the elderly,and other mobility disadvantaged groups.It is also an indispensable part of the low-carbon urban transportation and a necessary way to protect the rights of mobility disadvantaged groups in green travel.In this paper,the researchers conducted life log surveys on the travels of 10 wheelchair users residing in Beijing with IoT Inspector,a self-developed,wheelchairmountable intelligent sensing device.Wheelchair users’travel preferences and reasons were then analyzed using the image and textual data from the surveys.Combined with a mapping workshop,a comparative analysis was performed on the bumpiness of sidewalk paving materials.The study found that wheelchair travelers’preferred non-motor lanes over sidewalks;substandard curb ramps,unleveled tree pools,limited access widths,and bumpy pavement were the main problems faced by wheelchair users in sidewalk accessibility.In addition,the study explores the inclusive needs and challenges of non-motorized right-of-way for new transportation means at urban planning and traffic management levels.Based on multi-sourced data,this paper discusses the possibility of assessing urban barrier-free environment and representing a narrative of the needs of mobility disadvantaged groups,so as to provide practical experience and technical support to the improvement strategies of adaptive roads.
基金This study was financially supported by the National Key Research and Development Program of China(No.2016YFC1100701)the National Natural Science Foundation of China(Nos.52022095,51973216,and 51873207)+1 种基金the Science and Technology Development Program of jilin Province(No.20200404182YY)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019005)。
文摘Multidrug-resistance(MDR)featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the clinic.Compound nanoparticles comprising multiple cytostatics with different mechanisms of action are commonly developed to tackle the multifaceted nature of clinical MDR.However,the different pharmacokinetics and release profiles of various drugs result in inconsistent drug internalization and suboptimal drug synergy at the tumor sites.In the present study,a type of self-targeting hyaluronate(HA)nanogels((CDDPH)^ANG/DOX)to reverse drug resistance through the synchronized pharmacokinetics,intratumoral distribution,and intracellular release of topoisomerase II inhibitor doxorubicin(DOX)and DNA-crosslinking agent cisplatin(CDDP)is developed.With prolonged circulation time and enhanced intratumoral accumulation in vivo,(CDDP)^HANG/DOX shows efficient drug delivery into the drug-resistant MCF-7/ADR breast cancer cells and enhanced antitumor activity.Besides,fluorescence imaging of DOX combined with the micro-computed tomography(micro-CT)imaging of CDDP facilitates the visualization of this combination tumor chemotherapy.With visualizable synchronized drug delivery,the self-targeting in situ crosslinked nanoplatform may hold good potential in future clinical therapy of advanced cancers.
