Stem cell-or tissue-derived three-dimensional organ-like formations,known as organoids,are emerging as effective tools in biomedicine.Since they may be useful in developing customized therapeutic solutions and efficie...Stem cell-or tissue-derived three-dimensional organ-like formations,known as organoids,are emerging as effective tools in biomedicine.Since they may be useful in developing customized therapeutic solutions and efficient drug screening protocols,organoids can deepen our understanding of novel disease mechanisms.In doing so,they can facilitate advancements in drug discovery platforms,pharmacological safety,and clinical trials.This review explores various biomedical applications of organoids,including drug development and disease modeling,and highlights specific tools and analytical techniques that can be employed to investigate organoids and their microenvironments.Finally,we review recent clinical trials and patents related to organoids that show great promise for future clinical translation.展开更多
Dear Editor,Primary mediastinal large B-cell lymphoma(PMBCL)is a rare subtype of aggressive B cell lymphoma,accounting for 2%to 4%of total non-Hodgkin's lymphoma(NHL)cases(Savage,2022).Genomic rearrangements(e.g.,...Dear Editor,Primary mediastinal large B-cell lymphoma(PMBCL)is a rare subtype of aggressive B cell lymphoma,accounting for 2%to 4%of total non-Hodgkin's lymphoma(NHL)cases(Savage,2022).Genomic rearrangements(e.g.,isochromosome9p)and copy-number alterations at9p24.1 loci,which contain the genes encoding programmed death-ligand 1/2(PDL1/2)and JAK2,lead to the overexpression of these genes in PMBCL,distinguishing PMBCL from diffuse large B-cell lymphoma(DLBCL)(Green et al.,2010).展开更多
基金supported by the National Natural Science Foundation of China(No.82172567)Key R&D Plan of Jiangxi Province(No.2021BBG71006)the Key Project of Science and Technology Innovation of Health Commission of Jiangxi Province(Nos.2023ZD005 and 2024ZD008)。
文摘Stem cell-or tissue-derived three-dimensional organ-like formations,known as organoids,are emerging as effective tools in biomedicine.Since they may be useful in developing customized therapeutic solutions and efficient drug screening protocols,organoids can deepen our understanding of novel disease mechanisms.In doing so,they can facilitate advancements in drug discovery platforms,pharmacological safety,and clinical trials.This review explores various biomedical applications of organoids,including drug development and disease modeling,and highlights specific tools and analytical techniques that can be employed to investigate organoids and their microenvironments.Finally,we review recent clinical trials and patents related to organoids that show great promise for future clinical translation.
基金supported by the National Natural Science Foundation of China (82172567)Key R&D Plan of Jiangxi Province (2021BBG71006)Key project of Science and Technology Innovation of Health Commission of Jiangxi Province (2023ZD005 and 2024ZD008)。
文摘Dear Editor,Primary mediastinal large B-cell lymphoma(PMBCL)is a rare subtype of aggressive B cell lymphoma,accounting for 2%to 4%of total non-Hodgkin's lymphoma(NHL)cases(Savage,2022).Genomic rearrangements(e.g.,isochromosome9p)and copy-number alterations at9p24.1 loci,which contain the genes encoding programmed death-ligand 1/2(PDL1/2)and JAK2,lead to the overexpression of these genes in PMBCL,distinguishing PMBCL from diffuse large B-cell lymphoma(DLBCL)(Green et al.,2010).
