Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their development.The primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid ...Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their development.The primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid boron.In this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B system.This approach can be adopted to form various low-melting-point AM–Mg–B–O growth systems.These growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN chains.These findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.展开更多
The practical application of lithium-sulfur(Li-S)batteries is hindered by the sluggish redox kinetics of sulfur,significant volume expansion,and the shuttle effect of lithium polysulfides(LiPSs).To address these chall...The practical application of lithium-sulfur(Li-S)batteries is hindered by the sluggish redox kinetics of sulfur,significant volume expansion,and the shuttle effect of lithium polysulfides(LiPSs).To address these challenges,this study utilizes hollow carbon spheres(HCS)as a matrix,incorporating a heterojunction of transition metal sulfides(CoS_(2)/MoS_(2))as the sulfur host.The HCS,with their ultrahigh specific surface area,effectively mitigate structural damage to the cathode caused by sulfur’s volume expansion during charge and discharge cycles.Meanwhile,the CoS_(2)/MoS_(2)heterojunction provides abundant chemical adsorption and reaction sites,which accelerate the redox kinetics of sulfur and alleviating the shuttle effect of LiPSs.Density functional theory(DFT)calculations reveal that the coupling effect at the CoS_(2)/MoS_(2)heterointerface significantly enhances charge transfer and adsorption interactions between CoS_(2)/MoS_(2)and LiPSs.Experimental results demonstrate that Li-S batteries with S/CoS_(2)/MoS_(2)@HCS composites as the cathode exhibit an exceptionally low capacity decay rate of only 0.023%per cycle after 1200 cycles at 2.0 C.Even with high sulfur loading(7.9 mg cm^(−2))and a low electrolyte-to-sulfur(E/S)ratio(6.0μL mg^(−1)),the battery achieves an outstanding areal capacity of 6.86 mA h cm^(−2).This study develops a highly efficient CoS_(2)/MoS_(2)heterojunction within HCS for the adsorption and conversion of LiPSs,providing valuable insights into the design of high-performance cathode materials for Li-S batteries.展开更多
Tetracycline(TC)residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies.Herein,as inspired by the microc...Tetracycline(TC)residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies.Herein,as inspired by the microcompartment structure in living organisms,we adopt a synthetic biology approach to engineer the FerTiG,a modular enzyme assembly,to robustly scavenge TC residues with improved performance.The FerTiG consists of three functional modules,namely,a TC degradation module(Tet(X4)),a cofactor recycling module glucose dehydrogenase(GDH),and a protection module(ferritin),to organize diverse catalytic processes simultaneously as a biological circuit.The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate(NADPH)cofactor with glucose.The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions.Due to collaboration among functional modules,FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices.The degradation pathways and environmental/biological safety of FerTiG are then elaborated,indicating the promising readiness for the application of FerTiG.In summary,this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management.The FerTiG is engineered as a proof-of-principle for TC removal;however,this'microcompartment-mimick ing'concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied.展开更多
Metal oxides as support for constructing precious metal single-atom catalysts hold great promise for a wide range of industrial applications,but achieving a high-loading of thermally stable metal single atoms on such ...Metal oxides as support for constructing precious metal single-atom catalysts hold great promise for a wide range of industrial applications,but achieving a high-loading of thermally stable metal single atoms on such supports has been challenging.Herein,we report an innovative strategy for the fabrication of high-density single-atoms(Rh,Ru,Pd)catalysts on CaAl-layered double hydroxides(CaAl-LDH)via isomorphous substitution.The Rh species have occupied Ca^(2+)vacancies within CaAl-LDH laminate by ion-exchange,facilitating a substantial loading of isolated Rh single-atoms.Such catalysts displayed superior performance in the selective hydrogenation to quinoline,pivotal for liquid organic hydrogen storage,and the universality for the hydrogenation of N-heterocyclic aromatic hydrocarbons was also verified.Combining the experimental results and density functional theory calculations,the pathway of quinoline hydrogenation over Rh1CaAl-LDH was proposed.This synthetic strategy marks a significant advancement in the field of single-atom catalysts,expanding their horizons in green chemical processes.展开更多
Transient negative capacitance(NC),as an available dynamic charge effect achieved in resistor-ferroelectric capacitor(R-FEC)circuits,has triggered a series of theoretical and experimental works focusing on its physica...Transient negative capacitance(NC),as an available dynamic charge effect achieved in resistor-ferroelectric capacitor(R-FEC)circuits,has triggered a series of theoretical and experimental works focusing on its physical mechanism and device application.Here,we analytically derived the effects of different mechanical conditions on the transient NC behaviors in the R-FEC circuit based on the phenomenological model.It shows that the ferroelectric capacitor can exhibit either NC(i.e.,“single NC”and“double NC”)or positive capacitance,depending on the mechanical condition and temperature.Further numerical calculations show that the voltage drop caused by NC can be effectively controlled by temperature,applied stress,or strain.The relationship between NC voltage drop and system configurations including external resistance,dynamical coefficient of polarization,and input voltage are presented,showing diverse strategies to manipulate the NC effect.These results provide theoretical guidelines for rational design and efficient control of NC-related electronic devices.展开更多
Soil salinity is a worldwide problem that adversely affects plant growth and crop productivity. The salt overly sensitive (SOS) pathway is evolutionarily conserved and essential for plant salt tolerance. In this study...Soil salinity is a worldwide problem that adversely affects plant growth and crop productivity. The salt overly sensitive (SOS) pathway is evolutionarily conserved and essential for plant salt tolerance. In this study, we reveal how the maize shaggy/glycogen synthase kinase 3-like kinases ZmSK3 and ZmSK4, orthologs of brassinosteroid insensitive 2 in Arabidopsis thaliana, regulate the maize SOS pathway. ZmSK3 and ZmSK4 interact with and phosphorylate ZmSOS2, a core member of the maize SOS pathway. The mutants defective in ZmSK3 or ZmSK4 are hyposensitive to salt stress, with higher salt-induced activity of ZmSOS2 than that in the wild type. Furthermore, the Ca^(2+) sensors ZmSOS3 and ZmSOS3-like calcium binding protein 8 (ZmSCaBP8) activate ZmSOS2 to maintain Na^(+)/K^(+) homeostasis under salt stress and may participate in the regulation of ZmSOS2 by ZmSK3 and ZmSK4. These findings discover the regulation of the maize SOS pathway and provide important gene targets for breeding salt-tolerant maize.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not...BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not been fully elucidated to date.Some studies proved lower cerebral blood flow(CBF) in the hippocampus was associated with poor executive function and memory in T2DM.Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor(VEGF) expression and CBF changes in humans and animal models.In this study,we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional(3D) arterial spin labeling(3D-ASL) and VEGF expression in the hippocampus.AIM To assess the correlation between CBF(measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM.METHODS Forty Sprague-Dawley male rats were divided into control and T2DM groups.The T2DM group was established by feeding rats a high-fat diet and glucose to induce impaired glucose tolerance and then injecting them with streptozotocin to induce T2DM.Cognitive function was assessed using the Morris water maze experiment.The CBF changes were measured by 3D-ASL magnetic resonance imaging.VEGF expression was determined using immunofluorescence.RESULTS The escape latency time significantly reduced 15 wk after streptozotocin injection in the T2DM group.The total distance traveled was longer in the T2DM group;also,the platform was crossed fewer times.The percentage of distance in the target zone significantly decreased.CBF decreased in the bilateral hippocampus in the T2DM group.No difference was found between the right CBF value and the left CBF value in the T2DM group.The VEGF expression level in the hippocampus was lower in the T2DM group and correlated with the CBF value.The escape latency negatively correlated with the CBF value.The number of rats crossing the platform positively correlated with the CBF value.CONCLUSION Low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD.CBF measured by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM.展开更多
The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction orde...The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction order is only 0.08385, suggesting that the concentration of potassium dichromate has little influence on its adsorption on the galena surface. In addition, the simulation of CrO2 4- adsorption on the PbS （100） surface in the absence and presence of O2 was carried out by density functional theory （DFT）. The calculated results show that CrO2 4- species adsorb energetically at the Pb-S bond site, and the presence of O2 can enhance this adsorption.展开更多
Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis （CP） among Chinese urologists. Methods： A sample of 656 urologists from 29 provinces of China were asked to complete a questio...Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis （CP） among Chinese urologists. Methods： A sample of 656 urologists from 29 provinces of China were asked to complete a questionnaire that explored attitudes towards CP as well as diagnosis and treatment patterns in the management of CP. Both univariate and multivariate logistic regression analysis schemes were used to determine the factors that influence the diagnosis and treatment of CP. Results： A total of 656 questionnaires were given out. All were returned and 410 of those were included in the final univariate and multivariate analysis. Multivariate logistic regression analysis indicated that belief of bacterial infection in the etiology of CP （odds ratio [OR], 2.544; 95% confidence interval [CI], 1.650-3.923; P 〈 0.001） was the most significant factor influencing the routine performance of bacterial culture test. Using the same model, the type of hospital （OR, 2.799; 95% CI, 1.719-4.559; P 〈 0.001） and the routine use of the 4- or the 2-glass test （OR, 3.194; 95% CI, 2.069-4.931; P 〈 0.001） were determined to be significant factors influencing the use of the National Institutes of Health （NIH） new classification system. According to the same model, belief of bacterial infection in the etiology of CP （OR, 3.415; 95% CI, 2.024-5.762; P 〈 0.001） and the routine use of bacterial culture test （OR, 2.261; 95% CI, 1.364-3.749; P 〈 0.01） were important factors influencing the routine prescription of antibiotics. Conclusion： Our findings suggest that attitudes towards CP, and the characteristics of individual urologists＇ practices may influence the diagnosis and treatment of CP among Chinese urologists.展开更多
This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by...This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified.展开更多
Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synth...Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synthesis S,N co-doped carbon supported Co single atom catalysts(Co/SNC),which was used for transfer hydrogenation of quinoline with formic acid as the hydrogen donor.Given the unique ge-ometric and electronic properties of the Co single atoms,the excellent catalytic activity,selectivity and stability were observed.Benefiting from the quasi-continuous synthesis method,the as-obtained cata-lysts provide a reference for the large-scale preparation of single atom catalysts without amplification ef-fect.Highly catalytic performances and quasi-continuous preparation process,demonstrating a new and promising approach to rational design of atomically dispersed catalysts with maximum atomic efficiency in industrial.展开更多
Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in t...Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in the trans-verse and lower longitudinal directions.In this study,boron acid solution was brushed onto the tangential section of air-dried wood cubes and boron penetration along wood transverse direction was investigated under free dif-fusion,vacuum and HVEF treatments.Multi-scale boron distribution,FTIR measurement,leaching property,mechanical properties and fungistatic characteristic were investigated for free diffusion,vacuum and HVEF trea-ted samples respectively.The results revealed that boron exhibited high permeability along the transverse direc-tion with the penetration depth of≈35 mm for HVEF treated samples and≈1 mm for free diffusion and vacuum treated samples.For HVEF treated samples,no significant decrease of hardness,compression modulus of elasti-city and strength were found in the treated samples.Better fungistatic characteristic was showcased in HVEF trea-ted samples exposed to white rot fungi.Thus,HVEF treatment has a positive effect on boron permeability and the improvement of penetration depth of preservatives hence playing a significant role in wood protection and prolonging the service life of wood construction.展开更多
Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relati...Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relative mechanical properties of the material were tested and changes in the chemistry of fir were investigated using Fourier transform infrared spectroscopy(FTIR)and Xray photoelectron spectroscopy(XPS).The results indicated that the color difference between compressed and untreated wood increased gradually with the increase of temperature.Compared with the conventional hot pressing treatment,the color difference(ΔE*)of the Chinese fir treated by vacuum hot pressing decreased by 43.73%,69.91%,and 77.17%,respectively.The mechanical properties(bending elastic modulus and bending strength)of Chinese fir treated by vacuum hot pressing were significantly improved.The 24-hour water absorption thickness expansion rate of fir treated by vacuum hot pressing is smaller than that of conventional hot pressing.It is implied that vacuum hot pressing treatment is an effective method to produce compressed wood,which can improve the mechanical properties and dimensional stability of wood,and reduce the influence of carbonization on wood color.展开更多
In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized meth...In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized method of SE treatment,RPUF preparation and flame retardant treatment were selected to prepare SE-PSF/RPUF composites in this experiment.Physical and mechanical properties including density,water absorption capacity,thickness swelling rate,compressive strength,thermal conductivity and average sound absorption coefficient of SE-PSF/RPUF were investigated and compared with the control(PRUF).The results showed that the density,water absorption capacity,thickness swelling rate and thermal conductivity showed an increasing trend with the increase of SE-PSFs content.The strength of the composite material showed a downward trend with the increase of the SE-PSFs content.The average sound absorption coefficient of the SE-PSFs/RPUF compared with PRUF significant increased,and the average sound absorption coefficient of the SE-PSFs/RPUF with SE-PSFs 40%was 0.47.The study getted the best ratio of flame retardants for 10%EG and 3%DMMP.The oxygen index was 35.56 vol%.展开更多
Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which ...Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which enhanced whistler mode waves(~10^(−11) V^(2)/m^(2)/Hz)with frequency of 0.1 f_(ce)-0.5 f_(ce) occurred,based on MAVEN data,exactly corresponding to a significant decrease of suprathermal electron fluxes.The diffusion coefficients are calculated by using the observed electric field wave spectra.The pitch angle diffusion coefficient can approach 10^(−2) s^(−1),which is much larger,by~100 times,than the momentum diffusion coefficient,indicating that pitch angle scattering dominates the whistler-electron resonance process.The current results can successfully explain the dropout of the suprathermal electrons in this event.This study provides direct evidence for whistler-driven electron losses in the Martian magnetosphere.展开更多
Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor microenvironment(TME)for chemodynamic therapy(CDT)with high specificity.However,the low pH environment and insuffic...Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor microenvironment(TME)for chemodynamic therapy(CDT)with high specificity.However,the low pH environment and insufficient endogenous hydrogen peroxide(H_(2)O_(2))of the highly efficient Fenton reaction limits its practical application in clinic.Here,a Cu(Ⅱ)-doped mesoporous silica nanoagent(Cu-MSN)with excellent dispersity was successfully developed.After loaded with doxorubicin(DOX)and ascorbate(AA),Cu-MSN@DA was coated with active targeting ligand folic acid(FA),dimethyl maleic an-hydride(DMMA)and carboxymethyl chitosan(CMC)to obtain an active transporting nanoagent(FCDC@Cu-MSN@DA)with tunable charge-reversal property,which is more adaptable to the pH value of TME than Fe-based Fenton agents,and can self-supply exogenous H_(2)O_(2)by ascorbate to produce more toxic·OH to trigger the apoptosis of cancer cells.Meanwhile,the high level of glutathione(GSH)in TME can reduce Cu(Ⅱ)to Cu(I)by Fenton-like reaction,increasing the generation rate of·OH and relieving tumor antioxidant ability.The supply of exogenous H_(2)O_(2)significantly enhanced the synergistic effect of CDT by oxidative damage.Together with DOX-induced cell apoptosis,this novel nanoagent FCDC@Cu-MSN@DA can achieve maximum therapeutic efficacy,creating a new model of safe and effective tumor treatment with high specificity.展开更多
Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cl...Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cloud servers or edge services.While data encryption ensures data confidentiality,it can impede data sharing and retrieval.Attribute-based searchable encryption(ABSE)is proposed as an effective technique for enhancing data security and privacy.Nevertheless,ABSE has its limitations,such as single attribute authorization failure,privacy leakage during the search process,and high decryption overhead.This paper presents a novel approach called the blockchain-assisted efficientmulti-authority attribute-based searchable encryption scheme(BEM-ABSE)for cloudedge collaboration scenarios to address these issues.BEM-ABSE leverages a consortium blockchain to replace the central authentication center for global public parameter management.It incorporates smart contracts to facilitate reliable and fair ciphertext keyword search and decryption result verification.To minimize the computing burden on resource-constrained devices,BEM-ABSE adopts an online/offline hybrid mechanism during the encryption process and a verifiable edge-assisted decryption mechanism.This ensures both low computation cost and reliable ciphertext.Security analysis conducted under the random oracle model demonstrates that BEM-ABSE is resistant to indistinguishable chosen keyword attacks(IND-CKA)and indistinguishable chosen plaintext attacks(INDCPA).Theoretical analysis and simulation results confirm that BEM-ABSE significantly improves computational efficiency compared to existing solutions.展开更多
Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths w...Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths worldwide.^([1])However,there is still no validated medical treatment for ICH,with the role of surgery remaining controversial.^([2,3])Cusack et al^([4])demonstrated that lowering blood pressure rapidly in hypertensive ICH patients may be safe and at least partially effective in inhibiting hematoma expansion.展开更多
Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer w...Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer was searched for Wanfang,VIP,China National Knowledge Infrastructure(CNKI),SinoMed,and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018.Two researchers independently screened the literature based on inclusion and exclusion criteria,extracted the data,and assessed the risk of bias in the included studies.Meta analysis was performed using RevMan 5.3 software.Results:Finally,9 studies were included for analysis.Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiarreperfusion group(LDH:SMD=-4.75,95%CI[-6.56,-2.94],P<0.01,MDA:SMD=-2.27,95%CI[-3.07,-1.47],P<0.01),the difference was statistically significant(P<0.01).In the subgroup analysis of different doses of curcumin,different doses of curcumin(0.8,10,12.5,20,25,30,50 mg)were able to reduce LDH content compared with the ischemia-reperfusion group,and the differences were statistically significant.Different doses of curcumin(5,10,20,30,40mg)can reduce MDA content,and the difference is statistically significant;curcumin(0.8mg)group has no statistically significant effect on MDA content(SMD=-0.54,95%CI[-1.35,0.28],P=0.20).The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin(20 mg)group,the curcumin(40 mg)group could better reduce the MDA content,and the difference was statistically significant(P=0.03).Conclusion:Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,and has a protective effect on myocardium.Moreover,the ability to reduce the damage is related to the dose of curcumin.However,the sample of the included studies is limited,and this conclusion requires more high-quality experiments to verify.展开更多
基金supported by the National Natural Science Foundation of China(No.51972162)the Fundamental Research Funds for the Central Universities(No.2024300440).
文摘Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their development.The primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid boron.In this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B system.This approach can be adopted to form various low-melting-point AM–Mg–B–O growth systems.These growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN chains.These findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.
基金supported in part by the Institute for Advanced Study of Central South University and the High Performance Computing Center of Central South University。
文摘The practical application of lithium-sulfur(Li-S)batteries is hindered by the sluggish redox kinetics of sulfur,significant volume expansion,and the shuttle effect of lithium polysulfides(LiPSs).To address these challenges,this study utilizes hollow carbon spheres(HCS)as a matrix,incorporating a heterojunction of transition metal sulfides(CoS_(2)/MoS_(2))as the sulfur host.The HCS,with their ultrahigh specific surface area,effectively mitigate structural damage to the cathode caused by sulfur’s volume expansion during charge and discharge cycles.Meanwhile,the CoS_(2)/MoS_(2)heterojunction provides abundant chemical adsorption and reaction sites,which accelerate the redox kinetics of sulfur and alleviating the shuttle effect of LiPSs.Density functional theory(DFT)calculations reveal that the coupling effect at the CoS_(2)/MoS_(2)heterointerface significantly enhances charge transfer and adsorption interactions between CoS_(2)/MoS_(2)and LiPSs.Experimental results demonstrate that Li-S batteries with S/CoS_(2)/MoS_(2)@HCS composites as the cathode exhibit an exceptionally low capacity decay rate of only 0.023%per cycle after 1200 cycles at 2.0 C.Even with high sulfur loading(7.9 mg cm^(−2))and a low electrolyte-to-sulfur(E/S)ratio(6.0μL mg^(−1)),the battery achieves an outstanding areal capacity of 6.86 mA h cm^(−2).This study develops a highly efficient CoS_(2)/MoS_(2)heterojunction within HCS for the adsorption and conversion of LiPSs,providing valuable insights into the design of high-performance cathode materials for Li-S batteries.
基金supported by the National Natural Science Foundation of China(32121004 and 32102720)the Guangzhou Science and Technology Plan Project(2024A04J6509)+3 种基金the National Key Research and Development Program of China(2023YFD1800100)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02N054)the Double First-Class Discipline Promotion Project(2023B10564003)the 111 Project(D20008)。
文摘Tetracycline(TC)residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies.Herein,as inspired by the microcompartment structure in living organisms,we adopt a synthetic biology approach to engineer the FerTiG,a modular enzyme assembly,to robustly scavenge TC residues with improved performance.The FerTiG consists of three functional modules,namely,a TC degradation module(Tet(X4)),a cofactor recycling module glucose dehydrogenase(GDH),and a protection module(ferritin),to organize diverse catalytic processes simultaneously as a biological circuit.The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate(NADPH)cofactor with glucose.The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions.Due to collaboration among functional modules,FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices.The degradation pathways and environmental/biological safety of FerTiG are then elaborated,indicating the promising readiness for the application of FerTiG.In summary,this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management.The FerTiG is engineered as a proof-of-principle for TC removal;however,this'microcompartment-mimick ing'concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied.
文摘Metal oxides as support for constructing precious metal single-atom catalysts hold great promise for a wide range of industrial applications,but achieving a high-loading of thermally stable metal single atoms on such supports has been challenging.Herein,we report an innovative strategy for the fabrication of high-density single-atoms(Rh,Ru,Pd)catalysts on CaAl-layered double hydroxides(CaAl-LDH)via isomorphous substitution.The Rh species have occupied Ca^(2+)vacancies within CaAl-LDH laminate by ion-exchange,facilitating a substantial loading of isolated Rh single-atoms.Such catalysts displayed superior performance in the selective hydrogenation to quinoline,pivotal for liquid organic hydrogen storage,and the universality for the hydrogenation of N-heterocyclic aromatic hydrocarbons was also verified.Combining the experimental results and density functional theory calculations,the pathway of quinoline hydrogenation over Rh1CaAl-LDH was proposed.This synthetic strategy marks a significant advancement in the field of single-atom catalysts,expanding their horizons in green chemical processes.
基金This work was supported by the National Natural Science Foundation of China(Grants Nos.12222214,12132020,12002400,and 12172386)by Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices(Grant No.2022B1212010008)+1 种基金by the National Natural Science Foundation of Guangdong Province(Grant No.2021B1515020021)by the Shenzhen Science and Techonlogy Program(Grant Nos.202206193000001 and 20220818181805001).
文摘Transient negative capacitance(NC),as an available dynamic charge effect achieved in resistor-ferroelectric capacitor(R-FEC)circuits,has triggered a series of theoretical and experimental works focusing on its physical mechanism and device application.Here,we analytically derived the effects of different mechanical conditions on the transient NC behaviors in the R-FEC circuit based on the phenomenological model.It shows that the ferroelectric capacitor can exhibit either NC(i.e.,“single NC”and“double NC”)or positive capacitance,depending on the mechanical condition and temperature.Further numerical calculations show that the voltage drop caused by NC can be effectively controlled by temperature,applied stress,or strain.The relationship between NC voltage drop and system configurations including external resistance,dynamical coefficient of polarization,and input voltage are presented,showing diverse strategies to manipulate the NC effect.These results provide theoretical guidelines for rational design and efficient control of NC-related electronic devices.
基金This work was supported by grants from the National Key R&D Program of China(2022YFF1001601 and 2022YFA1303400)supported by grants from the National Natural Science Foundation of China(32100234 and 31921001).
文摘Soil salinity is a worldwide problem that adversely affects plant growth and crop productivity. The salt overly sensitive (SOS) pathway is evolutionarily conserved and essential for plant salt tolerance. In this study, we reveal how the maize shaggy/glycogen synthase kinase 3-like kinases ZmSK3 and ZmSK4, orthologs of brassinosteroid insensitive 2 in Arabidopsis thaliana, regulate the maize SOS pathway. ZmSK3 and ZmSK4 interact with and phosphorylate ZmSOS2, a core member of the maize SOS pathway. The mutants defective in ZmSK3 or ZmSK4 are hyposensitive to salt stress, with higher salt-induced activity of ZmSOS2 than that in the wild type. Furthermore, the Ca^(2+) sensors ZmSOS3 and ZmSOS3-like calcium binding protein 8 (ZmSCaBP8) activate ZmSOS2 to maintain Na^(+)/K^(+) homeostasis under salt stress and may participate in the regulation of ZmSOS2 by ZmSK3 and ZmSK4. These findings discover the regulation of the maize SOS pathway and provide important gene targets for breeding salt-tolerant maize.
基金Supported by The Endocrine Clinical Medical Center of Yunnan ProvinceNo.ZX20190202+2 种基金the Fund of the Diabetic Innovation Team in Yunnan Province,No.2019HC002the Special Joint Fund from Yunnan Provincial Department of Science and Technology and Kunming Medical University,Kunming,Yunnan,China,No.2018FE001(-267)the SKY Image Research Fund,China,No. Z-2014-07-2003-12。
文摘BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not been fully elucidated to date.Some studies proved lower cerebral blood flow(CBF) in the hippocampus was associated with poor executive function and memory in T2DM.Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor(VEGF) expression and CBF changes in humans and animal models.In this study,we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional(3D) arterial spin labeling(3D-ASL) and VEGF expression in the hippocampus.AIM To assess the correlation between CBF(measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM.METHODS Forty Sprague-Dawley male rats were divided into control and T2DM groups.The T2DM group was established by feeding rats a high-fat diet and glucose to induce impaired glucose tolerance and then injecting them with streptozotocin to induce T2DM.Cognitive function was assessed using the Morris water maze experiment.The CBF changes were measured by 3D-ASL magnetic resonance imaging.VEGF expression was determined using immunofluorescence.RESULTS The escape latency time significantly reduced 15 wk after streptozotocin injection in the T2DM group.The total distance traveled was longer in the T2DM group;also,the platform was crossed fewer times.The percentage of distance in the target zone significantly decreased.CBF decreased in the bilateral hippocampus in the T2DM group.No difference was found between the right CBF value and the left CBF value in the T2DM group.The VEGF expression level in the hippocampus was lower in the T2DM group and correlated with the CBF value.The escape latency negatively correlated with the CBF value.The number of rats crossing the platform positively correlated with the CBF value.CONCLUSION Low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD.CBF measured by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM.
基金financially supported by the National Natural Science Foundation of China(No.51164001)
文摘The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction order is only 0.08385, suggesting that the concentration of potassium dichromate has little influence on its adsorption on the galena surface. In addition, the simulation of CrO2 4- adsorption on the PbS （100） surface in the absence and presence of O2 was carried out by density functional theory （DFT）. The calculated results show that CrO2 4- species adsorb energetically at the Pb-S bond site, and the presence of O2 can enhance this adsorption.
文摘Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis （CP） among Chinese urologists. Methods： A sample of 656 urologists from 29 provinces of China were asked to complete a questionnaire that explored attitudes towards CP as well as diagnosis and treatment patterns in the management of CP. Both univariate and multivariate logistic regression analysis schemes were used to determine the factors that influence the diagnosis and treatment of CP. Results： A total of 656 questionnaires were given out. All were returned and 410 of those were included in the final univariate and multivariate analysis. Multivariate logistic regression analysis indicated that belief of bacterial infection in the etiology of CP （odds ratio [OR], 2.544; 95% confidence interval [CI], 1.650-3.923; P 〈 0.001） was the most significant factor influencing the routine performance of bacterial culture test. Using the same model, the type of hospital （OR, 2.799; 95% CI, 1.719-4.559; P 〈 0.001） and the routine use of the 4- or the 2-glass test （OR, 3.194; 95% CI, 2.069-4.931; P 〈 0.001） were determined to be significant factors influencing the use of the National Institutes of Health （NIH） new classification system. According to the same model, belief of bacterial infection in the etiology of CP （OR, 3.415; 95% CI, 2.024-5.762; P 〈 0.001） and the routine use of bacterial culture test （OR, 2.261; 95% CI, 1.364-3.749; P 〈 0.01） were important factors influencing the routine prescription of antibiotics. Conclusion： Our findings suggest that attitudes towards CP, and the characteristics of individual urologists＇ practices may influence the diagnosis and treatment of CP among Chinese urologists.
基金the funding support from The Bioenergy Technologies Office (BETO) within the US DOE’s Office of Energy Efficiency and Renewable Energythe funding support from the American Recovery and Reinvestment Actsupported by the US DOE’s Office of Science, Biological and Environmental Research program through contract DE-AC02-05CH11231 between Lawrence Berkeley National Laboratory and the U.S. Department of Energy
文摘This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified.
基金financial support from the National Natural Science Foundation of China(Nos.22078371,21938001,21961160741)Guangdong Provincial Key R&D Programme(No.2019B110206002)+4 种基金Special fund for Local Science and Technology Development by the Central Government,Local Innovative and Research Teams Project of Guangdong Pearl River Talents Pro-gram(No.2017BT01C102)the NSF of Guang-dong Province(No.2020A1515011141)the National key Research and Development Program Nanotechnology Specific Project(No.2020YFA0210900)the Science and Technology Key Project of Guangdong Province,China(No.2020B010188002)The Project Supported by Guangdong Natural Science Foundation(No.2021A1515010163).
文摘Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synthesis S,N co-doped carbon supported Co single atom catalysts(Co/SNC),which was used for transfer hydrogenation of quinoline with formic acid as the hydrogen donor.Given the unique ge-ometric and electronic properties of the Co single atoms,the excellent catalytic activity,selectivity and stability were observed.Benefiting from the quasi-continuous synthesis method,the as-obtained cata-lysts provide a reference for the large-scale preparation of single atom catalysts without amplification ef-fect.Highly catalytic performances and quasi-continuous preparation process,demonstrating a new and promising approach to rational design of atomically dispersed catalysts with maximum atomic efficiency in industrial.
基金The authors would like to express their sincere appreciation for the funding from the National Natural Science Foundation of China(Grant Nos.32071700 and 31901252)the National Key R&D Program of China(Grant No.2018YFD1101002)+1 种基金This study was also supported by the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20180276)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant Nos.18KJB220012 and 20KJB560010).
文摘Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in the trans-verse and lower longitudinal directions.In this study,boron acid solution was brushed onto the tangential section of air-dried wood cubes and boron penetration along wood transverse direction was investigated under free dif-fusion,vacuum and HVEF treatments.Multi-scale boron distribution,FTIR measurement,leaching property,mechanical properties and fungistatic characteristic were investigated for free diffusion,vacuum and HVEF trea-ted samples respectively.The results revealed that boron exhibited high permeability along the transverse direc-tion with the penetration depth of≈35 mm for HVEF treated samples and≈1 mm for free diffusion and vacuum treated samples.For HVEF treated samples,no significant decrease of hardness,compression modulus of elasti-city and strength were found in the treated samples.Better fungistatic characteristic was showcased in HVEF trea-ted samples exposed to white rot fungi.Thus,HVEF treatment has a positive effect on boron permeability and the improvement of penetration depth of preservatives hence playing a significant role in wood protection and prolonging the service life of wood construction.
基金The Authors acknowledge funding support by the National Key R&D Program of China(2017YFC0703501)the Doctorate Fellowship Foundation of the Nanjing Forestry University and the China Double First Class University Plan.
文摘Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relative mechanical properties of the material were tested and changes in the chemistry of fir were investigated using Fourier transform infrared spectroscopy(FTIR)and Xray photoelectron spectroscopy(XPS).The results indicated that the color difference between compressed and untreated wood increased gradually with the increase of temperature.Compared with the conventional hot pressing treatment,the color difference(ΔE*)of the Chinese fir treated by vacuum hot pressing decreased by 43.73%,69.91%,and 77.17%,respectively.The mechanical properties(bending elastic modulus and bending strength)of Chinese fir treated by vacuum hot pressing were significantly improved.The 24-hour water absorption thickness expansion rate of fir treated by vacuum hot pressing is smaller than that of conventional hot pressing.It is implied that vacuum hot pressing treatment is an effective method to produce compressed wood,which can improve the mechanical properties and dimensional stability of wood,and reduce the influence of carbonization on wood color.
基金from the National Key R&D Program of China(2017YFC0703501)the National Natural and Science Foundation(Nos.BK20170926 and BK20150878)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX18_0962)the Doctorate Fellowship Foundation of Nanjing Forestry University and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)LERMAB is supported by the French National Research Agency through the Laboratory of Excellence ARBRE(ANR-12-LABXARBRE-01).
文摘In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized method of SE treatment,RPUF preparation and flame retardant treatment were selected to prepare SE-PSF/RPUF composites in this experiment.Physical and mechanical properties including density,water absorption capacity,thickness swelling rate,compressive strength,thermal conductivity and average sound absorption coefficient of SE-PSF/RPUF were investigated and compared with the control(PRUF).The results showed that the density,water absorption capacity,thickness swelling rate and thermal conductivity showed an increasing trend with the increase of SE-PSFs content.The strength of the composite material showed a downward trend with the increase of the SE-PSFs content.The average sound absorption coefficient of the SE-PSFs/RPUF compared with PRUF significant increased,and the average sound absorption coefficient of the SE-PSFs/RPUF with SE-PSFs 40%was 0.47.The study getted the best ratio of flame retardants for 10%EG and 3%DMMP.The oxygen index was 35.56 vol%.
基金the National Natural Science Foundation of China grants 42230209, 42241136, 42374199, 42204171, 42274212the Natural Science Foundation of Hunan province Grant 2021JJ20010, 2023JJ20038
文摘Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which enhanced whistler mode waves(~10^(−11) V^(2)/m^(2)/Hz)with frequency of 0.1 f_(ce)-0.5 f_(ce) occurred,based on MAVEN data,exactly corresponding to a significant decrease of suprathermal electron fluxes.The diffusion coefficients are calculated by using the observed electric field wave spectra.The pitch angle diffusion coefficient can approach 10^(−2) s^(−1),which is much larger,by~100 times,than the momentum diffusion coefficient,indicating that pitch angle scattering dominates the whistler-electron resonance process.The current results can successfully explain the dropout of the suprathermal electrons in this event.This study provides direct evidence for whistler-driven electron losses in the Martian magnetosphere.
基金financially supported by the National Key Research and Development Program of China(No.2019YFA0705803)the National Natural Science Foundation of China Youth Fund(Nos.51803174,82102470)+4 种基金the Natural Science Foundation of Sichuan Province(No.24NSFSC4798)the Foundation of Sichuan Engineering Technology Research Center of Basalt Fiber Composites Development and Application of Southwest Petroleum University(No.2022SCXWYXWFC002)the support from the School of New Energy and Materials of Southwest Petroleum UniversitySichuan International Science and Technology Cooperation BaseDalian Institute of Chemical Physics of Chinese Academy of Sciences。
文摘Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor microenvironment(TME)for chemodynamic therapy(CDT)with high specificity.However,the low pH environment and insufficient endogenous hydrogen peroxide(H_(2)O_(2))of the highly efficient Fenton reaction limits its practical application in clinic.Here,a Cu(Ⅱ)-doped mesoporous silica nanoagent(Cu-MSN)with excellent dispersity was successfully developed.After loaded with doxorubicin(DOX)and ascorbate(AA),Cu-MSN@DA was coated with active targeting ligand folic acid(FA),dimethyl maleic an-hydride(DMMA)and carboxymethyl chitosan(CMC)to obtain an active transporting nanoagent(FCDC@Cu-MSN@DA)with tunable charge-reversal property,which is more adaptable to the pH value of TME than Fe-based Fenton agents,and can self-supply exogenous H_(2)O_(2)by ascorbate to produce more toxic·OH to trigger the apoptosis of cancer cells.Meanwhile,the high level of glutathione(GSH)in TME can reduce Cu(Ⅱ)to Cu(I)by Fenton-like reaction,increasing the generation rate of·OH and relieving tumor antioxidant ability.The supply of exogenous H_(2)O_(2)significantly enhanced the synergistic effect of CDT by oxidative damage.Together with DOX-induced cell apoptosis,this novel nanoagent FCDC@Cu-MSN@DA can achieve maximum therapeutic efficacy,creating a new model of safe and effective tumor treatment with high specificity.
基金supported by the National Natural Science Foundation of China(Nos.62162018,61972412)the Natural Science Foundation of Guangxi(No.2019GXNSFGA245004)+1 种基金the Guilin Science and Technology Project(20210226-1)the Innovation Project of Guangxi Graduate Education(No.YCSW2022296).
文摘Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cloud servers or edge services.While data encryption ensures data confidentiality,it can impede data sharing and retrieval.Attribute-based searchable encryption(ABSE)is proposed as an effective technique for enhancing data security and privacy.Nevertheless,ABSE has its limitations,such as single attribute authorization failure,privacy leakage during the search process,and high decryption overhead.This paper presents a novel approach called the blockchain-assisted efficientmulti-authority attribute-based searchable encryption scheme(BEM-ABSE)for cloudedge collaboration scenarios to address these issues.BEM-ABSE leverages a consortium blockchain to replace the central authentication center for global public parameter management.It incorporates smart contracts to facilitate reliable and fair ciphertext keyword search and decryption result verification.To minimize the computing burden on resource-constrained devices,BEM-ABSE adopts an online/offline hybrid mechanism during the encryption process and a verifiable edge-assisted decryption mechanism.This ensures both low computation cost and reliable ciphertext.Security analysis conducted under the random oracle model demonstrates that BEM-ABSE is resistant to indistinguishable chosen keyword attacks(IND-CKA)and indistinguishable chosen plaintext attacks(INDCPA).Theoretical analysis and simulation results confirm that BEM-ABSE significantly improves computational efficiency compared to existing solutions.
基金supported by a grant from Sichuan Science and Technology Program,China(2019YFS0251).
文摘Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths worldwide.^([1])However,there is still no validated medical treatment for ICH,with the role of surgery remaining controversial.^([2,3])Cusack et al^([4])demonstrated that lowering blood pressure rapidly in hypertensive ICH patients may be safe and at least partially effective in inhibiting hematoma expansion.
文摘Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer was searched for Wanfang,VIP,China National Knowledge Infrastructure(CNKI),SinoMed,and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018.Two researchers independently screened the literature based on inclusion and exclusion criteria,extracted the data,and assessed the risk of bias in the included studies.Meta analysis was performed using RevMan 5.3 software.Results:Finally,9 studies were included for analysis.Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiarreperfusion group(LDH:SMD=-4.75,95%CI[-6.56,-2.94],P<0.01,MDA:SMD=-2.27,95%CI[-3.07,-1.47],P<0.01),the difference was statistically significant(P<0.01).In the subgroup analysis of different doses of curcumin,different doses of curcumin(0.8,10,12.5,20,25,30,50 mg)were able to reduce LDH content compared with the ischemia-reperfusion group,and the differences were statistically significant.Different doses of curcumin(5,10,20,30,40mg)can reduce MDA content,and the difference is statistically significant;curcumin(0.8mg)group has no statistically significant effect on MDA content(SMD=-0.54,95%CI[-1.35,0.28],P=0.20).The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin(20 mg)group,the curcumin(40 mg)group could better reduce the MDA content,and the difference was statistically significant(P=0.03).Conclusion:Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,and has a protective effect on myocardium.Moreover,the ability to reduce the damage is related to the dose of curcumin.However,the sample of the included studies is limited,and this conclusion requires more high-quality experiments to verify.
