Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical ...Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the market.Identifying constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.展开更多
A pair of new enantiomeric furoquinoline alkaloids,(±)-zanthonitidine A(1),together with nine known ones(2-10)were isolated from the radix of Zanthoxylum nitidum.Their chemical structures were elucidated based on...A pair of new enantiomeric furoquinoline alkaloids,(±)-zanthonitidine A(1),together with nine known ones(2-10)were isolated from the radix of Zanthoxylum nitidum.Their chemical structures were elucidated based on the extensive spectroscopic analysis.The racemic mixture of 1 was separated by chiral column chromatography,and the absolute configurations of (+)-1 and(-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra.Antibacterial activities of compounds 1-9 were evaluated,and compounds(+)-1,(-)-1,3,7 and 8 showed antibacterial activities against Bacillus subtilis,Enterococcus faecalis or Staphylococcus aureus.展开更多
Animal-derived traditional Chinese medicines(ATCMs),which are prepared from whole animals,organs,or physiological and pathological products,have gained wide recognition and have become an integral part of traditional ...Animal-derived traditional Chinese medicines(ATCMs),which are prepared from whole animals,organs,or physiological and pathological products,have gained wide recognition and have become an integral part of traditional Chinese medicine in recent years.To provide a comprehensive reference on these agents,we systematically reviewed small-molecule compounds,analytical techniques,and pharmacological activities of ATCMs.Information and research progress regarding ATCMs were collected from scientific journals,Materials Medica,and scientific databases(PubMed,Google Scholar,Science Direct,Web of Science,and China National Knowledge Infrastructure).Various small-molecule compounds,including nitrogenous heterocyclic compounds,steroids,flavonoids,terpenoids,amino acids,and oligopeptides were summarized.Common analytical techniques applied to ATCMs include spectral and chromatographic techniques,of which hyphenated techniques are the most widely used.The primary pharmacological activities of small-molecule compounds in ATCMs include their effects on the cardiovascular and cerebrovascular systems,as well as their anti-cancer and anti-inflammatory activities.This systematic review provides a comprehensive reference for small-molecule ATCM compounds,analytical techniques,and pharmacological activities.展开更多
基金the Guangxi Science and Technology Major Program(Grant No.:GUIKEAA23023035)Key Program of National Natural Science Foundation of China(Grant No.:82130111)+1 种基金Guangxi Science and Technology Major Project(Grant No.:GUIKEAA22096029)Science and Technology Major Project of Inner Mongolia(Grant No.:2021ZD0017).
文摘Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the market.Identifying constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.
基金supported by the National Natural Science Foundation of China(31470428,21702231)the National New Drug Innovation Major Project of China(2017ZX09309027)the Program for Jiangsu Province Innovative Research Team,the Fund for Introduction of High-level Talents from China Pharmaceu-tical University and the Fundamental Research Funds for the Central Universities(2632017PY19).
文摘A pair of new enantiomeric furoquinoline alkaloids,(±)-zanthonitidine A(1),together with nine known ones(2-10)were isolated from the radix of Zanthoxylum nitidum.Their chemical structures were elucidated based on the extensive spectroscopic analysis.The racemic mixture of 1 was separated by chiral column chromatography,and the absolute configurations of (+)-1 and(-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra.Antibacterial activities of compounds 1-9 were evaluated,and compounds(+)-1,(-)-1,3,7 and 8 showed antibacterial activities against Bacillus subtilis,Enterococcus faecalis or Staphylococcus aureus.
基金financially supported by the Key Program of the National Natural Science Foundation of China(No.82130111)National Natural Science Foundation of China(No.81803716 and 32400325)Sanming Project of Medicine in Shenzhen(No.SZZYSM202106004)。
文摘Animal-derived traditional Chinese medicines(ATCMs),which are prepared from whole animals,organs,or physiological and pathological products,have gained wide recognition and have become an integral part of traditional Chinese medicine in recent years.To provide a comprehensive reference on these agents,we systematically reviewed small-molecule compounds,analytical techniques,and pharmacological activities of ATCMs.Information and research progress regarding ATCMs were collected from scientific journals,Materials Medica,and scientific databases(PubMed,Google Scholar,Science Direct,Web of Science,and China National Knowledge Infrastructure).Various small-molecule compounds,including nitrogenous heterocyclic compounds,steroids,flavonoids,terpenoids,amino acids,and oligopeptides were summarized.Common analytical techniques applied to ATCMs include spectral and chromatographic techniques,of which hyphenated techniques are the most widely used.The primary pharmacological activities of small-molecule compounds in ATCMs include their effects on the cardiovascular and cerebrovascular systems,as well as their anti-cancer and anti-inflammatory activities.This systematic review provides a comprehensive reference for small-molecule ATCM compounds,analytical techniques,and pharmacological activities.
