The erythroblastic island(EBI)is a multicellular structure defined by the presence of 1 or 2 central macrophages surrounded by at least 3 erythroblasts.EBIs were initially proposed as a specialized microenvironment ex...The erythroblastic island(EBI)is a multicellular structure defined by the presence of 1 or 2 central macrophages surrounded by at least 3 erythroblasts.EBIs were initially proposed as a specialized microenvironment exclusively for erythroid terminal differentiation.Recent advancements in techniques such as lineage tracing mouse models,imaging flow cytometry,and single-cell RNA sequencing,accumulating evidence has provided novel insights that challenge this conventional view.Notably,the erythropoietin receptor has been identified as a novel marker for EBI macrophages.Additionally,neutrophils have been identified as novel cellular components of EBIs,raising the intriguing hypothesis that EBIs may support other hematopoietic lineage cells as well.Beyond the diverse cellular components of various hematopoietic lineages,even within the erythroid lineage,an immune-prone erythroblast subpopulation has been reported,although it remains unclear whether and how these immune-prone erythroblasts mature in EBIs.These observations indicate that EBIs are a heterogeneous population.In this review,we summarize the most recent findings on EBIs,discuss their potential immune functions,and provide a perspective for future investigations.展开更多
Neuromorphic applications have shown great promise not only for efficient parallel computing mode to hold certain computational tasks,such as perception and recognition,but also as key biomimetic elements for th intel...Neuromorphic applications have shown great promise not only for efficient parallel computing mode to hold certain computational tasks,such as perception and recognition,but also as key biomimetic elements for th intelligent sensory system of next-generation robotics.However,achieving such a biomimetic nociceptor tha can adaptively switch operation mode with a stimulation threshold remains a challenge.Through rational design of material properties and device structures,we realized an easily-fabricated,low-energy,and reconfigurable no ciceptor.It is capable of threshold-triggered adaptive bi-mode jump that resembles the biological alarm system With a tunnel silicon nitride(Si_(3)N_(4))we mimicked the intensity-and rehearsal-triggered jump by means of th tunneling mode transition of Si_(3)N_(4)dielectric.Under threshold signals the device can also express some common synaptic functions with an extremely low energy density of 33.5 f J∕μm^(2).In addition,through the modulation o Si_(3)N_(4)thickness it is relatively easy to fabricate the device with differing pain degree.Our nociceptor analog based on a tunneling layer provides an opportunity for the analog pain alarm system and opens up a new path toward threshold-related novel applications.展开更多
基金supported by grants from the National Key Research and Development Program of China(2022YFA1103503 to L.S.,2024YFC2510500 to J.G.)the National Natural Science Foundation of China(82225003 to L.S.,82100152 to J.T.,U24A20749 to J.T.,82300141 to J.G.,82400148 to J.M.)+2 种基金the CAMS Innovation Fund for Medical Sciences(2023-I2M-2-007 to L.S.,2021-I2M-1-040 to L.S.,2021-I2M-1-073 to J.T.,2024-I2M-TS-036 to L.S.)Haihe Laboratory of Cell Ecosystem Innovation Fund(HH24KYZX0005 to L.S.)Tianjin Municipal Science and Technology Commission Grant(24ZXRKSY00010 to L.S.,24ZXZSSS00080 to J.T.,23ZXRKSY00010 to L.S.).
文摘The erythroblastic island(EBI)is a multicellular structure defined by the presence of 1 or 2 central macrophages surrounded by at least 3 erythroblasts.EBIs were initially proposed as a specialized microenvironment exclusively for erythroid terminal differentiation.Recent advancements in techniques such as lineage tracing mouse models,imaging flow cytometry,and single-cell RNA sequencing,accumulating evidence has provided novel insights that challenge this conventional view.Notably,the erythropoietin receptor has been identified as a novel marker for EBI macrophages.Additionally,neutrophils have been identified as novel cellular components of EBIs,raising the intriguing hypothesis that EBIs may support other hematopoietic lineage cells as well.Beyond the diverse cellular components of various hematopoietic lineages,even within the erythroid lineage,an immune-prone erythroblast subpopulation has been reported,although it remains unclear whether and how these immune-prone erythroblasts mature in EBIs.These observations indicate that EBIs are a heterogeneous population.In this review,we summarize the most recent findings on EBIs,discuss their potential immune functions,and provide a perspective for future investigations.
基金National Natural Science Youth Foundation(62106111)Wuxi"Taihu Light"Science and Technology Research Plan(K20231001)Wuxi University Research Start-up Fund for Introduced Talents(2021r011,2021r012)。
文摘Neuromorphic applications have shown great promise not only for efficient parallel computing mode to hold certain computational tasks,such as perception and recognition,but also as key biomimetic elements for th intelligent sensory system of next-generation robotics.However,achieving such a biomimetic nociceptor tha can adaptively switch operation mode with a stimulation threshold remains a challenge.Through rational design of material properties and device structures,we realized an easily-fabricated,low-energy,and reconfigurable no ciceptor.It is capable of threshold-triggered adaptive bi-mode jump that resembles the biological alarm system With a tunnel silicon nitride(Si_(3)N_(4))we mimicked the intensity-and rehearsal-triggered jump by means of th tunneling mode transition of Si_(3)N_(4)dielectric.Under threshold signals the device can also express some common synaptic functions with an extremely low energy density of 33.5 f J∕μm^(2).In addition,through the modulation o Si_(3)N_(4)thickness it is relatively easy to fabricate the device with differing pain degree.Our nociceptor analog based on a tunneling layer provides an opportunity for the analog pain alarm system and opens up a new path toward threshold-related novel applications.
