目的观察基于敦煌《灸经图》思想运用针刺治疗肾精亏虚型神经性耳鸣的临床疗效。方法将60例肾精亏虚型神经性耳鸣患者按随机数字表法分为治疗组(30例)和对照组(30例)。对照组采用常规针刺法,治疗组根据敦煌《灸经图》思想进行取穴行针...目的观察基于敦煌《灸经图》思想运用针刺治疗肾精亏虚型神经性耳鸣的临床疗效。方法将60例肾精亏虚型神经性耳鸣患者按随机数字表法分为治疗组(30例)和对照组(30例)。对照组采用常规针刺法,治疗组根据敦煌《灸经图》思想进行取穴行针刺治疗。治疗前后分别评估两组患者耳鸣的严重程度,比较两组治疗前后耳鸣障碍量表(tinnitus handicap inventory,THI)评分和耳鸣视觉模拟量表(visual analog scale,VAS)评分。比较两组临床疗效。结果治疗后,两组耳鸣VAS评分和THI评分均降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。结论基于敦煌《灸经图》思想运用针刺治疗肾精亏虚型神经性耳鸣的临床疗效优于常规针刺。展开更多
Metalloporphyrins have devastating effects on the deep processing and efficient utilization of petroleum resources. Various porphyrins are derived from porphin by substitution at the β, meso, or both positions. Herei...Metalloporphyrins have devastating effects on the deep processing and efficient utilization of petroleum resources. Various porphyrins are derived from porphin by substitution at the β, meso, or both positions. Herein, we focus on the interaction between nickel(Ⅱ) and the porphyrin skeleton. Five different density functionals were selected for determining a reliable approach to simulate porphyrin-nickel(Ⅱ) complexes. At D4h symmetry, the 10b1g, 15a1g, 4e1g and 9b2g were dominated by the 3d character of nickel. Compared with pure density functional, the hybrid functional gave larger highest occupied molecular orbital(HOMO) and lowest unoccupied molecular orbital(LUMO) gap, and the higher HOMO-LUMO gap also corresponded to a higher excitation energy. The characteristic Soret and Q bands modeled by timedependent density functional theory(TDDFT) calculations matched well with experimental results, and the absorption was discussed in detail with natural transition orbitals(NTO) analysis. Furthermore, the binding character of nickel(Ⅱ) with various substituted porphyrins were calculated at perdew-burke-ernzerhof(PBE) level, showed that the geometry and complexation behavior of porphyrin-nickel(Ⅱ) complexes could be significantly tuned by different substituents. The symmetry of the complex was reduced and the skeleton ring get distortion when introducing different substituents. Compared with ETIO porphyrin, the introduction of phenyl on the β position can expand the conjugated system and promote the covalent character of Ni-N bond.展开更多
文摘目的观察基于敦煌《灸经图》思想运用针刺治疗肾精亏虚型神经性耳鸣的临床疗效。方法将60例肾精亏虚型神经性耳鸣患者按随机数字表法分为治疗组(30例)和对照组(30例)。对照组采用常规针刺法,治疗组根据敦煌《灸经图》思想进行取穴行针刺治疗。治疗前后分别评估两组患者耳鸣的严重程度,比较两组治疗前后耳鸣障碍量表(tinnitus handicap inventory,THI)评分和耳鸣视觉模拟量表(visual analog scale,VAS)评分。比较两组临床疗效。结果治疗后,两组耳鸣VAS评分和THI评分均降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。结论基于敦煌《灸经图》思想运用针刺治疗肾精亏虚型神经性耳鸣的临床疗效优于常规针刺。
基金supported by National Key R & D program of China (No.2021YFA1501204)Contract Projects of China Petroleum & Chemical Corporation (SINOPEC Corp.) (grant number 123017grant number 121043-2)。
文摘Metalloporphyrins have devastating effects on the deep processing and efficient utilization of petroleum resources. Various porphyrins are derived from porphin by substitution at the β, meso, or both positions. Herein, we focus on the interaction between nickel(Ⅱ) and the porphyrin skeleton. Five different density functionals were selected for determining a reliable approach to simulate porphyrin-nickel(Ⅱ) complexes. At D4h symmetry, the 10b1g, 15a1g, 4e1g and 9b2g were dominated by the 3d character of nickel. Compared with pure density functional, the hybrid functional gave larger highest occupied molecular orbital(HOMO) and lowest unoccupied molecular orbital(LUMO) gap, and the higher HOMO-LUMO gap also corresponded to a higher excitation energy. The characteristic Soret and Q bands modeled by timedependent density functional theory(TDDFT) calculations matched well with experimental results, and the absorption was discussed in detail with natural transition orbitals(NTO) analysis. Furthermore, the binding character of nickel(Ⅱ) with various substituted porphyrins were calculated at perdew-burke-ernzerhof(PBE) level, showed that the geometry and complexation behavior of porphyrin-nickel(Ⅱ) complexes could be significantly tuned by different substituents. The symmetry of the complex was reduced and the skeleton ring get distortion when introducing different substituents. Compared with ETIO porphyrin, the introduction of phenyl on the β position can expand the conjugated system and promote the covalent character of Ni-N bond.
