Antiphospholipid syndrome(APS)is a systemic autoimmune disorder characterized by the presence of antiphospholipid antibodies and is associated with thrombotic events and pregnancy complications.The classification and ...Antiphospholipid syndrome(APS)is a systemic autoimmune disorder characterized by the presence of antiphospholipid antibodies and is associated with thrombotic events and pregnancy complications.The classification and management of APS has evolved over time.The classification criteria for APS include laboratory,macrovascular,microvascular,obstetric,cardiac,and hematologic domains.Management focuses on prevention of thrombotic events and/or anticoagulation as the primary treatment for thrombosis.Postpartum and long-term thromboprophylaxis after delivery are recommended to reduce the risk of thrombotic events.Despite these recommendations,optimal anticoagulation agents and intensity of treatment are still topics of debate.Further research is needed to understand the pathophysiology of APS and improve its management during pregnancy.In this review,we discuss the classification and pathophysiology of APS.Current treatment options and clinical trials are also discussed.展开更多
文摘Antiphospholipid syndrome(APS)is a systemic autoimmune disorder characterized by the presence of antiphospholipid antibodies and is associated with thrombotic events and pregnancy complications.The classification and management of APS has evolved over time.The classification criteria for APS include laboratory,macrovascular,microvascular,obstetric,cardiac,and hematologic domains.Management focuses on prevention of thrombotic events and/or anticoagulation as the primary treatment for thrombosis.Postpartum and long-term thromboprophylaxis after delivery are recommended to reduce the risk of thrombotic events.Despite these recommendations,optimal anticoagulation agents and intensity of treatment are still topics of debate.Further research is needed to understand the pathophysiology of APS and improve its management during pregnancy.In this review,we discuss the classification and pathophysiology of APS.Current treatment options and clinical trials are also discussed.
