The integration of artificial intelligence(AI)and machine learning(ML)into pharmaceutical sciences has catalyzed transformative advancements across drug discovery,clinical development,manufacturing,and post-market sur...The integration of artificial intelligence(AI)and machine learning(ML)into pharmaceutical sciences has catalyzed transformative advancements across drug discovery,clinical development,manufacturing,and post-market surveillance.This review comprehensively examines AI's role in modern pharmacotherapy,beginning with its historical evolution in life sciences and progressing to cutting-edge applications such as AlphaFold-driven protein modeling,natural language processing(NLP)for biomedical literature mining,and AI-augmented pharmacovigilance.Methodologically,we synthesize interdisciplinary insights from peer-reviewed literature(2013-2023),highlighting innovations in cheminformatics(e.g.,QSAR,RDKit),predictive toxi-cology,and personalized medicine.Case studies illustrate AI's capacity to compress drug development timelines,as seen in COVID-19 repurposing efforts and de novo kinase inhibitor design.However,challenges persist,including algorithmic bias,regulatory ambiguities,and the“black-box”nature of deep learning models.By critically evaluating successes and limitations,this review underscores AI's potential to redefine pharmaceutical innovation while advocating for robust frameworks to ensure ethical,transparent,and clinically translatable AI deployment.展开更多
Microneedle technology involves skin puncturing and has emerged as an innovative approach for drug delivery and cosmetic applications.MNs offer advantages over traditional injections,such as reduced pain,infection ris...Microneedle technology involves skin puncturing and has emerged as an innovative approach for drug delivery and cosmetic applications.MNs offer advantages over traditional injections,such as reduced pain,infection risks,and improved control of drug delivery.Cosmetic products aim to alter or enhance the appearance of the human body,while transdermal drug delivery involves administering drugs via the skin for local or systemic treatment.The use of MNs in combination with cosmetics has shown promise in improving nutrient delivery,skin healing,and penetration of cosmeceuticals.The development of microfabrication technologies has allowed the production of MNs in various sizes,shapes,and materials mainly used for loading cosmetic compounds.Clinical trial studies have explored MNs'clinical potential in drug delivery,diagnosis and administration of cosmeceuticals.The review highlights the superior efficacy of dissolving MNs in enhancing transdermal drug delivery compared to traditional methods,which are currently used by several researchers and evidenced by multiple clinical studies.The current review article compilation encompasses the microneedle in cosmetic delivery and its applications in managing various skin diseases.It differs from earlier available reviews on MNs in several aspects,novelty lies as it describes microneedle applications in cosmetics.It also focuses on recent technologies for transdermal delivery like iontophoresis,sonophoresis,magnetophoresis,electroporation,laser ablation,and jet injectors.It mainly covers the role of MNs in managing various diseases by covering case studies.It also covers challenges,commercial successes,safety measures,regulatory facts,and future perspectives of microneedles in cosmetic delivery.This article highlights the potential of MNs to revolutionize transdermal drug delivery,which will benefit various industries and patients worldwide.Furthermore,this article emphasizes the potential impact of ongoing research and commercialization of MNs.展开更多
文摘The integration of artificial intelligence(AI)and machine learning(ML)into pharmaceutical sciences has catalyzed transformative advancements across drug discovery,clinical development,manufacturing,and post-market surveillance.This review comprehensively examines AI's role in modern pharmacotherapy,beginning with its historical evolution in life sciences and progressing to cutting-edge applications such as AlphaFold-driven protein modeling,natural language processing(NLP)for biomedical literature mining,and AI-augmented pharmacovigilance.Methodologically,we synthesize interdisciplinary insights from peer-reviewed literature(2013-2023),highlighting innovations in cheminformatics(e.g.,QSAR,RDKit),predictive toxi-cology,and personalized medicine.Case studies illustrate AI's capacity to compress drug development timelines,as seen in COVID-19 repurposing efforts and de novo kinase inhibitor design.However,challenges persist,including algorithmic bias,regulatory ambiguities,and the“black-box”nature of deep learning models.By critically evaluating successes and limitations,this review underscores AI's potential to redefine pharmaceutical innovation while advocating for robust frameworks to ensure ethical,transparent,and clinically translatable AI deployment.
文摘Microneedle technology involves skin puncturing and has emerged as an innovative approach for drug delivery and cosmetic applications.MNs offer advantages over traditional injections,such as reduced pain,infection risks,and improved control of drug delivery.Cosmetic products aim to alter or enhance the appearance of the human body,while transdermal drug delivery involves administering drugs via the skin for local or systemic treatment.The use of MNs in combination with cosmetics has shown promise in improving nutrient delivery,skin healing,and penetration of cosmeceuticals.The development of microfabrication technologies has allowed the production of MNs in various sizes,shapes,and materials mainly used for loading cosmetic compounds.Clinical trial studies have explored MNs'clinical potential in drug delivery,diagnosis and administration of cosmeceuticals.The review highlights the superior efficacy of dissolving MNs in enhancing transdermal drug delivery compared to traditional methods,which are currently used by several researchers and evidenced by multiple clinical studies.The current review article compilation encompasses the microneedle in cosmetic delivery and its applications in managing various skin diseases.It differs from earlier available reviews on MNs in several aspects,novelty lies as it describes microneedle applications in cosmetics.It also focuses on recent technologies for transdermal delivery like iontophoresis,sonophoresis,magnetophoresis,electroporation,laser ablation,and jet injectors.It mainly covers the role of MNs in managing various diseases by covering case studies.It also covers challenges,commercial successes,safety measures,regulatory facts,and future perspectives of microneedles in cosmetic delivery.This article highlights the potential of MNs to revolutionize transdermal drug delivery,which will benefit various industries and patients worldwide.Furthermore,this article emphasizes the potential impact of ongoing research and commercialization of MNs.
