A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction ofacetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyI derivatives 3a-3c i...A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction ofacetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyI derivatives 3a-3c in the presence of potassium carbonate afforded the target compounds, namely ethyl 2-（4-acetyl-3-methyl-5-（phenylamino）thiophen-2-yl）-2-oxoacetate derivatives 4a-4e, ethyl 3-（4- acetyl-3-methyl-5-（phenylamino）thiophen-2-yl）-3-oxopropanoate derivatives 4f-4i, di（（4-acetyl-3- methyl-5-phenylamino）thiophen-2-yl）ketone derivatives 4j-4n in reasonable overall yields. The synthesized compounds were screened for antirnicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.展开更多
文摘A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction ofacetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyI derivatives 3a-3c in the presence of potassium carbonate afforded the target compounds, namely ethyl 2-（4-acetyl-3-methyl-5-（phenylamino）thiophen-2-yl）-2-oxoacetate derivatives 4a-4e, ethyl 3-（4- acetyl-3-methyl-5-（phenylamino）thiophen-2-yl）-3-oxopropanoate derivatives 4f-4i, di（（4-acetyl-3- methyl-5-phenylamino）thiophen-2-yl）ketone derivatives 4j-4n in reasonable overall yields. The synthesized compounds were screened for antirnicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.
