There is a renewed interest in ARBs （angiotensin receptor blockers） for their effects on inflammation, as they are commonly used in the elderly suffering from disorders like arthritis, atherosclerosis which may have...There is a renewed interest in ARBs （angiotensin receptor blockers） for their effects on inflammation, as they are commonly used in the elderly suffering from disorders like arthritis, atherosclerosis which may have a potential inflammatory etiology. But there have been conflicting reports on the effect of ARBs on inflammation. The present study was aimed to evaluate the anti-inflammatory effect of ARBs in rat model of acute inflammation. Albino Wistar rats were randomly assigned to seven groups, i.e., Control （1% CMC （carboxy methyl cellulose））, Aspirin, Losartan, Telmisartan, Valsartan, Candesartan and Irbesartan groups. Rats were orally pretreated with drugs for three consecutive days. On the 3rd day, rats were challenged by a subcutaneous injection of 0.05 mL of 1% carrageenan into the plantar side of right hind paw, 30 min after drug administration. Paw edema was measured using a mercury plethysmograph and paw diameter by micrometer screw-gauge at 0, 3, 6 and 24 h after carrageenan challenge. Percentage inhibition of edema was also calculated. All the ARBs showed a significant anti-inflammatory effect at 3, 6 and 24 h as compared to control, although not comparable to that of aspirin. This anti-inflammatory effect, although not comparable to a known anti-inflammatory agent like aspirin, would perhaps prove beneficial in elderly patients routinely treated with these drugs.展开更多
文摘There is a renewed interest in ARBs （angiotensin receptor blockers） for their effects on inflammation, as they are commonly used in the elderly suffering from disorders like arthritis, atherosclerosis which may have a potential inflammatory etiology. But there have been conflicting reports on the effect of ARBs on inflammation. The present study was aimed to evaluate the anti-inflammatory effect of ARBs in rat model of acute inflammation. Albino Wistar rats were randomly assigned to seven groups, i.e., Control （1% CMC （carboxy methyl cellulose））, Aspirin, Losartan, Telmisartan, Valsartan, Candesartan and Irbesartan groups. Rats were orally pretreated with drugs for three consecutive days. On the 3rd day, rats were challenged by a subcutaneous injection of 0.05 mL of 1% carrageenan into the plantar side of right hind paw, 30 min after drug administration. Paw edema was measured using a mercury plethysmograph and paw diameter by micrometer screw-gauge at 0, 3, 6 and 24 h after carrageenan challenge. Percentage inhibition of edema was also calculated. All the ARBs showed a significant anti-inflammatory effect at 3, 6 and 24 h as compared to control, although not comparable to that of aspirin. This anti-inflammatory effect, although not comparable to a known anti-inflammatory agent like aspirin, would perhaps prove beneficial in elderly patients routinely treated with these drugs.
