BACKGROUND Ovarian carcinoma has the highest mortality rate among all gynecological cancers.Several reproductive and hormonal risk factors,including early menarche,late menopause,limited use of oral contraceptives,and...BACKGROUND Ovarian carcinoma has the highest mortality rate among all gynecological cancers.Several reproductive and hormonal risk factors,including early menarche,late menopause,limited use of oral contraceptives,and a low pregnancy rate,have been identified as contributors to the increased susceptibility to ovarian cancer.Advancements in cancer therapy over the past century,including the emergence of precision oncology,underscore the importance of early detection and tailored interventions,factors particularly critical in ovarian cancer,where late-stage diagnosis remains a persistent barrier to survival.This challenge is compounded by the lack of a universally endorsed screening program,resulting in late-stage identification and widespread metastasis.AIM To evaluate demographic differences in ovarian cancer-related mortality from 1999 to 2020 among adult females aged≥25 years within the United States.METHODS Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database was used to collect de-identified death certificate data for malignant neoplasm of the ovaries related deaths in female adults aged 25 years and older from the year 1999 to 2020.Crude mortality rates and age-adjusted mortality rates(AAMRs)per 100000 people were calculated.Join point regression program was used to assess annual percent changes in mortality trends,with statistical significance set at P value<0.05.RESULTS Between 1999 and 2020,337619 deaths due to ovarian cancer occurred among United States females aged 25 to>85.The AAMR decreased from 14.62 in 1999 to 10.15 in 2020,with significant declines across various demographics.The AAMRs were highest among non-Hispanic White women,i.e.,13.53.Based on region,they were the highest in the Northeast(13.06)and Midwest(12.94).The steepest decline was observed in metropolitan areas as compared to nonmetropolitan ones.The study highlights significant progress in reducing ovarian cancer mortality across age,race/ethnicity,and geographic regions during this period.CONCLUSION The mortality trends for ovarian carcinoma patients showed an overall decrease,with the highest mortality rates observed among older individuals(65 to>85 years)and non-Hispanic Whites.These disparities underscore the need for equitable healthcare access and targeted policy interventions.展开更多
The rare earth element(REE)geochemical composition of sediments from two cores were used to investigate the provenances of the Late Pleistocene to Holocene sediments of Cauvery delta,South India.The chondrite-normaliz...The rare earth element(REE)geochemical composition of sediments from two cores were used to investigate the provenances of the Late Pleistocene to Holocene sediments of Cauvery delta,South India.The chondrite-normalized REE patterns and bi-variant plots of Th/Co vs.La/Sc and La/Th vs.Th/Yb indicated felsic source of sediments.Chondrite-normalized plots of REE in both cores are almost parallel and exhibit similar fractionation ratio(Ce/Yb)_N of^8.2.Furthermore,persistence in REEs patterns implies either uniform source rocks and/or efficient homogenization of sediments during transportation and deposition.Chondrite-normalized patterns of the samples show enrichment of light rare earth elements and flat pattern of heavy rare earth elements;such patterns imply dominance of felsic composition rocks in the provenance.Further,these samples show quite resemblance with Charnockites and Gneisses of Palani and Kodaikanal hill areas.Chondrite-normalized REE patterns of the Pleistocene sediments of Uttrangudi core show similar abundance,fractionation,and Eu anomaly values as of selected samples from Tertiary rocks near southwest part of the delta.We attribute the increased input from this region to the upliftment because of tectonic activity and lowering of sea level during the Pleistocene.展开更多
文摘BACKGROUND Ovarian carcinoma has the highest mortality rate among all gynecological cancers.Several reproductive and hormonal risk factors,including early menarche,late menopause,limited use of oral contraceptives,and a low pregnancy rate,have been identified as contributors to the increased susceptibility to ovarian cancer.Advancements in cancer therapy over the past century,including the emergence of precision oncology,underscore the importance of early detection and tailored interventions,factors particularly critical in ovarian cancer,where late-stage diagnosis remains a persistent barrier to survival.This challenge is compounded by the lack of a universally endorsed screening program,resulting in late-stage identification and widespread metastasis.AIM To evaluate demographic differences in ovarian cancer-related mortality from 1999 to 2020 among adult females aged≥25 years within the United States.METHODS Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database was used to collect de-identified death certificate data for malignant neoplasm of the ovaries related deaths in female adults aged 25 years and older from the year 1999 to 2020.Crude mortality rates and age-adjusted mortality rates(AAMRs)per 100000 people were calculated.Join point regression program was used to assess annual percent changes in mortality trends,with statistical significance set at P value<0.05.RESULTS Between 1999 and 2020,337619 deaths due to ovarian cancer occurred among United States females aged 25 to>85.The AAMR decreased from 14.62 in 1999 to 10.15 in 2020,with significant declines across various demographics.The AAMRs were highest among non-Hispanic White women,i.e.,13.53.Based on region,they were the highest in the Northeast(13.06)and Midwest(12.94).The steepest decline was observed in metropolitan areas as compared to nonmetropolitan ones.The study highlights significant progress in reducing ovarian cancer mortality across age,race/ethnicity,and geographic regions during this period.CONCLUSION The mortality trends for ovarian carcinoma patients showed an overall decrease,with the highest mortality rates observed among older individuals(65 to>85 years)and non-Hispanic Whites.These disparities underscore the need for equitable healthcare access and targeted policy interventions.
基金DST,New Delhi for financial assistance in form of a research grant(No.SR/S4/ES-21/Cauvery/P1)to P.S and JRF/SRF to M.Z.Aanalytical support from DST FIST Facility to the Department of Earth Sciences,Pondicherry University,Puducherry。
文摘The rare earth element(REE)geochemical composition of sediments from two cores were used to investigate the provenances of the Late Pleistocene to Holocene sediments of Cauvery delta,South India.The chondrite-normalized REE patterns and bi-variant plots of Th/Co vs.La/Sc and La/Th vs.Th/Yb indicated felsic source of sediments.Chondrite-normalized plots of REE in both cores are almost parallel and exhibit similar fractionation ratio(Ce/Yb)_N of^8.2.Furthermore,persistence in REEs patterns implies either uniform source rocks and/or efficient homogenization of sediments during transportation and deposition.Chondrite-normalized patterns of the samples show enrichment of light rare earth elements and flat pattern of heavy rare earth elements;such patterns imply dominance of felsic composition rocks in the provenance.Further,these samples show quite resemblance with Charnockites and Gneisses of Palani and Kodaikanal hill areas.Chondrite-normalized REE patterns of the Pleistocene sediments of Uttrangudi core show similar abundance,fractionation,and Eu anomaly values as of selected samples from Tertiary rocks near southwest part of the delta.We attribute the increased input from this region to the upliftment because of tectonic activity and lowering of sea level during the Pleistocene.
