Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion batteries.Herein,we unveil a series of P3/P2 monophasic and biphasic Al-substitut...Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion batteries.Herein,we unveil a series of P3/P2 monophasic and biphasic Al-substituted Na_(3/4)Mn_(5-x/8)Al_(2x/8)Ni_(3-x/8)O_(2)layered oxide cathodes that lie along the‘zero Mn^(3+)line’in the Na_(3/4)(Mn-Al-Ni)O_(2)pseudo-ternary system.The structural analysis showed a larger Na^(+)conduction bottleneck area in both P3 and P2 structures with a higher Al3+content,which enhanced their rate performance.In each composition,the P3/P2 biphasic compound with nearly equal fractions of P3 and P2 phases outperformed their monophasic counterparts in almost all electrochemical performance parameters.Operando synchrotron XRD measurements obtained for the monophasic P3 and biphasic P2/P3 samples revealed the absence of the O3 phase during cycling.The high structure stability and faster Na^(+)transport kinetics in the biphasic samples underpins the enhancement of electrochemical properties in the Al-substituted P3/P2 cathodes.These results highlight fixed oxidation state lines as a novel tool to identify and design layered oxide cathodes for Na-ion batteries in pseudo-ternary diagrams involving Jahn-Teller active cations.展开更多
Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to the...Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to Sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.展开更多
BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous system.Given its low prevalence,collecting data on large cohorts of patients with WD is chal...BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous system.Given its low prevalence,collecting data on large cohorts of patients with WD is challenging.Comprehensive insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare diseases.AIM To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims database.METHODS This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product database.All patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study end.Patients were divided into two groups by whether or not they were documented to have received a specific treatment for WD.Clinical manifestations,hospital-isations,liver transplantation and death were documented.RESULTS Overall,5376 patients with an ICD-10 diagnostic code for WD were identified.The mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter purchase.At inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented treatment.During follow-up,273 patients(5.1%)died.Compared with the American general population,the standardised mortality ratio was 2.19.The proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 years.CONCLUSION Patients treated for WD in the United States had an excess early mortality compared with the American population.These findings indicate that there is a significant unmet need for effective treatment for WD in the United States.展开更多
AIM:To study and assess clinical outcomes of various modes of treatment for perforated giant gastric ulcer in an emergency setting.METHODS:From May 2010 to February 2013,20cases of perforated giant gastric ulcer(>2...AIM:To study and assess clinical outcomes of various modes of treatment for perforated giant gastric ulcer in an emergency setting.METHODS:From May 2010 to February 2013,20cases of perforated giant gastric ulcer(>2 cm)were operated on in an emergency setting.All the patients presented with features of peritonitis and were resuscitated aggressively before taking for surgery.In the first4 cases,primary closure was done after taking a biopsy and among these,the 3rdcase also underwent partial distal gastrectomy and gastrojejunostomy and the 4th case underwent a radical subtotal gastrectomy with D2 lymphadenectomy and gastrojejunostomy for malignancy.All the remaining 16 cases underwent partial distal gastrectomy and gastrojejunostomy.RESULTS:Among the first 4 cases,2 had an uneventful recovery and were discharged on the 6thpostoperative day.The 3rdand 4thpatients developed gastricfistula,leading to prolonged hospitalization.For the 3rd patient,conservative management was tried for 1 wk,followed by partial distal gastrectomy and gastrojejunostomy,and he was discharged on the 20thday after admission,while the 4thpatient underwent a radical subtotal gastrectomy with D2 lymphadenectomy and gastrojejunostomy.Postoperatively,he developed adult respiratory distress syndrome,multiorgan dysfunction syndrome and expired on the 3rdpostoperative day of the second surgery.All the remaining 16 patients underwent partial distal gastrectomy and gastrojejunostomy and recovered well.Among these,4 of them were malignant and the remaining were benign ulcers.All had an uneventful recovery.The percentage of malignancy in our series was 30%(6 out of 20 cases).In our study,86%had an uneventful recovery,complications were seen in about 10%,and mortality was about 5%.CONCLUSION:In giant gastric ulcer,the chances of malignancy and leak after primary closure are high.So,we feel that partial distal gastrectomy and gastrojejunostomy is better.展开更多
Fisher Island and Broknes Peninsula in the Larsemann Hills constitute part of a polar lowland periglacial environment between marine and glacial ecosystems. The landscape is characterized by gently rolling hills and b...Fisher Island and Broknes Peninsula in the Larsemann Hills constitute part of a polar lowland periglacial environment between marine and glacial ecosystems. The landscape is characterized by gently rolling hills and broad valleys interspersed with lakes formed in glacially scoured basins. We analyzed the physieochemical parameters and the ionic constituents of water samples from 10 lakes in each of these two locations. Our results showed considerable differences between the two regions and demon- strated the influence of lithology and processes including weathering, evaporation, and atmospheric precipitation. All major cations and anions in the lake waters showed positive correlations indicating balanced ionic concentrations. Unconsolidated sediments were sparsely distributed and scattered over glacial deposits, valley fills, and occasional moraine ridges. The type and rate of sedi- mentation was mainly controlled by surface run-off and aeolian influx. The sediment samples from lake beds and the catchment area on Fisher Island were immature and poorly to very poorly sorted, consisting of gravelly sand with negligible silt and finer fractions. Sediments had a polymodal grain size distribution with the two major populations lying between -2 and 1 phi and be- tween 0 and 1.5 phi. The sediments were lithic arenite to arkosic in composition and the microtextures imprinted over quartz grains were dominated by mechanical textures resulting from several stages of glacial crushing and grinding. The presence of deep disso- lution cavities, cryptocrystalline precipitation, and euhedral crystal growth signified the effect of chemical activity after the deposition of grains in the lacustrine environment.展开更多
A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having d...A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（~3x） in describing the antimicrobial activity of synthesized hydrazides.展开更多
Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders.Wedelolactone(WDL),a major bioactive compo...Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders.Wedelolactone(WDL),a major bioactive compound in Eclipta prostrata L(Eclipta alba L),has been reported with potential benefits in human health against chronic diseases.However,a comprehensive study on WDL pharmacological benefits in various ailments,to the best of our knowledge,is not yet reported.Thereof,the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases,including cardiovascular,cancer,diabetes mellitus,liver disease,Alzheimer’s disease,and androgenetic alopecia.In this study,we collected all the relevant experimental information on WDL from Scientific databases such as PubMed,Web of Science,Science Direct,and Google Scholar.Conclusively,WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and disorders.Hence,WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.展开更多
This paper presents a study on the process engineering aspects of relevance to the industrial implementation of ThO2 and (Th, U)O2 mixed oxide (MOX) pellet type fuel manufacturing. The paper in particular focuses on t...This paper presents a study on the process engineering aspects of relevance to the industrial implementation of ThO2 and (Th, U)O2 mixed oxide (MOX) pellet type fuel manufacturing. The paper in particular focuses on the recycling of thoria based fuel production scrap which is an economically important component in the fuel manufacturing process. The thoria based fuels are envisaged for Advanced Heavy Water Reactor (AHWR) and other reactors important to the Indian Nuclear Power Programme. A process was developed for recycling the chemically clean, off-specification and defective sintered ThO2 and (Th, U)O2 MOX nuclear fuel pellets. ThO2 doesn’t undergo oxidation or reduction and thus, more traditional methods of recycling are impractical. The integrated process was developed by combining three basic approaches of recycling namely mechanical micronisation, air oxidation (for MOX) and microwave dissolution-denitration. A thorough investigation of the influence of several variables as heating method, UO2 content, fluoride and polyvinyl alcohol (PVA) addition during microwave dissolution-denitration was recorded on the product characteristics. The suitability evaluation of the recycled powder for re-fabrication of the fuel was carried out by analyzing the particle size, BET specific surface area, phase using XRD, bulk density and impurities. The physical and chemical properties of recycled powder obtained from the sintered (Th1-y, Uy)O2 (y;0 - 30 wt%) pellets advocate 100% utilisation for fuel re-fabrication. Recycled ThO2 by integrated process showed distinctly high sinterability compared to standard powder evaluated in terms of surface area and particle size.展开更多
In this paper, a technical review with recent advances of the microstrip antennas loaded with shorting posts is presented. The overall size of the antenna is significantly reduced by a single shorting posts and the ef...In this paper, a technical review with recent advances of the microstrip antennas loaded with shorting posts is presented. The overall size of the antenna is significantly reduced by a single shorting posts and the effect of the various parameters of shorting posts on short-circuit microstrip antenna is also discussed.展开更多
Many prevalent practices and guidelines related to Gastrointestinal endoscopy and procedural sedation are at odds with the widely available scientific-physiological and clinical outcome data. In many institutions, str...Many prevalent practices and guidelines related to Gastrointestinal endoscopy and procedural sedation are at odds with the widely available scientific-physiological and clinical outcome data. In many institutions, strict policy of pre-procedural extended fasting is still rigorously enforced, despite no evidence of increased incidence of aspiration after recent oral intake prior to sedation. Supplemental oxygen administration in the setting of GI procedural sedation has been increasingly adopted as reported in the medical journals, despite clear evidence that supplemental oxygen blunts the usefulness of pulse oximetry in timely detection of sedation induced hypoventilation, leading to increased number of adverse cardiopulmonary outcomes. Use of Propofol by Gastroenterologist-Nurse team is erroneously considered dangerous and often prohibited in various institutions, at the same time worldwide reports of remarkable safety and patient satisfaction continue to be published, dating back more than a decade. Of patient monitoring practices that have been advocated to be standard, many merely add cost, not value. Advances in the technology often are not incorporated in a timely manner in guidelines or clinical practices, e.g., Capsule endoscopy or electrocautery during GI procedures do not interfere with proper functioning of the current pacemakers or defibrillators. Orthopedic surgeons have continued to recommend prophylactic antibiotics for joint replacement patientsprior to GI procedures, without any evidence of need. These myths are explored for a succint review to prompt a change in clinical practices and institutional policies.展开更多
In this paper, an analytical model for computing the resonant frequency of the gap-coupled ring microstrip patch antennas is developed. The analytical model is based upon the cavity model along with circuit theory. Us...In this paper, an analytical model for computing the resonant frequency of the gap-coupled ring microstrip patch antennas is developed. The analytical model is based upon the cavity model along with circuit theory. Using the field expressions and boundary conditions, the transcendental equation for the structure is developed. The analytically computed results are compared with the simulated results. The simulation work is carried out by using computer simulation technology(CST) microwave studio simulator.The comparison between simulated and computed results shows good agreement.展开更多
Single-phase pristine and cation-substituted calcium manganite（Ca1-xBixMn1-yVyO3-δ） polycrystalline samples were synthesized by the solid state reaction technique. Their thermoelectric properties were measured by a...Single-phase pristine and cation-substituted calcium manganite（Ca1-xBixMn1-yVyO3-δ） polycrystalline samples were synthesized by the solid state reaction technique. Their thermoelectric properties were measured by a set up that was designed and assembled in the laboratory. The Ca1-x BixMn1-yVyO3-δsample with x = y = 0.04 has shown a power factor（S^2σ） of 176 μW/m/K^2 at 423 K, which is nearly two orders of magnitude higher than that of the pristine sample（2.1 μW/m/K2）. The power factor of the substituted oxide remains almost temperature independent as the Seebeck coefficient increases monotonically with temperature, along with the simultaneous decrease in electrical resistivity which is attributed to enhanced electron density due to co-doping of bismuth and vanadium and grain boundary scattering. These cation-substituted calcium manganites can be used as a potential candidate for an n-type leg in a thermoelectric generator（module）.展开更多
Objective:To optimize the cryopreservation of buffalo bull semen by altering freezing rates within critical temperature range (4℃ to -60℃). Methods: A total of 20 ejaculates each from 5 Murrah buffalo bulls were cry...Objective:To optimize the cryopreservation of buffalo bull semen by altering freezing rates within critical temperature range (4℃ to -60℃). Methods: A total of 20 ejaculates each from 5 Murrah buffalo bulls were cryopreserved using programmable biofreezer in 2 phases. In the 1st phase, 9 freezing rates were applied at -2, -5, -10, -20, -30, -40, -50, -60 or -4℃/min (control) from 4℃ to -15℃;at -40℃/min from -15℃ to -60℃. In the 2nd phase, a fixed freezing rate was applied at -30℃/min from 4℃ to -15℃. Six freezing rates were applied at -10, -20, -30, -40 (control), -50 or -60℃/min from -15℃ to -60℃. The freezing from -60℃ to -140℃ were fixed at -50℃/min in both the phases. Post thaw semen quality was assessed in terms of motility, viability, membrane integrity (hypo-osmotic swelling test), sperm abnormalities, and active mitochondria. Data were arc sine transformed and analyzed through one-way analysis of variance using SPSS software. Results: In the 1st phase, percent individual motility, progressive motility and viability were similar among various protocols. Percent hypo-osmotic swelling reactive sperm was higher with freezing at -30℃/min. In the 2nd phase, percent individual motility, viability and hypo-osmotic swelling reactive sperm was higher with freezing at -50℃/min. Sperm head abnormalities were lower at -30℃/min in the 1st phase, but were similar among the protocols of the 2nd phase. Percent active mitochondria were higher at -30℃/min in the 1st phase and at -50℃/min in the 2nd phase.Conclusions:The optimum post thaw semen quality of buffalo bull could be obtained by applying freezing rate at -30℃/min (4℃ to -15℃) and at -50℃/min (-15℃ to -140℃), followed by plunging of straws in into liquid nitrogen for storage.展开更多
Frequency selective surfaces(FSSs)play an important role in wireless systems as these can be used as filters,in isolating the unwanted radiation,in microstrip patch antennas for improving the performance of these ante...Frequency selective surfaces(FSSs)play an important role in wireless systems as these can be used as filters,in isolating the unwanted radiation,in microstrip patch antennas for improving the performance of these antennas and in other 5G applications.The analysis and design of the double concentric ring frequency selective surface(DCRFSS)is presented in this research.In the sub-6 GHz 5G FR1 spectrum,a computational synthesis technique for creating DCRFSS based spatial filters is proposed.The analytical tools presented in this study can be used to gain a better understanding of filtering processes and for constructing the spatial filters.Variation of the loop sizes,angles of incidence,and polarization of the concentric rings are the factors which influence the transmission coefficient as per the thorough investigation performed in this paper.A novel synthesis approach based on mathematical equations that may be used to determine the physical parameters ofDCRFSSbased spatial filters is presented.The proposed synthesis technique is validated by comparing results from high frequency structure simulator(HFSS),Ansys electronic desktop circuit editor,and an experimental setup.Furthermore,the findings acquired from a unit cell are expanded to a 2×2 array,which shows identical performance and therefore proves its stability.展开更多
Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases,considered as neglected tropical diseases(NTDs)that infect around two billion people worldwide.Plants have been used as anthelmint...Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases,considered as neglected tropical diseases(NTDs)that infect around two billion people worldwide.Plants have been used as anthelmintics from ancient times.This review is a compilation of plants as source of anthelmintic drug.All information presented in this review article regarding the anthelmintic activities of plants from 2005 and has been acquired by approaching various electronic databases,including Scopus,Google scholar,Web of science and PubMed.Literature was surveyed for anthelmintic activity of plants which showed that secondary metabolites of plants like terpenes,glycosides,saponins,flavonoids,tannins and alkaloids were having anthelmintic activity.Since this review is a compilation of anthelmintic activity of plants from the year 2005,it will definitely be a fruitful study for researchers working in this field.展开更多
Clozapine is an atypical antipsychotic which is described to have higher efficacy among all available antipsychotic medications. Clozapine is reserved especially for resistant schizophrenia due to its side effects. Cl...Clozapine is an atypical antipsychotic which is described to have higher efficacy among all available antipsychotic medications. Clozapine is reserved especially for resistant schizophrenia due to its side effects. Clozapine-induced metabolic syndrome and hyperglycaemia are common longterm side effects and are responsible for increased mortality in patients with schizophrenia. In this case, a patient with resistant schizophrenia was presented with acute-onset hyperglycaemia and delirium with the use of clozapine within a week. Withdrawal of clozapine in the patient led to the improvement in delirium and hyperglycaemia without the use of any hypoglycaemic agent. This case s叩ports the notion that in certain cases clozapine can induce hyperglycemia through possible direct pathophysiological mechanisms within a shorter time frame.展开更多
Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Liste...Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects ofCN vapour inhalation. This may be attributed to immunotoxic effects of CN on Tcells mediated macrophage functions.展开更多
An analysis is made for the steady two-dimensional laminar boundary layer flow of a viscous, incompressible, electrically conducting fluid near a stagnation point past a shrinking sheet with slip in the presence of a ...An analysis is made for the steady two-dimensional laminar boundary layer flow of a viscous, incompressible, electrically conducting fluid near a stagnation point past a shrinking sheet with slip in the presence of a magnetic field. The governing boundary layer equations are transformed to ordinary differential equations by taking suitable similarity variables and solved numerically by Shooting method. The effects of the various parameters such as velocity ratio parameter, slip parameter, Prandtl number, Eckert number and magnetic parameter for velocity and temperature distributions have been discussed in detail through graphical representation.展开更多
Sedentary crop-livestock mixed farming is the predominant agricultural land use in Central Himalaya upland and largely rainfed;agrochemicals are not used at all. Farmers focus on increasing yields with poor soil ferti...Sedentary crop-livestock mixed farming is the predominant agricultural land use in Central Himalaya upland and largely rainfed;agrochemicals are not used at all. Farmers focus on increasing yields with poor soil fertility management practices resulted in sharp decline in production of pea crop in the study site. Therefore in present study options are being looked into devising some conservation strategies that increase yields of pea while reducing harm to soil biodiversity at a local scale here. The present study explores the efficiency of P. excavatus as endemic earthworm species for vermicomposting, the potential utilization of Conventional oak based farmyard manure (FM-O);Conventional pine based farmyard manure(FM-P);Earthworm fed ? Cow dung + oak leaves based vermicompost (VC-O);Earthworm fed ? Cow dung + pine leaves based vermicompost (VC-P);freshly fallen leaf litter (LM) on pea crop productivity and soil faunal diversity in agricultural system, and if the changed soil faunal biodiversity scenario in any way affected the crop production. The higher uptake of nitrogen, higher germination percentage enhanced seedling growth, early emergence flower, increase number of pods, seed, husk , and root biomass was significantly higher in plants which received VC-O followed by VC-P as manure input treatments. The change in the diversity of soil micro arthropods in relation to quality change in organic residues input in experimental plots and expressed as the Simpsons diversity index showed that the diversity of soil fauna is related to improvements in soil conditions resulting from nutrient manipulations through vermicompost and conventional compost treatments. This response of soil biota to increased production most likely represents an increase in the availability of resources through addition of vermicompost when compared to other compost treatments. Alternatively, an increase in predators and therefore predation, could, increase the diversity of its prey, thereby decreasing dominant competitors and reducing the possibility of competitive exclusion, but this needs further studies. Chronosequence study during cropping season indicated that the composition and abundance of soil fauna in agricultural fields changed considerably with time under cultivation. This technology has now been adopted by the farmers in the area once again for growing the pea crop.展开更多
Projective change between two Finsler metrics arises from Information Geom-etry. Such metrics have special geometric properties and will play an important role in Finsler geometry. The purpose of the present paper is ...Projective change between two Finsler metrics arises from Information Geom-etry. Such metrics have special geometric properties and will play an important role in Finsler geometry. The purpose of the present paper is to find a relation to characterize the projective change between generalized (α, β) - metric ( μ1, μ2 and μ3 ≠ 0 are constants) and Randers metric , where α and are two Riemannian metrics, β and are 1-forms. Further, we study such projective change when generalized (α, β) -metric F has some curvature property.展开更多
基金the Science and Engineering Research Board(SERB),Govt.of India,for the financial support(grant number:CRG/2021/005548).
文摘Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion batteries.Herein,we unveil a series of P3/P2 monophasic and biphasic Al-substituted Na_(3/4)Mn_(5-x/8)Al_(2x/8)Ni_(3-x/8)O_(2)layered oxide cathodes that lie along the‘zero Mn^(3+)line’in the Na_(3/4)(Mn-Al-Ni)O_(2)pseudo-ternary system.The structural analysis showed a larger Na^(+)conduction bottleneck area in both P3 and P2 structures with a higher Al3+content,which enhanced their rate performance.In each composition,the P3/P2 biphasic compound with nearly equal fractions of P3 and P2 phases outperformed their monophasic counterparts in almost all electrochemical performance parameters.Operando synchrotron XRD measurements obtained for the monophasic P3 and biphasic P2/P3 samples revealed the absence of the O3 phase during cycling.The high structure stability and faster Na^(+)transport kinetics in the biphasic samples underpins the enhancement of electrochemical properties in the Al-substituted P3/P2 cathodes.These results highlight fixed oxidation state lines as a novel tool to identify and design layered oxide cathodes for Na-ion batteries in pseudo-ternary diagrams involving Jahn-Teller active cations.
文摘Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to Sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.
文摘BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous system.Given its low prevalence,collecting data on large cohorts of patients with WD is challenging.Comprehensive insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare diseases.AIM To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims database.METHODS This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product database.All patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study end.Patients were divided into two groups by whether or not they were documented to have received a specific treatment for WD.Clinical manifestations,hospital-isations,liver transplantation and death were documented.RESULTS Overall,5376 patients with an ICD-10 diagnostic code for WD were identified.The mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter purchase.At inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented treatment.During follow-up,273 patients(5.1%)died.Compared with the American general population,the standardised mortality ratio was 2.19.The proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 years.CONCLUSION Patients treated for WD in the United States had an excess early mortality compared with the American population.These findings indicate that there is a significant unmet need for effective treatment for WD in the United States.
文摘AIM:To study and assess clinical outcomes of various modes of treatment for perforated giant gastric ulcer in an emergency setting.METHODS:From May 2010 to February 2013,20cases of perforated giant gastric ulcer(>2 cm)were operated on in an emergency setting.All the patients presented with features of peritonitis and were resuscitated aggressively before taking for surgery.In the first4 cases,primary closure was done after taking a biopsy and among these,the 3rdcase also underwent partial distal gastrectomy and gastrojejunostomy and the 4th case underwent a radical subtotal gastrectomy with D2 lymphadenectomy and gastrojejunostomy for malignancy.All the remaining 16 cases underwent partial distal gastrectomy and gastrojejunostomy.RESULTS:Among the first 4 cases,2 had an uneventful recovery and were discharged on the 6thpostoperative day.The 3rdand 4thpatients developed gastricfistula,leading to prolonged hospitalization.For the 3rd patient,conservative management was tried for 1 wk,followed by partial distal gastrectomy and gastrojejunostomy,and he was discharged on the 20thday after admission,while the 4thpatient underwent a radical subtotal gastrectomy with D2 lymphadenectomy and gastrojejunostomy.Postoperatively,he developed adult respiratory distress syndrome,multiorgan dysfunction syndrome and expired on the 3rdpostoperative day of the second surgery.All the remaining 16 patients underwent partial distal gastrectomy and gastrojejunostomy and recovered well.Among these,4 of them were malignant and the remaining were benign ulcers.All had an uneventful recovery.The percentage of malignancy in our series was 30%(6 out of 20 cases).In our study,86%had an uneventful recovery,complications were seen in about 10%,and mortality was about 5%.CONCLUSION:In giant gastric ulcer,the chances of malignancy and leak after primary closure are high.So,we feel that partial distal gastrectomy and gastrojejunostomy is better.
文摘Fisher Island and Broknes Peninsula in the Larsemann Hills constitute part of a polar lowland periglacial environment between marine and glacial ecosystems. The landscape is characterized by gently rolling hills and broad valleys interspersed with lakes formed in glacially scoured basins. We analyzed the physieochemical parameters and the ionic constituents of water samples from 10 lakes in each of these two locations. Our results showed considerable differences between the two regions and demon- strated the influence of lithology and processes including weathering, evaporation, and atmospheric precipitation. All major cations and anions in the lake waters showed positive correlations indicating balanced ionic concentrations. Unconsolidated sediments were sparsely distributed and scattered over glacial deposits, valley fills, and occasional moraine ridges. The type and rate of sedi- mentation was mainly controlled by surface run-off and aeolian influx. The sediment samples from lake beds and the catchment area on Fisher Island were immature and poorly to very poorly sorted, consisting of gravelly sand with negligible silt and finer fractions. Sediments had a polymodal grain size distribution with the two major populations lying between -2 and 1 phi and be- tween 0 and 1.5 phi. The sediments were lithic arenite to arkosic in composition and the microtextures imprinted over quartz grains were dominated by mechanical textures resulting from several stages of glacial crushing and grinding. The presence of deep disso- lution cavities, cryptocrystalline precipitation, and euhedral crystal growth signified the effect of chemical activity after the deposition of grains in the lacustrine environment.
文摘A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（~3x） in describing the antimicrobial activity of synthesized hydrazides.
文摘Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders.Wedelolactone(WDL),a major bioactive compound in Eclipta prostrata L(Eclipta alba L),has been reported with potential benefits in human health against chronic diseases.However,a comprehensive study on WDL pharmacological benefits in various ailments,to the best of our knowledge,is not yet reported.Thereof,the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases,including cardiovascular,cancer,diabetes mellitus,liver disease,Alzheimer’s disease,and androgenetic alopecia.In this study,we collected all the relevant experimental information on WDL from Scientific databases such as PubMed,Web of Science,Science Direct,and Google Scholar.Conclusively,WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and disorders.Hence,WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.
文摘This paper presents a study on the process engineering aspects of relevance to the industrial implementation of ThO2 and (Th, U)O2 mixed oxide (MOX) pellet type fuel manufacturing. The paper in particular focuses on the recycling of thoria based fuel production scrap which is an economically important component in the fuel manufacturing process. The thoria based fuels are envisaged for Advanced Heavy Water Reactor (AHWR) and other reactors important to the Indian Nuclear Power Programme. A process was developed for recycling the chemically clean, off-specification and defective sintered ThO2 and (Th, U)O2 MOX nuclear fuel pellets. ThO2 doesn’t undergo oxidation or reduction and thus, more traditional methods of recycling are impractical. The integrated process was developed by combining three basic approaches of recycling namely mechanical micronisation, air oxidation (for MOX) and microwave dissolution-denitration. A thorough investigation of the influence of several variables as heating method, UO2 content, fluoride and polyvinyl alcohol (PVA) addition during microwave dissolution-denitration was recorded on the product characteristics. The suitability evaluation of the recycled powder for re-fabrication of the fuel was carried out by analyzing the particle size, BET specific surface area, phase using XRD, bulk density and impurities. The physical and chemical properties of recycled powder obtained from the sintered (Th1-y, Uy)O2 (y;0 - 30 wt%) pellets advocate 100% utilisation for fuel re-fabrication. Recycled ThO2 by integrated process showed distinctly high sinterability compared to standard powder evaluated in terms of surface area and particle size.
文摘In this paper, a technical review with recent advances of the microstrip antennas loaded with shorting posts is presented. The overall size of the antenna is significantly reduced by a single shorting posts and the effect of the various parameters of shorting posts on short-circuit microstrip antenna is also discussed.
文摘Many prevalent practices and guidelines related to Gastrointestinal endoscopy and procedural sedation are at odds with the widely available scientific-physiological and clinical outcome data. In many institutions, strict policy of pre-procedural extended fasting is still rigorously enforced, despite no evidence of increased incidence of aspiration after recent oral intake prior to sedation. Supplemental oxygen administration in the setting of GI procedural sedation has been increasingly adopted as reported in the medical journals, despite clear evidence that supplemental oxygen blunts the usefulness of pulse oximetry in timely detection of sedation induced hypoventilation, leading to increased number of adverse cardiopulmonary outcomes. Use of Propofol by Gastroenterologist-Nurse team is erroneously considered dangerous and often prohibited in various institutions, at the same time worldwide reports of remarkable safety and patient satisfaction continue to be published, dating back more than a decade. Of patient monitoring practices that have been advocated to be standard, many merely add cost, not value. Advances in the technology often are not incorporated in a timely manner in guidelines or clinical practices, e.g., Capsule endoscopy or electrocautery during GI procedures do not interfere with proper functioning of the current pacemakers or defibrillators. Orthopedic surgeons have continued to recommend prophylactic antibiotics for joint replacement patientsprior to GI procedures, without any evidence of need. These myths are explored for a succint review to prompt a change in clinical practices and institutional policies.
文摘In this paper, an analytical model for computing the resonant frequency of the gap-coupled ring microstrip patch antennas is developed. The analytical model is based upon the cavity model along with circuit theory. Using the field expressions and boundary conditions, the transcendental equation for the structure is developed. The analytically computed results are compared with the simulated results. The simulation work is carried out by using computer simulation technology(CST) microwave studio simulator.The comparison between simulated and computed results shows good agreement.
文摘Single-phase pristine and cation-substituted calcium manganite（Ca1-xBixMn1-yVyO3-δ） polycrystalline samples were synthesized by the solid state reaction technique. Their thermoelectric properties were measured by a set up that was designed and assembled in the laboratory. The Ca1-x BixMn1-yVyO3-δsample with x = y = 0.04 has shown a power factor（S^2σ） of 176 μW/m/K^2 at 423 K, which is nearly two orders of magnitude higher than that of the pristine sample（2.1 μW/m/K2）. The power factor of the substituted oxide remains almost temperature independent as the Seebeck coefficient increases monotonically with temperature, along with the simultaneous decrease in electrical resistivity which is attributed to enhanced electron density due to co-doping of bismuth and vanadium and grain boundary scattering. These cation-substituted calcium manganites can be used as a potential candidate for an n-type leg in a thermoelectric generator（module）.
文摘Objective:To optimize the cryopreservation of buffalo bull semen by altering freezing rates within critical temperature range (4℃ to -60℃). Methods: A total of 20 ejaculates each from 5 Murrah buffalo bulls were cryopreserved using programmable biofreezer in 2 phases. In the 1st phase, 9 freezing rates were applied at -2, -5, -10, -20, -30, -40, -50, -60 or -4℃/min (control) from 4℃ to -15℃;at -40℃/min from -15℃ to -60℃. In the 2nd phase, a fixed freezing rate was applied at -30℃/min from 4℃ to -15℃. Six freezing rates were applied at -10, -20, -30, -40 (control), -50 or -60℃/min from -15℃ to -60℃. The freezing from -60℃ to -140℃ were fixed at -50℃/min in both the phases. Post thaw semen quality was assessed in terms of motility, viability, membrane integrity (hypo-osmotic swelling test), sperm abnormalities, and active mitochondria. Data were arc sine transformed and analyzed through one-way analysis of variance using SPSS software. Results: In the 1st phase, percent individual motility, progressive motility and viability were similar among various protocols. Percent hypo-osmotic swelling reactive sperm was higher with freezing at -30℃/min. In the 2nd phase, percent individual motility, viability and hypo-osmotic swelling reactive sperm was higher with freezing at -50℃/min. Sperm head abnormalities were lower at -30℃/min in the 1st phase, but were similar among the protocols of the 2nd phase. Percent active mitochondria were higher at -30℃/min in the 1st phase and at -50℃/min in the 2nd phase.Conclusions:The optimum post thaw semen quality of buffalo bull could be obtained by applying freezing rate at -30℃/min (4℃ to -15℃) and at -50℃/min (-15℃ to -140℃), followed by plunging of straws in into liquid nitrogen for storage.
文摘Frequency selective surfaces(FSSs)play an important role in wireless systems as these can be used as filters,in isolating the unwanted radiation,in microstrip patch antennas for improving the performance of these antennas and in other 5G applications.The analysis and design of the double concentric ring frequency selective surface(DCRFSS)is presented in this research.In the sub-6 GHz 5G FR1 spectrum,a computational synthesis technique for creating DCRFSS based spatial filters is proposed.The analytical tools presented in this study can be used to gain a better understanding of filtering processes and for constructing the spatial filters.Variation of the loop sizes,angles of incidence,and polarization of the concentric rings are the factors which influence the transmission coefficient as per the thorough investigation performed in this paper.A novel synthesis approach based on mathematical equations that may be used to determine the physical parameters ofDCRFSSbased spatial filters is presented.The proposed synthesis technique is validated by comparing results from high frequency structure simulator(HFSS),Ansys electronic desktop circuit editor,and an experimental setup.Furthermore,the findings acquired from a unit cell are expanded to a 2×2 array,which shows identical performance and therefore proves its stability.
文摘Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases,considered as neglected tropical diseases(NTDs)that infect around two billion people worldwide.Plants have been used as anthelmintics from ancient times.This review is a compilation of plants as source of anthelmintic drug.All information presented in this review article regarding the anthelmintic activities of plants from 2005 and has been acquired by approaching various electronic databases,including Scopus,Google scholar,Web of science and PubMed.Literature was surveyed for anthelmintic activity of plants which showed that secondary metabolites of plants like terpenes,glycosides,saponins,flavonoids,tannins and alkaloids were having anthelmintic activity.Since this review is a compilation of anthelmintic activity of plants from the year 2005,it will definitely be a fruitful study for researchers working in this field.
文摘Clozapine is an atypical antipsychotic which is described to have higher efficacy among all available antipsychotic medications. Clozapine is reserved especially for resistant schizophrenia due to its side effects. Clozapine-induced metabolic syndrome and hyperglycaemia are common longterm side effects and are responsible for increased mortality in patients with schizophrenia. In this case, a patient with resistant schizophrenia was presented with acute-onset hyperglycaemia and delirium with the use of clozapine within a week. Withdrawal of clozapine in the patient led to the improvement in delirium and hyperglycaemia without the use of any hypoglycaemic agent. This case s叩ports the notion that in certain cases clozapine can induce hyperglycemia through possible direct pathophysiological mechanisms within a shorter time frame.
文摘Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects ofCN vapour inhalation. This may be attributed to immunotoxic effects of CN on Tcells mediated macrophage functions.
文摘An analysis is made for the steady two-dimensional laminar boundary layer flow of a viscous, incompressible, electrically conducting fluid near a stagnation point past a shrinking sheet with slip in the presence of a magnetic field. The governing boundary layer equations are transformed to ordinary differential equations by taking suitable similarity variables and solved numerically by Shooting method. The effects of the various parameters such as velocity ratio parameter, slip parameter, Prandtl number, Eckert number and magnetic parameter for velocity and temperature distributions have been discussed in detail through graphical representation.
文摘Sedentary crop-livestock mixed farming is the predominant agricultural land use in Central Himalaya upland and largely rainfed;agrochemicals are not used at all. Farmers focus on increasing yields with poor soil fertility management practices resulted in sharp decline in production of pea crop in the study site. Therefore in present study options are being looked into devising some conservation strategies that increase yields of pea while reducing harm to soil biodiversity at a local scale here. The present study explores the efficiency of P. excavatus as endemic earthworm species for vermicomposting, the potential utilization of Conventional oak based farmyard manure (FM-O);Conventional pine based farmyard manure(FM-P);Earthworm fed ? Cow dung + oak leaves based vermicompost (VC-O);Earthworm fed ? Cow dung + pine leaves based vermicompost (VC-P);freshly fallen leaf litter (LM) on pea crop productivity and soil faunal diversity in agricultural system, and if the changed soil faunal biodiversity scenario in any way affected the crop production. The higher uptake of nitrogen, higher germination percentage enhanced seedling growth, early emergence flower, increase number of pods, seed, husk , and root biomass was significantly higher in plants which received VC-O followed by VC-P as manure input treatments. The change in the diversity of soil micro arthropods in relation to quality change in organic residues input in experimental plots and expressed as the Simpsons diversity index showed that the diversity of soil fauna is related to improvements in soil conditions resulting from nutrient manipulations through vermicompost and conventional compost treatments. This response of soil biota to increased production most likely represents an increase in the availability of resources through addition of vermicompost when compared to other compost treatments. Alternatively, an increase in predators and therefore predation, could, increase the diversity of its prey, thereby decreasing dominant competitors and reducing the possibility of competitive exclusion, but this needs further studies. Chronosequence study during cropping season indicated that the composition and abundance of soil fauna in agricultural fields changed considerably with time under cultivation. This technology has now been adopted by the farmers in the area once again for growing the pea crop.
文摘Projective change between two Finsler metrics arises from Information Geom-etry. Such metrics have special geometric properties and will play an important role in Finsler geometry. The purpose of the present paper is to find a relation to characterize the projective change between generalized (α, β) - metric ( μ1, μ2 and μ3 ≠ 0 are constants) and Randers metric , where α and are two Riemannian metrics, β and are 1-forms. Further, we study such projective change when generalized (α, β) -metric F has some curvature property.
