AIM To study if anxiety, depression and experience of stress are associated with gastrointestinal(GI) symptoms in patients with bipolar disorder.METHODS A total of 136 patients with bipolar disorder(mean age 49.9 year...AIM To study if anxiety, depression and experience of stress are associated with gastrointestinal(GI) symptoms in patients with bipolar disorder.METHODS A total of 136 patients with bipolar disorder(mean age 49.9 years; 61% women) and 136 controls from the general population(mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome(GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale(HADS) and stress-proneness with Perceived Stress Questionnaire. Over a ten year period, all visits in primary care were retrospectively recorded in order to identify functional GI disorders.RESULTS In subjects with low total HADS-score, there were no significant differences in GI-symptoms between patients and controls(GSRS-IBS 7.0 vs 6.5, P = 0.513). In the patients with bipolar disorder there were significant correlations between all GSRS and HADS subscores for all symptom clusters except for "constipation" and "reflux". Factors associated to GI symptoms in the patient group were female sex(adjusted OR = 2.37, 95%CI: 1.07-5.24) and high HADS-Depression score(adjusted OR = 3.64, 95%CI: 1.07-12.4). These patients had also significantly more visits for IBS than patients with low HADS-Depression scores(29% vs 8%, P = 0.008). However, there was no significant differences in consulting behaviour for functional GI disorders between patients and controls(25% vs 17%, P = 0.108).CONCLUSION Female patients and patients with high HADS depression score reported significantly more GI symptoms, whereas patients with low HADS scores did not differ from control subjects.展开更多
Background:The prevalence of irritable bowel syndrome(IBS)-like symptoms is high in untreated patients with microscopic colitis(MC),but there is uncertainty of the prevalence of IBS-like symptoms in treated patients.W...Background:The prevalence of irritable bowel syndrome(IBS)-like symptoms is high in untreated patients with microscopic colitis(MC),but there is uncertainty of the prevalence of IBS-like symptoms in treated patients.We assessed the degree of IBS-like symptoms in patients with MC in comparison to control subjects,and investigated the association between IBS-like symptoms and faecal calprotectin(FC)in MC patients.Methods:Patients with an established MC diagnosis(n=57)were compared to sex-and age-matched controls(n=138)for scores in the GSRS-IBS(Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome)and HADS(Hospital Anxiety Depression Scale).In MC patients,an FC level was simultaneously analysed.Results:The median interval from MC diagnoses to the time the subjects participated in the study was 5.5 years(25th-75th percentiles;4.5-9.5 years).The total GSRS-IBS score,subscores for abdominal pain,bloating,and diarrhoea were significantly higher in MC patients compared to controls(all P<0.001).There was a significant correlation between FC levels and reported bowel frequency(P=0.023),but there was no correlation between FC levels and GSRS-IBS scores.Patients with MC had significantly higher scores on anxiety(HADS-A)(P<0.001)and used more selective serotonin-reuptake-inhibitor drugs(P=0.016)than the control subjects.However,only the control subjects(not the patients with MC)showed significant correlations between GSRS-IBS scores and HADS scores.Conclusions:Patients with MC reported more IBS-like symptoms and anxiety than control subjects but neither FC levels nor symptoms of affectivity were significantly correlated with IBS-like symptoms.展开更多
文摘AIM To study if anxiety, depression and experience of stress are associated with gastrointestinal(GI) symptoms in patients with bipolar disorder.METHODS A total of 136 patients with bipolar disorder(mean age 49.9 years; 61% women) and 136 controls from the general population(mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome(GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale(HADS) and stress-proneness with Perceived Stress Questionnaire. Over a ten year period, all visits in primary care were retrospectively recorded in order to identify functional GI disorders.RESULTS In subjects with low total HADS-score, there were no significant differences in GI-symptoms between patients and controls(GSRS-IBS 7.0 vs 6.5, P = 0.513). In the patients with bipolar disorder there were significant correlations between all GSRS and HADS subscores for all symptom clusters except for "constipation" and "reflux". Factors associated to GI symptoms in the patient group were female sex(adjusted OR = 2.37, 95%CI: 1.07-5.24) and high HADS-Depression score(adjusted OR = 3.64, 95%CI: 1.07-12.4). These patients had also significantly more visits for IBS than patients with low HADS-Depression scores(29% vs 8%, P = 0.008). However, there was no significant differences in consulting behaviour for functional GI disorders between patients and controls(25% vs 17%, P = 0.108).CONCLUSION Female patients and patients with high HADS depression score reported significantly more GI symptoms, whereas patients with low HADS scores did not differ from control subjects.
文摘Background:The prevalence of irritable bowel syndrome(IBS)-like symptoms is high in untreated patients with microscopic colitis(MC),but there is uncertainty of the prevalence of IBS-like symptoms in treated patients.We assessed the degree of IBS-like symptoms in patients with MC in comparison to control subjects,and investigated the association between IBS-like symptoms and faecal calprotectin(FC)in MC patients.Methods:Patients with an established MC diagnosis(n=57)were compared to sex-and age-matched controls(n=138)for scores in the GSRS-IBS(Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome)and HADS(Hospital Anxiety Depression Scale).In MC patients,an FC level was simultaneously analysed.Results:The median interval from MC diagnoses to the time the subjects participated in the study was 5.5 years(25th-75th percentiles;4.5-9.5 years).The total GSRS-IBS score,subscores for abdominal pain,bloating,and diarrhoea were significantly higher in MC patients compared to controls(all P<0.001).There was a significant correlation between FC levels and reported bowel frequency(P=0.023),but there was no correlation between FC levels and GSRS-IBS scores.Patients with MC had significantly higher scores on anxiety(HADS-A)(P<0.001)and used more selective serotonin-reuptake-inhibitor drugs(P=0.016)than the control subjects.However,only the control subjects(not the patients with MC)showed significant correlations between GSRS-IBS scores and HADS scores.Conclusions:Patients with MC reported more IBS-like symptoms and anxiety than control subjects but neither FC levels nor symptoms of affectivity were significantly correlated with IBS-like symptoms.
