Cyclic variability is a factor adversely affecting engine performance. In this paper a cyclic moving average regulation approach to cylinder pressure at top dead center （TDC） is proposed, where the ignition time is ...Cyclic variability is a factor adversely affecting engine performance. In this paper a cyclic moving average regulation approach to cylinder pressure at top dead center （TDC） is proposed, where the ignition time is adopted as the control input. The dynamics from ignition time to the moving average index is described by ARMA model. With this model, a one-step ahead prediction-based minimum variance controller （MVC） is developed for regulation. The performance of the proposed controller is illustrated by experiments with a commercial car engine and experimental results show that the controller has a reliable effect on index regulation when the engine works under different fuel injection strategies, load changing and throttle opening disturbance.展开更多
Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health worldwide.The aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-gluc...Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health worldwide.The aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-glucan(FLA),in a concanavalin A(Con A)-induced AIH mouse model and to determine the underlying liver-protective mechanism.The results showed that compared with the model group,the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased,and the degree of inflammatory cell infiltration in liver,thymus and spleen was significantly reduced.Quantitative polymerase chain reaction,immunohistochemistry,and Western blotting showed that FLA pre-treatment inhibited the Con A-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of BCL-2.Further research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling pathway.Thus,FLA may improve liver injury in mice by shifting gut microbial composition to reduce the release of inflammatory cytokines in the serum and prevent the necrosis of hepatocytes.Up-regulation of NRF2 signaling pathway,down-regulation of TRAF6/NF-κB signaling pathway,and an increase in the relative abundance of Lactobacillus_johnsonii and Ligilactobacillus_murinus play a protective role in liver.展开更多
文摘Cyclic variability is a factor adversely affecting engine performance. In this paper a cyclic moving average regulation approach to cylinder pressure at top dead center （TDC） is proposed, where the ignition time is adopted as the control input. The dynamics from ignition time to the moving average index is described by ARMA model. With this model, a one-step ahead prediction-based minimum variance controller （MVC） is developed for regulation. The performance of the proposed controller is illustrated by experiments with a commercial car engine and experimental results show that the controller has a reliable effect on index regulation when the engine works under different fuel injection strategies, load changing and throttle opening disturbance.
基金supported by the Shanghai Lithy One-Health Group Technology Co.,Ltd.,Project(114-KH210230A)。
文摘Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health worldwide.The aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-glucan(FLA),in a concanavalin A(Con A)-induced AIH mouse model and to determine the underlying liver-protective mechanism.The results showed that compared with the model group,the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased,and the degree of inflammatory cell infiltration in liver,thymus and spleen was significantly reduced.Quantitative polymerase chain reaction,immunohistochemistry,and Western blotting showed that FLA pre-treatment inhibited the Con A-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of BCL-2.Further research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling pathway.Thus,FLA may improve liver injury in mice by shifting gut microbial composition to reduce the release of inflammatory cytokines in the serum and prevent the necrosis of hepatocytes.Up-regulation of NRF2 signaling pathway,down-regulation of TRAF6/NF-κB signaling pathway,and an increase in the relative abundance of Lactobacillus_johnsonii and Ligilactobacillus_murinus play a protective role in liver.
