The epicenter of the Luxian M_(S)6.0 earthquake on September 16,2021,was located in the southern Sichuan Basin,which is a historically seismically quiescent area.In recent years,the frequency of earthquakes has increa...The epicenter of the Luxian M_(S)6.0 earthquake on September 16,2021,was located in the southern Sichuan Basin,which is a historically seismically quiescent area.In recent years,the frequency of earthquakes has increased with the large-scale exploitation of shale gas.No evident surface fractures or seismic faults were observed after the Luxian earthquake.Based on high-quality data recorded by a dense seismic array composed of 70 portable stations with an average spacing of 2-3 km,a highresolution seismic catalog was constructed for 7 days before and 36 days after the M_(S)6.0 earthquake using LOC-FLOW,an effective workflow of phase picking,phase association,and earthquake location.Based on the new earthquake catalog,four earthquake clusters that occurred within the Yujiasi Syncline during this period were identified.Among them,the M_(S)6.0 main earthquake sequence had a NW-SE trend and inclined towards the SW,with a length of approximately 8 km and width of 5 km.The M_(S)6.0 earthquake sequence only appeared after the mainshock.The other three clusters were located in the northeast direction of the M_(S)6.0 earthquake sequence,all of which were NE-SW trending strips and had no evident direct correlation with the M_(S)6.0 mainshock.The focal depth was concentrated in the range of 2-7 km.Based on the seismic sequence profile and structural background,the M_(S)6.0 seismic structure may be a blind buried fault zone with a NW strike composed of multiple small conjugate faults with NE and SW dip.The fault was not exposed on the surface and was related to the detachment structure in the deep part of the Sichuan Basin.展开更多
As human‐machine interaction(HMI)in healthcare continues to evolve,the issue of trust in HMI in healthcare has been raised and explored.It is critical for the development and safety of healthcare that humans have pro...As human‐machine interaction(HMI)in healthcare continues to evolve,the issue of trust in HMI in healthcare has been raised and explored.It is critical for the development and safety of healthcare that humans have proper trust in medical machines.Intelligent machines that have applied machine learning(ML)technologies continue to penetrate deeper into the medical environment,which also places higher demands on intelligent healthcare.In order to make machines play a role in HMI in healthcare more effectively and make human‐machine cooperation more harmonious,the authors need to build good humanmachine trust(HMT)in healthcare.This article provides a systematic overview of the prominent research on ML and HMT in healthcare.In addition,this study explores and analyses ML and three important factors that influence HMT in healthcare,and then proposes a HMT model in healthcare.Finally,general trends are summarised and issues to consider addressing in future research on HMT in healthcare are identified.展开更多
On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again att...On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone.展开更多
While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We co...While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index（BMI）, lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics（FIGO） grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride（TG）, and high density lipoproteins（HDL） differed significantly among different stages of epithelial ovarian cancer（P〈0.05）. In the logistic regression model, elevated TG（OR： 1.883; 95% CI= 1.207-2.937）, and low HDL（OR： 0.497; 95% CI = 0.298-0.829） levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.展开更多
Depression has become one of the most common mental illnesses in the world.For better prediction and diagnosis,methods of automatic depression recognition based on speech signal are constantly proposed and updated,wit...Depression has become one of the most common mental illnesses in the world.For better prediction and diagnosis,methods of automatic depression recognition based on speech signal are constantly proposed and updated,with a transition from the early traditional methods based on hand‐crafted features to the application of architectures of deep learning.This paper systematically and precisely outlines the most prominent and up‐to‐date research of automatic depression recognition by intelligent speech signal processing so far.Furthermore,methods for acoustic feature extraction,algorithms for classification and regression,as well as end to end deep models are investigated and analysed.Finally,general trends are summarised and key unresolved issues are identified to be considered in future studies of automatic speech depression recognition.展开更多
The nitrogen and sulfur co-doped carbon dots(N, S-CDs) with increased luminescence were synthesized by a hydrothermal process in one green pot by using glucose, and a new sulfur-doping source of sodium sulfite was dev...The nitrogen and sulfur co-doped carbon dots(N, S-CDs) with increased luminescence were synthesized by a hydrothermal process in one green pot by using glucose, and a new sulfur-doping source of sodium sulfite was developed.The synergistic effect of the N and S groups was well discussed through the structure analysis of Fourier transform infrared spectra and x-ray photoelectron spectra. The surface states of N, S-CDs embody more complicated functional groups, and S element exists as –SSO3, –C–SO3, and SO-42groups due to the introduction of sodium sulfite. The sulfur-containing groups passivate the surface of the CDs, and the relatively high sulfur groups may reduce the non-radiation centers. The fluorescence is affected by the hydroxyl group of the solvent. The quenching of Fe3+ ion to fluorescence and the sensitivity of fluorescence to p H were also investigated.展开更多
On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dim...On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dimensional S-wave velocity model from ambient noise tomography using data from a newly deployed dense seismic array around the epicenter,by extracting and jointly inverting the Rayleigh phase and group velocities in the period of 1.6–7.2 s.The results showed that the velocity model varied significantly beneath different geological units.The Yujiasi syncline is characterized by low velocity at depths of~3.0–4.0 km,corresponding to the stable sedimentary layer in the Sichuan Basin.The eastern and western branches of the Huayingshan fault belt generally exhibit high velocities in the NE-SW direction,with a few local low-velocity zones.The Luxian MS6.0 earthquake epicenter is located at the boundary between the high-and low-velocity zones,and the earthquake sequences expand eastward from the epicenter at depths of 3.0–5.0 km.Integrated with the velocity variations around the epicenter,distribution of aftershock sequences,and focal mechanism solution,it is speculated that the seismogenic mechanism of the main shock might be interpreted as the reactivation of pre-existing faults by hydraulic fracturing.展开更多
Objective:To investigate the effects and mechanisms of Polygonatum sibiricum polysaccharide(PSP)on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Methods:The mouse BMSCs were cultured and indu...Objective:To investigate the effects and mechanisms of Polygonatum sibiricum polysaccharide(PSP)on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Methods:The mouse BMSCs were cultured and induced in osteoblast medium(OBM)containing finalconcentrations(0 mg/L,12.5 mg/L,25 mg/L,and 50 mg/L)of PSP.The proliferation and cytotoxicity of BMSCs were detected by MTT assay.Alkaline phosphatase(ALP)and Alizarin red S staining were performed after 7 days' ossification-inducing culture.The mRNA expressions of ALP,Runx2 and osteocalcin(OCN)were determined by fluorescence quantitative PCR(qPCR).The mRNA and protein expressions of Tafazzin(TAZ)(a key effector of Hippo pathway)were measured by qPCR and western blotting,respectively.Results:PSP was non-cytotoxicwithin the dose range of 12.5-50 mg/L and had no impact on the proliferation of BMSCs.The activity of ALP,the intensity of ALP staining,and the formation of mineralized nodules were increased by PSP treatment(25 and50 mg/L)(P<0.01).Moreover,administration of 25 mg/L PSP significantly enhanced the mRNA levels of osteoblastic differentiation makers ALP,Runx2 and OCN as well as the mRNA and protein expressions of TAZ(P<0.01).Conclusion:PSP could promote osteogenic differentiation of BMSCs,and the mechanisms might be related to the activation of TAZ in the Hippo signaling pathway.展开更多
Iron-based catalysts possess the advantages of cost-effectiveness and environmental benignity,showing promising prospects for propane dehydrogenation(PDH)applications.In this work,with the assistance of the iminodisuc...Iron-based catalysts possess the advantages of cost-effectiveness and environmental benignity,showing promising prospects for propane dehydrogenation(PDH)applications.In this work,with the assistance of the iminodisuccinate(IDS)ligand,Fe species are successfully incorporated into the silicalite-1 zeolite framework through one-pot synthesis,and the thus obtained IDS-S_(1)catalyst shows excellent catalytic performance in PDH,which exhibits a propane conversion rate of 20.8%and a propylene selectivity of 84.8%,and it also shows exceptional catalytic stability(kd=0.003 h^(-1))over 48 h of continuous reaction.Characterizations indicate that the framework iron species,instead of extraframework iron species and Brønsted acid sites,are the favorable active centers for PDH.These framework iron species are stabilized by the Si-O structure of the zeolite and possess unique acidic properties,which improve the PDH performance of the catalyst by enhancing propane adsorption activation and facilitating propylene desorption.展开更多
The reliability and sustainability of innovation in megaprojects are of critical importance with complex stakeholders and substantial resource investments.In that respect,responsible innovation management is the key t...The reliability and sustainability of innovation in megaprojects are of critical importance with complex stakeholders and substantial resource investments.In that respect,responsible innovation management is the key to the sustainable development of megaprojects.This paper proposes the concept of megaproject responsible innovation(MRI)and develops a holistic framework for MRI with four dimensions:(1)anticipation across the megaproject life cycle,(2)inclusion of various parties in a relationship of symbiosis,competition,and cooperation,(3)reflexivity of social responsibility,and(4)responsiveness to social expectations.Based on an ecosystem approach to megaproject innovation,we propose an ecological governance strategy for MIR.Moreover,different approaches are needed in innovation organizations which are part of specific ecological niches for effective and efficient governance.展开更多
基金supported by Fundamental Research Funds from the Institute of Geophysics,China Earthquake Administration(Nos.DQJB22B26 and DQJB22B19)the National Key Research and Development Program of China(No.2020YFA0710603-02).
文摘The epicenter of the Luxian M_(S)6.0 earthquake on September 16,2021,was located in the southern Sichuan Basin,which is a historically seismically quiescent area.In recent years,the frequency of earthquakes has increased with the large-scale exploitation of shale gas.No evident surface fractures or seismic faults were observed after the Luxian earthquake.Based on high-quality data recorded by a dense seismic array composed of 70 portable stations with an average spacing of 2-3 km,a highresolution seismic catalog was constructed for 7 days before and 36 days after the M_(S)6.0 earthquake using LOC-FLOW,an effective workflow of phase picking,phase association,and earthquake location.Based on the new earthquake catalog,four earthquake clusters that occurred within the Yujiasi Syncline during this period were identified.Among them,the M_(S)6.0 main earthquake sequence had a NW-SE trend and inclined towards the SW,with a length of approximately 8 km and width of 5 km.The M_(S)6.0 earthquake sequence only appeared after the mainshock.The other three clusters were located in the northeast direction of the M_(S)6.0 earthquake sequence,all of which were NE-SW trending strips and had no evident direct correlation with the M_(S)6.0 mainshock.The focal depth was concentrated in the range of 2-7 km.Based on the seismic sequence profile and structural background,the M_(S)6.0 seismic structure may be a blind buried fault zone with a NW strike composed of multiple small conjugate faults with NE and SW dip.The fault was not exposed on the surface and was related to the detachment structure in the deep part of the Sichuan Basin.
基金Qinglan Project of Jiangsu Province of China,Grant/Award Number:BK20180820National Natural Science Foundation of China,Grant/Award Numbers:12271255,61701243,71771125,72271126,12227808+2 种基金Major Projects of Natural Sciences of University in Jiangsu Province of China,Grant/Award Numbers:21KJA630001,22KJA630001Postgraduate Research and Practice Innovation Program of Jiangsu Province,Grant/Award Number:KYCX23_2343supported by the National Natural Science Foundation of China(no.72271126,12271255,61701243,71771125,12227808)。
文摘As human‐machine interaction(HMI)in healthcare continues to evolve,the issue of trust in HMI in healthcare has been raised and explored.It is critical for the development and safety of healthcare that humans have proper trust in medical machines.Intelligent machines that have applied machine learning(ML)technologies continue to penetrate deeper into the medical environment,which also places higher demands on intelligent healthcare.In order to make machines play a role in HMI in healthcare more effectively and make human‐machine cooperation more harmonious,the authors need to build good humanmachine trust(HMT)in healthcare.This article provides a systematic overview of the prominent research on ML and HMT in healthcare.In addition,this study explores and analyses ML and three important factors that influence HMT in healthcare,and then proposes a HMT model in healthcare.Finally,general trends are summarised and issues to consider addressing in future research on HMT in healthcare are identified.
基金This research was supported by the National Natural Science Foundation of China(No.41974066,No.41474057)ChinArray Project-Northern Section of South-North Seismic Belt(201308011)+1 种基金Project of Science for Earthquake Resilience(XH20051)the Science and Technology Innovation Fund of Sichuan Earthquake Administration(201804).
文摘On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone.
基金supported by Jiangsu Cancer Hospital (ZK201606ZK201610)
文摘While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index（BMI）, lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics（FIGO） grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride（TG）, and high density lipoproteins（HDL） differed significantly among different stages of epithelial ovarian cancer（P〈0.05）. In the logistic regression model, elevated TG（OR： 1.883; 95% CI= 1.207-2.937）, and low HDL（OR： 0.497; 95% CI = 0.298-0.829） levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.
基金supported by the National Natural Science Foundation of China(NSFC,no.61701243,71771125)the Major Project of Natural Science Foundation of Jiangsu Education Department(no.19KJA180002).
文摘Depression has become one of the most common mental illnesses in the world.For better prediction and diagnosis,methods of automatic depression recognition based on speech signal are constantly proposed and updated,with a transition from the early traditional methods based on hand‐crafted features to the application of architectures of deep learning.This paper systematically and precisely outlines the most prominent and up‐to‐date research of automatic depression recognition by intelligent speech signal processing so far.Furthermore,methods for acoustic feature extraction,algorithms for classification and regression,as well as end to end deep models are investigated and analysed.Finally,general trends are summarised and key unresolved issues are identified to be considered in future studies of automatic speech depression recognition.
基金Project by the National Natural Science Foundation of China(Grant Nos.51571085,11805052,and 61705062)the Research Project for Basic and Forefront Technology of Henan Province,China(Grant No.162300410219)the Doctor Foundation of Henan Polytechnic University,China(Grant No.B2014049)
文摘The nitrogen and sulfur co-doped carbon dots(N, S-CDs) with increased luminescence were synthesized by a hydrothermal process in one green pot by using glucose, and a new sulfur-doping source of sodium sulfite was developed.The synergistic effect of the N and S groups was well discussed through the structure analysis of Fourier transform infrared spectra and x-ray photoelectron spectra. The surface states of N, S-CDs embody more complicated functional groups, and S element exists as –SSO3, –C–SO3, and SO-42groups due to the introduction of sodium sulfite. The sulfur-containing groups passivate the surface of the CDs, and the relatively high sulfur groups may reduce the non-radiation centers. The fluorescence is affected by the hydroxyl group of the solvent. The quenching of Fe3+ ion to fluorescence and the sensitivity of fluorescence to p H were also investigated.
基金This work was supported by the Special Fund of the Institute of Geophysics,China Earthquake Administration(Nos.DQJB22B19,DQJB22R29 and DQJB22B26)the National Natural Science Foundation of China(Nos.41974066,U1839209 and 42074053)。
文摘On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dimensional S-wave velocity model from ambient noise tomography using data from a newly deployed dense seismic array around the epicenter,by extracting and jointly inverting the Rayleigh phase and group velocities in the period of 1.6–7.2 s.The results showed that the velocity model varied significantly beneath different geological units.The Yujiasi syncline is characterized by low velocity at depths of~3.0–4.0 km,corresponding to the stable sedimentary layer in the Sichuan Basin.The eastern and western branches of the Huayingshan fault belt generally exhibit high velocities in the NE-SW direction,with a few local low-velocity zones.The Luxian MS6.0 earthquake epicenter is located at the boundary between the high-and low-velocity zones,and the earthquake sequences expand eastward from the epicenter at depths of 3.0–5.0 km.Integrated with the velocity variations around the epicenter,distribution of aftershock sequences,and focal mechanism solution,it is speculated that the seismogenic mechanism of the main shock might be interpreted as the reactivation of pre-existing faults by hydraulic fracturing.
基金supported by grants from National Natural Science Foundation of China(No.81360279)Guangxi Natural Science Foundation(No.2015GXNSFAA139150)
文摘Objective:To investigate the effects and mechanisms of Polygonatum sibiricum polysaccharide(PSP)on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Methods:The mouse BMSCs were cultured and induced in osteoblast medium(OBM)containing finalconcentrations(0 mg/L,12.5 mg/L,25 mg/L,and 50 mg/L)of PSP.The proliferation and cytotoxicity of BMSCs were detected by MTT assay.Alkaline phosphatase(ALP)and Alizarin red S staining were performed after 7 days' ossification-inducing culture.The mRNA expressions of ALP,Runx2 and osteocalcin(OCN)were determined by fluorescence quantitative PCR(qPCR).The mRNA and protein expressions of Tafazzin(TAZ)(a key effector of Hippo pathway)were measured by qPCR and western blotting,respectively.Results:PSP was non-cytotoxicwithin the dose range of 12.5-50 mg/L and had no impact on the proliferation of BMSCs.The activity of ALP,the intensity of ALP staining,and the formation of mineralized nodules were increased by PSP treatment(25 and50 mg/L)(P<0.01).Moreover,administration of 25 mg/L PSP significantly enhanced the mRNA levels of osteoblastic differentiation makers ALP,Runx2 and OCN as well as the mRNA and protein expressions of TAZ(P<0.01).Conclusion:PSP could promote osteogenic differentiation of BMSCs,and the mechanisms might be related to the activation of TAZ in the Hippo signaling pathway.
基金supported by the Natural Science Foundation of China(grant nos.22372197,22302230,22478431,and W2421003)the Natural Science Foundation of Shandong Province(grant no.ZR2021QB082)+2 种基金the Postdoctoral Fellowship Program of CPSF(grant no.GZC20241291)co-funding from PetroChina(grant nos.KYWX-22-012 and KYWX-22-017)the State Key Laboratory of Heavy Oil Processing(grant no.SKLHOP202402007).
文摘Iron-based catalysts possess the advantages of cost-effectiveness and environmental benignity,showing promising prospects for propane dehydrogenation(PDH)applications.In this work,with the assistance of the iminodisuccinate(IDS)ligand,Fe species are successfully incorporated into the silicalite-1 zeolite framework through one-pot synthesis,and the thus obtained IDS-S_(1)catalyst shows excellent catalytic performance in PDH,which exhibits a propane conversion rate of 20.8%and a propylene selectivity of 84.8%,and it also shows exceptional catalytic stability(kd=0.003 h^(-1))over 48 h of continuous reaction.Characterizations indicate that the framework iron species,instead of extraframework iron species and Brønsted acid sites,are the favorable active centers for PDH.These framework iron species are stabilized by the Si-O structure of the zeolite and possess unique acidic properties,which improve the PDH performance of the catalyst by enhancing propane adsorption activation and facilitating propylene desorption.
基金supported by National Natural Science Foundation of China(Grant No.72271126)Major Project of Natural Science Foundation of Jiangsu Education Department,China(Grant No.22KJA630001)+1 种基金Qinglan Project of Jiangsu Province,Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.SJCX23_0988)Innovation Ability Training Program for Postgraduate Students of Guangzhou University,China(Grant No.2022GDJC-D04).
文摘The reliability and sustainability of innovation in megaprojects are of critical importance with complex stakeholders and substantial resource investments.In that respect,responsible innovation management is the key to the sustainable development of megaprojects.This paper proposes the concept of megaproject responsible innovation(MRI)and develops a holistic framework for MRI with four dimensions:(1)anticipation across the megaproject life cycle,(2)inclusion of various parties in a relationship of symbiosis,competition,and cooperation,(3)reflexivity of social responsibility,and(4)responsiveness to social expectations.Based on an ecosystem approach to megaproject innovation,we propose an ecological governance strategy for MIR.Moreover,different approaches are needed in innovation organizations which are part of specific ecological niches for effective and efficient governance.
基金financially supported by the National Key R&D Program of China (2022YFA1503400)the National Natural Science Foundation of China (21991091)+2 种基金the Key Projects of Shandong Key R&D plan (2019JZZY010506)Taishan Scholar Foundation (tspd20210308)the Petro China Research and Development Projects (2020A-1816 and 2020A-1817)。
