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子宫内膜腺癌中piR-34377的表达及其临床病理意义
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作者 施平平 王成海 《临床医学进展》 2025年第6期594-600,共7页
目的:探讨piR-34377在子宫内膜腺癌及癌旁正常组织中的表达、临床病理意义和预后价值。方法:通过piRNA表达谱芯片筛选出子宫内膜腺癌及癌旁正常组织差异表达的piR-34377;选择69例子宫内膜腺癌通过qRT-PCR实验进行验证;分析piR-34377表... 目的:探讨piR-34377在子宫内膜腺癌及癌旁正常组织中的表达、临床病理意义和预后价值。方法:通过piRNA表达谱芯片筛选出子宫内膜腺癌及癌旁正常组织差异表达的piR-34377;选择69例子宫内膜腺癌通过qRT-PCR实验进行验证;分析piR-34377表达与子宫内膜腺癌患者临床病理特征和预后之间的关联。结果:piRNA表达谱测序结果得到包含piR-34377在内的2个piRNA表达水平下降。qRT-PCR实验验证结果表明,piR-34377 (1.962 ± 0.1152)表达水平明显低于癌旁正常组织(4.337 ± 0.2228),t = 8.976,P < 0.05。子宫内膜腺癌组织中,piR-34377表达与淋巴结转移和分期密切相关(均P < 0.05)。并且piR-34377阴性表达组5年生存率低于正常或高表达组。单因素和多因素分析得出淋巴结转移和piR-34377表达水平可能是影响子宫内膜腺癌预后的独立危险因素(P < 0.05)。结论:piR-34377在子宫内膜腺癌组织中表达水平下调,piR-34377表达与淋巴结转移和分期密切相关和不良预后密切相关。 展开更多
关键词 子宫内膜腺癌 piR-34377 临床病理意义 预后
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Cultural Integration and Adaptation Challenge:A Study of International Students in Wenzhou
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作者 Yujie Su Altayeb Salih Ahmed Mohammed +2 位作者 Yujun Yao pingping shi Yumeng Zhang 《教育技术与创新》 2025年第2期39-52,共14页
This study explores the cultural,social,and academic adaptation experiences of international students in Wenzhou,China.Based on surveys and interviews with 52 students from 20 countries—predominantly Morocco—the res... This study explores the cultural,social,and academic adaptation experiences of international students in Wenzhou,China.Based on surveys and interviews with 52 students from 20 countries—predominantly Morocco—the research investigates key challenges and coping strategies related to local integration.The findings indicate that while Wenzhou offers a generally supportive academic environment—enhanced by AI integration and practical teaching methods—language barriers continue to hinder students’daily life,academic engagement,and social interactions.Limited Mandarin proficiency made it difficult for many students to build friendships with locals and navigate everyday tasks.Cultural adaptation also presented obstacles,particularly in adjusting to local food and social norms.Despite these challenges,students employed various strategies to facilitate integration,such as attending HSK language courses,watching Chinese media,and initiating conversations with local peers.While most participants described the local community as welcoming,perceptions varied based on individual experiences and language ability.The study highlights the importance of enhanced language support and structured cross-cultural exchange initiatives in improving international students’experiences.It contributes to the broader discourse on international student mobility by offering insights from a second-tier Chinese city,emphasizing the role of institutional practices in shaping adaptation outcomes. 展开更多
关键词 international students adaptation challenges language barriers cultural adaptation
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Comprehensive Benefit Evaluation Method of Mountain Flood Disaster Prevention and Control in Jiangxi Province Based on Matter-Element Extension Model 被引量:2
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作者 Peixun Liu Yanbin Shao +3 位作者 Jiawen Ye pingping shi Dingbo Yuan Zhengwen Xu 《Journal of Geoscience and Environment Protection》 2024年第10期347-354,共8页
Taking the mountain flood disaster prevention and control project in Jiangxi province as the research object, the evaluation period is 2010-2015, and 29 evaluation indexes are selected from 7 aspects. In this paper, g... Taking the mountain flood disaster prevention and control project in Jiangxi province as the research object, the evaluation period is 2010-2015, and 29 evaluation indexes are selected from 7 aspects. In this paper, game theory is introduced to optimize the subjective and objective weights of the index, and the comprehensive weights are obtained by normalization. The results show that the eigenvalues of the grade variables of benefit evaluation decreased from 3.43 to 2.03, indicating that the project of mountain flood disaster prevention and control in Jiangxi province brings into play the benefits year by year, and the eigenvalues tend to decrease steadily after 2012, it is consistent with the changes of various engineering measures and non-engineering measures in the project. 展开更多
关键词 Index System Numerical Model Comprehensive Evaluation
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Tunable phase transition, band gap and SHG properties by halogen replacement of hybrid perovskites [(thiomorpholinium)PbX_(3), X = Cl,Br,I]
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作者 Simin Liu Lei He +2 位作者 Yuzhen Wang pingping shi Qiong Ye 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第2期1032-1036,共5页
By the replacement of halogen anion,three new multifunctional organic-inorganic hybrid perovskites(thiomorpholinium)PbX_(3)(X=Cl,Br,I)were successfully synthesized and underwent reversible struc-tural transformation a... By the replacement of halogen anion,three new multifunctional organic-inorganic hybrid perovskites(thiomorpholinium)PbX_(3)(X=Cl,Br,I)were successfully synthesized and underwent reversible struc-tural transformation above room temperature,accompanied by the anomalous change of dielectric con-stant.With the adjustment of the halogen anion from Cl to I in the inorganic skeleton,the space group is transformed from centrosymmetric space group P2_(1)/c((thiomorpholinium)PbCl_(3))to chiral one P2_(1)2_(1)2_(1)((thiomorpholinium)PbBr3,(thiomorpholinium)PbI_(3))at room temperature.The ordered-disordered tran-sition of organic cations and the change of hydrogen bonds with the increase of temperature lead to above-room-temperature phase transitions.Ultraviolet absorption and second-harmonic generation(SHG)measurements confirmed that both the band gap and SHG activity of(thiomorpholinium)PbX_(3)(X=Cl,Br,I)crystals were tunable.The band gaps reveal a broadening trend with 3.532 e V,3.410 e V and 3.175 e V along the Cl→Br→I series.This work provides an effective molecular design for multifunctional organic-inorganic perovskites. 展开更多
关键词 Phase transition Band gap Nonlinear optical Organic-inorganic hybrid perovskite Halogen replacement
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High-temperature dielectric switch and second harmonic generation integrated in a stimulus responsive material
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作者 Yingsong Xue Zhixu Zhang +3 位作者 pingping shi Wanying Zhang Qiong Ye Dawei Fu 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期539-542,共4页
Stimulus re s ponsive materials can provide a variety of desirable properties in one equipment unit,such as optoelectronic devices,data communications,actuators,memories,sensors and capacitors.However,it remains a lar... Stimulus re s ponsive materials can provide a variety of desirable properties in one equipment unit,such as optoelectronic devices,data communications,actuators,memories,sensors and capacitors.However,it remains a large challenge to design such stimulus responsive materials,especially functional materials having both dielectric switch and second harmonic generation(SHG).Here,a new stimuli-responsive switchable material [(CH_(3))_(3)N(CH_(2))_(2)Cl]_(2)]Mn(SCN)_(4)(H_(2)O)_(2)] was discovered as a potential secondharmonic generation(SHG) dielectric switch.It is worth noting that it has SHG characteristics before and after undergoing reversible high-temperature phase transitions.In this work,we successfully refined the tetramethylammonium cation to obtain a quasi-spherical cation,which is tetramethylchloroethylamine(TMCEM) cation.By substituting H with a halogen,the increased steric hindrance of the molecular makes energy barrier increased,resulting in the reversible high-temperature phase transition.At the same time,the interactions of quasi-spherical cations and [Mn(SCN)_(4)(H_(2)O)_(2)]^(2-) anions affect a noncentrosymmetric structure to induce the SHG effect.These findings provide a new approach to design novel functional switch materials. 展开更多
关键词 Dielectric switch Second harmonic generation High-temperature Phase transition Stimulus responsive material
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Operational Decisions of Online Dual-channel Supply Chain Considering Products Quality Difference under Different Financing Modes
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作者 pingping shi Bangjie Zhou +2 位作者 Boli Yan Yaogang Hu Hao Huang 《Journal of Systems Science and Systems Engineering》 2026年第2期229-256,共28页
This paper examines the optimal decisions on operations and financing modes of a capital-constrained manufacturer selling two different quality levels of products through an online dual-channel.The manufacturer can mi... This paper examines the optimal decisions on operations and financing modes of a capital-constrained manufacturer selling two different quality levels of products through an online dual-channel.The manufacturer can mitigate financial constrains by leveraging either e-commerce platform financing or bank financing.The Stackelberg game models are established under both financing modes to analyze the optimal decisions of the manufacturer and the e-commerce platform.Additionally,the study explores the effects of financing interest rates and product quality differences on equilibrium outcomes in the online dual-channel.The findings reveal the following:(i)As financing interest rates increase,total product sales decline.While product prices may rise,this does not necessarily intensify price competition within the online dual-channel.(ii)When the e-commerce platform’s financing rate exceeds the bank rate,the manufacturer sets higher direct sales prices.Beyond a specific threshold,distribution prices rise,and total sales decrease.(iii)When consumers are indifferent to the two online channels,the manufacturer will distribute high-quality products under both financing modes at high interest rates,more lenient condition under e-commerce financing.(iv)When the financing interest rates of the e-commerce platform and the bank are the same,the manufacturer prefers e-commerce financing for distributing high-quality products,but opts for bank financing when directly selling high-quality products with a significant quality gap. 展开更多
关键词 Different financing modes quality difference online dual-channel supply chain operational decisions
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Exploring Bilingual Education in the Wenzhou Region Under the CLIL Teaching Philosophy
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作者 Yumeng Zhang Yujie Su +2 位作者 pingping shi Yujun Yao Jiayi Song 《教育技术与创新》 2026年第1期40-48,共9页
This study addresses the cultural identity and educational transition challenges faced by the“overseas Chinese children”(Qiao Tong)group in Wenzhou.Utilizing the CLIL(Content and Language Integrated Learning)teachin... This study addresses the cultural identity and educational transition challenges faced by the“overseas Chinese children”(Qiao Tong)group in Wenzhou.Utilizing the CLIL(Content and Language Integrated Learning)teaching model,it explores an innovative pathway for patriotic education that uses bilingualism as a bridge and local culture as its foundation.Through the compilation of school-based teaching materials and practical teaching implementation,this research employs case study and questionnaire survey methods to systematically examine the application effectiveness of the CLIL model.Empirical results indicate that CLIL-based bilingual courses can significantly enhance students’sense of cultural identity.The study confirms that systematic,guided CLIL instruction is an effective approach to constructing cultural identity for overseas Chinese children,offering a replicable“Wenzhou Experience”for educational governance in hometowns of overseas Chinese and for“telling China’s story well”. 展开更多
关键词 overseas Chinese children in Wenzhou CLIL cultural identity bilingual patriotic education
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Full-temperature covered switching material with triple optic-dielectric states in a lead-free hybrid perovskite 被引量:4
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作者 Tie Zhang Lulu Chu +5 位作者 Zhixu Zhang Jie Li Wanying Zhang pingping shi Qiong Ye Da-Wei Fu 《Science China Materials》 SCIE EI CSCD 2020年第11期2281-2288,共8页
Optic-electric responsive materials have attracted much attention for their applications in temperaturesensing,actuators,and memory switches.However,it is a challenge to integrate various functions to form multifuncti... Optic-electric responsive materials have attracted much attention for their applications in temperaturesensing,actuators,and memory switches.However,it is a challenge to integrate various functions to form multifunctional responsive materials.As molecule-based hybrid materials usually consist of organic and inorganic components,the introduction of multiple functions can be achieved through structural construction.Thus far,even though fulltemperature cover is required for device applications,fulltemperature covered multi-switchable hybrid materials have rarely been successfully synthesized.Herein,the dynamic[(CH3)3NOH]+cation and luminous center Mn(II)were introduced to form a hybrid material[(CH3)3NOH][Mn Cl3],showing multiple temperature-responsive behaviors.Upon temperature change,it exhibits multi-state dielectric switching response and intensity or peak shift response of luminous in full-temperature range(low,room,and high temperatures).These responsive behaviors are triggered by the motion or reorientation of[(CH3)3NOH]+cations and inorganic framework.Overall,the switchable photoelectric material has potential applications in multiple encrypted storage and sensor devices. 展开更多
关键词 responsive material multiple dielectric states crystal PEROVSKITE
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