Metabolic-associated fatty liver disease(MAFLD)is the most prevalent chronic liver disease globally,with no effective pharmacological treatments available for early-stage cases.Rutin,a bioactive flavonoid from Sophora...Metabolic-associated fatty liver disease(MAFLD)is the most prevalent chronic liver disease globally,with no effective pharmacological treatments available for early-stage cases.Rutin,a bioactive flavonoid from Sophora japonica L.,exhibits diverse pharmacological effects,but its multi-pathway mechanisms in improving MAFLD remain unclear.In this study,we employed a high-fat diet(HFD)-induced MAFLD mouse model to investigate the therapeutic effects of rutin supplementation.Rutin supplementation significantly reduced blood lipid and liver lipid levels and alleviated liver injury in MAFLD model mice.Fecal microbiota transplantation experiments revealed that rutin alleviated MAFLD by modulating the gut microbiota composition.Through 16S rRNA sequencing analysis and non-targeted metabolomics analysis of the normal control(NC),HFD and rutin groups,rutin was found to alter key species(Ruminococcus torques)and associated metabolites(e.g.,7-dehydrocholesterol,short-chain fatty acids),suggesting a mechanism involving the gut microbiota.Antibiotic treatment experiments revealed that rutin alleviates MAFLD via the blood entry pathway.Network pharmacology analysis showed that rutin can directly act on targets closely related to MAFLD development,including tumor protein p53,epidermal growth factor receptor,and prostaglandin-endoperoxide synthase 2,as well as key signaling pathways such as PI3K/AKT and MAPK.Transcriptomics analysis of the NC,HFD and rutin groups revealed that rutin may ameliorate MAFLD through PI3K/AKT and MAPK signaling pathways,which might be enhanced by the gut microbiota and blood entry pathways.In conclusion,rutin can treat MAFLD through both the gut microbiota and blood entry pathways,resulting in a synergistic effect.Our study provides a novel strategy for evaluating functional food components and offers a scientific basis for dietary flavonoid-based interventions against MAFLD.展开更多
Stroke is an acute cerebrovascular event characterized by focal neurological deficits resulting from the interruption of cerebral blood flow.As the second leading cause of death globally,stroke is responsible for appr...Stroke is an acute cerebrovascular event characterized by focal neurological deficits resulting from the interruption of cerebral blood flow.As the second leading cause of death globally,stroke is responsible for approximately 6.5 million deaths annually,with a disability rate as high as 50%.Survivors often experience long-term motor,cognitive,and psychological impairments,placing substantial burdens on families and healthcare systems.Stroke is classified into two primary types:ischemic stroke,caused by cerebral artery embolism or thrombosis,and hemorrhagic stroke,resulting from blood vessel rupture.Clinically,it manifests as the sudden onset of neurological dysfunction,with typical symptoms including hemiparesis,dysarthria,sensory disturbances,aphasia,and visual impairments.展开更多
Monoterpenes(MTs)play crucial roles not only in atmospheric chemistry and global climate change but also in soil processes and soil ecology.Elevated nitrogen(N)deposition can influence soil microbial community and lit...Monoterpenes(MTs)play crucial roles not only in atmospheric chemistry and global climate change but also in soil processes and soil ecology.Elevated nitrogen(N)deposition can influence soil microbial community and litter decomposition,and consequently alters MT fluxes from forest floors and litter.Yet,the responses of soil and litter MT to increased N deposition remain poorly understood and the influences of N addition are sometimes contradictory.In the present study,static chambers were placed in masson pine forest(PF)and in monsoon evergreen broad-leaf forest(BF)at Dinghushan,subtropical China.The preconcentrator-GC–MS was used to analyze the effect of N addition on MT fluxes from the forest floors and litter.The results showed that under control treatment(without N addition),the total MT emission rates were 279.90±137.17 and 102.70±45.36 pmol m^(–2)s^(–1) in the PF and BF floors,respectively,withα-pinene being the largest MT species in the PF and limonene in the BF.α-pinene andβ-pinene emission rates decreased significantly in both forest floors after N addition,whereas a diverse trend was found for limonene and camphene in the PF floor.Furthermore,some MT fluxes showed significant negative correlations with soil respiration and soil temperature.Litter was important in MT fluxes from forest floors and its emission rates were enhanced by N addition.Moreover,different MT response to elevated N was found between the forest floor and litter.This study indicated that the elevated N deposition in the future would inhibit the MT emissions from the subtropical forest floor.展开更多
Wearable devices,such as data gloves and electronic skins,can perceive human instructions,behaviors and even emotions by tracking a hand's motion,with the help of knowledge learning.The shape or position single-mo...Wearable devices,such as data gloves and electronic skins,can perceive human instructions,behaviors and even emotions by tracking a hand's motion,with the help of knowledge learning.The shape or position single-mode sensor in such devices often lacks comprehensive information to perceive interactive gestures.Meanwhile,the limited computing power of wearable applications restricts the multimode fusion of different sensing data and the deployment of deep learning networks.We propose a perceptive fusion electronic skin(PFES)with a bioinspired hierarchical structure that utilizes the magnetization state of a magnetostrictive alloy film to be sensitive to external strain or magnetic field.Installed at the joints of a hand,the PFES realizes perception of curvature(joint shape)and magnetism(joint position)information by mapping corresponding signals to the two-directional continuous distribution such that the two edges represent the contributions of curvature radius and magnetic field,respectively.By autonomously selecting knowledge closer to the user's hand movement characteristics,the reinforced knowledge distillation method is developed to learn and compress a teacher model for rapid deployment on wearable devices.The PFES integrating the autonomous learning algorithm can fuse curvature-magnetism dual information,ultimately achieving human machine interaction with gesture recognition and haptic feedback for cross-space perception and manipulation.展开更多
Cerebrovascular disease is among the most common causes of permanent disability and mortality in adults and places immense pressure on health care resources.Metabolic diseases caused by susceptibility genes and unheal...Cerebrovascular disease is among the most common causes of permanent disability and mortality in adults and places immense pressure on health care resources.Metabolic diseases caused by susceptibility genes and unhealthy lifestyle play a key role in the development of cerebrovascular disease.Cardiometabolic disease is now well established and rapidly evolving.Cardiometabolic medicine,which considers metabolic issues and cardiovascular disease as an integrated whole,has been implemented in many countries worldwide.However,integrated management of metabolic risk factors and cerebrovascular disease is still in the initial stages.In this minireview,we propose a concept and definition of cerebrometabolic disease,describe its possible pathogenesis,summarize the recently proposed integrative therapeutic approach,and discuss future developments as well as challenges,with the aim of promoting a deeper understanding and integrated management of metabolic issues and cerebrovascular disease.展开更多
基金funded by the Natural Science Foundation of Shandong Province(ZR2023MH263)the China Postdoctoral Science Foundation(2023M733918,2023T160729)the Central Government Guidance Foundation for Local Science and Technology Development(YDZX2024133).
文摘Metabolic-associated fatty liver disease(MAFLD)is the most prevalent chronic liver disease globally,with no effective pharmacological treatments available for early-stage cases.Rutin,a bioactive flavonoid from Sophora japonica L.,exhibits diverse pharmacological effects,but its multi-pathway mechanisms in improving MAFLD remain unclear.In this study,we employed a high-fat diet(HFD)-induced MAFLD mouse model to investigate the therapeutic effects of rutin supplementation.Rutin supplementation significantly reduced blood lipid and liver lipid levels and alleviated liver injury in MAFLD model mice.Fecal microbiota transplantation experiments revealed that rutin alleviated MAFLD by modulating the gut microbiota composition.Through 16S rRNA sequencing analysis and non-targeted metabolomics analysis of the normal control(NC),HFD and rutin groups,rutin was found to alter key species(Ruminococcus torques)and associated metabolites(e.g.,7-dehydrocholesterol,short-chain fatty acids),suggesting a mechanism involving the gut microbiota.Antibiotic treatment experiments revealed that rutin alleviates MAFLD via the blood entry pathway.Network pharmacology analysis showed that rutin can directly act on targets closely related to MAFLD development,including tumor protein p53,epidermal growth factor receptor,and prostaglandin-endoperoxide synthase 2,as well as key signaling pathways such as PI3K/AKT and MAPK.Transcriptomics analysis of the NC,HFD and rutin groups revealed that rutin may ameliorate MAFLD through PI3K/AKT and MAPK signaling pathways,which might be enhanced by the gut microbiota and blood entry pathways.In conclusion,rutin can treat MAFLD through both the gut microbiota and blood entry pathways,resulting in a synergistic effect.Our study provides a novel strategy for evaluating functional food components and offers a scientific basis for dietary flavonoid-based interventions against MAFLD.
基金supported by grants from the National Natural Science Foundation of China(82071331)National Key Research and Development Program of China(2018YFC1312200)Canadian Institutes of Health Research(VWY).
文摘Stroke is an acute cerebrovascular event characterized by focal neurological deficits resulting from the interruption of cerebral blood flow.As the second leading cause of death globally,stroke is responsible for approximately 6.5 million deaths annually,with a disability rate as high as 50%.Survivors often experience long-term motor,cognitive,and psychological impairments,placing substantial burdens on families and healthcare systems.Stroke is classified into two primary types:ischemic stroke,caused by cerebral artery embolism or thrombosis,and hemorrhagic stroke,resulting from blood vessel rupture.Clinically,it manifests as the sudden onset of neurological dysfunction,with typical symptoms including hemiparesis,dysarthria,sensory disturbances,aphasia,and visual impairments.
基金the National Natural Science Foundation of China(Grant Nos.41877326 and 41473083)。
文摘Monoterpenes(MTs)play crucial roles not only in atmospheric chemistry and global climate change but also in soil processes and soil ecology.Elevated nitrogen(N)deposition can influence soil microbial community and litter decomposition,and consequently alters MT fluxes from forest floors and litter.Yet,the responses of soil and litter MT to increased N deposition remain poorly understood and the influences of N addition are sometimes contradictory.In the present study,static chambers were placed in masson pine forest(PF)and in monsoon evergreen broad-leaf forest(BF)at Dinghushan,subtropical China.The preconcentrator-GC–MS was used to analyze the effect of N addition on MT fluxes from the forest floors and litter.The results showed that under control treatment(without N addition),the total MT emission rates were 279.90±137.17 and 102.70±45.36 pmol m^(–2)s^(–1) in the PF and BF floors,respectively,withα-pinene being the largest MT species in the PF and limonene in the BF.α-pinene andβ-pinene emission rates decreased significantly in both forest floors after N addition,whereas a diverse trend was found for limonene and camphene in the PF floor.Furthermore,some MT fluxes showed significant negative correlations with soil respiration and soil temperature.Litter was important in MT fluxes from forest floors and its emission rates were enhanced by N addition.Moreover,different MT response to elevated N was found between the forest floor and litter.This study indicated that the elevated N deposition in the future would inhibit the MT emissions from the subtropical forest floor.
基金supported by the National Natural Science Foundation of China(No.51801053,52077052,52377007)the Natural Science Foundation of Hebei Province(E2022202067)the Central Guidance on Local Science and Technology Development Fund(No.226Z1704G).
文摘Wearable devices,such as data gloves and electronic skins,can perceive human instructions,behaviors and even emotions by tracking a hand's motion,with the help of knowledge learning.The shape or position single-mode sensor in such devices often lacks comprehensive information to perceive interactive gestures.Meanwhile,the limited computing power of wearable applications restricts the multimode fusion of different sensing data and the deployment of deep learning networks.We propose a perceptive fusion electronic skin(PFES)with a bioinspired hierarchical structure that utilizes the magnetization state of a magnetostrictive alloy film to be sensitive to external strain or magnetic field.Installed at the joints of a hand,the PFES realizes perception of curvature(joint shape)and magnetism(joint position)information by mapping corresponding signals to the two-directional continuous distribution such that the two edges represent the contributions of curvature radius and magnetic field,respectively.By autonomously selecting knowledge closer to the user's hand movement characteristics,the reinforced knowledge distillation method is developed to learn and compress a teacher model for rapid deployment on wearable devices.The PFES integrating the autonomous learning algorithm can fuse curvature-magnetism dual information,ultimately achieving human machine interaction with gesture recognition and haptic feedback for cross-space perception and manipulation.
基金the National Natural Science Foundation of China(grants no:82,071,331 and 81,870,942)National Key Research and Development Program of China(grant no:2018YFC1312200).
文摘Cerebrovascular disease is among the most common causes of permanent disability and mortality in adults and places immense pressure on health care resources.Metabolic diseases caused by susceptibility genes and unhealthy lifestyle play a key role in the development of cerebrovascular disease.Cardiometabolic disease is now well established and rapidly evolving.Cardiometabolic medicine,which considers metabolic issues and cardiovascular disease as an integrated whole,has been implemented in many countries worldwide.However,integrated management of metabolic risk factors and cerebrovascular disease is still in the initial stages.In this minireview,we propose a concept and definition of cerebrometabolic disease,describe its possible pathogenesis,summarize the recently proposed integrative therapeutic approach,and discuss future developments as well as challenges,with the aim of promoting a deeper understanding and integrated management of metabolic issues and cerebrovascular disease.
